IMP: Integrative Multi-species Prediction

Drosophila melanogaster

0 known processes

CG10863 (Dmel_CG10863)

CG10863 gene product from transcript CG10863-RA

(Aliases: Dmel\CG10863,BcDNA:GH10614,dm1/AKR2E3)

Entrez: 38463
FLYBASE: FBgn0027552
UniProtKB: Q9Y112

Process Predictions
Disease Predictions

CG10863 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
small molecule metabolic process	GO:0044281	305	0.226	Human Rat
organonitrogen compound metabolic process	GO:1901564	318	0.113
sulfur compound metabolic process	GO:0006790	59	0.105
thiosulfate transport	GO:0015709	2	0.094
single organism biosynthetic process	GO:0044711	206	0.093	Human Mouse Rat
appendage development	GO:0048736	401	0.092
glutathione metabolic process	GO:0006749	37	0.089
organic hydroxy compound metabolic process	GO:1901615	83	0.086	Human
appendage morphogenesis	GO:0035107	397	0.086
small molecule biosynthetic process	GO:0044283	37	0.083	Human
cellular response to chemical stimulus	GO:0070887	199	0.075	Human
establishment of localization in cell	GO:0051649	402	0.075	Human
protein complex biogenesis	GO:0070271	201	0.071	Human
wing disc morphogenesis	GO:0007472	344	0.067
response to metal ion	GO:0010038	23	0.062	Human
ion transmembrane transport	GO:0034220	122	0.061
imaginal disc derived appendage development	GO:0048737	399	0.058
organic substance transport	GO:0071702	257	0.056	Human
oxoacid metabolic process	GO:0043436	103	0.056	Human
organic acid metabolic process	GO:0006082	103	0.055	Human
cellular aldehyde metabolic process	GO:0006081	10	0.055	Human
carboxylic acid metabolic process	GO:0019752	92	0.055	Human
organic substance catabolic process	GO:1901575	308	0.053	Human
response to oxygen containing compound	GO:1901700	200	0.053	Human
cellular lipid metabolic process	GO:0044255	83	0.053	Human
cellular amino acid metabolic process	GO:0006520	61	0.050
phosphate ion transmembrane transport	GO:0035435	4	0.049
peptide metabolic process	GO:0006518	80	0.049
post embryonic appendage morphogenesis	GO:0035120	385	0.048
imaginal disc derived wing morphogenesis	GO:0007476	337	0.048
ion transport	GO:0006811	145	0.046
cellular modified amino acid metabolic process	GO:0006575	45	0.043
response to oxidative stress	GO:0006979	86	0.042	Human
response to organic substance	GO:0010033	284	0.042	Human Rat
fatty acid metabolic process	GO:0006631	20	0.041	Human
homeostatic process	GO:0042592	199	0.041
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.040
anion transmembrane transport	GO:0098656	26	0.040
cellular protein modification process	GO:0006464	438	0.038
pyridine containing compound metabolic process	GO:0072524	3	0.037
malate transport	GO:0015743	1	0.036
synapse assembly	GO:0007416	143	0.035
single organism intracellular transport	GO:1902582	207	0.035	Human
organonitrogen compound catabolic process	GO:1901565	128	0.034
carboxylic acid biosynthetic process	GO:0046394	15	0.034	Human
transmembrane transport	GO:0055085	139	0.033
nicotinamide nucleotide metabolic process	GO:0046496	2	0.033
kidney development	GO:0001822	3	0.032
acetaldehyde metabolic process	GO:0006117	5	0.032
lipid biosynthetic process	GO:0008610	46	0.032	Human Mouse Rat
protein localization	GO:0008104	284	0.032	Human
intracellular transport	GO:0046907	228	0.031	Human
regulation of cell cycle	GO:0051726	291	0.030
nucleotide metabolic process	GO:0009117	161	0.030
organophosphate metabolic process	GO:0019637	195	0.030
protein complex assembly	GO:0006461	200	0.030	Human
localization of cell	GO:0051674	257	0.029
response to organic cyclic compound	GO:0014070	89	0.029	Human Rat
telencephalon development	GO:0021537	2	0.029	Rat
camera type eye development	GO:0043010	4	0.029
single organism catabolic process	GO:0044712	228	0.028	Human
nucleobase containing small molecule metabolic process	GO:0055086	174	0.028
ameboidal type cell migration	GO:0001667	151	0.027
organonitrogen compound biosynthetic process	GO:1901566	117	0.027
response to abiotic stimulus	GO:0009628	341	0.027
nucleoside phosphate metabolic process	GO:0006753	162	0.027
lipid metabolic process	GO:0006629	121	0.026	Human Mouse Rat
digestive tract morphogenesis	GO:0048546	127	0.026
cellular amide metabolic process	GO:0043603	80	0.026
cellular catabolic process	GO:0044248	372	0.025	Human
epidermis development	GO:0008544	65	0.025	Human
digestive system development	GO:0055123	149	0.025
anion homeostasis	GO:0055081	3	0.025
acyl coa metabolic process	GO:0006637	3	0.025
