IMP: Integrative Multi-species Prediction

Drosophila melanogaster

214 known processes

p38b (Dmel_CG7393)

CG7393 gene product from transcript CG7393-RA

(Aliases: dp38b,186F5S,D-p38,p38beta,p38 MAPK,D-p38 MAPK,Dp38,CG7393,p38,p38B,p38 beta,anon-sts23,ESTS:186F5S,BG:DS00797.3,Dm p38b,D-p38b,Mpk34C,Dmel\CG7393)

Entrez: 34780
FLYBASE: FBgn0024846
UniProtKB: O61443

Process Predictions
Disease Predictions

p38b biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
response to oxygen radical	GO:0000305	3	0.994	Worm
determination of adult lifespan	GO:0008340	137	0.982
immune response	GO:0006955	246	0.960
response to oxidative stress	GO:0006979	86	0.959
response to superoxide	GO:0000303	3	0.950	Worm
innate immune response	GO:0045087	144	0.915
cellular response to oxidative stress	GO:0034599	28	0.914
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.900
intracellular signal transduction	GO:0035556	300	0.896
defense response to fungus	GO:0050832	48	0.878
positive regulation of signal transduction	GO:0009967	223	0.868
response to biotic stimulus	GO:0009607	294	0.846
regulation of intracellular signal transduction	GO:1902531	236	0.837	Fly
response to bacterium	GO:0009617	198	0.836
negative regulation of cell communication	GO:0010648	223	0.825	Mouse Fly
response to external biotic stimulus	GO:0043207	293	0.815
negative regulation of signaling	GO:0023057	219	0.808	Mouse Fly
regulation of multi organism process	GO:0043900	131	0.807	Fly
negative regulation of cellular metabolic process	GO:0031324	382	0.803	Fly
negative regulation of response to stimulus	GO:0048585	258	0.798	Mouse Fly
stress activated mapk cascade	GO:0051403	52	0.779	Mouse Rat Worm Fly
negative regulation of signal transduction	GO:0009968	206	0.766	Mouse Fly
positive regulation of response to stimulus	GO:0048584	323	0.759
paracrine signaling	GO:0038001	7	0.707
autophagy	GO:0006914	108	0.677	Fly
positive regulation of biosynthetic process	GO:0009891	316	0.674	Yeast Mouse Worm
response to other organism	GO:0051707	293	0.671
immune system process	GO:0002376	347	0.665
regulation of response to biotic stimulus	GO:0002831	63	0.662	Fly
mapk cascade	GO:0000165	107	0.622
programmed cell death	GO:0012501	257	0.606	Worm
regulation of phosphate metabolic process	GO:0019220	210	0.589
aging	GO:0007568	143	0.578
regulation of biosynthetic process of antibacterial peptides active against gram positive bacteria	GO:0002816	3	0.575
regulation of response to stress	GO:0080134	200	0.574
cellular response to chemical stimulus	GO:0070887	199	0.573
regulation of cellular response to stress	GO:0080135	89	0.570
death	GO:0016265	284	0.557	Worm
cellular response to reactive oxygen species	GO:0034614	14	0.547
defense response	GO:0006952	300	0.532
cellular response to arsenic containing substance	GO:0071243	6	0.523
jnk cascade	GO:0007254	50	0.504	Fly
negative regulation of phosphorylation	GO:0042326	35	0.492	Fly
homeostatic process	GO:0042592	199	0.488	Mouse
regulation of transferase activity	GO:0051338	58	0.484	Fly
regulation of immune system process	GO:0002682	176	0.484
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.482	Yeast Mouse Worm
regulation of stress activated mapk cascade	GO:0032872	41	0.482	Fly
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.476	Human
regulation of multicellular organismal development	GO:2000026	414	0.457
positive regulation of reactive oxygen species metabolic process	GO:2000379	0	0.456	Human
melanin metabolic process	GO:0006582	47	0.450	Fly
cellular response to starvation	GO:0009267	61	0.442
bmp signaling pathway	GO:0030509	27	0.438
regulation of immune effector process	GO:0002697	52	0.431
