IMP: Integrative Multi-species Prediction

Drosophila melanogaster

108 known processes

spict (Dmel_CG12292)

spichthyin

(Aliases: spg6,Dmel\CG12292,CG12292,Spict)

Entrez: 34681
FLYBASE: FBgn0032451
UniProtKB: Q9VK62
UniProtKB: M9PD12

Process Predictions
Disease Predictions

spict biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
imaginal disc derived appendage development	GO:0048737	399	0.578
wing disc morphogenesis	GO:0007472	344	0.498
neuromuscular junction development	GO:0007528	149	0.462
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.433
appendage morphogenesis	GO:0035107	397	0.387
post embryonic appendage morphogenesis	GO:0035120	385	0.383
appendage development	GO:0048736	401	0.357
establishment of localization in cell	GO:0051649	402	0.318
synaptic vesicle recycling	GO:0036465	28	0.231
cell migration	GO:0016477	238	0.216
epithelial cell development	GO:0002064	274	0.189
synaptic transmission	GO:0007268	288	0.188
protein localization	GO:0008104	284	0.183
localization of cell	GO:0051674	257	0.178
secretion by cell	GO:0032940	101	0.172
regulation of nervous system development	GO:0051960	248	0.161
imaginal disc derived wing morphogenesis	GO:0007476	337	0.156
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.143
regionalization	GO:0003002	416	0.142
regulation of multicellular organismal development	GO:2000026	414	0.132
regulation of localization	GO:0032879	275	0.125
negative regulation of developmental growth	GO:0048640	64	0.112
organic substance transport	GO:0071702	257	0.111
cellular protein localization	GO:0034613	160	0.111
intracellular transport	GO:0046907	228	0.107
regulation of cellular component biogenesis	GO:0044087	201	0.104
autophagy	GO:0006914	108	0.093
protein modification process	GO:0036211	438	0.091
cellular macromolecule localization	GO:0070727	220	0.089
synapse organization	GO:0050808	196	0.087
protein transport	GO:0015031	155	0.087
synaptic growth at neuromuscular junction	GO:0051124	119	0.084
cellular component assembly involved in morphogenesis	GO:0010927	151	0.084
single organism catabolic process	GO:0044712	228	0.084
cell division	GO:0051301	248	0.077
ovarian follicle cell development	GO:0030707	248	0.074
ribose phosphate metabolic process	GO:0019693	145	0.073
cellular protein modification process	GO:0006464	438	0.073
regulation of developmental growth	GO:0048638	174	0.072
regulation of anatomical structure size	GO:0090066	163	0.072
establishment of vesicle localization	GO:0051650	51	0.072
regulation of phosphorus metabolic process	GO:0051174	210	0.066
vesicle mediated transport	GO:0016192	381	0.066
purine ribonucleotide metabolic process	GO:0009150	145	0.065
multicellular organismal aging	GO:0010259	140	0.064
tube development	GO:0035295	244	0.063
single organism intracellular transport	GO:1902582	207	0.062
bmp signaling pathway	GO:0030509	27	0.059
intracellular protein transport	GO:0006886	104	0.058
establishment of protein localization	GO:0045184	163	0.057
posttranscriptional regulation of gene expression	GO:0010608	145	0.057
neurotransmitter transport	GO:0006836	37	0.053
tissue morphogenesis	GO:0048729	297	0.053
columnar cuboidal epithelial cell development	GO:0002066	249	0.052
regulation of cell development	GO:0060284	215	0.052
lipid metabolic process	GO:0006629	121	0.051
developmental maturation	GO:0021700	172	0.050
secretion	GO:0046903	109	0.049
response to biotic stimulus	GO:0009607	294	0.049
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.047
ameboidal type cell migration	GO:0001667	151	0.046
muscle structure development	GO:0061061	224	0.045
synapse assembly	GO:0007416	143	0.045
determination of adult lifespan	GO:0008340	137	0.045
organelle assembly	GO:0070925	198	0.044
neurotransmitter secretion	GO:0007269	35	0.044
establishment of synaptic vesicle localization	GO:0097480	50	0.042
protein prenylation	GO:0018342	3	0.042
regulation of synapse organization	GO:0050807	110	0.040
axonogenesis	GO:0007409	290	0.040
organonitrogen compound metabolic process	GO:1901564	318	0.039
regulation of cell cycle	GO:0051726	291	0.039