negative regulation of gene expression	GO:0010629	387	0.024	Mouse
response to temperature stimulus	GO:0009266	106	0.024
response to inorganic substance	GO:0010035	44	0.024	Human
oxidation reduction process	GO:0055114	123	0.024	Human Mouse Rat
tube morphogenesis	GO:0035239	191	0.023
protein modification process	GO:0036211	438	0.023
forebrain development	GO:0030900	2	0.023	Rat
regulation of cell death	GO:0010941	173	0.022	Human
positive regulation of signaling	GO:0023056	243	0.022	Human
programmed cell death	GO:0012501	257	0.022	Human
organic acid biosynthetic process	GO:0016053	15	0.022	Human
response to endogenous stimulus	GO:0009719	119	0.022	Human Rat
synapse organization	GO:0050808	196	0.021
cellular amine metabolic process	GO:0044106	12	0.021
dephosphorylation	GO:0016311	51	0.021
epithelial cell development	GO:0002064	274	0.021
intracellular signal transduction	GO:0035556	300	0.021	Human
tube development	GO:0035295	244	0.021
digestive tract development	GO:0048565	149	0.021
response to acid chemical	GO:0001101	25	0.020	Human
positive regulation of macromolecule metabolic process	GO:0010604	405	0.020
response to organonitrogen compound	GO:0010243	75	0.020
establishment of protein localization	GO:0045184	163	0.020	Human
oxaloacetate 2 transmembrane transport	GO:1902356	1	0.020
macromolecular complex assembly	GO:0065003	256	0.019	Human
positive regulation of signal transduction	GO:0009967	223	0.019	Human
amine catabolic process	GO:0009310	1	0.019
cell proliferation	GO:0008283	299	0.019	Human
positive regulation of cell death	GO:0010942	69	0.019	Human
malate transmembrane transport	GO:0071423	1	0.019
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.019	Mouse
spermatogenesis	GO:0007283	200	0.019
cellular macromolecule localization	GO:0070727	220	0.019	Human
positive regulation of response to stimulus	GO:0048584	323	0.019	Human
cellular biogenic amine catabolic process	GO:0042402	1	0.018
catabolic process	GO:0009056	409	0.018	Human
single organism carbohydrate metabolic process	GO:0044723	72	0.018
carbohydrate derivative biosynthetic process	GO:1901137	85	0.018
developmental growth	GO:0048589	280	0.018
negative regulation of cellular biosynthetic process	GO:0031327	277	0.018	Human
lateral inhibition	GO:0046331	206	0.018
cellular protein localization	GO:0034613	160	0.018	Human
regulation of cellular protein metabolic process	GO:0032268	243	0.018
organic hydroxy compound catabolic process	GO:1901616	4	0.018	Human
response to lipopolysaccharide	GO:0032496	4	0.017
negative regulation of signal transduction	GO:0009968	206	0.017
response to nitrogen compound	GO:1901698	90	0.017
response to mercury ion	GO:0046689	3	0.017
neuron projection guidance	GO:0097485	241	0.017
negative regulation of cell communication	GO:0010648	223	0.017
thioester biosynthetic process	GO:0035384	2	0.017
cell migration	GO:0016477	238	0.017
amine metabolic process	GO:0009308	12	0.017
peptidyl lysine modification	GO:0018205	57	0.017
regulation of programmed cell death	GO:0043067	152	0.016	Human
positive regulation of cell communication	GO:0010647	250	0.016	Human
embryonic morphogenesis	GO:0048598	206	0.016
acetylcholine metabolic process	GO:0008291	2	0.016
regulation of localization	GO:0032879	275	0.016
nadh metabolic process	GO:0006734	1	0.016
mushroom body development	GO:0016319	70	0.016	Fly
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.015
retina development in camera type eye	GO:0060041	4	0.015
protein transport	GO:0015031	155	0.015	Human
epithelial cell differentiation	GO:0030855	322	0.015	Human
succinate transport	GO:0015744	2	0.015
polyol biosynthetic process	GO:0046173	3	0.015
response to organophosphorus	GO:0046683	2	0.015	Human
negative regulation of response to stimulus	GO:0048585	258	0.015
glutamine family amino acid catabolic process	GO:0009065	3	0.015
monocarboxylic acid biosynthetic process	GO:0072330	7	0.015	Human
regulation of multicellular organismal development	GO:2000026	414	0.015
positive regulation of protein metabolic process	GO:0051247	128	0.015
oxidoreduction coenzyme metabolic process	GO:0006733	2	0.015
neurological system process	GO:0050877	358	0.015
multicellular organismal aging	GO:0010259	140	0.015
ovarian follicle cell development	GO:0030707	248	0.015
connective tissue development	GO:0061448	3	0.015
protein acetylation	GO:0006473	39	0.015
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.015	Mouse
glycosyl compound metabolic process	GO:1901657	127	0.014	Human
