IMP: Integrative Multi-species Prediction

Drosophila melanogaster

156 known processes

Tl (Dmel_CG5490)

Toll

(Aliases: Fs(3)Tl,dToll,tl,mat(3)9,mel(3)10,Dmel\CG5490,mel(3)9,Toll-1,Toll1,T1,CG5490,dToll1,TL,CT17414,Fs(1)Tl,toll,toll-1)

FLYBASE: FBgn0003717
Entrez: 43222
UniProtKB: P08953
UniProtKB: T2GGK5

Process Predictions
Disease Predictions

Tl biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
immune system process	GO:0002376	347	0.999
motor neuron axon guidance	GO:0008045	58	0.999
regulation of immune effector process	GO:0002697	52	0.998
regulation of antifungal peptide production	GO:0002788	6	0.996
taxis	GO:0042330	304	0.996
immune effector process	GO:0002252	98	0.992
positive regulation of antifungal peptide production	GO:0002804	6	0.991
regulation of humoral immune response	GO:0002920	51	0.989
regulation of response to external stimulus	GO:0032101	115	0.988
cellular amide metabolic process	GO:0043603	80	0.987
humoral immune response	GO:0006959	117	0.982
regulation of antimicrobial peptide production	GO:0002784	44	0.981
neuron projection guidance	GO:0097485	241	0.980
peptide metabolic process	GO:0006518	80	0.979
regulation of defense response to fungus	GO:1900150	6	0.971
hemocyte differentiation	GO:0042386	38	0.970
antimicrobial humoral response	GO:0019730	99	0.966
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.948	Mouse
tissue morphogenesis	GO:0048729	297	0.948
immune response	GO:0006955	246	0.938
antimicrobial peptide production	GO:0002775	46	0.933
regulation of antifungal peptide biosynthetic process	GO:0002810	5	0.931
response to virus	GO:0009615	28	0.928	Zebrafish Mouse
regulation of multi organism process	GO:0043900	131	0.928
cell motility	GO:0048870	251	0.925
intracellular signal transduction	GO:0035556	300	0.921	Mouse
axon guidance	GO:0007411	233	0.920
positive regulation of signal transduction	GO:0009967	223	0.918	Mouse
transcription from rna polymerase ii promoter	GO:0006366	368	0.905	Mouse
defense response to fungus	GO:0050832	48	0.904
regulation of immune response	GO:0050776	118	0.904
oocyte development	GO:0048599	124	0.904
gastrulation	GO:0007369	70	0.902
regulation of antimicrobial peptide biosynthetic process	GO:0002805	38	0.891
embryonic hemopoiesis	GO:0035162	26	0.887
regulation of developmental growth	GO:0048638	174	0.883
production of molecular mediator of immune response	GO:0002440	46	0.877
regulation of cellular amide metabolic process	GO:0034248	39	0.833
phosphorylation	GO:0016310	294	0.831	Mouse
chemotaxis	GO:0006935	249	0.823
oocyte axis specification	GO:0007309	108	0.792
regulation of response to biotic stimulus	GO:0002831	63	0.790
defense response	GO:0006952	300	0.785
positive regulation of gene expression	GO:0010628	290	0.783	Mouse
positive regulation of rna biosynthetic process	GO:1902680	266	0.768	Mouse
mesoderm morphogenesis	GO:0048332	22	0.762
hemopoiesis	GO:0030097	46	0.760
oocyte differentiation	GO:0009994	145	0.758
regionalization	GO:0003002	416	0.757
positive regulation of transcription dna templated	GO:0045893	266	0.740	Mouse
protein localization to nucleus	GO:0034504	55	0.734
negative regulation of signaling	GO:0023057	219	0.719
cellular response to chemical stimulus	GO:0070887	199	0.692
immune response activating signal transduction	GO:0002757	2	0.686	Mouse
antifungal humoral response	GO:0019732	12	0.686
larval lymph gland hemopoiesis	GO:0035167	17	0.674
dorsal ventral pattern formation	GO:0009953	133	0.671
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.666
embryonic development via the syncytial blastoderm	GO:0001700	148	0.645
bmp signaling pathway	GO:0030509	27	0.641
positive regulation of response to stimulus	GO:0048584	323	0.634
response to nitrogen compound	GO:1901698	90	0.627	Mouse
synapse assembly	GO:0007416	143	0.613
protein complex localization	GO:0031503	4	0.611
regulation of immune system process	GO:0002682	176	0.576
formation of primary germ layer	GO:0001704	24	0.571
peptide biosynthetic process	GO:0043043	42	0.551
positive regulation of intracellular signal transduction	GO:1902533	116	0.549	Mouse
