IMP: Integrative Multi-species Prediction

Drosophila melanogaster

93 known processes

Clk (Dmel_CG7391)

Clock

(Aliases: dclk,Jerk,CLOCK,CG7391,clk,CLK,Jrk,bHLHe10,dClck,dCLK,dClock,PAS1,jrk,Dmel\CG7391,dCLOCK,dClk,clock,dCLK/JRK)

Entrez: 38872
FLYBASE: FBgn0023076
UniProtKB: O61735

Process Predictions
Disease Predictions

Clk biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
circadian rhythm	GO:0007623	105	1.000
rhythmic process	GO:0048511	106	0.999
rhythmic behavior	GO:0007622	76	0.997
circadian behavior	GO:0048512	76	0.987
circadian sleep wake cycle process	GO:0022410	24	0.968
single organism behavior	GO:0044708	391	0.960
regulation of circadian sleep wake cycle sleep	GO:0045187	21	0.901
regulation of circadian sleep wake cycle	GO:0042749	25	0.835
locomotory behavior	GO:0007626	176	0.796
regulation of circadian rhythm	GO:0042752	49	0.751
circadian sleep wake cycle sleep	GO:0050802	23	0.736
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.660
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.651	Mouse
sleep	GO:0030431	49	0.635
locomotor rhythm	GO:0045475	56	0.630
circadian sleep wake cycle	GO:0042745	28	0.599
regulation of behavior	GO:0050795	75	0.522
response to radiation	GO:0009314	155	0.487	Human Zebrafish
transcription from rna polymerase ii promoter	GO:0006366	368	0.480
detection of abiotic stimulus	GO:0009582	66	0.453
purine containing compound biosynthetic process	GO:0072522	30	0.364
g protein coupled receptor signaling pathway	GO:0007186	136	0.346
positive regulation of macromolecule metabolic process	GO:0010604	405	0.293
regulation of multicellular organismal development	GO:2000026	414	0.280	Mouse
photoperiodism	GO:0009648	10	0.276	Zebrafish
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.275	Mouse
regulation of localization	GO:0032879	275	0.269	Mouse
detection of light stimulus	GO:0009583	58	0.255
entrainment of circadian clock	GO:0009649	16	0.253
synaptic transmission	GO:0007268	288	0.249
negative regulation of cellular metabolic process	GO:0031324	382	0.248	Mouse
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.247
response to light stimulus	GO:0009416	124	0.245	Zebrafish
ion transmembrane transport	GO:0034220	122	0.240
organonitrogen compound metabolic process	GO:1901564	318	0.238
phototransduction	GO:0007602	52	0.236
positive regulation of behavior	GO:0048520	19	0.227
regulation of cellular localization	GO:0060341	136	0.226	Mouse
cellular response to light stimulus	GO:0071482	37	0.221
positive regulation of rna biosynthetic process	GO:1902680	266	0.217
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.214	Mouse
negative regulation of biosynthetic process	GO:0009890	277	0.213	Mouse
sensory perception	GO:0007600	196	0.206
gliogenesis	GO:0042063	80	0.205
positive regulation of biosynthetic process	GO:0009891	316	0.200
camp biosynthetic process	GO:0006171	17	0.191
negative regulation of rna metabolic process	GO:0051253	251	0.190	Mouse
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.190	Mouse
cyclic nucleotide biosynthetic process	GO:0009190	25	0.189
entrainment of circadian clock by photoperiod	GO:0043153	9	0.188
regulation of lyase activity	GO:0051339	14	0.184
phenol containing compound metabolic process	GO:0018958	57	0.181
negative regulation of cellular biosynthetic process	GO:0031327	277	0.180	Mouse
negative regulation of rna biosynthetic process	GO:1902679	240	0.180	Mouse
regulation of transport	GO:0051049	181	0.178	Mouse
negative regulation of gene expression	GO:0010629	387	0.178	Mouse
negative regulation of camp biosynthetic process	GO:0030818	3	0.173
secretion	GO:0046903	109	0.172	Mouse
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.171
response to abiotic stimulus	GO:0009628	341	0.162
ion transport	GO:0006811	145	0.161
cellular amino acid metabolic process	GO:0006520	61	0.157
regulation of secretion by cell	GO:1903530	39	0.156	Mouse
signal release	GO:0023061	49	0.156	Mouse
regulation of r7 cell differentiation	GO:0045676	15	0.154