cellular ketone metabolic process	GO:0042180	24	0.014	Human Rat
response to external biotic stimulus	GO:0043207	293	0.014
thioester metabolic process	GO:0035383	3	0.014
single organism behavior	GO:0044708	391	0.014
neuron recognition	GO:0008038	101	0.014
defense response	GO:0006952	300	0.014
death	GO:0016265	284	0.014	Human
carbohydrate metabolic process	GO:0005975	82	0.014
cellular nitrogen compound catabolic process	GO:0044270	165	0.014
purine nucleotide metabolic process	GO:0006163	146	0.014
cellular response to organic substance	GO:0071310	132	0.014	Human
cell aging	GO:0007569	2	0.013
axon guidance	GO:0007411	233	0.013
monocarboxylic acid transport	GO:0015718	3	0.013
sterol homeostasis	GO:0055092	4	0.013
alcohol metabolic process	GO:0006066	25	0.013	Human
neutral lipid catabolic process	GO:0046461	3	0.013
response to calcium ion	GO:0051592	1	0.013	Human
columnar cuboidal epithelial cell development	GO:0002066	249	0.013
inorganic ion transmembrane transport	GO:0098660	73	0.013
cellular response to extracellular stimulus	GO:0031668	64	0.013	Human
nucleoside phosphate biosynthetic process	GO:1901293	34	0.013
cell motility	GO:0048870	251	0.013
mrna processing	GO:0006397	104	0.013	Mouse
regulation of molecular function	GO:0065009	217	0.013
intracellular protein transport	GO:0006886	104	0.012	Human
monocarboxylic acid metabolic process	GO:0032787	29	0.012	Human
male sex differentiation	GO:0046661	25	0.012	Human
regulation of cellular amino acid metabolic process	GO:0006521	0	0.012
regulation of proteolysis	GO:0030162	87	0.012
gastrulation	GO:0007369	70	0.012
positive regulation of gene expression	GO:0010628	290	0.012
positive regulation of lipid metabolic process	GO:0045834	4	0.012
internal protein amino acid acetylation	GO:0006475	38	0.012
regulation of cellular amine metabolic process	GO:0033238	3	0.012
membrane organization	GO:0061024	112	0.012
nucleoside metabolic process	GO:0009116	127	0.012
male gonad development	GO:0008584	9	0.012	Human
alcohol catabolic process	GO:0046164	4	0.012	Human
regulation of apoptotic process	GO:0042981	130	0.012	Human
single organism cellular localization	GO:1902580	180	0.012	Human
response to alcohol	GO:0097305	95	0.012
development of primary sexual characteristics	GO:0045137	50	0.011	Human
regionalization	GO:0003002	416	0.011
response to hexose	GO:0009746	3	0.011
chromosome segregation	GO:0007059	157	0.011
development of primary male sexual characteristics	GO:0046546	9	0.011	Human
growth	GO:0040007	359	0.011
regulation of developmental growth	GO:0048638	174	0.011
chaeta development	GO:0022416	97	0.011	Fly
organophosphate catabolic process	GO:0046434	112	0.011
protein targeting to nucleus	GO:0044744	51	0.011	Human
aging	GO:0007568	143	0.011
regulation of rna splicing	GO:0043484	69	0.011	Mouse
g protein coupled receptor signaling pathway	GO:0007186	136	0.011	Human
neutral lipid biosynthetic process	GO:0046460	2	0.011
proteolysis	GO:0006508	192	0.011
regulation of catalytic activity	GO:0050790	185	0.011
positive regulation of catalytic activity	GO:0043085	118	0.011
positive regulation of intracellular signal transduction	GO:1902533	116	0.011	Human
cellular response to carbohydrate stimulus	GO:0071322	4	0.011
regulation of anatomical structure size	GO:0090066	163	0.010
axonogenesis	GO:0007409	290	0.010
cell death	GO:0008219	279	0.010	Human
regulation of protein metabolic process	GO:0051246	256	0.010
negative regulation of rna metabolic process	GO:0051253	251	0.010	Mouse
negative regulation of cellular component organization	GO:0051129	108	0.010
pyridine nucleotide metabolic process	GO:0019362	2	0.010
endomembrane system organization	GO:0010256	119	0.010
regulation of hydrolase activity	GO:0051336	97	0.010
regulation of organelle organization	GO:0033043	196	0.010
female meiosis chromosome segregation	GO:0016321	33	0.010
organic acid transport	GO:0015849	18	0.010
negative regulation of signaling	GO:0023057	219	0.010
rna processing	GO:0006396	147	0.010	Mouse
response to lipid	GO:0033993	38	0.010	Human Rat

CG10863 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability	Func Analog Org
disease of anatomical entity	DOID:7	0.026
disease of metabolism	DOID:0014667	0.011	Human
glucose metabolism disease	DOID:4194	0.011
acquired metabolic disease	DOID:0060158	0.011
carbohydrate metabolism disease	DOID:0050013	0.011
nervous system disease	DOID:863	0.011

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