axonogenesis	GO:0007409	290	0.539
positive regulation of i kappab kinase nf kappab signaling	GO:0043123	1	0.537	Mouse
innate immune response	GO:0045087	144	0.533
positive regulation of multicellular organismal process	GO:0051240	143	0.527	Mouse
positive regulation of phosphate metabolic process	GO:0045937	139	0.527	Mouse
oocyte construction	GO:0007308	112	0.523
ribonucleoside metabolic process	GO:0009119	127	0.522
regulation of production of molecular mediator of immune response	GO:0002700	44	0.522
regulation of cell differentiation	GO:0045595	302	0.511
regulation of nf kappab import into nucleus	GO:0042345	1	0.500
positive regulation of pathway restricted smad protein phosphorylation	GO:0010862	1	0.488
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.488	Mouse
localization of cell	GO:0051674	257	0.488
negative regulation of cell communication	GO:0010648	223	0.483
positive regulation of signaling	GO:0023056	243	0.476	Mouse
embryonic organ development	GO:0048568	50	0.467
regulation of cell morphogenesis	GO:0022604	163	0.467
endodermal cell differentiation	GO:0035987	3	0.464
neuromuscular junction development	GO:0007528	149	0.456
guanosine containing compound metabolic process	GO:1901068	74	0.446
determination of dorsal ventral asymmetry	GO:0048262	3	0.441
protein targeting to nucleus	GO:0044744	51	0.439
regulation of protein transport	GO:0051223	57	0.435
cell maturation	GO:0048469	144	0.433
regulation of localization	GO:0032879	275	0.426
digestive system development	GO:0055123	149	0.425
regulation of hemocyte differentiation	GO:0045610	22	0.423
negative regulation of signal transduction	GO:0009968	206	0.414
cell migration	GO:0016477	238	0.411
embryonic heart tube development	GO:0035050	22	0.408
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.407	Mouse
regulation of i kappab kinase nf kappab signaling	GO:0043122	2	0.399	Mouse
amide biosynthetic process	GO:0043604	42	0.396
axis specification	GO:0009798	167	0.381
forebrain development	GO:0030900	2	0.380
torso signaling pathway	GO:0008293	21	0.376
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	65	0.375
anterior posterior axis specification embryo	GO:0008595	103	0.375
single organism cellular localization	GO:1902580	180	0.372
positive regulation of antimicrobial peptide production	GO:0002225	28	0.369
positive regulation of bmp signaling pathway	GO:0030513	5	0.366
mesoderm formation	GO:0001707	21	0.359
imaginal disc derived wing morphogenesis	GO:0007476	337	0.357
post embryonic hemopoiesis	GO:0035166	17	0.356
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.351
immune system development	GO:0002520	57	0.343
regulation of cuticle pigmentation	GO:0048079	16	0.341
cell division	GO:0051301	248	0.339
response to external biotic stimulus	GO:0043207	293	0.338
tube development	GO:0035295	244	0.336
regulation of cholesterol transport	GO:0032374	1	0.326
protein transport	GO:0015031	155	0.323
apoptotic signaling pathway	GO:0097190	27	0.316
post embryonic appendage morphogenesis	GO:0035120	385	0.315
activation of innate immune response	GO:0002218	4	0.315	Mouse
heart development	GO:0007507	82	0.309
striated muscle tissue development	GO:0014706	27	0.304
positive regulation of cell communication	GO:0010647	250	0.301	Mouse
blastoderm segmentation	GO:0007350	159	0.296
positive regulation of nucleocytoplasmic transport	GO:0046824	24	0.296
regulation of intracellular signal transduction	GO:1902531	236	0.294	Mouse
organonitrogen compound metabolic process	GO:1901564	318	0.293
axon development	GO:0061564	297	0.292
regulation of intracellular protein transport	GO:0033157	46	0.288
protein localization	GO:0008104	284	0.288
single organism nuclear import	GO:1902593	51	0.284
regulation of catabolic process	GO:0009894	170	0.282
regulation of bmp signaling pathway	GO:0030510	23	0.280
positive regulation of cellular component biogenesis	GO:0044089	80	0.278
i kappab kinase nf kappab signaling	GO:0007249	6	0.274	Mouse
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.273
purine nucleoside catabolic process	GO:0006152	112	0.271