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.153	Mouse
positive regulation of cellular biosynthetic process	GO:0031328	316	0.152
positive regulation of adenylate cyclase activity involved in g protein coupled receptor signaling pathway	GO:0010579	7	0.151
protein localization	GO:0008104	284	0.151
organelle fission	GO:0048285	340	0.147
localization of cell	GO:0051674	257	0.145
positive regulation of response to stimulus	GO:0048584	323	0.142	Human Mouse
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger	GO:0007187	17	0.140
organic substance transport	GO:0071702	257	0.137	Mouse
positive regulation of rna metabolic process	GO:0051254	271	0.133
establishment of localization in cell	GO:0051649	402	0.124	Mouse
regulation of molecular function	GO:0065009	217	0.121	Mouse
regulation of protein metabolic process	GO:0051246	256	0.120
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.117
modification dependent macromolecule catabolic process	GO:0043632	79	0.117	Mouse
eye development	GO:0001654	323	0.116
male mating behavior	GO:0060179	70	0.114
negative regulation of signal transduction	GO:0009968	206	0.114	Mouse
adult behavior	GO:0030534	137	0.113
detection of stimulus	GO:0051606	156	0.110
cellular homeostasis	GO:0019725	80	0.108
epithelial cell differentiation	GO:0030855	322	0.107	Mouse
taxis	GO:0042330	304	0.106
proteolysis	GO:0006508	192	0.102	Mouse
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.099
regulation of organ morphogenesis	GO:2000027	78	0.098
regulation of cell cycle	GO:0051726	291	0.097
positive regulation of cyclic nucleotide metabolic process	GO:0030801	9	0.097
neuropeptide signaling pathway	GO:0007218	45	0.095
cellular response to radiation	GO:0071478	52	0.093	Human
neurological system process	GO:0050877	358	0.092
protein import	GO:0017038	55	0.092
regulation of transmembrane transport	GO:0034762	27	0.092
regulation of cellular amine metabolic process	GO:0033238	3	0.092
single organism cellular localization	GO:1902580	180	0.090
protein transport	GO:0015031	155	0.089
response to extracellular stimulus	GO:0009991	116	0.088
positive regulation of transcription dna templated	GO:0045893	266	0.088
nucleobase containing small molecule metabolic process	GO:0055086	174	0.088
protein targeting to nucleus	GO:0044744	51	0.087
catabolic process	GO:0009056	409	0.085	Mouse
regulation of hormone levels	GO:0010817	40	0.085	Mouse
cellular protein modification process	GO:0006464	438	0.084	Human Mouse
organic acid transport	GO:0015849	18	0.083
response to temperature stimulus	GO:0009266	106	0.082
regulation of sequestering of calcium ion	GO:0051282	3	0.082
compound eye photoreceptor cell differentiation	GO:0001751	140	0.081
positive regulation of multicellular organismal process	GO:0051240	143	0.079
regulation of cell development	GO:0060284	215	0.079	Mouse
ubiquitin dependent protein catabolic process	GO:0006511	78	0.078	Mouse
protein modification process	GO:0036211	438	0.076	Human Mouse
regulation of response to external stimulus	GO:0032101	115	0.076	Mouse
ribose phosphate metabolic process	GO:0019693	145	0.074
single organism biosynthetic process	GO:0044711	206	0.074
small molecule metabolic process	GO:0044281	305	0.073
regulation of camp biosynthetic process	GO:0030817	12	0.073
eye photoreceptor cell differentiation	GO:0001754	145	0.073
regulation of protein catabolic process	GO:0042176	55	0.073
negative regulation of homeostatic process	GO:0032845	2	0.072
cellular amine metabolic process	GO:0044106	12	0.072
regulation of tor signaling	GO:0032006	21	0.071
regulation of cyclic nucleotide metabolic process	GO:0030799	13	0.070
response to alkaloid	GO:0043279	26	0.070
ion homeostasis	GO:0050801	55	0.070
negative regulation of cyclic nucleotide biosynthetic process	GO:0030803	3	0.070
organic substance catabolic process	GO:1901575	308	0.069	Mouse
cellular chemical homeostasis	GO:0055082	40	0.069
purine containing compound metabolic process	GO:0072521	155	0.068
protein catabolic process	GO:0030163	101	0.068	Mouse