regulation of molecular function	GO:0065009	217	0.401	Fly
mucosal immune response	GO:0002385	10	0.387	Fly
regulation of phosphorylation	GO:0042325	147	0.380
response to extracellular stimulus	GO:0009991	116	0.369
immune response regulating signaling pathway	GO:0002764	2	0.366
cellular response to external stimulus	GO:0071496	66	0.360
stress activated protein kinase signaling cascade	GO:0031098	55	0.357	Mouse Rat Worm Fly
regulation of catabolic process	GO:0009894	170	0.354	Fly
regulation of autophagy	GO:0010506	62	0.350	Fly
cell death	GO:0008219	279	0.349	Worm
regulation of anatomical structure size	GO:0090066	163	0.347
molting cycle chitin based cuticle	GO:0007591	56	0.346
regulation of protein modification process	GO:0031399	112	0.342
defense response to bacterium	GO:0042742	178	0.341
regulation of response to external stimulus	GO:0032101	115	0.341	Fly
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.340	Yeast Mouse Worm
regulation of mapk cascade	GO:0043408	92	0.333	Fly
intrinsic apoptotic signaling pathway	GO:0097193	16	0.333
phosphorylation	GO:0016310	294	0.332
regulation of jnk cascade	GO:0046328	40	0.332	Fly
cellular response to nutrient levels	GO:0031669	62	0.330
cellular response to organic substance	GO:0071310	132	0.327
transcription from rna polymerase ii promoter	GO:0006366	368	0.324	Yeast Mouse Worm
positive regulation of immune response	GO:0050778	63	0.321
negative regulation of immune system process	GO:0002683	50	0.316	Fly
regulation of cellular response to oxidative stress	GO:1900407	4	0.312
peptide metabolic process	GO:0006518	80	0.308
growth	GO:0040007	359	0.301
immune response activating signal transduction	GO:0002757	2	0.291
small molecule metabolic process	GO:0044281	305	0.288	Mouse
regulation of phosphorus metabolic process	GO:0051174	210	0.285
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.282
negative regulation of multicellular organismal process	GO:0051241	142	0.281
positive regulation of autophagy	GO:0010508	21	0.279	Fly
multicellular organismal aging	GO:0010259	140	0.278
macromolecule catabolic process	GO:0009057	161	0.271
regulation of immune response	GO:0050776	118	0.265
defense response to other organism	GO:0098542	225	0.265
developmental growth	GO:0048589	280	0.257
regulation of multicellular organism growth	GO:0040014	40	0.256
cellular response to extracellular stimulus	GO:0031668	64	0.254
response to ionizing radiation	GO:0010212	32	0.253	Human
regulation of cell differentiation	GO:0045595	302	0.248	Yeast Mouse
positive regulation of cell size	GO:0045793	21	0.237
catabolic process	GO:0009056	409	0.237	Fly
pattern recognition receptor signaling pathway	GO:0002221	2	0.232
negative regulation of intracellular signal transduction	GO:1902532	57	0.226	Fly
regulation of protein phosphorylation	GO:0001932	64	0.225
negative regulation of apoptotic process	GO:0043066	63	0.223
regulation of protein kinase activity	GO:0045859	51	0.220	Fly
regulation of programmed cell death	GO:0043067	152	0.213
regulation of stress activated protein kinase signaling cascade	GO:0070302	42	0.213	Fly
regionalization	GO:0003002	416	0.205
positive regulation of multicellular organismal process	GO:0051240	143	0.204
regulation of innate immune response	GO:0045088	71	0.203
response to organic substance	GO:0010033	284	0.197
cellular protein modification process	GO:0006464	438	0.197
cellular amide metabolic process	GO:0043603	80	0.197
apoptotic process	GO:0006915	159	0.196
positive regulation of signaling	GO:0023056	243	0.195
positive regulation of immune effector process	GO:0002699	28	0.194
oxoacid metabolic process	GO:0043436	103	0.194	Mouse
regulation of apoptotic process	GO:0042981	130	0.188