pattern recognition receptor signaling pathway	GO:0002221	2	0.269	Mouse
embryonic morphogenesis	GO:0048598	206	0.268
protein import	GO:0017038	55	0.261
digestive tract morphogenesis	GO:0048546	127	0.260
synaptic growth at neuromuscular junction	GO:0051124	119	0.256
segmentation	GO:0035282	207	0.254
regulation of developmental pigmentation	GO:0048070	24	0.254
regulation of response to stress	GO:0080134	200	0.248
morphogenesis of embryonic epithelium	GO:0016331	94	0.246
cellular macromolecule localization	GO:0070727	220	0.246
carbohydrate derivative metabolic process	GO:1901135	217	0.244	Fly
negative regulation of nf kappab import into nucleus	GO:0042347	1	0.241
protein import into nucleus	GO:0006606	51	0.240
nucleoside catabolic process	GO:0009164	112	0.236
regulation of multicellular organismal development	GO:2000026	414	0.235
glycosyl compound catabolic process	GO:1901658	112	0.233
regulation of response to wounding	GO:1903034	19	0.233	Mouse
nuclear import	GO:0051170	51	0.232
positive regulation of biosynthetic process	GO:0009891	316	0.232
negative regulation of multicellular organismal process	GO:0051241	142	0.222	Mouse
nucleocytoplasmic transport	GO:0006913	72	0.218
cardiac cell fate commitment	GO:0060911	17	0.214
neuron recognition	GO:0008038	101	0.213
purine ribonucleoside catabolic process	GO:0046130	112	0.211
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	38	0.209
zygotic determination of anterior posterior axis embryo	GO:0007354	27	0.209
regulation of cell migration	GO:0030334	22	0.208
central nervous system development	GO:0007417	201	0.207
regulation of phosphate metabolic process	GO:0019220	210	0.206	Mouse
protein modification process	GO:0036211	438	0.205	Fly
positive regulation of defense response	GO:0031349	59	0.204
guanosine containing compound catabolic process	GO:1901069	74	0.204
regulation of cell motility	GO:2000145	23	0.201
regulation of anatomical structure morphogenesis	GO:0022603	242	0.200
digestive tract development	GO:0048565	149	0.199
dendrite morphogenesis	GO:0048813	199	0.197
protein phosphorylation	GO:0006468	169	0.192
protein targeting	GO:0006605	64	0.191
response to endogenous stimulus	GO:0009719	119	0.188
antifungal peptide biosynthetic process	GO:0002783	5	0.188
morphogenesis of an epithelium	GO:0002009	276	0.186
developmental maturation	GO:0021700	172	0.184
regulation of nervous system development	GO:0051960	248	0.182
regulation of catalytic activity	GO:0050790	185	0.181
muscle structure development	GO:0061061	224	0.181
regulation of cellular localization	GO:0060341	136	0.179
positive regulation of immune effector process	GO:0002699	28	0.178
endodermal cell fate commitment	GO:0001711	3	0.176
positive regulation of phosphorylation	GO:0042327	87	0.175	Mouse
carbohydrate derivative catabolic process	GO:1901136	118	0.174
gtp metabolic process	GO:0046039	72	0.174
response to biotic stimulus	GO:0009607	294	0.174
regulation of protein import into nucleus	GO:0042306	28	0.172
dorsal closure	GO:0007391	79	0.171
mesoderm development	GO:0007498	78	0.169
regulation of autophagy	GO:0010506	62	0.169
positive regulation of antifungal peptide biosynthetic process	GO:0006967	5	0.168
cell proliferation involved in imaginal disc derived wing morphogenesis	GO:0090255	2	0.167
antibacterial humoral response	GO:0019731	44	0.167
regulation of phosphorylation	GO:0042325	147	0.164	Mouse
positive regulation of cell motility	GO:2000147	3	0.163
regulation of cytoplasmic transport	GO:1903649	47	0.163
cell proliferation	GO:0008283	299	0.161
hematopoietic or lymphoid organ development	GO:0048534	57	0.160
tripartite regional subdivision	GO:0007351	103	0.159
establishment of protein localization	GO:0045184	163	0.159
response to fungus	GO:0009620	50	0.159
regulation of phosphorus metabolic process	GO:0051174	210	0.158	Mouse
cytoplasmic transport	GO:0016482	130	0.157
wing disc morphogenesis	GO:0007472	344	0.155
defense response to other organism	GO:0098542	225	0.155
female meiotic division	GO:0007143	70	0.153
regulation of protein kinase activity	GO:0045859	51	0.153
