Drosophila melanogaster

16 known processes

His2Av (Dmel_CG5499)

Histone H2A variant

(Aliases: H2avD,h2AvD,gamma-HIS2AV,5499,HIS2AVD,l(3)05146,H2A.X,H2A.Z,H2A.F/Z,H2av,His2AV,His2AvD,HIS2AV,H2AV_DROM,his,H2a.V,gamma-His2Av,H2Av,Hist2av,l(3)97Dd,l(3)810,l(3)L1602,H2AvD,H2AX,H2AZ,gamma-H2Av,HisH2Av,Dmel\CG5499,H2AV,CG5499)

His2Av biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
chromatin silencingGO:0006342760.999
Yeast
negative regulation of gene expression epigeneticGO:0045814770.996
Yeast
negative regulation of transcription dna templatedGO:00458922370.986
Yeast
negative regulation of rna metabolic processGO:00512532510.982
Yeast
negative regulation of gene expressionGO:00106293870.975
Yeast Worm
negative regulation of macromolecule biosynthetic processGO:00105582700.972
Yeast
negative regulation of rna biosynthetic processGO:19026792400.967
Yeast
protein dna complex subunit organizationGO:0071824860.967
negative regulation of cellular biosynthetic processGO:00313272770.949
Yeast
mitotic g2 m transition checkpointGO:0044818700.948
meiotic cell cycle processGO:19030461320.944
Worm
regulation of gene expression epigeneticGO:00400291280.935
Yeast Worm
chromatin remodelingGO:0006338720.934
Yeast
dna integrity checkpointGO:0031570810.922
chromatin organizationGO:00063252070.911
Yeast
internal protein amino acid acetylationGO:0006475380.902
negative regulation of cellular macromolecule biosynthetic processGO:20001132670.870
Yeast
negative regulation of cellular metabolic processGO:00313243820.866
Yeast
dna damage checkpointGO:0000077780.861
negative regulation of nucleobase containing compound metabolic processGO:00459342610.857
Yeast
histone acetylationGO:0016573380.841
atp dependent chromatin remodelingGO:0043044220.827
nucleosome organizationGO:0034728590.824
mitotic g2 dna damage checkpointGO:0007095690.801
mitotic dna integrity checkpointGO:0044774750.758
g2 dna damage checkpointGO:0031572690.754
regulation of cell cycle phase transitionGO:19019871300.742
histone exchangeGO:0043486210.720
cellular protein modification processGO:00064644380.716
cellular response to dna damage stimulusGO:00069742230.672
negative regulation of biosynthetic processGO:00098902770.672
Yeast
chromatin assemblyGO:0031497480.664
mitotic dna damage checkpointGO:0044773740.631
gene silencingGO:00164581380.609
Yeast Worm
protein dna complex assemblyGO:0065004630.601
dna conformation changeGO:00711031050.600
negative regulation of nucleic acid templated transcriptionGO:19035072400.591
Yeast
negative regulation of cell cycle phase transitionGO:19019881030.580
protein acetylationGO:0006473390.577
histone modificationGO:00165701060.543
negative regulation of nitrogen compound metabolic processGO:00511722650.539
Yeast
mrna processingGO:00063971040.528
meiotic cell cycleGO:00513211710.462
Worm
chromatin modificationGO:00165681470.458
Yeast
internal peptidyl lysine acetylationGO:0018393380.453
dna packagingGO:0006323910.441
positive regulation of nitrogen compound metabolic processGO:00511733540.441
Human
macromolecular complex assemblyGO:00650032560.421
covalent chromatin modificationGO:00165691060.416
negative regulation of signalingGO:00230572190.410
regulation of chromatin silencingGO:0031935360.408
meiotic nuclear divisionGO:00071261510.398
Worm
regulation of gene silencingGO:0060968630.388
nucleotide excision repairGO:000628980.372
negative regulation of cell communicationGO:00106482230.366
meiosis iGO:0007127590.356
sex differentiationGO:0007548810.351
Worm
multi organism behaviorGO:00517051750.347
nuclear divisionGO:00002803320.336
Worm
regulation of mitotic cell cycleGO:00073461900.328
negative regulation of cell cycle processGO:00109481090.327
transcription from rna polymerase ii promoterGO:00063663680.326
Human Yeast
reproductive system developmentGO:0061458740.324
Worm
mrna metabolic processGO:00160711240.322
Yeast
endocytosisGO:00068973100.317
catabolic processGO:00090564090.300
Yeast
body morphogenesisGO:001017120.291
Worm