transcription from rna polymerase ii promoter	GO:0006366	368	0.038
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.038
protein complex assembly	GO:0006461	200	0.038
regulation of neurogenesis	GO:0050767	158	0.038
peptidyl amino acid modification	GO:0018193	105	0.037
chorion containing eggshell formation	GO:0007304	105	0.037
single organism biosynthetic process	GO:0044711	206	0.037
homeostatic process	GO:0042592	199	0.037
embryonic morphogenesis	GO:0048598	206	0.037
cytokinesis	GO:0000910	90	0.037
endomembrane system organization	GO:0010256	119	0.037
synaptic vesicle endocytosis	GO:0048488	28	0.035
positive regulation of biosynthetic process	GO:0009891	316	0.035
purine nucleotide metabolic process	GO:0006163	146	0.035
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.035
regulation of neurotransmitter levels	GO:0001505	38	0.034
spermatogenesis	GO:0007283	200	0.034
negative regulation of cell cycle	GO:0045786	116	0.034
regulation of phosphate metabolic process	GO:0019220	210	0.034
regulation of membrane potential	GO:0042391	35	0.033
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.033
epithelial cell migration	GO:0010631	148	0.033
cytoskeleton dependent cytokinesis	GO:0061640	81	0.032
ribonucleotide metabolic process	GO:0009259	145	0.032
embryonic pattern specification	GO:0009880	174	0.032
nucleotide metabolic process	GO:0009117	161	0.032
lipid biosynthetic process	GO:0008610	46	0.031
oocyte dorsal ventral axis specification	GO:0007310	34	0.031
response to external biotic stimulus	GO:0043207	293	0.031
nucleoside catabolic process	GO:0009164	112	0.031
regulation of cellular component size	GO:0032535	98	0.030
nucleobase containing small molecule metabolic process	GO:0055086	174	0.030
positive regulation of cellular component organization	GO:0051130	156	0.030
regulation of cell proliferation	GO:0042127	163	0.030
macromolecular complex assembly	GO:0065003	256	0.030
purine nucleotide catabolic process	GO:0006195	109	0.030
response to organic substance	GO:0010033	284	0.030
digestive system development	GO:0055123	149	0.029
intracellular signal transduction	GO:0035556	300	0.029
negative regulation of calcium ion import	GO:0090281	2	0.029
cellular lipid metabolic process	GO:0044255	83	0.029
macroautophagy	GO:0016236	42	0.029
carbohydrate derivative metabolic process	GO:1901135	217	0.028
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.028
regulation of cellular protein metabolic process	GO:0032268	243	0.027
organic substance catabolic process	GO:1901575	308	0.027
positive regulation of lipid storage	GO:0010884	4	0.027
cell death	GO:0008219	279	0.027
signal release	GO:0023061	49	0.027
purine nucleoside catabolic process	GO:0006152	112	0.027
epithelial cell differentiation	GO:0030855	322	0.027
positive regulation of signaling	GO:0023056	243	0.026
nucleoside triphosphate metabolic process	GO:0009141	120	0.026
regulation of secretion by cell	GO:1903530	39	0.026
small molecule metabolic process	GO:0044281	305	0.026
organelle fission	GO:0048285	340	0.025
autophagic vacuole assembly	GO:0000045	2	0.025
protein acylation	GO:0043543	42	0.025
embryo development ending in birth or egg hatching	GO:0009792	152	0.025
regulation of synapse assembly	GO:0051963	94	0.025
regulation of cell size	GO:0008361	63	0.024
regulation of cell projection organization	GO:0031344	92	0.024
purine containing compound metabolic process	GO:0072521	155	0.024
anterior posterior axis specification embryo	GO:0008595	103	0.024
positive regulation of phosphorus metabolic process	GO:0010562	139	0.024
response to other organism	GO:0051707	293	0.024
dorsal ventral axis specification	GO:0009950	66	0.024
positive regulation of cell communication	GO:0010647	250	0.023
mitotic cytokinesis	GO:0000281	50	0.023
tripartite regional subdivision	GO:0007351	103	0.023
cellular catabolic process	GO:0044248	372	0.023
response to nutrient levels	GO:0031667	114	0.023
nucleoside phosphate metabolic process	GO:0006753	162	0.023
forebrain development	GO:0030900	2	0.023