response to growth factor	GO:0070848	31	0.149
regulation of cell development	GO:0060284	215	0.148
nuclear transport	GO:0051169	72	0.146
positive regulation of peptidyl tyrosine phosphorylation	GO:0050731	4	0.145
imaginal disc derived appendage development	GO:0048737	399	0.144
i kappab phosphorylation	GO:0007252	3	0.141
regulation of kinase activity	GO:0043549	53	0.138
intracellular protein transport	GO:0006886	104	0.137
regulation of growth	GO:0040008	233	0.136
positive regulation of response to external stimulus	GO:0032103	44	0.134
purine ribonucleoside metabolic process	GO:0046128	127	0.133
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.131
regulation of establishment of protein localization	GO:0070201	61	0.131
stem cell division	GO:0017145	69	0.129
gonad development	GO:0008406	50	0.127
regulation of pathway restricted smad protein phosphorylation	GO:0060393	1	0.125
development of primary sexual characteristics	GO:0045137	50	0.125
antimicrobial peptide biosynthetic process	GO:0002777	38	0.125
regulation of transport	GO:0051049	181	0.125
positive regulation of growth	GO:0045927	75	0.121
extrinsic apoptotic signaling pathway	GO:0097191	1	0.121
cell activation	GO:0001775	9	0.119	Mouse
determination of ventral identity	GO:0048264	1	0.118
connective tissue development	GO:0061448	3	0.116
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.115	Mouse
renal tubule development	GO:0061326	64	0.113
peripheral nervous system development	GO:0007422	52	0.110	Fly
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.108	Mouse
inositol lipid mediated signaling	GO:0048017	4	0.108
positive regulation of cellular component organization	GO:0051130	156	0.105
ribonucleoside catabolic process	GO:0042454	112	0.103
catabolic process	GO:0009056	409	0.102
nf kappab import into nucleus	GO:0042348	1	0.101
negative regulation of immune system process	GO:0002683	50	0.101
gtp catabolic process	GO:0006184	72	0.101
regulation of cell junction assembly	GO:1901888	2	0.100
organic acid metabolic process	GO:0006082	103	0.100
carboxylic acid metabolic process	GO:0019752	92	0.099
response to osmotic stress	GO:0006970	14	0.099
organonitrogen compound biosynthetic process	GO:1901566	117	0.098
cellular protein localization	GO:0034613	160	0.095
pathway restricted smad protein phosphorylation	GO:0060389	1	0.094
purine nucleoside metabolic process	GO:0042278	127	0.094
activation of protein kinase activity	GO:0032147	12	0.093
regulation of nucleocytoplasmic transport	GO:0046822	35	0.092
regulation of neurogenesis	GO:0050767	158	0.091
regulation of innate immune response	GO:0045088	71	0.091	Mouse
stress activated mapk cascade	GO:0051403	52	0.088	Mouse
regulation of cellular catabolic process	GO:0031329	157	0.088
melanotic encapsulation of foreign target	GO:0035011	30	0.088
regulation of synaptic growth at neuromuscular junction	GO:0008582	89	0.085
immune response regulating signaling pathway	GO:0002764	2	0.085	Mouse
positive regulation of molecular function	GO:0044093	136	0.085	Mouse
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.085
anterior posterior axis specification	GO:0009948	109	0.085
regulation of protein modification process	GO:0031399	112	0.085	Fly
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090100	9	0.084
regulation of protein localization	GO:0032880	76	0.082
negative regulation of autophagy	GO:0010507	16	0.081
dorsal ventral axis specification	GO:0009950	66	0.080
positive regulation of phosphorus metabolic process	GO:0010562	139	0.079	Mouse
malpighian tubule development	GO:0072002	64	0.077
regulation of protein targeting	GO:1903533	29	0.077
head development	GO:0060322	135	0.077
regulation of organ morphogenesis	GO:2000027	78	0.077
cell fate commitment involved in formation of primary germ layer	GO:0060795	10	0.076
positive regulation of cell adhesion	GO:0045785	10	0.074
unidimensional cell growth	GO:0009826	15	0.072
germ cell migration	GO:0008354	43	0.072
regulation of intracellular transport	GO:0032386	64	0.072