cellular macromolecule catabolic processGO:00442651360.282
Yeast
negative regulation of mitotic cell cycleGO:00459301090.277
rna splicing via transesterification reactions with bulged adenosine as nucleophileGO:0000377730.276
protein modification processGO:00362114380.270
phosphorylationGO:00163102940.270
regulation of mitotic cell cycle phase transitionGO:19019901300.264
chromatin assembly or disassemblyGO:0006333520.264
histone h2a acetylationGO:004396810.247
negative regulation of mitotic cell cycle phase transitionGO:19019911030.243
mitotic cell cycle checkpointGO:0007093880.239
cellular macromolecular complex assemblyGO:00346221530.228
heterocycle catabolic processGO:00467001660.227
Yeast
gonad developmentGO:0008406500.225
Worm
organelle fissionGO:00482853400.225
Worm
embryo development ending in birth or egg hatchingGO:00097921520.211
Worm
spindle organizationGO:00070512530.208
cellular nitrogen compound catabolic processGO:00442701650.200
Yeast
regulation of mrna splicing via spliceosomeGO:0048024640.196
peptidyl lysine acetylationGO:0018394390.195
protein localizationGO:00081042840.192
nucleosome mobilizationGO:004276690.190
deathGO:00162652840.181
chromosome organizationGO:00512763600.159
Yeast
organic substance catabolic processGO:19015753080.156
Yeast
dna repairGO:0006281540.156
reproductive behaviorGO:00190981220.144
negative regulation of response to stimulusGO:00485852580.139
cell deathGO:00082192790.134
dna replicationGO:0006260480.131
macromolecule catabolic processGO:00090571610.130
Yeast
dna metabolic processGO:00062592270.130
negative regulation of signal transductionGO:00099682060.129
development of primary sexual characteristicsGO:0045137500.127
Worm
negative regulation of meiotic cell cycleGO:005144720.126
nucleotide metabolic processGO:00091171610.124
immune system processGO:00023763470.122
nucleobase containing compound catabolic processGO:00346551650.117
Yeast
regulation of transcription from rna polymerase ii promoterGO:00063573780.117
Human Yeast
regulation of cell deathGO:00109411730.113
protein acylationGO:0043543420.112
histone h4 acetylationGO:0043967130.111
nucleosome assemblyGO:0006334350.109
regulation of mrna processingGO:0050684710.108
multicellular organismal reproductive behaviorGO:00330571100.106
chromosome segregationGO:00070591570.106
Worm
peptidyl amino acid modificationGO:00181931050.106
regulation of cellular response to stressGO:0080135890.105
regulation of cell cycleGO:00517262910.104
aromatic compound catabolic processGO:00194391660.103
Yeast
dendrite guidanceGO:0070983210.103
organonitrogen compound metabolic processGO:19015643180.103
regulation of heterochromatin assemblyGO:003144580.102
regulation of dna metabolic processGO:0051052340.102
spindle assembly involved in mitosisGO:0090307500.101
positive regulation of rna biosynthetic processGO:19026802660.100
Human
mitotic spindle organizationGO:00070522200.099
mitotic cell cycle phase transitionGO:00447721380.097
positive regulation of signal transductionGO:00099672230.097
mrna splicing via spliceosomeGO:0000398730.097
dna recombinationGO:0006310320.096
protein complex biogenesisGO:00702712010.094
rna processingGO:00063961470.093
dna double strand break processingGO:000072930.092
regulation of small gtpase mediated signal transductionGO:0051056930.092
negative regulation of cell differentiationGO:00455961430.089
peptidyl lysine modificationGO:0018205570.088
positive regulation of signalingGO:00230562430.088
regulation of rna splicingGO:0043484690.088
microtubule cytoskeleton organization involved in mitosisGO:1902850520.087
regulation of meiosisGO:004002030.087
histone h4 k20 methylationGO:003477040.086
regulation of cell differentiationGO:00455953020.083
rna splicingGO:0008380830.083
vesicle mediated transportGO:00161923810.081
telomere cappingGO:0016233110.080
programmed cell deathGO:00125012570.079
response to abiotic stimulusGO:00096283410.077
nucleoside phosphate metabolic processGO:00067531620.076