cellular nitrogen compound catabolic process	GO:0044270	165	0.023
adenylate cyclase modulating g protein coupled receptor signaling pathway	GO:0007188	17	0.023
cytoplasmic transport	GO:0016482	130	0.023
dorsal ventral pattern formation	GO:0009953	133	0.023
protein targeting	GO:0006605	64	0.023
protein phosphorylation	GO:0006468	169	0.022
negative regulation of growth	GO:0045926	84	0.022
regulation of synaptic transmission	GO:0050804	69	0.022
regulation of hydrolase activity	GO:0051336	97	0.022
catabolic process	GO:0009056	409	0.022
tube morphogenesis	GO:0035239	191	0.022
positive regulation of protein metabolic process	GO:0051247	128	0.022
neuromuscular synaptic transmission	GO:0007274	67	0.022
lipid modification	GO:0030258	24	0.022
calcium ion transport	GO:0006816	24	0.022
negative regulation of cell cycle process	GO:0010948	109	0.022
embryonic development via the syncytial blastoderm	GO:0001700	148	0.022
actin filament based process	GO:0030029	220	0.021
notch signaling pathway	GO:0007219	120	0.021
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.021
positive regulation of phosphate metabolic process	GO:0045937	139	0.021
embryonic hindgut morphogenesis	GO:0048619	48	0.021
cellular ketone metabolic process	GO:0042180	24	0.021
membrane organization	GO:0061024	112	0.021
ribonucleoside metabolic process	GO:0009119	127	0.021
male gamete generation	GO:0048232	201	0.021
purine containing compound catabolic process	GO:0072523	112	0.021
positive regulation of catalytic activity	GO:0043085	118	0.021
chromosome segregation	GO:0007059	157	0.021
positive regulation of response to stimulus	GO:0048584	323	0.021
regulation of protein localization	GO:0032880	76	0.020
blastoderm segmentation	GO:0007350	159	0.020
tissue migration	GO:0090130	155	0.020
digestive tract development	GO:0048565	149	0.020
developmental growth	GO:0048589	280	0.020
synaptic vesicle localization	GO:0097479	53	0.020
endocytosis	GO:0006897	310	0.020
regulation of catalytic activity	GO:0050790	185	0.020
glycosyl compound metabolic process	GO:1901657	127	0.019
regulation of transport	GO:0051049	181	0.019
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.019
organic cyclic compound catabolic process	GO:1901361	168	0.019
protein geranylgeranylation	GO:0018344	3	0.019
carbohydrate derivative catabolic process	GO:1901136	118	0.019
regulation of molecular function	GO:0065009	217	0.019
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.019
epithelial structure maintenance	GO:0010669	17	0.019
neuron neuron synaptic transmission	GO:0007270	14	0.019
cell motility	GO:0048870	251	0.018
metal ion transport	GO:0030001	74	0.018
single organism cellular localization	GO:1902580	180	0.018
taxis	GO:0042330	304	0.018
single organism behavior	GO:0044708	391	0.018
response to oxygen containing compound	GO:1901700	200	0.018
regulation of cellular catabolic process	GO:0031329	157	0.018
cellular response to nutrient levels	GO:0031669	62	0.018
response to starvation	GO:0042594	97	0.018
regulation of tube architecture open tracheal system	GO:0035152	68	0.018
positive regulation of molecular function	GO:0044093	136	0.017
chemotaxis	GO:0006935	249	0.017
positive regulation of catabolic process	GO:0009896	105	0.017
negative regulation of developmental process	GO:0051093	201	0.017
nucleoside phosphate catabolic process	GO:1901292	110	0.017
positive regulation of phosphorylation	GO:0042327	87	0.017
regulation of cellular amine metabolic process	GO:0033238	3	0.017
aging	GO:0007568	143	0.017
phosphorylation	GO:0016310	294	0.017
glycoprotein metabolic process	GO:0009100	41	0.017
endosomal transport	GO:0016197	44	0.017
nucleoside triphosphate catabolic process	GO:0009143	108	0.017
regulation of cell morphogenesis	GO:0022604	163	0.017
nucleoside metabolic process	GO:0009116	127	0.016
response to bacterium	GO:0009617	198	0.016
positive regulation of macromolecule metabolic process	GO:0010604	405	0.016
ribonucleoside catabolic process	GO:0042454	112	0.016
exocytosis	GO:0006887	28	0.016
ethanolamine containing compound metabolic process	GO:0042439	4	0.016