positive regulation of gene expression	GO:0010628	290	0.067
cytoplasmic transport	GO:0016482	130	0.066
monocarboxylic acid transport	GO:0015718	3	0.066
nuclear division	GO:0000280	332	0.066
regulation of mitotic cell cycle	GO:0007346	190	0.065
regulation of phosphate metabolic process	GO:0019220	210	0.064
eye morphogenesis	GO:0048592	260	0.064
establishment of protein localization	GO:0045184	163	0.064
transmembrane transport	GO:0055085	139	0.064
cellular response to oxidative stress	GO:0034599	28	0.063
cellular macromolecule localization	GO:0070727	220	0.063
camera type eye development	GO:0043010	4	0.063
sensory organ morphogenesis	GO:0090596	260	0.062
regulation of synaptic transmission	GO:0050804	69	0.061
regulation of reproductive process	GO:2000241	54	0.061
response to bacterium	GO:0009617	198	0.060
heart process	GO:0003015	37	0.060
homeostatic process	GO:0042592	199	0.060
negative regulation of nucleotide biosynthetic process	GO:0030809	3	0.059
negative regulation of developmental process	GO:0051093	201	0.059
regulation of anatomical structure morphogenesis	GO:0022603	242	0.059
regulation of catalytic activity	GO:0050790	185	0.058
positive regulation of signal transduction	GO:0009967	223	0.058
negative regulation of cell communication	GO:0010648	223	0.058	Mouse
intracellular transport	GO:0046907	228	0.057
regulation of secretion	GO:0051046	44	0.056	Mouse
axonogenesis	GO:0007409	290	0.056
cellular ketone metabolic process	GO:0042180	24	0.055
deactivation of rhodopsin mediated signaling	GO:0016059	17	0.055
compound eye development	GO:0048749	307	0.055
endocytosis	GO:0006897	310	0.055
phototaxis	GO:0042331	21	0.055
axon guidance	GO:0007411	233	0.054
regulation of nucleotide metabolic process	GO:0006140	62	0.054
adult locomotory behavior	GO:0008344	76	0.054
cellular response to chemical stimulus	GO:0070887	199	0.054
negative regulation of transcription dna templated	GO:0045892	237	0.054	Mouse
head development	GO:0060322	135	0.053
photoreceptor cell differentiation	GO:0046530	170	0.053
positive regulation of cell differentiation	GO:0045597	64	0.053
response to nitrogen compound	GO:1901698	90	0.053
eye photoreceptor cell development	GO:0042462	81	0.053
nuclear import	GO:0051170	51	0.052
modification dependent protein catabolic process	GO:0019941	78	0.052	Mouse
regulation of lipid metabolic process	GO:0019216	15	0.052
secretion by cell	GO:0032940	101	0.052	Mouse
heart contraction	GO:0060047	26	0.052
central nervous system development	GO:0007417	201	0.052
neuron projection guidance	GO:0097485	241	0.051
purine ribonucleotide metabolic process	GO:0009150	145	0.051
detection of external stimulus	GO:0009581	66	0.051
nucleoside phosphate biosynthetic process	GO:1901293	34	0.050
protein localization to nucleus	GO:0034504	55	0.049
chemical homeostasis	GO:0048878	92	0.049
cellular response to insulin stimulus	GO:0032869	28	0.049
regulation of camp metabolic process	GO:0030814	12	0.049
rhabdomere development	GO:0042052	38	0.048
multicellular organismal aging	GO:0010259	140	0.048
negative regulation of cyclic nucleotide metabolic process	GO:0030800	3	0.048
protein import into nucleus	GO:0006606	51	0.047
ribose phosphate biosynthetic process	GO:0046390	28	0.047
vesicle mediated transport	GO:0016192	381	0.047
axon development	GO:0061564	297	0.046
cyclic purine nucleotide metabolic process	GO:0052652	25	0.046
regulation of steroid metabolic process	GO:0019218	2	0.046
positive regulation of signaling	GO:0023056	243	0.046
positive regulation of cell communication	GO:0010647	250	0.046
response to organonitrogen compound	GO:0010243	75	0.046
carbohydrate derivative biosynthetic process	GO:1901137	85	0.045
cellular protein localization	GO:0034613	160	0.045
regulation of intracellular signal transduction	GO:1902531	236	0.045
regulation of neurotransmitter levels	GO:0001505	38	0.044
response to nutrient levels	GO:0031667	114	0.044
regulation of cellular ketone metabolic process	GO:0010565	3	0.044
