IMP: Integrative Multi-species Prediction

Drosophila melanogaster

22 known processes

esn (Dmel_CG12833)

espinas

(Aliases: CG12833,Dmel\CG12833)

FLYBASE: FBgn0028642
Entrez: 53557
UniProtKB: Q9U1I1
UniProtKB: E2QC70

Process Predictions
Disease Predictions

esn biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
inter male aggressive behavior	GO:0002121	60	0.636
imaginal disc derived appendage development	GO:0048737	399	0.331	Fly
positive regulation of signaling	GO:0023056	243	0.297
positive regulation of cell communication	GO:0010647	250	0.232
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.210	Fly
positive regulation of response to stimulus	GO:0048584	323	0.195
positive regulation of signal transduction	GO:0009967	223	0.125
defense response to gram positive bacterium	GO:0050830	41	0.124
toll signaling pathway	GO:0008063	25	0.116
dendrite development	GO:0016358	204	0.111
sensory perception	GO:0007600	196	0.110
regulation of toll signaling pathway	GO:0008592	17	0.109
defense response to bacterium	GO:0042742	178	0.107
defense response to fungus	GO:0050832	48	0.105
aggressive behavior	GO:0002118	63	0.099
post embryonic appendage morphogenesis	GO:0035120	385	0.095	Fly
androgen metabolic process	GO:0008209	1	0.094
neurological system process	GO:0050877	358	0.090
catabolic process	GO:0009056	409	0.085	Human
appendage development	GO:0048736	401	0.085	Fly
dendrite morphogenesis	GO:0048813	199	0.085
innate immune response	GO:0045087	144	0.083
regulation of cell development	GO:0060284	215	0.082	Human
ion homeostasis	GO:0050801	55	0.080
regulation of anatomical structure morphogenesis	GO:0022603	242	0.076
regulation of cell differentiation	GO:0045595	302	0.068	Human
regulation of dendrite morphogenesis	GO:0048814	28	0.066
defense response to gram negative bacterium	GO:0050829	94	0.066
response to bacterium	GO:0009617	198	0.063
homeostatic process	GO:0042592	199	0.062
regulation of multicellular organismal development	GO:2000026	414	0.058	Human
imaginal disc derived wing morphogenesis	GO:0007476	337	0.056	Fly
negative regulation of gene expression	GO:0010629	387	0.054	Human
negative regulation of developmental process	GO:0051093	201	0.047	Human
defense response to other organism	GO:0098542	225	0.047
chromosome organization	GO:0051276	360	0.046
proteolysis	GO:0006508	192	0.045	Human
response to fungus	GO:0009620	50	0.043
regulation of dendrite development	GO:0050773	37	0.042
protein localization	GO:0008104	284	0.041	Human Rat
appendage morphogenesis	GO:0035107	397	0.040	Fly
response to external biotic stimulus	GO:0043207	293	0.039
regulation of nervous system development	GO:0051960	248	0.039
cellular response to ethanol	GO:0071361	4	0.039
immune system process	GO:0002376	347	0.039
regulation of cell morphogenesis	GO:0022604	163	0.038
head development	GO:0060322	135	0.037	Zebrafish
eye morphogenesis	GO:0048592	260	0.036	Fly
response to other organism	GO:0051707	293	0.036
cation homeostasis	GO:0055080	51	0.035
sensory perception of chemical stimulus	GO:0007606	116	0.035
cellular response to ketone	GO:1901655	17	0.033
estrogen metabolic process	GO:0008210	1	0.032
immune response	GO:0006955	246	0.032
sensory organ morphogenesis	GO:0090596	260	0.032	Fly
aromatic compound catabolic process	GO:0019439	166	0.031
wing disc morphogenesis	GO:0007472	344	0.031	Fly
detection of light stimulus	GO:0009583	58	0.031
multi organism behavior	GO:0051705	175	0.030
metal ion transport	GO:0030001	74	0.029
defense response	GO:0006952	300	0.029
eye development	GO:0001654	323	0.028	Zebrafish Fly
positive regulation of cellular component organization	GO:0051130	156	0.027
cellular protein modification process	GO:0006464	438	0.027	Human
hormone catabolic process	GO:0042447	3	0.027
regulation of cell projection organization	GO:0031344	92	0.027
metal ion homeostasis	GO:0055065	44	0.027
cellular protein catabolic process	GO:0044257	83	0.026	Human
forebrain development	GO:0030900	2	0.026