positive regulation of cellular catabolic process	GO:0031331	95	0.071
phosphatidylinositol 3 kinase signaling	GO:0014065	4	0.071
small molecule metabolic process	GO:0044281	305	0.071
positive regulation of developmental growth	GO:0048639	62	0.070
cell cycle g1 s phase transition	GO:0044843	31	0.070
secondary metabolic process	GO:0019748	75	0.069
dephosphorylation	GO:0016311	51	0.068
establishment of protein localization to organelle	GO:0072594	62	0.067
anterior posterior pattern specification imaginal disc	GO:0007448	16	0.066
developmental growth	GO:0048589	280	0.066
regulation of programmed cell death	GO:0043067	152	0.066
retinal ganglion cell axon guidance	GO:0031290	12	0.066
organophosphate metabolic process	GO:0019637	195	0.065
endoderm formation	GO:0001706	3	0.065
positive regulation of immune system process	GO:0002684	68	0.065
positive regulation of protein metabolic process	GO:0051247	128	0.064	Mouse
nucleoside triphosphate metabolic process	GO:0009141	120	0.064
cellular response to endogenous stimulus	GO:0071495	80	0.064
cell rearrangement involved in malpighian tubule morphogenesis	GO:0061334	3	0.062
actin cytoskeleton organization	GO:0030036	206	0.062
hindgut morphogenesis	GO:0007442	58	0.062
regulation of locomotion	GO:0040012	42	0.062
purine containing compound metabolic process	GO:0072521	155	0.062
imaginal disc pattern formation	GO:0007447	91	0.061
regulation of epithelial cell migration	GO:0010632	12	0.061
hematopoietic progenitor cell differentiation	GO:0002244	1	0.061
negative regulation of cell death	GO:0060548	81	0.060
cell fate determination	GO:0001709	91	0.060
antifungal peptide production	GO:0002781	7	0.059
instar larval development	GO:0002168	55	0.057
positive regulation of secretion	GO:0051047	22	0.057
pigment metabolic process	GO:0042440	84	0.057
cellular amino acid metabolic process	GO:0006520	61	0.056
defense response to bacterium	GO:0042742	178	0.056
membrane organization	GO:0061024	112	0.054
negative regulation of lipid storage	GO:0010888	3	0.054
regulation of apoptotic process	GO:0042981	130	0.053
regulation of jun kinase activity	GO:0043506	8	0.053
regulation of cell projection organization	GO:0031344	92	0.053
regulation of hydrolase activity	GO:0051336	97	0.053
positive regulation of protein localization to nucleus	GO:1900182	21	0.052
cellular response to organic substance	GO:0071310	132	0.052
organic substance transport	GO:0071702	257	0.052
positive regulation of protein import into nucleus	GO:0042307	21	0.052
positive regulation of cell differentiation	GO:0045597	64	0.052
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.052
positive regulation of developmental process	GO:0051094	143	0.052
convergent extension	GO:0060026	2	0.051
regulation of cell cell adhesion	GO:0022407	21	0.051
regulation of cell proliferation	GO:0042127	163	0.051
regulation of dendrite development	GO:0050773	37	0.050
chorion containing eggshell pattern formation	GO:0030381	11	0.050
chromatin modification	GO:0016568	147	0.050
mapk cascade	GO:0000165	107	0.049	Mouse
oxoacid metabolic process	GO:0043436	103	0.049
body morphogenesis	GO:0010171	2	0.048	Worm
negative regulation of synapse assembly	GO:0051964	39	0.048
positive regulation of macromolecule metabolic process	GO:0010604	405	0.048	Mouse
regulation of transferase activity	GO:0051338	58	0.048
cellular response to growth factor stimulus	GO:0071363	30	0.047
positive regulation of nervous system development	GO:0051962	69	0.047
regulation of cell morphogenesis involved in differentiation	GO:0010769	61	0.047
negative regulation of apoptotic process	GO:0043066	63	0.047
positive regulation of mapk cascade	GO:0043410	63	0.046	Mouse
positive regulation of jun kinase activity	GO:0043507	4	0.046
positive regulation of response to biotic stimulus	GO:0002833	31	0.046
positive regulation of cell migration	GO:0030335	2	0.046
stem cell proliferation	GO:0072089	88	0.046
positive regulation of intracellular transport	GO:0032388	42	0.045
adult locomotory behavior	GO:0008344	76	0.044
neuroblast division	GO:0055057	35	0.044
autophagy	GO:0006914	108	0.044