antibacterial humoral response	GO:0019731	44	0.187	Fly
heart contraction	GO:0060047	26	0.184
single organism intracellular transport	GO:1902582	207	0.179	Mouse
myotube cell development	GO:0014904	3	0.178	Mouse
organic hydroxy compound metabolic process	GO:1901615	83	0.178	Fly
regulation of kinase activity	GO:0043549	53	0.177	Fly
regulation of catalytic activity	GO:0050790	185	0.175	Fly
signal transduction by phosphorylation	GO:0023014	107	0.174
imaginal disc derived appendage development	GO:0048737	399	0.174
anatomical structure homeostasis	GO:0060249	97	0.174
phagocytosis	GO:0006909	215	0.172	Fly
cell migration	GO:0016477	238	0.170	Fly
organic substance transport	GO:0071702	257	0.165	Mouse
nucleocytoplasmic transport	GO:0006913	72	0.165	Mouse
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.164	Yeast Mouse Worm
response to fungus	GO:0009620	50	0.159
negative regulation of stress activated protein kinase signaling cascade	GO:0070303	20	0.158	Fly
regulation of defense response	GO:0031347	102	0.154
melanization defense response	GO:0035006	45	0.152	Fly
protein localization	GO:0008104	284	0.152	Mouse Worm
positive regulation of cellular biosynthetic process	GO:0031328	316	0.151	Yeast Mouse Worm
ameboidal type cell migration	GO:0001667	151	0.149	Fly
defense response to virus	GO:0051607	23	0.140
regulation of bmp signaling pathway	GO:0030510	23	0.139
immune effector process	GO:0002252	98	0.137
response to radiation	GO:0009314	155	0.136	Human
establishment of protein localization	GO:0045184	163	0.136	Mouse
mitochondrion organization	GO:0007005	65	0.135
gtp metabolic process	GO:0046039	72	0.133
appendage development	GO:0048736	401	0.133
columnar cuboidal epithelial cell development	GO:0002066	249	0.132	Fly
regulation of growth	GO:0040008	233	0.131
organonitrogen compound metabolic process	GO:1901564	318	0.130
response to nutrient levels	GO:0031667	114	0.130
mitochondrion degradation	GO:0000422	8	0.130
response to starvation	GO:0042594	97	0.130
negative regulation of developmental process	GO:0051093	201	0.126	Yeast
cell motility	GO:0048870	251	0.123	Fly
regulation of wnt signaling pathway	GO:0030111	68	0.122	Mouse
embryonic development via the syncytial blastoderm	GO:0001700	148	0.121	Fly
regulation of cellular component biogenesis	GO:0044087	201	0.121
positive regulation of phosphate metabolic process	GO:0045937	139	0.120
cellular amino acid metabolic process	GO:0006520	61	0.117
regulation of production of molecular mediator of immune response	GO:0002700	44	0.117
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	GO:0070059	4	0.117
negative regulation of immune response	GO:0050777	39	0.114	Fly
positive regulation of cell communication	GO:0010647	250	0.114
response to oxygen containing compound	GO:1901700	200	0.113
negative regulation of phosphorus metabolic process	GO:0010563	45	0.113	Fly
positive regulation of protein metabolic process	GO:0051247	128	0.113
protein modification process	GO:0036211	438	0.113
negative regulation of stress activated mapk cascade	GO:0032873	19	0.110	Fly
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.108	Yeast Mouse Worm
positive regulation of production of molecular mediator of immune response	GO:0002702	28	0.108
cellular lipid metabolic process	GO:0044255	83	0.107	Mouse
ovarian follicle cell development	GO:0030707	248	0.105	Fly
organ or tissue specific immune response	GO:0002251	10	0.103	Fly
spindle assembly	GO:0051225	80	0.103
positive regulation of programmed cell death	GO:0043068	62	0.103
response to endogenous stimulus	GO:0009719	119	0.102
cellular response to cadmium ion	GO:0071276	6	0.101
