IMP: Integrative Multi-species Prediction

Drosophila melanogaster

46 known processes

clt (Dmel_CG9858)

cricklet

(Aliases: Est-R,anon-57Fb,Dmel\CG9858,CG9858)

Entrez: 117300
FLYBASE: FBgn0000326
UniProtKB: Q9W2F4

Process Predictions
Disease Predictions

clt biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
lipid catabolic process	GO:0016042	21	0.531
organonitrogen compound metabolic process	GO:1901564	318	0.460	Fly
cellular lipid catabolic process	GO:0044242	16	0.375
secondary metabolite biosynthetic process	GO:0044550	24	0.360
catabolic process	GO:0009056	409	0.352	Fly
single organism catabolic process	GO:0044712	228	0.299	Fly
organic substance catabolic process	GO:1901575	308	0.287	Fly
lipid metabolic process	GO:0006629	121	0.271
secondary metabolic process	GO:0019748	75	0.253
single organism biosynthetic process	GO:0044711	206	0.183
hormone biosynthetic process	GO:0042446	20	0.170
cellular catabolic process	GO:0044248	372	0.169	Fly
response to extracellular stimulus	GO:0009991	116	0.152
multicellular organismal aging	GO:0010259	140	0.150	Fly
response to oxidative stress	GO:0006979	86	0.138
response to abiotic stimulus	GO:0009628	341	0.134	Fly
cellular lipid metabolic process	GO:0044255	83	0.130
response to starvation	GO:0042594	97	0.126
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.119
pheromone biosynthetic process	GO:0042811	3	0.102
hormone metabolic process	GO:0042445	33	0.098
small molecule metabolic process	GO:0044281	305	0.094	Fly
organic acid metabolic process	GO:0006082	103	0.091
oxoacid metabolic process	GO:0043436	103	0.086
response to nutrient levels	GO:0031667	114	0.086
triglyceride catabolic process	GO:0019433	3	0.085
single organism behavior	GO:0044708	391	0.082
imaginal disc derived wing morphogenesis	GO:0007476	337	0.081
post embryonic appendage morphogenesis	GO:0035120	385	0.077
aging	GO:0007568	143	0.076	Fly
acylglycerol catabolic process	GO:0046464	3	0.074
small molecule catabolic process	GO:0044282	21	0.074	Fly
innate immune response	GO:0045087	144	0.070
lipid homeostasis	GO:0055088	33	0.070
acylglycerol biosynthetic process	GO:0046463	2	0.068
oxidation reduction process	GO:0055114	123	0.067
cellular ketone metabolic process	GO:0042180	24	0.067
localization of cell	GO:0051674	257	0.062	Fly
response to biotic stimulus	GO:0009607	294	0.062	Fly
cellular amino acid metabolic process	GO:0006520	61	0.061
response to oxygen containing compound	GO:1901700	200	0.057
cellular response to chemical stimulus	GO:0070887	199	0.055
mating behavior	GO:0007617	106	0.054
response to organic substance	GO:0010033	284	0.053	Fly
triglyceride biosynthetic process	GO:0019432	2	0.051
multi organism reproductive behavior	GO:0044705	121	0.049
adult behavior	GO:0030534	137	0.046
carboxylic acid metabolic process	GO:0019752	92	0.046
carbohydrate derivative metabolic process	GO:1901135	217	0.045
cellular response to extracellular stimulus	GO:0031668	64	0.043
positive regulation of macromolecule metabolic process	GO:0010604	405	0.042
multi organism behavior	GO:0051705	175	0.040
growth	GO:0040007	359	0.040
positive regulation of lipid metabolic process	GO:0045834	4	0.040
defense response	GO:0006952	300	0.039	Fly
purine ribonucleoside metabolic process	GO:0046128	127	0.039
glycosyl compound metabolic process	GO:1901657	127	0.039
purine containing compound metabolic process	GO:0072521	155	0.037
positive regulation of response to stimulus	GO:0048584	323	0.037
medium chain fatty acid metabolic process	GO:0051791	1	0.037
lipid modification	GO:0030258	24	0.036
