IMP: Integrative Multi-species Prediction

Drosophila melanogaster

94 known processes

RpA-70 (Dmel_CG9633)

Replication Protein A 70

(Aliases: RPA,RPA 70,i164,dRP-A,RPA1,DmRPA,D-SSB,CG9633,Dmel\CG9633,dmrpa1,Ssb-70,Rpa-70,RP-A,D-RPA70,RpA70,DRP-A,RPA70)

Entrez: 40972
FLYBASE: FBgn0010173
UniProtKB: Q24492

Process Predictions
Disease Predictions

RpA-70 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
dna repair	GO:0006281	54	0.977	Human
double strand break repair	GO:0006302	26	0.964	Human
cellular response to dna damage stimulus	GO:0006974	223	0.883
negative regulation of cellular metabolic process	GO:0031324	382	0.250
cellular catabolic process	GO:0044248	372	0.213
chemotaxis	GO:0006935	249	0.181
positive regulation of developmental process	GO:0051094	143	0.178
developmental growth	GO:0048589	280	0.177
regulation of mitotic cell cycle	GO:0007346	190	0.174
regulation of multicellular organism growth	GO:0040014	40	0.153
chromatin organization	GO:0006325	207	0.151
positive regulation of cellular biosynthetic process	GO:0031328	316	0.137
mitotic cell cycle phase transition	GO:0044772	138	0.137
dna metabolic process	GO:0006259	227	0.126
response to ionizing radiation	GO:0010212	32	0.125
proteolysis	GO:0006508	192	0.118
double strand break repair via nonhomologous end joining	GO:0006303	5	0.114
regulation of cellular response to stress	GO:0080135	89	0.111
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.111
regulation of developmental growth	GO:0048638	174	0.102
regulation of response to stress	GO:0080134	200	0.097
negative regulation of response to stimulus	GO:0048585	258	0.096
regulation of gene expression epigenetic	GO:0040029	128	0.095
nuclear transport	GO:0051169	72	0.093
response to external biotic stimulus	GO:0043207	293	0.093
regulation of molecular function	GO:0065009	217	0.092
growth	GO:0040007	359	0.090
dna integrity checkpoint	GO:0031570	81	0.089
cellular amino acid metabolic process	GO:0006520	61	0.085
regulation of cell cycle phase transition	GO:1901987	130	0.076
establishment of localization in cell	GO:0051649	402	0.074
regulation of endopeptidase activity	GO:0052548	36	0.071
central nervous system development	GO:0007417	201	0.071
taxis	GO:0042330	304	0.070
recombinational repair	GO:0000725	13	0.064	Human
embryo development ending in birth or egg hatching	GO:0009792	152	0.063
negative regulation of gene expression	GO:0010629	387	0.063
double strand break repair via homologous recombination	GO:0000724	13	0.059	Human
dna damage checkpoint	GO:0000077	78	0.057
positive regulation of developmental growth	GO:0048639	62	0.055
regulation of cell differentiation	GO:0045595	302	0.053
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.051
macromolecule catabolic process	GO:0009057	161	0.050
positive regulation of endopeptidase activity	GO:0010950	26	0.050
ribonucleoside monophosphate catabolic process	GO:0009158	39	0.049
positive regulation of cellular protein metabolic process	GO:0032270	118	0.047
cellular response to chemical stimulus	GO:0070887	199	0.047
cell recognition	GO:0008037	102	0.046
cell death	GO:0008219	279	0.046
positive regulation of multicellular organismal process	GO:0051240	143	0.044
telomere organization	GO:0032200	21	0.044	Human
cellular macromolecule localization	GO:0070727	220	0.043
lateral inhibition	GO:0046331	206	0.043
anatomical structure homeostasis	GO:0060249	97	0.042	Human
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.042
protein targeting to nucleus	GO:0044744	51	0.042
regulation of cellular protein metabolic process	GO:0032268	243	0.039
brain development	GO:0007420	120	0.039
negative regulation of transcription dna templated	GO:0045892	237	0.039
positive regulation of macromolecule metabolic process	GO:0010604	405	0.039
muscle structure development	GO:0061061	224	0.039
homeostatic process	GO:0042592	199	0.039	Human
apoptotic process	GO:0006915	159	0.038
organic cyclic compound catabolic process	GO:1901361	168	0.037
positive regulation of protein metabolic process	GO:0051247	128	0.037
cell cycle phase transition	GO:0044770	140	0.036
programmed cell death	GO:0012501	257	0.036
protein localization	GO:0008104	284	0.036
cellular macromolecule catabolic process	GO:0044265	136	0.035
embryonic heart tube development	GO:0035050	22	0.035
transcription from rna polymerase ii promoter	GO:0006366	368	0.035
multicellular organism growth	GO:0035264	46	0.035
chromatin remodeling	GO:0006338	72	0.035
negative regulation of molecular function	GO:0044092	51	0.034
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.034