positive regulation of developmental process	GO:0051094	143	0.098
protein import into nucleus	GO:0006606	51	0.098	Mouse
regulation of protein metabolic process	GO:0051246	256	0.097
cellular protein localization	GO:0034613	160	0.097	Mouse Worm
response to hydrogen peroxide	GO:0042542	11	0.097
positive regulation of gene expression	GO:0010628	290	0.096	Yeast Mouse Worm
cell growth	GO:0016049	108	0.095	Fly
heart process	GO:0003015	37	0.095
single organism nuclear import	GO:1902593	51	0.094	Mouse
localization of cell	GO:0051674	257	0.094	Fly
hyperosmotic response	GO:0006972	1	0.093	Yeast Worm
molting cycle	GO:0042303	56	0.093
myotube differentiation	GO:0014902	46	0.092	Mouse
regulation of developmental growth	GO:0048638	174	0.091
epithelial cell differentiation	GO:0030855	322	0.091	Fly
lipid homeostasis	GO:0055088	33	0.090
epithelial cell development	GO:0002064	274	0.090	Fly
response to axon injury	GO:0048678	12	0.089	Fly
cytoskeleton dependent intracellular transport	GO:0030705	44	0.089
activation of innate immune response	GO:0002218	4	0.089
positive regulation of catalytic activity	GO:0043085	118	0.088
organonitrogen compound biosynthetic process	GO:1901566	117	0.088
notch signaling pathway	GO:0007219	120	0.085
vesicle mediated transport	GO:0016192	381	0.084	Fly
guanosine containing compound catabolic process	GO:1901069	74	0.084
innate immune response activating signal transduction	GO:0002758	2	0.083
autophagic vacuole assembly	GO:0000045	2	0.079
regulation of cell size	GO:0008361	63	0.077
positive regulation of rna metabolic process	GO:0051254	271	0.077	Yeast Mouse Worm
positive regulation of defense response	GO:0031349	59	0.077
response to virus	GO:0009615	28	0.076
regulation of cell death	GO:0010941	173	0.076
regulation of cellular response to insulin stimulus	GO:1900076	17	0.075
regulation of antimicrobial humoral response	GO:0002759	50	0.074	Fly
reactive oxygen species metabolic process	GO:0072593	22	0.074
positive regulation of protein modification process	GO:0031401	58	0.073
macromolecular complex assembly	GO:0065003	256	0.072
covalent chromatin modification	GO:0016569	106	0.072
antimicrobial peptide production	GO:0002775	46	0.072
regulation of localization	GO:0032879	275	0.071	Mouse Worm
organic substance catabolic process	GO:1901575	308	0.071
taxis	GO:0042330	304	0.070	Fly
cellular catabolic process	GO:0044248	372	0.070	Fly
terminal button organization	GO:0072553	19	0.069
positive regulation of cellular catabolic process	GO:0031331	95	0.069	Fly
negative regulation of molecular function	GO:0044092	51	0.069	Fly
regulation of cell development	GO:0060284	215	0.067	Mouse
positive regulation of protein transport	GO:0051222	37	0.066	Mouse
positive regulation of protein phosphorylation	GO:0001934	34	0.066
heart morphogenesis	GO:0003007	32	0.065
positive regulation of phosphorylation	GO:0042327	87	0.065
single organism catabolic process	GO:0044712	228	0.064
humoral immune response	GO:0006959	117	0.064	Fly
establishment of localization in cell	GO:0051649	402	0.063	Mouse
negative regulation of kinase activity	GO:0033673	16	0.062	Fly
regulation of defense response to virus	GO:0050688	14	0.061
regulation of reactive oxygen species metabolic process	GO:2000377	8	0.061	Human
organelle fission	GO:0048285	340	0.060
organophosphate metabolic process	GO:0019637	195	0.060
regulation of cell proliferation	GO:0042127	163	0.059
positive regulation of catabolic process	GO:0009896	105	0.059	Fly
single organism biosynthetic process	GO:0044711	206	0.058	Yeast
carboxylic acid metabolic process	GO:0019752	92	0.058	Mouse
eggshell formation	GO:0030703	105	0.058	Fly
negative regulation of cell death	GO:0060548	81	0.058