defense response	GO:0006952	300	0.044	Mouse
carboxylic acid metabolic process	GO:0019752	92	0.044
mitotic nuclear division	GO:0007067	213	0.044
cell motility	GO:0048870	251	0.044
regulation of cell death	GO:0010941	173	0.043	Human
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.043
dopamine biosynthetic process	GO:0042416	3	0.043
regulation of phosphorus metabolic process	GO:0051174	210	0.042
positive regulation of developmental process	GO:0051094	143	0.042
regulation of heart rate	GO:0002027	11	0.042
regulation of blood circulation	GO:1903522	21	0.042
regulation of cellular protein metabolic process	GO:0032268	243	0.042
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.042	Mouse
positive regulation of phosphate metabolic process	GO:0045937	139	0.041
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.041
regulation of epithelial cell differentiation	GO:0030856	4	0.041	Mouse
male gamete generation	GO:0048232	201	0.041	Mouse
response to organic substance	GO:0010033	284	0.041
regulation of nervous system development	GO:0051960	248	0.041
positive regulation of protein metabolic process	GO:0051247	128	0.041
pigmentation	GO:0043473	75	0.041
mating behavior	GO:0007617	106	0.040
regulation of chitin based cuticle tanning	GO:0007564	14	0.040
cellular protein catabolic process	GO:0044257	83	0.040	Mouse
positive regulation of apoptotic signaling pathway	GO:2001235	4	0.039
columnar cuboidal epithelial cell development	GO:0002066	249	0.038	Mouse
organic acid metabolic process	GO:0006082	103	0.038
tyrosine metabolic process	GO:0006570	1	0.038
negative regulation of signaling	GO:0023057	219	0.037	Mouse
macromolecule catabolic process	GO:0009057	161	0.037	Mouse
cellular response to lipopolysaccharide	GO:0071222	3	0.037
cell division	GO:0051301	248	0.037
photoreceptor cell development	GO:0042461	96	0.037
lipid metabolic process	GO:0006629	121	0.037
regulation of transmembrane transporter activity	GO:0022898	6	0.037
regulation of ion transport	GO:0043269	39	0.037
regulation of system process	GO:0044057	36	0.037
organophosphate metabolic process	GO:0019637	195	0.037
dephosphorylation	GO:0016311	51	0.037
aging	GO:0007568	143	0.037
intracellular receptor signaling pathway	GO:0030522	19	0.036	Mouse
response to organic cyclic compound	GO:0014070	89	0.036
positive regulation of catalytic activity	GO:0043085	118	0.036
regulation of membrane potential	GO:0042391	35	0.036
protein targeting	GO:0006605	64	0.036
posttranscriptional regulation of gene expression	GO:0010608	145	0.036
negative regulation of purine nucleotide biosynthetic process	GO:1900372	3	0.036
regionalization	GO:0003002	416	0.035
nucleotide metabolic process	GO:0009117	161	0.035
peptidyl threonine phosphorylation	GO:0018107	2	0.035
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	54	0.035	Mouse
muscle organ development	GO:0007517	127	0.035
response to inorganic substance	GO:0010035	44	0.035
positive regulation of circadian sleep wake cycle sleep	GO:0045938	8	0.035
cell aging	GO:0007569	2	0.035
intracellular signal transduction	GO:0035556	300	0.035
nucleoside phosphate metabolic process	GO:0006753	162	0.035
negative regulation of sequestering of calcium ion	GO:0051283	2	0.034
positive regulation of molecular function	GO:0044093	136	0.034	Mouse
enteroendocrine cell differentiation	GO:0035883	1	0.034	Mouse
intracellular protein transport	GO:0006886	104	0.034
compound eye morphogenesis	GO:0001745	249	0.034
regulation of hydrolase activity	GO:0051336	97	0.033
cellular catabolic process	GO:0044248	372	0.033	Mouse
organic hydroxy compound metabolic process	GO:1901615	83	0.033
regulation of photoreceptor cell differentiation	GO:0046532	34	0.033
response to external biotic stimulus	GO:0043207	293	0.033
single organism membrane organization	GO:0044802	93	0.033
developmental maturation	GO:0021700	172	0.032
amine metabolic process	GO:0009308	12	0.032
oxoacid metabolic process	GO:0043436	103	0.032
positive regulation of cell death	GO:0010942	69	0.032