dendrite development	GO:0016358	204	0.044
larval development	GO:0002164	104	0.044	Worm
gland development	GO:0048732	191	0.044
negative regulation of transforming growth factor beta receptor signaling pathway	GO:0030512	4	0.044
transforming growth factor beta receptor signaling pathway	GO:0007179	16	0.043
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.043
negative regulation of synaptic growth at neuromuscular junction	GO:0045886	39	0.043
regulation of cellular component movement	GO:0051270	42	0.042
response to uv	GO:0009411	24	0.042
regulation of reproductive process	GO:2000241	54	0.041
embryonic pattern specification	GO:0009880	174	0.041
cell elongation involved in imaginal disc derived wing morphogenesis	GO:0090254	5	0.041
jak stat cascade	GO:0007259	49	0.041
determination of bilateral symmetry	GO:0009855	13	0.040
positive regulation of protein transport	GO:0051222	37	0.040
tor signaling	GO:0031929	32	0.040
signal transduction by phosphorylation	GO:0023014	107	0.040	Mouse
jnk cascade	GO:0007254	50	0.040	Mouse
positive regulation of cell size	GO:0045793	21	0.040
embryo development ending in birth or egg hatching	GO:0009792	152	0.039	Worm
cell projection assembly	GO:0030031	94	0.039
cellular protein modification process	GO:0006464	438	0.039	Fly
regulation of jnk cascade	GO:0046328	40	0.038	Mouse
cellular lipid metabolic process	GO:0044255	83	0.038
negative regulation of wnt signaling pathway	GO:0030178	28	0.038
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.037
nucleotide metabolic process	GO:0009117	161	0.037
embryonic axis specification	GO:0000578	107	0.037
positive regulation of catabolic process	GO:0009896	105	0.037
peptidyl threonine modification	GO:0018210	3	0.036
regulation of stress activated mapk cascade	GO:0032872	41	0.036	Mouse
mitochondrion organization	GO:0007005	65	0.036
regulation of lipid transport	GO:0032368	3	0.036
cellular response to transforming growth factor beta stimulus	GO:0071560	18	0.036
peptidyl amino acid modification	GO:0018193	105	0.036
purine ribonucleotide metabolic process	GO:0009150	145	0.035
negative regulation of programmed cell death	GO:0043069	72	0.035
negative regulation of cell cell adhesion	GO:0022408	8	0.035
purine containing compound catabolic process	GO:0072523	112	0.035
cardiocyte differentiation	GO:0035051	29	0.035
positive regulation of protein kinase activity	GO:0045860	25	0.035
nucleoside metabolic process	GO:0009116	127	0.035
imaginal disc derived wing vein morphogenesis	GO:0008586	44	0.035
compound eye development	GO:0048749	307	0.034
wing disc anterior posterior pattern formation	GO:0048100	5	0.034
mitotic spindle organization	GO:0007052	220	0.034
nucleobase containing small molecule metabolic process	GO:0055086	174	0.034
positive regulation of immune response	GO:0050778	63	0.033
brain development	GO:0007420	120	0.033
regulation of transcription factor import into nucleus	GO:0042990	22	0.033
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.033
positive regulation of cell morphogenesis involved in differentiation	GO:0010770	12	0.033
cardiac cell fate determination	GO:0060913	3	0.033
negative regulation of cellular component organization	GO:0051129	108	0.033
head involution	GO:0008258	35	0.033
response to lipopolysaccharide	GO:0032496	4	0.032
regulation of cell death	GO:0010941	173	0.032
regulation of membrane potential	GO:0042391	35	0.032
regulation of neuron differentiation	GO:0045664	103	0.032
nucleobase containing compound catabolic process	GO:0034655	165	0.032
negative regulation of response to stimulus	GO:0048585	258	0.032
tube morphogenesis	GO:0035239	191	0.032
encapsulation of foreign target	GO:0035010	38	0.031
pole plasm mrna localization	GO:0019094	49	0.031
regulation of cell adhesion	GO:0030155	27	0.031
bmp signaling pathway involved in malpighian tubule cell chemotaxis	GO:0061353	3	0.031
activation of immune response	GO:0002253	5	0.031	Mouse
purine ribonucleotide catabolic process	GO:0009154	109	0.030
single organism carbohydrate metabolic process	GO:0044723	72	0.030	Fly