regulation of protein metabolic process	GO:0051246	256	0.032
positive regulation of signal transduction	GO:0009967	223	0.032
multicellular organismal reproductive behavior	GO:0033057	110	0.031
positive regulation of rna metabolic process	GO:0051254	271	0.031
vesicle mediated transport	GO:0016192	381	0.031
cardiovascular system development	GO:0072358	82	0.031
organonitrogen compound metabolic process	GO:1901564	318	0.031
regulation of cell death	GO:0010941	173	0.030
atp metabolic process	GO:0046034	49	0.030
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.030
regionalization	GO:0003002	416	0.030
negative regulation of biosynthetic process	GO:0009890	277	0.030
death	GO:0016265	284	0.029
single organism biosynthetic process	GO:0044711	206	0.029
organic substance transport	GO:0071702	257	0.028
muscle organ development	GO:0007517	127	0.028
endocytosis	GO:0006897	310	0.027
anterior posterior pattern specification	GO:0009952	136	0.027
regulation of peptidase activity	GO:0052547	39	0.027
positive regulation of phosphorus metabolic process	GO:0010562	139	0.026
phosphorylation	GO:0016310	294	0.026
aromatic compound catabolic process	GO:0019439	166	0.026
positive regulation of biosynthetic process	GO:0009891	316	0.026
protein maturation	GO:0051604	71	0.025
positive regulation of peptidase activity	GO:0010952	29	0.024
mitotic dna damage checkpoint	GO:0044773	74	0.024
chromosome organization	GO:0051276	360	0.024	Human
single organism intracellular transport	GO:1902582	207	0.024
positive regulation of response to stimulus	GO:0048584	323	0.024
segmentation	GO:0035282	207	0.024
positive regulation of cell death	GO:0010942	69	0.023
protein catabolic process	GO:0030163	101	0.023
cellular response to oxygen containing compound	GO:1901701	79	0.023
nucleotide excision repair	GO:0006289	8	0.023	Human
gene silencing	GO:0016458	138	0.023
negative regulation of signaling	GO:0023057	219	0.023
compound eye development	GO:0048749	307	0.023
head development	GO:0060322	135	0.023
regulation of cell cycle process	GO:0010564	181	0.023
aging	GO:0007568	143	0.023
response to abiotic stimulus	GO:0009628	341	0.023
response to organic substance	GO:0010033	284	0.022
notch signaling pathway	GO:0007219	120	0.022
macromolecular complex assembly	GO:0065003	256	0.022
determination of adult lifespan	GO:0008340	137	0.021
positive regulation of gene expression	GO:0010628	290	0.021
response to radiation	GO:0009314	155	0.020
nucleoside monophosphate metabolic process	GO:0009123	52	0.020
nuclear import	GO:0051170	51	0.020
positive regulation of signaling	GO:0023056	243	0.020
regulation of localization	GO:0032879	275	0.020
blastoderm segmentation	GO:0007350	159	0.019
positive regulation of molecular function	GO:0044093	136	0.019
negative regulation of cellular protein metabolic process	GO:0032269	85	0.019
positive regulation of proteolysis	GO:0045862	52	0.019
protein import	GO:0017038	55	0.019
negative regulation of cell communication	GO:0010648	223	0.019
positive regulation of cell communication	GO:0010647	250	0.018
intracellular transport	GO:0046907	228	0.018
dendrite development	GO:0016358	204	0.018
response to other organism	GO:0051707	293	0.018
multi organism reproductive behavior	GO:0044705	121	0.018
response to biotic stimulus	GO:0009607	294	0.018
catabolic process	GO:0009056	409	0.018
organ growth	GO:0035265	56	0.017
regulation of growth	GO:0040008	233	0.017
positive regulation of rna biosynthetic process	GO:1902680	266	0.017
ribonucleoside monophosphate metabolic process	GO:0009161	51	0.017
organic substance catabolic process	GO:1901575	308	0.017
anterior posterior axis specification embryo	GO:0008595	103	0.017
negative regulation of intrinsic apoptotic signaling pathway	GO:2001243	1	0.017
regulation of multicellular organismal development	GO:2000026	414	0.016
positive regulation of epidermal growth factor activated receptor activity	GO:0045741	1	0.016
regulation of cellular ketone metabolic process	GO:0010565	3	0.016
purine nucleoside monophosphate catabolic process	GO:0009128	38	0.016
positive regulation of intracellular signal transduction	GO:1902533	116	0.016
cellular nitrogen compound catabolic process	GO:0044270	165	0.016
regulation of proteolysis	GO:0030162	87	0.016
compound eye morphogenesis	GO:0001745	249	0.016
regulation of nervous system development	GO:0051960	248	0.016
atp catabolic process	GO:0006200	38	0.016
cellular protein catabolic process	GO:0044257	83	0.016
cell cycle g1 s phase transition	GO:0044843	31	0.015
regulation of establishment of protein localization	GO:0070201	61	0.015
nucleoside phosphate metabolic process	GO:0006753	162	0.015