regulation of pathway restricted smad protein phosphorylation	GO:0060393	1	0.032
regulation of catabolic process	GO:0009894	170	0.032
regulation of adenylate cyclase activity	GO:0045761	12	0.032
chemotaxis	GO:0006935	249	0.032
positive regulation of ion transmembrane transporter activity	GO:0032414	4	0.032
regulation of cellular component biogenesis	GO:0044087	201	0.031
respiratory system development	GO:0060541	213	0.031
response to metal ion	GO:0010038	23	0.031
regulation of peptide hormone secretion	GO:0090276	5	0.031	Mouse
dendrite development	GO:0016358	204	0.031
regulation of multi organism process	GO:0043900	131	0.031
cation transmembrane transport	GO:0098655	88	0.031
response to other organism	GO:0051707	293	0.031
myotube cell development	GO:0014904	3	0.031
chitin based cuticle sclerotization	GO:0007593	19	0.031
phosphorylation	GO:0016310	294	0.031
acid secretion	GO:0046717	1	0.031
carboxylic acid transport	GO:0046942	18	0.031
lateral inhibition	GO:0046331	206	0.031
cell cycle phase transition	GO:0044770	140	0.031
indole containing compound biosynthetic process	GO:0042435	4	0.030
developmental growth	GO:0048589	280	0.030
regulation of purine nucleotide biosynthetic process	GO:1900371	14	0.030
regulation of ion transmembrane transport	GO:0034765	27	0.030
regulation of transcription regulatory region dna binding	GO:2000677	3	0.030
single organism nuclear import	GO:1902593	51	0.030
divalent inorganic cation homeostasis	GO:0072507	29	0.029
glial cell migration	GO:0008347	31	0.029
regulation of programmed cell death	GO:0043067	152	0.029
detection of visible light	GO:0009584	38	0.029
retina development in camera type eye	GO:0060041	4	0.029
negative regulation of multicellular organismal process	GO:0051241	142	0.029
appendage morphogenesis	GO:0035107	397	0.029
positive regulation of phosphorus metabolic process	GO:0010562	139	0.029
negative regulation of molecular function	GO:0044092	51	0.029
memory	GO:0007613	94	0.029
cellular response to molecule of bacterial origin	GO:0071219	3	0.029
cell migration	GO:0016477	238	0.029
response to hypoxia	GO:0001666	53	0.029
negative regulation of phosphorus metabolic process	GO:0010563	45	0.028
organophosphate biosynthetic process	GO:0090407	46	0.028
sensory perception of chemical stimulus	GO:0007606	116	0.028
detection of chemical stimulus involved in sensory perception of taste	GO:0050912	13	0.028
protein complex biogenesis	GO:0070271	201	0.028
ribonucleotide metabolic process	GO:0009259	145	0.028
immune system process	GO:0002376	347	0.028
negative regulation of insulin secretion	GO:0046676	1	0.028
single organism intracellular transport	GO:1902582	207	0.028
cellular ion homeostasis	GO:0006873	39	0.028
cell death	GO:0008219	279	0.027	Human
negative regulation of camp metabolic process	GO:0030815	3	0.027
protein complex assembly	GO:0006461	200	0.027
neurotransmitter transport	GO:0006836	37	0.027
anterior posterior axis specification embryo	GO:0008595	103	0.027
regulation of cyclase activity	GO:0031279	13	0.027
carbohydrate derivative metabolic process	GO:1901135	217	0.027
response to hexose	GO:0009746	3	0.026
positive regulation of cellular component biogenesis	GO:0044089	80	0.026
regulation of rhodopsin mediated signaling pathway	GO:0022400	17	0.026
positive regulation of camp metabolic process	GO:0030816	8	0.026
skeletal muscle organ development	GO:0060538	48	0.026
tube morphogenesis	GO:0035239	191	0.026
cellular response to dna damage stimulus	GO:0006974	223	0.026	Human
response to lipopolysaccharide	GO:0032496	4	0.026
muscle structure development	GO:0061061	224	0.026
anterior posterior axis specification	GO:0009948	109	0.026
lipopolysaccharide mediated signaling pathway	GO:0031663	1	0.026
regulation of canonical wnt signaling pathway	GO:0060828	15	0.026
long term memory	GO:0007616	62	0.026
negative regulation of transcription regulatory region dna binding	GO:2000678	3	0.026
response to biotic stimulus	GO:0009607	294	0.026
response to oxygen containing compound	GO:1901700	200	0.025