positive regulation of response to stimulusGO:00485843230.076
agingGO:00075681430.068
regulation of protein metabolic processGO:00512462560.067
dendrite developmentGO:00163582040.066
negative regulation of cell cycleGO:00457861160.064
positive regulation of nucleic acid templated transcriptionGO:19035082660.064
Human
positive regulation of dna metabolic processGO:0051054120.063
cell cycle checkpointGO:0000075950.063
appendage morphogenesisGO:00351073970.063
single organism biosynthetic processGO:00447112060.062
protein alkylationGO:0008213430.061
positive regulation of cell communicationGO:00106472500.061
regulation of cell cycle g1 s phase transitionGO:1902806230.061
male gamete generationGO:00482322010.060
regulation of mrna metabolic processGO:1903311720.058
regulation of phosphate metabolic processGO:00192202100.058
genitalia developmentGO:0048806260.057
Worm
recombinational repairGO:0000725130.057
establishment of localization in cellGO:00516494020.055
regulation of cellular protein metabolic processGO:00322682430.055
alternative mrna splicing via spliceosomeGO:0000380600.054
positive regulation of biosynthetic processGO:00098913160.054
Human
positive regulation of cellular component organizationGO:00511301560.053
cell agingGO:000756920.053
regulation of catalytic activityGO:00507901850.051
heart developmentGO:0007507820.049
positive regulation of phosphorus metabolic processGO:00105621390.047
response to organic cyclic compoundGO:0014070890.046
Human
double strand break repairGO:0006302260.046
positive regulation of chromatin silencingGO:0031937160.045
regulation of intracellular signal transductionGO:19025312360.045
regulation of phosphorus metabolic processGO:00511742100.044
histone methylationGO:0016571400.044
nuclear body organizationGO:003057560.043
appendage developmentGO:00487364010.042
negative regulation of transcription from rna polymerase ii promoterGO:00001221190.042
purine nucleotide metabolic processGO:00061631460.042
regulation of phosphorylationGO:00423251470.041
positive regulation of macromolecule metabolic processGO:00106044050.040
Human
ribonucleoprotein complex subunit organizationGO:0071826280.040
organelle assemblyGO:00709251980.039
protein complex assemblyGO:00064612000.039
cellular catabolic processGO:00442483720.039
Yeast
positive regulation of gene expressionGO:00106282900.039
Human
meiotic chromosome segregationGO:0045132590.039
Worm
determination of dorsal ventral asymmetryGO:004826230.038
taxisGO:00423303040.038
positive regulation of macromolecule biosynthetic processGO:00105572830.038
Human
positive regulation of protein metabolic processGO:00512471280.037
small molecule metabolic processGO:00442813050.037
ovipositionGO:0018991190.036
rna splicing via transesterification reactionsGO:0000375730.036
regulation of dna recombinationGO:000001840.036
organic cyclic compound catabolic processGO:19013611680.036
Yeast
dna alkylationGO:000630540.035
dendrite morphogenesisGO:00488131990.035
purine ribonucleoside metabolic processGO:00461281270.035
response to light stimulusGO:00094161240.034
regulation of developmental growthGO:00486381740.034
regulation of localizationGO:00328792750.033
nucleobase containing small molecule metabolic processGO:00550861740.033
reproductive structure developmentGO:0048608740.032
Worm
regulation of response to dna damage stimulusGO:2001020230.032
positive regulation of growthGO:0045927750.031
regulation of alternative mrna splicing via spliceosomeGO:0000381600.031
protein phosphorylationGO:00064681690.030
regulation of cell cycle processGO:00105641810.030
positive regulation of heterochromatin assemblyGO:003145350.029
cell cycle phase transitionGO:00447701400.029
central nervous system developmentGO:00074172010.029
positive regulation of phosphate metabolic processGO:00459371390.029
mitotic chromosome condensationGO:0007076220.029
cell proliferationGO:00082832990.028
regulation of growthGO:00400082330.028
imaginal disc derived wing morphogenesisGO:00074763370.027