neurological system process	GO:0050877	358	0.058
regulation of cellular component size	GO:0032535	98	0.058
cellular response to endogenous stimulus	GO:0071495	80	0.057
cell aging	GO:0007569	2	0.057	Human
nucleotide catabolic process	GO:0009166	109	0.056
negative regulation of transcription dna templated	GO:0045892	237	0.056
nuclear import	GO:0051170	51	0.055	Mouse
positive regulation of macromolecule metabolic process	GO:0010604	405	0.054
negative regulation of mapk cascade	GO:0043409	23	0.054	Fly
regulation of response to oxidative stress	GO:1902882	4	0.053
negative regulation of programmed cell death	GO:0043069	72	0.052
regulation of protein localization	GO:0032880	76	0.052	Mouse Worm
intracellular transport	GO:0046907	228	0.052	Mouse
peptidoglycan metabolic process	GO:0000270	3	0.051
regulation of adult chitin containing cuticle pigmentation	GO:0048082	13	0.051
biosynthetic process of antibacterial peptides active against gram negative bacteria	GO:0002812	14	0.051
positive regulation of intracellular signal transduction	GO:1902533	116	0.051
carbohydrate derivative catabolic process	GO:1901136	118	0.049
positive regulation of multi organism process	GO:0043902	40	0.049
response to peptide	GO:1901652	29	0.048	Mouse
apoptotic signaling pathway	GO:0097190	27	0.048
regulation of insulin receptor signaling pathway	GO:0046626	17	0.048
organic acid metabolic process	GO:0006082	103	0.048	Mouse
intracellular protein transport	GO:0006886	104	0.047	Mouse
muscle organ development	GO:0007517	127	0.047	Mouse
defense response to gram negative bacterium	GO:0050829	94	0.046	Worm
endocytosis	GO:0006897	310	0.046	Fly
positive regulation of defense response to bacterium	GO:1900426	23	0.046
positive regulation of protein kinase activity	GO:0045860	25	0.046
regulation of map kinase activity	GO:0043405	17	0.046	Fly
cellular macromolecule localization	GO:0070727	220	0.045	Mouse Worm
regulation of cellular catabolic process	GO:0031329	157	0.045	Fly
negative regulation of protein phosphorylation	GO:0001933	17	0.045	Fly
connective tissue development	GO:0061448	3	0.045	Mouse
regulation of notch signaling pathway	GO:0008593	100	0.045
response to peptidoglycan	GO:0032494	2	0.044
protein localization to nucleus	GO:0034504	55	0.044	Mouse Worm
regulation of protein import into nucleus	GO:0042306	28	0.043	Mouse
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	65	0.043
negative regulation of cell differentiation	GO:0045596	143	0.043	Yeast
response to lipopolysaccharide	GO:0032496	4	0.043	Human Mouse
multicellular organismal homeostasis	GO:0048871	41	0.043
dna damage checkpoint	GO:0000077	78	0.043	Mouse
regulation of steroid metabolic process	GO:0019218	2	0.042
signal transduction in response to dna damage	GO:0042770	3	0.041	Human
canonical wnt signaling pathway	GO:0060070	21	0.040	Mouse
molting cycle process	GO:0022404	29	0.039
axon guidance	GO:0007411	233	0.039	Fly
chromosome organization	GO:0051276	360	0.039
cellular response to oxygen containing compound	GO:1901701	79	0.039
cellular response to ionizing radiation	GO:0071479	15	0.039	Human
response to organonitrogen compound	GO:0010243	75	0.038	Mouse
tor signaling	GO:0031929	32	0.038
skeletal muscle organ development	GO:0060538	48	0.037	Mouse
regulation of antimicrobial peptide production	GO:0002784	44	0.037
insulin receptor signaling pathway	GO:0008286	25	0.037
eye development	GO:0001654	323	0.037
multicellular organism growth	GO:0035264	46	0.037
imaginal disc derived wing vein morphogenesis	GO:0008586	44	0.036
regulation of cell cycle	GO:0051726	291	0.036	Yeast Rat
regulation of cellular amide metabolic process	GO:0034248	39	0.036
ion transport	GO:0006811	145	0.036