neutral lipid biosynthetic process	GO:0046460	2	0.036
glycerolipid catabolic process	GO:0046503	3	0.035
cell motility	GO:0048870	251	0.035	Fly
cell migration	GO:0016477	238	0.035	Fly
hormone catabolic process	GO:0042447	3	0.035
regulation of apoptotic process	GO:0042981	130	0.034
nucleoside phosphate metabolic process	GO:0006753	162	0.034
homeostatic process	GO:0042592	199	0.034
response to external biotic stimulus	GO:0043207	293	0.033	Fly
male mating behavior	GO:0060179	70	0.033
response to metal ion	GO:0010038	23	0.033
nucleobase containing small molecule metabolic process	GO:0055086	174	0.033
appendage development	GO:0048736	401	0.032
immune response	GO:0006955	246	0.032
imaginal disc derived appendage development	GO:0048737	399	0.032
cellular response to oxygen containing compound	GO:1901701	79	0.032
neutral lipid catabolic process	GO:0046461	3	0.031
purine nucleoside metabolic process	GO:0042278	127	0.031
cell death	GO:0008219	279	0.031
cellular nitrogen compound catabolic process	GO:0044270	165	0.030
spermatid differentiation	GO:0048515	114	0.030	Fly
organonitrogen compound catabolic process	GO:1901565	128	0.030	Fly
reproductive behavior	GO:0019098	122	0.029
regulation of programmed cell death	GO:0043067	152	0.029
cholesterol homeostasis	GO:0042632	3	0.029
organic cyclic compound catabolic process	GO:1901361	168	0.029
regulation of cellular ketone metabolic process	GO:0010565	3	0.029
acetylcholine metabolic process	GO:0008291	2	0.029	Fly
nucleobase containing compound catabolic process	GO:0034655	165	0.028
ribonucleoside metabolic process	GO:0009119	127	0.028
response to bacterium	GO:0009617	198	0.028
male gamete generation	GO:0048232	201	0.028	Fly
mitochondrion organization	GO:0007005	65	0.027
neurotransmitter metabolic process	GO:0042133	2	0.027	Fly
regulation of molecular function	GO:0065009	217	0.027
defense response to bacterium	GO:0042742	178	0.027
programmed cell death	GO:0012501	257	0.026
positive regulation of gene expression	GO:0010628	290	0.026
cellular response to oxidative stress	GO:0034599	28	0.026
lipid biosynthetic process	GO:0008610	46	0.026
response to inorganic substance	GO:0010035	44	0.025
positive regulation of cellular biosynthetic process	GO:0031328	316	0.025
organophosphate metabolic process	GO:0019637	195	0.025
death	GO:0016265	284	0.024
response to other organism	GO:0051707	293	0.024	Fly
regulation of cell death	GO:0010941	173	0.024
heterocycle catabolic process	GO:0046700	166	0.023
nucleotide metabolic process	GO:0009117	161	0.023
sterol homeostasis	GO:0055092	4	0.023
wing disc morphogenesis	GO:0007472	344	0.023
dendrite morphogenesis	GO:0048813	199	0.023
positive regulation of cell communication	GO:0010647	250	0.023
nucleoside metabolic process	GO:0009116	127	0.023
appendage morphogenesis	GO:0035107	397	0.023
response to alcohol	GO:0097305	95	0.022
response to temperature stimulus	GO:0009266	106	0.022
regulation of protein metabolic process	GO:0051246	256	0.022
chemical homeostasis	GO:0048878	92	0.022
embryo development ending in birth or egg hatching	GO:0009792	152	0.022
steroid catabolic process	GO:0006706	1	0.022
regulation of organelle organization	GO:0033043	196	0.022
regulation of cellular catabolic process	GO:0031329	157	0.022
germ cell migration	GO:0008354	43	0.022
amine metabolic process	GO:0009308	12	0.022	Fly
regulation of growth	GO:0040008	233	0.022
organelle fission	GO:0048285	340	0.021	Fly
regulation of defense response	GO:0031347	102	0.021
mushroom body development	GO:0016319	70	0.021
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.021