regulation of synaptic transmission	GO:0050804	69	0.030
regulation of protein complex assembly	GO:0043254	42	0.030
endocytosis	GO:0006897	310	0.029
exocrine system development	GO:0035272	162	0.029
vesicle mediated transport	GO:0016192	381	0.029
carbohydrate metabolic process	GO:0005975	82	0.029	Fly
regulation of synapse assembly	GO:0051963	94	0.028
single organism catabolic process	GO:0044712	228	0.028
negative regulation of rna biosynthetic process	GO:1902679	240	0.028
salivary gland development	GO:0007431	162	0.028
oocyte microtubule cytoskeleton organization	GO:0016325	35	0.027
glycosyl compound metabolic process	GO:1901657	127	0.027
muscle cell fate specification	GO:0042694	7	0.027
positive regulation of humoral immune response	GO:0002922	28	0.027
establishment of localization in cell	GO:0051649	402	0.027
ectodermal placode formation	GO:0060788	4	0.027
positive regulation of protein complex assembly	GO:0031334	22	0.027
regulation of apoptotic signaling pathway	GO:2001233	10	0.027
neuroblast proliferation	GO:0007405	74	0.027
regulation of cell proliferation involved in imaginal disc derived wing morphogenesis	GO:0090256	2	0.026
adult chitin containing cuticle pigmentation	GO:0048085	16	0.026
positive regulation of lipid metabolic process	GO:0045834	4	0.026
positive regulation of synapse assembly	GO:0051965	29	0.026
regulation of cell size	GO:0008361	63	0.026
cell adhesion	GO:0007155	136	0.026	Fly
antibacterial peptide biosynthetic process	GO:0002780	22	0.026
positive regulation of gtpase activity	GO:0043547	43	0.026
response to wounding	GO:0009611	94	0.025	Mouse
regulation of cellular amine metabolic process	GO:0033238	3	0.025
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.025
regulation of axonogenesis	GO:0050770	32	0.025
cell cycle phase transition	GO:0044770	140	0.025
purine nucleotide metabolic process	GO:0006163	146	0.025
ribonucleoprotein complex disassembly	GO:0032988	1	0.025
maintenance of protein location in cell	GO:0032507	26	0.025
negative regulation of rna metabolic process	GO:0051253	251	0.024
negative regulation of cell differentiation	GO:0045596	143	0.024
trunk segmentation	GO:0035290	8	0.024
eye antennal disc development	GO:0035214	60	0.024
positive regulation of hydrolase activity	GO:0051345	78	0.024
adherens junction assembly	GO:0034333	11	0.024
growth	GO:0040007	359	0.024
muscle cell fate commitment	GO:0042693	14	0.024
specification of symmetry	GO:0009799	13	0.023
nucleoside phosphate metabolic process	GO:0006753	162	0.023
organophosphate catabolic process	GO:0046434	112	0.023
melanization defense response	GO:0035006	45	0.023
purine nucleotide catabolic process	GO:0006195	109	0.023
regulation of protein phosphorylation	GO:0001932	64	0.022
proteolysis	GO:0006508	192	0.022
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.022
pole plasm rna localization	GO:0007316	52	0.022
appendage morphogenesis	GO:0035107	397	0.022
enteroendocrine cell differentiation	GO:0035883	1	0.022
death	GO:0016265	284	0.022
biological adhesion	GO:0022610	138	0.022	Fly
regulation of molecular function	GO:0065009	217	0.022	Mouse
negative regulation of cell cycle process	GO:0010948	109	0.022
regulation of ion transport	GO:0043269	39	0.021
gland morphogenesis	GO:0022612	145	0.021
positive regulation of synaptic growth at neuromuscular junction	GO:0045887	26	0.021
regulation of nucleotide catabolic process	GO:0030811	48	0.021
regulation of defense response	GO:0031347	102	0.021
mesenchymal cell differentiation	GO:0048762	1	0.021
tissue homeostasis	GO:0001894	36	0.021	Mouse
chaeta development	GO:0022416	97	0.021
oocyte microtubule cytoskeleton polarization	GO:0008103	22	0.021

Tl disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of cellular proliferation	DOID:14566	0.071
cancer	DOID:162	0.071
organ system cancer	DOID:0050686	0.039
disease of anatomical entity	DOID:7	0.027
meningioma	DOID:3565	0.027
nervous system cancer	DOID:3093	0.027
familial meningioma	DOID:4586	0.027
central nervous system cancer	DOID:3620	0.027

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