purine ribonucleoside metabolic process	GO:0046128	127	0.016
regulation of cell death	GO:0010941	173	0.016
actin cytoskeleton organization	GO:0030036	206	0.016
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.016
regulation of bmp signaling pathway	GO:0030510	23	0.016
regulation of protein metabolic process	GO:0051246	256	0.015
regulation of catabolic process	GO:0009894	170	0.015
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.015
cell proliferation	GO:0008283	299	0.015
vacuolar transport	GO:0007034	13	0.015
axis specification	GO:0009798	167	0.015
negative regulation of biosynthetic process	GO:0009890	277	0.015
negative regulation of mitotic cell cycle	GO:0045930	109	0.015
positive regulation of signal transduction	GO:0009967	223	0.015
glycosyl compound catabolic process	GO:1901658	112	0.015
cellular amine metabolic process	GO:0044106	12	0.015
eggshell formation	GO:0030703	105	0.015
adult locomotory behavior	GO:0008344	76	0.015
regulation of multi organism process	GO:0043900	131	0.015
membrane budding	GO:0006900	4	0.015
regulation of secretion	GO:0051046	44	0.015
peptidyl threonine phosphorylation	GO:0018107	2	0.015
regulation of autophagy	GO:0010506	62	0.014
regulation of programmed cell death	GO:0043067	152	0.014
vesicle localization	GO:0051648	55	0.014
regulation of cell differentiation	GO:0045595	302	0.014
heterocycle catabolic process	GO:0046700	166	0.014
anterior posterior axis specification	GO:0009948	109	0.014
gtp catabolic process	GO:0006184	72	0.014
organophosphate catabolic process	GO:0046434	112	0.014
adult behavior	GO:0030534	137	0.014
neutral lipid biosynthetic process	GO:0046460	2	0.014
anatomical structure homeostasis	GO:0060249	97	0.014
phagocytosis	GO:0006909	215	0.014
positive regulation of transport	GO:0051050	92	0.014
synaptic vesicle exocytosis	GO:0016079	16	0.014
regulation of steroid metabolic process	GO:0019218	2	0.014
aromatic compound catabolic process	GO:0019439	166	0.014
response to nitrogen compound	GO:1901698	90	0.014
regulation of synapse structure and activity	GO:0050803	128	0.014
small gtpase mediated signal transduction	GO:0007264	88	0.014
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.014
acylglycerol biosynthetic process	GO:0046463	2	0.014
oocyte construction	GO:0007308	112	0.014
organophosphate metabolic process	GO:0019637	195	0.013
regulation of mitotic cell cycle	GO:0007346	190	0.013
divalent metal ion transport	GO:0070838	26	0.013
locomotory behavior	GO:0007626	176	0.013
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	65	0.013
negative regulation of synaptic growth at neuromuscular junction	GO:0045886	39	0.013
amine metabolic process	GO:0009308	12	0.013
glycoprotein biosynthetic process	GO:0009101	41	0.013
protein complex biogenesis	GO:0070271	201	0.013
cellular protein complex assembly	GO:0043623	71	0.013
epithelium migration	GO:0090132	148	0.013
positive regulation of multicellular organismal process	GO:0051240	143	0.013
positive regulation of purine nucleotide metabolic process	GO:1900544	55	0.013
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.013
dorsal closure	GO:0007391	79	0.013
response to lipopolysaccharide	GO:0032496	4	0.013
regulation of phosphorylation	GO:0042325	147	0.013
positive regulation of intracellular signal transduction	GO:1902533	116	0.013
positive regulation of hydrolase activity	GO:0051345	78	0.013
defense response to bacterium	GO:0042742	178	0.013
positive regulation of nervous system development	GO:0051962	69	0.013
ribonucleotide catabolic process	GO:0009261	109	0.012
positive regulation of cell development	GO:0010720	61	0.012
guanosine containing compound catabolic process	GO:1901069	74	0.012
regulation of cell shape	GO:0008360	113	0.012
regulation of organelle organization	GO:0033043	196	0.012
digestive tract morphogenesis	GO:0048546	127	0.012
death	GO:0016265	284	0.012
cholesterol homeostasis	GO:0042632	3	0.012
negative regulation of nervous system development	GO:0051961	92	0.012
positive regulation of nucleotide catabolic process	GO:0030813	46	0.012