monocarboxylic acid metabolic process	GO:0032787	29	0.021
protein modification process	GO:0036211	438	0.021
alcohol metabolic process	GO:0006066	25	0.021	Fly
lipid localization	GO:0010876	54	0.021	Fly
regulation of catabolic process	GO:0009894	170	0.021
organic substance transport	GO:0071702	257	0.021
cellular amine metabolic process	GO:0044106	12	0.020	Fly
digestive tract morphogenesis	GO:0048546	127	0.020
regulation of sequestering of triglyceride	GO:0010889	3	0.020
regulation of cell cycle	GO:0051726	291	0.020
regulation of response to stress	GO:0080134	200	0.020
aromatic compound catabolic process	GO:0019439	166	0.020
forebrain development	GO:0030900	2	0.020
positive regulation of biosynthetic process	GO:0009891	316	0.020
response to copper ion	GO:0046688	4	0.019
purine ribonucleotide metabolic process	GO:0009150	145	0.019
macromolecular complex assembly	GO:0065003	256	0.019
anion homeostasis	GO:0055081	3	0.019
organonitrogen compound biosynthetic process	GO:1901566	117	0.019
regulation of multi organism process	GO:0043900	131	0.019
carbohydrate derivative catabolic process	GO:1901136	118	0.019
regulation of response to external stimulus	GO:0032101	115	0.019
purine nucleotide metabolic process	GO:0006163	146	0.019
ribose phosphate metabolic process	GO:0019693	145	0.019
taxis	GO:0042330	304	0.019	Fly
organelle assembly	GO:0070925	198	0.019
regulation of immune response	GO:0050776	118	0.019
intracellular signal transduction	GO:0035556	300	0.019
dna metabolic process	GO:0006259	227	0.019
ribonucleotide metabolic process	GO:0009259	145	0.019
defense response to gram negative bacterium	GO:0050829	94	0.018
carbohydrate metabolic process	GO:0005975	82	0.018
positive regulation of signal transduction	GO:0009967	223	0.018
cellular protein modification process	GO:0006464	438	0.018
regulation of cellular amine metabolic process	GO:0033238	3	0.018
circadian rhythm	GO:0007623	105	0.018
peptide metabolic process	GO:0006518	80	0.018
determination of adult lifespan	GO:0008340	137	0.018	Fly
immune system process	GO:0002376	347	0.018
imaginal disc pattern formation	GO:0007447	91	0.017
regulation of cellular protein metabolic process	GO:0032268	243	0.017
negative regulation of apoptotic process	GO:0043066	63	0.017
ribonucleoside catabolic process	GO:0042454	112	0.017
apoptotic process	GO:0006915	159	0.017
positive regulation of cellular catabolic process	GO:0031331	95	0.017
protein localization	GO:0008104	284	0.017
developmental growth	GO:0048589	280	0.017
central nervous system development	GO:0007417	201	0.017
regulation of response to biotic stimulus	GO:0002831	63	0.017
regulation of catalytic activity	GO:0050790	185	0.016
protein complex assembly	GO:0006461	200	0.016
protein complex biogenesis	GO:0070271	201	0.016
regulation of localization	GO:0032879	275	0.016
spermatogenesis	GO:0007283	200	0.016	Fly
purine containing compound catabolic process	GO:0072523	112	0.016
positive regulation of catabolic process	GO:0009896	105	0.016
regulation of immune system process	GO:0002682	176	0.016
regulation of mitotic cell cycle	GO:0007346	190	0.016
negative regulation of growth	GO:0045926	84	0.016
sulfur compound metabolic process	GO:0006790	59	0.015
positive regulation of multicellular organismal process	GO:0051240	143	0.015
positive regulation of signaling	GO:0023056	243	0.015
positive regulation of cell motility	GO:2000147	3	0.015
transcription from rna polymerase ii promoter	GO:0006366	368	0.015
positive regulation of cell migration	GO:0030335	2	0.015
developmental maturation	GO:0021700	172	0.015