regulation of cytoplasmic transport	GO:1903649	47	0.025
response to organophosphorus	GO:0046683	2	0.025
cognition	GO:0050890	141	0.025
immune response activating signal transduction	GO:0002757	2	0.025
temperature homeostasis	GO:0001659	2	0.025
axis specification	GO:0009798	167	0.025
cellular response to abiotic stimulus	GO:0071214	58	0.025	Human
nucleocytoplasmic transport	GO:0006913	72	0.025
tripartite regional subdivision	GO:0007351	103	0.025
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.025
macromolecular complex assembly	GO:0065003	256	0.025
regulation of gene expression epigenetic	GO:0040029	128	0.025
regulation of heart contraction	GO:0008016	21	0.024
death	GO:0016265	284	0.024	Human
cellular response to peptide hormone stimulus	GO:0071375	28	0.024
positive regulation of cellular protein metabolic process	GO:0032270	118	0.024
regulation of retinal cell programmed cell death	GO:0046668	18	0.024
anterior posterior pattern specification	GO:0009952	136	0.024
cellular response to nitrogen compound	GO:1901699	51	0.024
regulation of immune system process	GO:0002682	176	0.024
regulation of cell division	GO:0051302	72	0.024
adenylate cyclase activating g protein coupled receptor signaling pathway	GO:0007189	9	0.024
spermatogenesis	GO:0007283	200	0.024	Mouse
cellular macromolecule catabolic process	GO:0044265	136	0.024	Mouse
energy taxis	GO:0009453	21	0.023
regulation of proteolysis	GO:0030162	87	0.023
regulation of defense response	GO:0031347	102	0.023	Mouse
tissue morphogenesis	GO:0048729	297	0.023
detection of light stimulus involved in sensory perception	GO:0050962	9	0.023
mating	GO:0007618	120	0.023
phagocytosis	GO:0006909	215	0.023
purine ribonucleotide biosynthetic process	GO:0009152	28	0.023
forebrain development	GO:0030900	2	0.023
intracellular steroid hormone receptor signaling pathway	GO:0030518	12	0.023	Mouse
aromatic amino acid family metabolic process	GO:0009072	3	0.023
optomotor response	GO:0071632	3	0.023
cellular cation homeostasis	GO:0030003	38	0.023
anion transport	GO:0006820	41	0.023
mitotic cell cycle phase transition	GO:0044772	138	0.023
positive regulation of calcium ion transport	GO:0051928	4	0.023
detection of stimulus involved in sensory perception	GO:0050906	92	0.023
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.023
oxidation reduction process	GO:0055114	123	0.022
cyclic nucleotide metabolic process	GO:0009187	28	0.022
nitrogen compound transport	GO:0071705	85	0.022	Mouse
gene silencing by rna	GO:0031047	57	0.022
olfactory learning	GO:0008355	56	0.022
organonitrogen compound catabolic process	GO:1901565	128	0.022
l amino acid import	GO:0043092	2	0.022
negative regulation of cell differentiation	GO:0045596	143	0.022
regulation of response to stress	GO:0080134	200	0.022	Human Mouse
positive regulation of cellular component organization	GO:0051130	156	0.022
appendage development	GO:0048736	401	0.022
neuromuscular junction development	GO:0007528	149	0.022
response to starvation	GO:0042594	97	0.022
lipid localization	GO:0010876	54	0.022
regulation of ion transmembrane transporter activity	GO:0032412	6	0.022
organic anion transport	GO:0015711	28	0.021
protein phosphorylation	GO:0006468	169	0.021
positive regulation of cell cycle	GO:0045787	43	0.021
immune response	GO:0006955	246	0.021
catechol containing compound biosynthetic process	GO:0009713	3	0.021
gene silencing	GO:0016458	138	0.021
regulation of adenylate cyclase activity involved in g protein coupled receptor signaling pathway	GO:0010578	8	0.021
response to endogenous stimulus	GO:0009719	119	0.021
cellular response to biotic stimulus	GO:0071216	4	0.021
glial cell differentiation	GO:0010001	35	0.021
phototransduction visible light	GO:0007603	27	0.021
myotube differentiation	GO:0014902	46	0.021
multi organism behavior	GO:0051705	175	0.021
molting cycle process	GO:0022404	29	0.021
regulation of nucleotide biosynthetic process	GO:0030808	14	0.021
metal ion homeostasis	GO:0055065	44	0.020