regulation of macroautophagy	GO:0016241	15	0.036
regulation of antibacterial peptide biosynthetic process	GO:0002808	22	0.036
cell proliferation	GO:0008283	299	0.036
response to inorganic substance	GO:0010035	44	0.035
regulation of intracellular protein transport	GO:0033157	46	0.034	Mouse
lipid metabolic process	GO:0006629	121	0.034	Mouse
response to reactive oxygen species	GO:0000302	24	0.034
negative regulation of phosphate metabolic process	GO:0045936	45	0.034	Fly
protein complex biogenesis	GO:0070271	201	0.034
positive regulation of apoptotic signaling pathway	GO:2001235	4	0.034
wing disc morphogenesis	GO:0007472	344	0.034
negative regulation of transferase activity	GO:0051348	18	0.034	Fly
negative regulation of defense response	GO:0031348	35	0.033
tissue migration	GO:0090130	155	0.033	Fly
positive regulation of developmental growth	GO:0048639	62	0.033
protein targeting	GO:0006605	64	0.032	Mouse
regulation of hydrolase activity	GO:0051336	97	0.032
organic cyclic compound catabolic process	GO:1901361	168	0.032
negative regulation of sequence specific dna binding transcription factor activity	GO:0043433	4	0.032
regulation of nucleocytoplasmic transport	GO:0046822	35	0.032	Mouse
regulation of protein transport	GO:0051223	57	0.032	Mouse
macroautophagy	GO:0016236	42	0.031
regulation of canonical wnt signaling pathway	GO:0060828	15	0.031	Mouse
negative regulation of gene expression	GO:0010629	387	0.031
protein maturation	GO:0051604	71	0.031
reproductive system development	GO:0061458	74	0.031	Worm Fly
positive regulation of cell death	GO:0010942	69	0.031
protein targeting to nucleus	GO:0044744	51	0.030	Mouse
positive regulation of cell motility	GO:2000147	3	0.030
larval development	GO:0002164	104	0.030	Worm
cellular carbohydrate metabolic process	GO:0044262	22	0.030
establishment of organelle localization	GO:0051656	122	0.029
chromatin modification	GO:0016568	147	0.029
transmembrane transport	GO:0055085	139	0.029
dorsal ventral pattern formation	GO:0009953	133	0.029
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.028
imaginal disc derived wing morphogenesis	GO:0007476	337	0.028
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.028
organelle assembly	GO:0070925	198	0.028
response to salt stress	GO:0009651	11	0.028
response to wounding	GO:0009611	94	0.027	Mouse Fly
circulatory system process	GO:0003013	37	0.027
positive regulation of cellular protein metabolic process	GO:0032270	118	0.027
salivary gland development	GO:0007431	162	0.027
regulation of defense response to virus by host	GO:0050691	10	0.027
protein processing	GO:0016485	68	0.027
positive regulation of antibacterial peptide production	GO:0002803	20	0.027
germ line stem cell maintenance	GO:0030718	50	0.027
positive regulation of molecular function	GO:0044093	136	0.027
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.027	Fly
negative regulation of rna biosynthetic process	GO:1902679	240	0.026
peptidyl amino acid modification	GO:0018193	105	0.026	Human Mouse Worm
phenol containing compound metabolic process	GO:0018958	57	0.026	Fly
protein complex assembly	GO:0006461	200	0.026
adult chitin containing cuticle pigmentation	GO:0048085	16	0.026
protein phosphorylation	GO:0006468	169	0.026
single organism carbohydrate metabolic process	GO:0044723	72	0.025	Mouse
cellular component assembly involved in morphogenesis	GO:0010927	151	0.025	Yeast Fly
antimicrobial humoral response	GO:0019730	99	0.025	Fly
ion homeostasis	GO:0050801	55	0.025
specification of symmetry	GO:0009799	13	0.025	Fly
regulation of nervous system development	GO:0051960	248	0.025
retina development in camera type eye	GO:0060041	4	0.025