regulation of cell cycle process	GO:0010564	181	0.015
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.015
regulation of cellular component biogenesis	GO:0044087	201	0.015
regulation of cell size	GO:0008361	63	0.015
positive regulation of rna biosynthetic process	GO:1902680	266	0.015
peptidyl amino acid modification	GO:0018193	105	0.015
negative regulation of cell cycle	GO:0045786	116	0.015
response to lipopolysaccharide	GO:0032496	4	0.015
monocarboxylic acid catabolic process	GO:0072329	10	0.015
humoral immune response	GO:0006959	117	0.015
nucleoside phosphate catabolic process	GO:1901292	110	0.015
regulation of innate immune response	GO:0045088	71	0.014
nucleoside catabolic process	GO:0009164	112	0.014
phosphorylation	GO:0016310	294	0.014
cellular response to nutrient levels	GO:0031669	62	0.014
purine nucleoside catabolic process	GO:0006152	112	0.014
body morphogenesis	GO:0010171	2	0.014
purine ribonucleoside catabolic process	GO:0046130	112	0.014
generation of precursor metabolites and energy	GO:0006091	42	0.014
cell growth	GO:0016049	108	0.014
isoprenoid metabolic process	GO:0006720	8	0.014
ovarian follicle cell development	GO:0030707	248	0.014	Fly
dendrite development	GO:0016358	204	0.014
positive regulation of rna metabolic process	GO:0051254	271	0.014
sesquiterpenoid metabolic process	GO:0006714	3	0.014
cellular component assembly involved in morphogenesis	GO:0010927	151	0.014
regulation of nervous system development	GO:0051960	248	0.014
establishment of localization in cell	GO:0051649	402	0.014
defense response to other organism	GO:0098542	225	0.014	Fly
organophosphate catabolic process	GO:0046434	112	0.014
response to hypoxia	GO:0001666	53	0.014
response to heat	GO:0009408	63	0.014
activation of innate immune response	GO:0002218	4	0.014
cellular response to organic substance	GO:0071310	132	0.014
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.014
phagocytosis	GO:0006909	215	0.013
negative regulation of cell death	GO:0060548	81	0.013
triglyceride metabolic process	GO:0006641	12	0.013
pattern recognition receptor signaling pathway	GO:0002221	2	0.013
chaeta development	GO:0022416	97	0.013
cellular response to external stimulus	GO:0071496	66	0.013
response to organophosphorus	GO:0046683	2	0.013	Fly
negative regulation of mitotic cell cycle	GO:0045930	109	0.013
oxidoreduction coenzyme metabolic process	GO:0006733	2	0.013
glycosyl compound catabolic process	GO:1901658	112	0.013
biological adhesion	GO:0022610	138	0.013	Fly
connective tissue development	GO:0061448	3	0.013
negative regulation of programmed cell death	GO:0043069	72	0.013
positive regulation of molecular function	GO:0044093	136	0.013
molting cycle chitin based cuticle	GO:0007591	56	0.013
embryonic morphogenesis	GO:0048598	206	0.013
secondary metabolite catabolic process	GO:0090487	1	0.013
autophagy	GO:0006914	108	0.013
nucleoside monophosphate metabolic process	GO:0009123	52	0.013
fatty acid metabolic process	GO:0006631	20	0.012
response to ethanol	GO:0045471	59	0.012
tube morphogenesis	GO:0035239	191	0.012
chromosome organization	GO:0051276	360	0.012
cholesterol transport	GO:0030301	2	0.012
adult locomotory behavior	GO:0008344	76	0.012
response to oxygen levels	GO:0070482	59	0.012
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.012
positive regulation of programmed cell death	GO:0043068	62	0.012
cilium organization	GO:0044782	41	0.012
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.012
response to nitrogen compound	GO:1901698	90	0.012
positive regulation of defense response	GO:0031349	59	0.012