response to alcoholGO:0097305950.027
Human
cytoplasmic transportGO:00164821300.027
response to oxidative stressGO:0006979860.027
striated muscle myosin thick filament assemblyGO:007168830.026
negative regulation of cellular protein metabolic processGO:0032269850.026
regulation of protein deacetylationGO:009031120.026
intraspecies interaction between organismsGO:005170340.026
regulation of molecular functionGO:00650092170.026
purine ribonucleotide metabolic processGO:00091501450.025
positive regulation of molecular functionGO:00440931360.025
regionalizationGO:00030024160.024
dna dependent dna replicationGO:0006261170.024
intracellular transportGO:00469072280.024
dna methylation or demethylationGO:004472840.024
positive regulation of cellular protein metabolic processGO:00322701180.023
establishment of spindle orientationGO:0051294180.023
amine metabolic processGO:0009308120.023
histone h3 acetylationGO:0043966110.023
regulation of i kappab kinase nf kappab signalingGO:004312220.023
single organism intracellular transportGO:19025822070.023
spermatogenesisGO:00072832000.022
regulation of cellular localizationGO:00603411360.022
regulation of cellular amine metabolic processGO:003323830.022
ribonucleoprotein complex assemblyGO:0022618230.022
regulation of peptidase activityGO:0052547390.022
single organism catabolic processGO:00447122280.022
cellular component assembly involved in morphogenesisGO:00109271510.022
enzyme linked receptor protein signaling pathwayGO:00071671790.022
positive regulation of rna metabolic processGO:00512542710.022
Human
ribonucleotide metabolic processGO:00092591450.022
positive regulation of nucleobase containing compound metabolic processGO:00459353320.022
Human
ras protein signal transductionGO:0007265880.021
nucleus organizationGO:0006997450.021
protein processingGO:0016485680.021
regulation of transcription by chromatin organizationGO:003440130.021
response to radiationGO:00093141550.020
telencephalon developmentGO:002153720.020
mitotic cell cycle embryonicGO:0045448380.020
regulation of apoptotic processGO:00429811300.020
transcription initiation from rna polymerase ii promoterGO:0006367250.020
mitotic sister chromatid segregationGO:0000070870.020
negative regulation of cell deathGO:0060548810.019
negative regulation of organelle organizationGO:0010639560.019
positive regulation of cellular amine metabolic processGO:003324000.019
regulation of cellular ketone metabolic processGO:001056530.019
intracellular signal transductionGO:00355563000.019
positive regulation of developmental growthGO:0048639620.019
male meiosisGO:0007140520.019
dna templated transcription initiationGO:0006352250.019
multi organism reproductive behaviorGO:00447051210.019
regulation of phosphatase activityGO:001092130.019
positive regulation of nucleotide metabolic processGO:0045981550.018
apoptotic processGO:00069151590.018
larval developmentGO:00021641040.018
Worm
oocyte differentiationGO:00099941450.018
wnt signaling pathwayGO:0016055980.018
homeostatic processGO:00425921990.017
negative regulation of apoptotic processGO:0043066630.017
negative regulation of protein metabolic processGO:0051248850.017
mrna catabolic processGO:0006402330.017
Yeast
modification dependent macromolecule catabolic processGO:0043632790.017
multi multicellular organism processGO:00447061230.017
rna localizationGO:00064031150.017
regulation of chromatin organizationGO:1902275320.017
regulation of cellular amino acid metabolic processGO:000652100.017
regulation of cell divisionGO:0051302720.017
heterochromatin organizationGO:0070828250.017
modification dependent protein catabolic processGO:0019941780.017
double strand break repair via nonhomologous end joiningGO:000630350.017
positive regulation of transcription dna templatedGO:00458932660.016
Human
mitotic nuclear divisionGO:00070672130.016
adult behaviorGO:00305341370.016
ribonucleoprotein complex biogenesisGO:0022613310.016
axonogenesisGO:00074092900.015
purine nucleoside metabolic processGO:00422781270.015