single organism membrane organization	GO:0044802	93	0.012
sterol homeostasis	GO:0055092	4	0.012
regulation of intracellular signal transduction	GO:1902531	236	0.012
immune response regulating signaling pathway	GO:0002764	2	0.012
purine nucleoside monophosphate metabolic process	GO:0009126	50	0.012
synaptic vesicle transport	GO:0048489	50	0.012
regulation of protein modification process	GO:0031399	112	0.012
golgi vesicle transport	GO:0048193	27	0.012
regulation of cell morphogenesis involved in differentiation	GO:0010769	61	0.012
sphingolipid metabolic process	GO:0006665	19	0.012
response to monosaccharide	GO:0034284	4	0.012
protein secretion	GO:0009306	45	0.012
organic acid metabolic process	GO:0006082	103	0.012
regulation of epithelial cell proliferation	GO:0050678	4	0.012
defense response to other organism	GO:0098542	225	0.012
purine ribonucleoside monophosphate metabolic process	GO:0009167	50	0.012
regulation of neuron differentiation	GO:0045664	103	0.012
triglyceride biosynthetic process	GO:0019432	2	0.012
nuclear division	GO:0000280	332	0.011
positive regulation of lipid metabolic process	GO:0045834	4	0.011
response to alcohol	GO:0097305	95	0.011
negative regulation of multicellular organismal process	GO:0051241	142	0.011
apoptotic process	GO:0006915	159	0.011
nucleoside monophosphate metabolic process	GO:0009123	52	0.011
regulation of vesicle mediated transport	GO:0060627	59	0.011
regulation of establishment of protein localization	GO:0070201	61	0.011
eye morphogenesis	GO:0048592	260	0.011
purine ribonucleoside catabolic process	GO:0046130	112	0.011
cellular response to lipopolysaccharide	GO:0071222	3	0.011
regulation of cellular ketone metabolic process	GO:0010565	3	0.011
ras protein signal transduction	GO:0007265	88	0.011
sensory organ morphogenesis	GO:0090596	260	0.011
integrin mediated signaling pathway	GO:0007229	3	0.011
oocyte development	GO:0048599	124	0.011
body morphogenesis	GO:0010171	2	0.011
cellular response to extracellular stimulus	GO:0031668	64	0.011
learning or memory	GO:0007611	141	0.011
epithelial tube morphogenesis	GO:0060562	88	0.011
synaptic transmission glutamatergic	GO:0035249	7	0.011
cellular response to chemical stimulus	GO:0070887	199	0.011
anterior posterior pattern specification	GO:0009952	136	0.011
positive regulation of lipid biosynthetic process	GO:0046889	3	0.011
immune response	GO:0006955	246	0.011
lateral inhibition	GO:0046331	206	0.011
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.011
positive regulation of rna biosynthetic process	GO:1902680	266	0.011
cellular response to molecule of bacterial origin	GO:0071219	3	0.011
negative regulation of transforming growth factor beta receptor signaling pathway	GO:0030512	4	0.010
malpighian tubule development	GO:0072002	64	0.010
positive regulation of apoptotic signaling pathway	GO:2001235	4	0.010
regulation of dendrite development	GO:0050773	37	0.010
gland development	GO:0048732	191	0.010
gtp metabolic process	GO:0046039	72	0.010
organonitrogen compound catabolic process	GO:1901565	128	0.010
negative regulation of cellular biosynthetic process	GO:0031327	277	0.010
positive regulation of rna metabolic process	GO:0051254	271	0.010
cellular response to biotic stimulus	GO:0071216	4	0.010
defense response	GO:0006952	300	0.010
endoplasmic reticulum organization	GO:0007029	13	0.010
dendrite morphogenesis	GO:0048813	199	0.010
purine ribonucleotide catabolic process	GO:0009154	109	0.010
response to organic cyclic compound	GO:0014070	89	0.010
vesicle organization	GO:0016050	44	0.010
protein palmitoylation	GO:0018345	2	0.010
septate junction assembly	GO:0019991	26	0.010
open tracheal system development	GO:0007424	204	0.010
embryonic axis specification	GO:0000578	107	0.010
cognition	GO:0050890	141	0.010
imaginal disc derived wing vein morphogenesis	GO:0008586	44	0.010

spict disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	disease of anatomical entity	DOID:7	0	0.016
	cardiovascular system disease	DOID:1287	0	0.011

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