locomotory behavior	GO:0007626	176	0.012
cell cycle phase transition	GO:0044770	140	0.012
wound healing	GO:0042060	75	0.012
positive regulation of cellular protein metabolic process	GO:0032270	118	0.012
negative regulation of neuron death	GO:1901215	18	0.012
glycerolipid metabolic process	GO:0046486	34	0.012
columnar cuboidal epithelial cell development	GO:0002066	249	0.012	Fly
negative regulation of cellular metabolic process	GO:0031324	382	0.012
nitrogen compound transport	GO:0071705	85	0.012
carboxylic acid catabolic process	GO:0046395	16	0.012
regulation of cellular amino acid metabolic process	GO:0006521	0	0.012
digestive system development	GO:0055123	149	0.012
positive regulation of transcription dna templated	GO:0045893	266	0.011
very long chain fatty acid metabolic process	GO:0000038	4	0.011
regulation of cellular component size	GO:0032535	98	0.011
organic acid catabolic process	GO:0016054	16	0.011
endomembrane system organization	GO:0010256	119	0.011
response to decreased oxygen levels	GO:0036293	58	0.011
rna processing	GO:0006396	147	0.011
tube development	GO:0035295	244	0.011
cell maturation	GO:0048469	144	0.011
positive regulation of protein metabolic process	GO:0051247	128	0.011
purine nucleotide catabolic process	GO:0006195	109	0.011
mitotic nuclear division	GO:0007067	213	0.011
polyol biosynthetic process	GO:0046173	3	0.011
macromolecule catabolic process	GO:0009057	161	0.011
positive regulation of immune response	GO:0050778	63	0.011
response to organonitrogen compound	GO:0010243	75	0.011
acylglycerol metabolic process	GO:0006639	12	0.011
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.011
jak stat cascade	GO:0007259	49	0.011
guanosine containing compound metabolic process	GO:1901068	74	0.011
regulation of lipid metabolic process	GO:0019216	15	0.011
open tracheal system development	GO:0007424	204	0.011	Fly
epithelium migration	GO:0090132	148	0.011	Fly
cellular hormone metabolic process	GO:0034754	23	0.011
neurological system process	GO:0050877	358	0.010
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.010
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.010
proteolysis	GO:0006508	192	0.010
fat soluble vitamin biosynthetic process	GO:0042362	1	0.010
spindle organization	GO:0007051	253	0.010
lateral inhibition	GO:0046331	206	0.010
positive regulation of cell death	GO:0010942	69	0.010
regulation of chromosome organization	GO:0033044	64	0.010
regulation of multicellular organismal development	GO:2000026	414	0.010
xenobiotic catabolic process	GO:0042178	1	0.010
steroid biosynthetic process	GO:0006694	16	0.010
lipid storage	GO:0019915	38	0.010	Fly
steroid metabolic process	GO:0008202	20	0.010
telencephalon development	GO:0021537	2	0.010
response to wounding	GO:0009611	94	0.010
guanosine containing compound catabolic process	GO:1901069	74	0.010
behavioral response to ethanol	GO:0048149	49	0.010
purine ribonucleotide catabolic process	GO:0009154	109	0.010
negative regulation of response to stimulus	GO:0048585	258	0.010
regulation of immune effector process	GO:0002697	52	0.010
negative regulation of cell cycle phase transition	GO:1901988	103	0.010
single organism carbohydrate metabolic process	GO:0044723	72	0.010

clt disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of metabolism	DOID:0014667	0.034
disease of anatomical entity	DOID:7	0.025
lipid metabolism disorder	DOID:3146	0.015
inherited metabolic disorder	DOID:655	0.015
nervous system disease	DOID:863	0.014
central nervous system disease	DOID:331	0.010

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