positive regulation of transferase activity	GO:0051347	26	0.025
negative regulation of protein metabolic process	GO:0051248	85	0.024	Fly
regulation of antibacterial peptide production	GO:0002786	22	0.024
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.024
developmental cell growth	GO:0048588	52	0.024	Fly
regulation of protein serine threonine kinase activity	GO:0071900	25	0.024	Fly
axon development	GO:0061564	297	0.024	Fly
regulation of purine nucleotide catabolic process	GO:0033121	48	0.024
carbohydrate metabolic process	GO:0005975	82	0.023	Mouse
cellular response to peptide hormone stimulus	GO:0071375	28	0.023
synapse organization	GO:0050808	196	0.023
regulation of cellular amine metabolic process	GO:0033238	3	0.023
nucleoside catabolic process	GO:0009164	112	0.023
cell division	GO:0051301	248	0.023
cellular response to biotic stimulus	GO:0071216	4	0.023	Human Mouse
carbohydrate derivative biosynthetic process	GO:1901137	85	0.023
inositol lipid mediated signaling	GO:0048017	4	0.022
aromatic compound catabolic process	GO:0019439	166	0.022
chromatin organization	GO:0006325	207	0.022
regulation of developmental pigmentation	GO:0048070	24	0.022
modification dependent protein catabolic process	GO:0019941	78	0.022
small gtpase mediated signal transduction	GO:0007264	88	0.022
positive regulation of nucleotide metabolic process	GO:0045981	55	0.022
positive regulation of innate immune response	GO:0045089	38	0.022
dna metabolic process	GO:0006259	227	0.022	Yeast
defense response to gram positive bacterium	GO:0050830	41	0.022	Worm
histone modification	GO:0016570	106	0.022
positive regulation of immune system process	GO:0002684	68	0.021	Mouse
regulation of cellular ketone metabolic process	GO:0010565	3	0.021
regulation of heart contraction	GO:0008016	21	0.021
regulation of cellular protein metabolic process	GO:0032268	243	0.021
regulation of humoral immune response	GO:0002920	51	0.021	Fly
protein transport	GO:0015031	155	0.021	Mouse
embryo development ending in birth or egg hatching	GO:0009792	152	0.021	Worm Fly
positive regulation of multicellular organism growth	GO:0040018	21	0.021
positive regulation of mapk cascade	GO:0043410	63	0.021
skeletal muscle fiber development	GO:0048741	3	0.021	Mouse
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.021
negative regulation of cellular biosynthetic process	GO:0031327	277	0.021
negative regulation of cellular protein metabolic process	GO:0032269	85	0.020	Fly
regulation of organ morphogenesis	GO:2000027	78	0.020
secondary metabolic process	GO:0019748	75	0.020	Fly
regulation of terminal button organization	GO:2000331	11	0.020
regulation of synapse organization	GO:0050807	110	0.020
negative regulation of nervous system development	GO:0051961	92	0.020
maintenance of location	GO:0051235	73	0.020
metal ion homeostasis	GO:0055065	44	0.020
cell adhesion	GO:0007155	136	0.020
protein heterooligomerization	GO:0051291	4	0.019
skeletal muscle tissue development	GO:0007519	13	0.019	Mouse
organophosphate biosynthetic process	GO:0090407	46	0.019
dna integrity checkpoint	GO:0031570	81	0.019	Mouse
body morphogenesis	GO:0010171	2	0.019
gland development	GO:0048732	191	0.019
positive regulation of defense response to virus by host	GO:0002230	10	0.019
response to abiotic stimulus	GO:0009628	341	0.019
striated muscle tissue development	GO:0014706	27	0.019	Mouse
cell cycle arrest	GO:0007050	4	0.019
positive regulation of protein serine threonine kinase activity	GO:0071902	15	0.019
negative regulation of response to external stimulus	GO:0032102	22	0.019	Fly
rna processing	GO:0006396	147	0.018
gtp catabolic process	GO:0006184	72	0.018