negative regulation of rna biosynthetic process	GO:1902679	240	0.015
cellular amine metabolic process	GO:0044106	12	0.015
cell division	GO:0051301	248	0.015
negative regulation of mitotic cell cycle	GO:0045930	109	0.015
positive regulation of cell development	GO:0010720	61	0.015
positive regulation of cellular amine metabolic process	GO:0033240	0	0.015
telencephalon development	GO:0021537	2	0.015
protein phosphorylation	GO:0006468	169	0.015
positive regulation of programmed cell death	GO:0043068	62	0.015
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.015
ribose phosphate metabolic process	GO:0019693	145	0.015
carboxylic acid metabolic process	GO:0019752	92	0.015
neuron projection guidance	GO:0097485	241	0.014
heterocycle catabolic process	GO:0046700	166	0.014
mitotic spindle organization	GO:0007052	220	0.014
intracellular protein transport	GO:0006886	104	0.014
axon guidance	GO:0007411	233	0.014
nitrogen compound transport	GO:0071705	85	0.014
regulation of cysteine type endopeptidase activity	GO:2000116	27	0.014
positive regulation of nervous system development	GO:0051962	69	0.014
striated muscle tissue development	GO:0014706	27	0.014
nucleocytoplasmic transport	GO:0006913	72	0.013
regulation of intracellular protein transport	GO:0033157	46	0.013
purine nucleoside monophosphate metabolic process	GO:0009126	50	0.013
protein localization to nucleus	GO:0034504	55	0.013
striated muscle myosin thick filament assembly	GO:0071688	3	0.013
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.013
nucleobase containing compound catabolic process	GO:0034655	165	0.013
photoreceptor cell differentiation	GO:0046530	170	0.013
single organism nuclear import	GO:1902593	51	0.013
regulation of double strand break repair	GO:2000779	3	0.013
positive regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043280	23	0.013
body morphogenesis	GO:0010171	2	0.013
maternal determination of anterior posterior axis embryo	GO:0008358	74	0.013
regulation of neurogenesis	GO:0050767	158	0.013
defense response to gram negative bacterium	GO:0050829	94	0.013
small molecule metabolic process	GO:0044281	305	0.013
eye development	GO:0001654	323	0.013
tube morphogenesis	GO:0035239	191	0.013
inositol lipid mediated signaling	GO:0048017	4	0.013
chitin based larval cuticle pattern formation	GO:0035293	11	0.013
single organism catabolic process	GO:0044712	228	0.013
response to bacterium	GO:0009617	198	0.012
developmental maturation	GO:0021700	172	0.012
positive regulation of cell differentiation	GO:0045597	64	0.012
regulation of catalytic activity	GO:0050790	185	0.012
postreplication repair	GO:0006301	2	0.012
positive regulation of histone deacetylation	GO:0031065	2	0.012
protein transport	GO:0015031	155	0.012
defense response	GO:0006952	300	0.012
response to oxygen containing compound	GO:1901700	200	0.012
embryonic axis specification	GO:0000578	107	0.012
positive regulation of cellular component organization	GO:0051130	156	0.012
immune system process	GO:0002376	347	0.012
purine ribonucleoside monophosphate metabolic process	GO:0009167	50	0.012
larval development	GO:0002164	104	0.011
regulation of behavior	GO:0050795	75	0.011
protein processing	GO:0016485	68	0.011
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.011
tripartite regional subdivision	GO:0007351	103	0.011
regulation of defense response	GO:0031347	102	0.011
chromatin assembly or disassembly	GO:0006333	52	0.011
regulation of phosphate metabolic process	GO:0019220	210	0.011
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.011
regulation of transport	GO:0051049	181	0.011
non recombinational repair	GO:0000726	7	0.011
defense response to bacterium	GO:0042742	178	0.011
positive regulation of phosphate metabolic process	GO:0045937	139	0.011
purine nucleotide catabolic process	GO:0006195	109	0.011
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.011
protein import into nucleus	GO:0006606	51	0.011
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.011
eye photoreceptor cell differentiation	GO:0001754	145	0.010
endomembrane system organization	GO:0010256	119	0.010
cellular macromolecular complex assembly	GO:0034622	153	0.010
synapse organization	GO:0050808	196	0.010
cell cycle checkpoint	GO:0000075	95	0.010
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.010
regulation of cellular catabolic process	GO:0031329	157	0.010

RpA-70 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	disease of cellular proliferation	DOID:14566	0	0.035
	benign neoplasm	DOID:0060072	0	0.035

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