protein kinase a signaling	GO:0010737	2	0.020
rna processing	GO:0006396	147	0.020
response to symbiotic bacterium	GO:0009609	2	0.020
defense response to bacterium	GO:0042742	178	0.020
serotonin metabolic process	GO:0042428	2	0.020
positive regulation of proteolysis involved in cellular protein catabolic process	GO:1903052	24	0.020
regulation of synapse organization	GO:0050807	110	0.020
positive regulation of canonical wnt signaling pathway	GO:0090263	7	0.020
response to glucose	GO:0009749	2	0.020
regulation of vesicle mediated transport	GO:0060627	59	0.020
regulation of developmental growth	GO:0048638	174	0.020
positive regulation of catabolic process	GO:0009896	105	0.020
anatomical structure homeostasis	GO:0060249	97	0.019
nuclear transport	GO:0051169	72	0.019
cation transport	GO:0006812	110	0.019
immune response regulating signaling pathway	GO:0002764	2	0.019
negative regulation of intracellular signal transduction	GO:1902532	57	0.019
release of sequestered calcium ion into cytosol	GO:0051209	1	0.019
cellular metal ion homeostasis	GO:0006875	31	0.019
cellular amide metabolic process	GO:0043603	80	0.019
wnt signaling pathway	GO:0016055	98	0.019
dopamine metabolic process	GO:0042417	7	0.019
innate immune response	GO:0045087	144	0.019
neurotransmitter secretion	GO:0007269	35	0.019
catecholamine biosynthetic process	GO:0042423	3	0.019
regulation of muscle organ development	GO:0048634	13	0.019
regulation of immune response	GO:0050776	118	0.019
positive regulation of cell migration	GO:0030335	2	0.019
olfactory behavior	GO:0042048	97	0.019
embryonic pattern specification	GO:0009880	174	0.019
protein import into nucleus translocation	GO:0000060	6	0.018
growth	GO:0040007	359	0.018
circadian regulation of gene expression	GO:0032922	5	0.018
purine nucleotide biosynthetic process	GO:0006164	29	0.018
regulation of cell differentiation	GO:0045595	302	0.018	Mouse
regulation of i kappab kinase nf kappab signaling	GO:0043122	2	0.018
regulation of cellular component movement	GO:0051270	42	0.018
cytosolic calcium ion transport	GO:0060401	2	0.018
regulation of purine nucleotide metabolic process	GO:1900542	62	0.018
segmentation	GO:0035282	207	0.018
negative regulation of cell proliferation	GO:0008285	69	0.018
telencephalon development	GO:0021537	2	0.018
peptidyl threonine modification	GO:0018210	3	0.018
dna metabolic process	GO:0006259	227	0.018	Human
positive regulation of developmental growth	GO:0048639	62	0.018
catechol containing compound metabolic process	GO:0009712	10	0.018
male courtship behavior veined wing generated song production	GO:0045433	20	0.018
regulation of neurotransmitter secretion	GO:0046928	14	0.017
regulation of developmental pigmentation	GO:0048070	24	0.017
mrna processing	GO:0006397	104	0.017
cellular response to carbohydrate stimulus	GO:0071322	4	0.017
positive regulation of proteolysis	GO:0045862	52	0.017
programmed cell death	GO:0012501	257	0.017
positive regulation of protein catabolic process	GO:0045732	34	0.017
dopamine receptor signaling pathway	GO:0007212	4	0.017
translation	GO:0006412	69	0.017
regulation of cellular response to insulin stimulus	GO:1900076	17	0.017
feeding behavior	GO:0007631	50	0.017
neuroblast proliferation	GO:0007405	74	0.017
positive regulation of lyase activity	GO:0051349	10	0.017
organonitrogen compound biosynthetic process	GO:1901566	117	0.017
regulation of phosphorylation	GO:0042325	147	0.017
synapse assembly	GO:0007416	143	0.017
regulation of neurogenesis	GO:0050767	158	0.017
cellular response to oxygen containing compound	GO:1901701	79	0.017
cellular response to organic substance	GO:0071310	132	0.017

Clk disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.113
nervous system disease	DOID:863	0.087
neurodegenerative disease	DOID:1289	0.020
central nervous system disease	DOID:331	0.020
cardiovascular system disease	DOID:1287	0.020
eye and adnexa disease	DOID:1492	0.019
sensory system disease	DOID:0050155	0.019

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