positive regulation of jun kinase activity	GO:0043507	4	0.018
forebrain development	GO:0030900	2	0.018
negative regulation of innate immune response	GO:0045824	30	0.018
cellular response to molecule of bacterial origin	GO:0071219	3	0.018	Human Mouse
positive regulation of kinase activity	GO:0033674	25	0.018
epithelial cell migration	GO:0010631	148	0.018	Fly
regulation of mitochondrial fusion	GO:0010635	5	0.018
cell type specific apoptotic process	GO:0097285	38	0.018
cellular amine metabolic process	GO:0044106	12	0.017
positive regulation of biosynthetic process of antibacterial peptides active against gram positive bacteria	GO:0006965	3	0.017
developmental programmed cell death	GO:0010623	138	0.017
cellular hyperosmotic response	GO:0071474	1	0.017
stem cell maintenance	GO:0019827	67	0.017
response to alcohol	GO:0097305	95	0.017
positive regulation of cell differentiation	GO:0045597	64	0.017	Mouse
cellular response to lipid	GO:0071396	20	0.017	Human Mouse
sensory organ morphogenesis	GO:0090596	260	0.017
carbohydrate derivative metabolic process	GO:1901135	217	0.016
organelle localization	GO:0051640	148	0.016
fatty acid catabolic process	GO:0009062	9	0.016
nucleoside phosphate catabolic process	GO:1901292	110	0.016
sprouting of injured axon	GO:0048682	3	0.016	Fly
muscle tissue development	GO:0060537	30	0.016	Mouse
regulation of nucleotide catabolic process	GO:0030811	48	0.016
positive regulation of purine nucleotide metabolic process	GO:1900544	55	0.016
negative regulation of growth	GO:0045926	84	0.016
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.016	Yeast Mouse Worm
nucleoside phosphate biosynthetic process	GO:1901293	34	0.016
axon regeneration	GO:0031103	8	0.016	Fly
oxidation reduction process	GO:0055114	123	0.016	Mouse
microtubule based transport	GO:0010970	42	0.016
embryonic morphogenesis	GO:0048598	206	0.016	Fly
response to growth factor	GO:0070848	31	0.016
purine nucleotide metabolic process	GO:0006163	146	0.016
positive regulation of growth	GO:0045927	75	0.016
negative regulation of cell proliferation	GO:0008285	69	0.015
determination of digestive tract left right asymmetry	GO:0071907	6	0.015	Fly
compound eye development	GO:0048749	307	0.015
imaginal disc fusion thorax closure	GO:0046529	19	0.015	Fly
phosphatidylinositol mediated signaling	GO:0048015	4	0.015
regulation of mitochondrial fission	GO:0090140	7	0.015
lipopolysaccharide mediated signaling pathway	GO:0031663	1	0.015	Mouse
positive regulation of apoptotic process	GO:0043065	47	0.015
central nervous system development	GO:0007417	201	0.015
age dependent general metabolic decline	GO:0007571	3	0.015
cellular nitrogen compound catabolic process	GO:0044270	165	0.015
regulation of protein localization to nucleus	GO:1900180	29	0.015	Mouse Worm
negative regulation of response to biotic stimulus	GO:0002832	12	0.015	Fly
negative regulation of biosynthetic process	GO:0009890	277	0.014
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	38	0.014
purine containing compound biosynthetic process	GO:0072522	30	0.014
striated muscle cell differentiation	GO:0051146	90	0.014	Mouse
nucleobase containing compound catabolic process	GO:0034655	165	0.014
muscle contraction	GO:0006936	13	0.014

p38b disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.055
musculoskeletal system disease	DOID:17	0.031
connective tissue disease	DOID:65	0.031
bone disease	DOID:0080001	0.031
disease of cellular proliferation	DOID:14566	0.028
organ system cancer	DOID:0050686	0.014
cancer	DOID:162	0.014
central nervous system disease	DOID:331	0.014
motor neuron disease	DOID:231	0.014
nervous system disease	DOID:863	0.014

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