gene silencing by rnaGO:0031047570.015
Worm
oxidation reduction processGO:00551141230.015
protein transportGO:00150311550.015
dna hypermethylationGO:004402630.015
muscle organ developmentGO:00075171270.015
negative regulation of molecular functionGO:0044092510.015
organophosphate metabolic processGO:00196371950.015
cellular amine metabolic processGO:0044106120.015
proteasome mediated ubiquitin dependent protein catabolic processGO:0043161540.014
regulation of multicellular organismal developmentGO:20000264140.014
Worm
muscle structure developmentGO:00610612240.014
regulation of sister chromatid cohesionGO:000706320.014
response to temperature stimulusGO:00092661060.014
regulation of chromatin modificationGO:1903308280.014
dna methylationGO:000630640.014
purine ribonucleoside triphosphate metabolic processGO:00092051190.014
dna templated transcription elongationGO:0006354180.014
imaginal disc derived appendage morphogenesisGO:00351143950.013
regulation of cellular catabolic processGO:00313291570.013
positive regulation of mitotic cell cycleGO:0045931340.013
multicellular organism growthGO:0035264460.013
determination of adult lifespanGO:00083401370.013
negative regulation of programmed cell deathGO:0043069720.013
positive regulation of intracellular signal transductionGO:19025331160.013
nucleoside triphosphate metabolic processGO:00091411200.013
regulation of protein phosphorylationGO:0001932640.013
regulation of wnt signaling pathwayGO:0030111680.013
cellular amino acid metabolic processGO:0006520610.013
immune responseGO:00069552460.013
regulation of histone h3 k9 methylationGO:005157030.013
positive regulation of protein modification processGO:0031401580.013
regulation of histone modificationGO:0031056200.013
syncytial blastoderm mitotic cell cycleGO:0035186210.013
forebrain developmentGO:003090020.012
macromolecule methylationGO:0043414450.012
signal transduction in response to dna damageGO:004277030.012
translationGO:0006412690.012
protein catabolic processGO:00301631010.012
multicellular organismal agingGO:00102591400.012
camera type eye developmentGO:004301040.012
macromolecule deacylationGO:0098732110.012
negative regulation of proteolysisGO:0045861310.011
peptidyl lysine trimethylationGO:001802360.011
regulation of reactive oxygen species biosynthetic processGO:190342600.011
regulation of meiotic cell cycleGO:005144590.011
organic acid metabolic processGO:00060821030.011
positive regulation of catalytic activityGO:00430851180.011
exocrine system developmentGO:00352721620.011
gene silencing by mirnaGO:0035195220.011
glycosyl compound metabolic processGO:19016571270.011
transcription elongation from rna polymerase ii promoterGO:0006368180.011
heterochromatin assemblyGO:0031507130.011
ribonucleoside metabolic processGO:00091191270.011
regulation of programmed cell deathGO:00430671520.011
purine ribonucleotide catabolic processGO:00091541090.011
ribonucleoside triphosphate metabolic processGO:00091991190.011
organic substance transportGO:00717022570.011
positive regulation of transcription from rna polymerase ii promoterGO:00459442040.010
Human
notch signaling pathwayGO:00072191200.010
digestive tract morphogenesisGO:00485461270.010
telomere maintenanceGO:0000723210.010
tube morphogenesisGO:00352391910.010
purine containing compound metabolic processGO:00725211550.010
regulation of proteolysis involved in cellular protein catabolic processGO:1903050440.010
regulation of catabolic processGO:00098941700.010
proteasomal protein catabolic processGO:0010498590.010
histone lysine methylationGO:0034968320.010
peptidyl lysine dimethylationGO:001802730.010
immune system developmentGO:0002520570.010
positive regulation of phosphorylationGO:0042327870.010
positive regulation of lipid catabolic processGO:005099610.010

His2Av disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
cancerDOID:16200.018
organ system cancerDOID:005068600.018
disease of cellular proliferationDOID:1456600.018
chromosomal diseaseDOID:008001400.012