notch signaling pathway	GO:0007219	120	0.026	Fly
cell recognition	GO:0008037	102	0.026
response to radiation	GO:0009314	155	0.026
regulation of catalytic activity	GO:0050790	185	0.024
secretion by cell	GO:0032940	101	0.024
response to biotic stimulus	GO:0009607	294	0.024
detection of stimulus involved in sensory perception	GO:0050906	92	0.023
protein dna complex subunit organization	GO:0071824	86	0.023
alternative mrna splicing via spliceosome	GO:0000380	60	0.023
negative regulation of signal transduction	GO:0009968	206	0.023	Human Fly
small molecule metabolic process	GO:0044281	305	0.023
detection of stimulus	GO:0051606	156	0.022
regulation of localization	GO:0032879	275	0.022
response to oxygen containing compound	GO:1901700	200	0.022
body morphogenesis	GO:0010171	2	0.022
response to ketone	GO:1901654	34	0.022
regulation of cellular component biogenesis	GO:0044087	201	0.021
response to lipopolysaccharide	GO:0032496	4	0.021
secondary metabolic process	GO:0019748	75	0.021
regulation of neuron projection development	GO:0010975	69	0.021
regulation of cellular protein metabolic process	GO:0032268	243	0.021	Human
carbohydrate derivative metabolic process	GO:1901135	217	0.021
purine nucleotide metabolic process	GO:0006163	146	0.020
negative regulation of cell communication	GO:0010648	223	0.020	Human Fly
regulation of cell morphogenesis involved in differentiation	GO:0010769	61	0.020
mrna processing	GO:0006397	104	0.020
localization of cell	GO:0051674	257	0.020	Zebrafish
vesicle mediated transport	GO:0016192	381	0.020
positive regulation of cell projection organization	GO:0031346	29	0.020
negative regulation of cellular biosynthetic process	GO:0031327	277	0.019	Human
organic cyclic compound catabolic process	GO:1901361	168	0.019
cation transport	GO:0006812	110	0.019
response to starvation	GO:0042594	97	0.019
nucleosome organization	GO:0034728	59	0.019
dendrite self avoidance	GO:0070593	8	0.018
regulation of phosphorus metabolic process	GO:0051174	210	0.018
regulation of neuron differentiation	GO:0045664	103	0.018
regulation of intracellular signal transduction	GO:1902531	236	0.018
transcription from rna polymerase ii promoter	GO:0006366	368	0.018
steroid catabolic process	GO:0006706	1	0.018
protein transport	GO:0015031	155	0.018	Human Rat
ras protein signal transduction	GO:0007265	88	0.018
positive regulation of intracellular signal transduction	GO:1902533	116	0.017
cellular catabolic process	GO:0044248	372	0.017	Human
regulation of molecular function	GO:0065009	217	0.017
cytoplasmic transport	GO:0016482	130	0.017	Human Rat
intracellular transport	GO:0046907	228	0.017	Human Rat
mrna metabolic process	GO:0016071	124	0.017
establishment of localization in cell	GO:0051649	402	0.017	Human Zebrafish Rat
dna conformation change	GO:0071103	105	0.017
salivary gland development	GO:0007431	162	0.017
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.017	Human
regulation of anatomical structure size	GO:0090066	163	0.016
negative regulation of response to stimulus	GO:0048585	258	0.016	Human Fly
phosphorylation	GO:0016310	294	0.016
negative regulation of cellular component organization	GO:0051129	108	0.016
nucleotide metabolic process	GO:0009117	161	0.016
tube development	GO:0035295	244	0.016	Human Zebrafish
exocrine system development	GO:0035272	162	0.016
response to organic substance	GO:0010033	284	0.016
small gtpase mediated signal transduction	GO:0007264	88	0.016
protein modification by small protein conjugation or removal	GO:0070647	106	0.016	Human
gland morphogenesis	GO:0022612	145	0.016
benzene containing compound metabolic process	GO:0042537	3	0.016
regulation of notch signaling pathway	GO:0008593	100	0.015	Fly
compound eye development	GO:0048749	307	0.015	Fly
detection of abiotic stimulus	GO:0009582	66	0.015
germarium derived egg chamber formation	GO:0007293	101	0.015
nuclear transport	GO:0051169	72	0.015	Human Rat
positive regulation of molecular function	GO:0044093	136	0.015
response to ethanol	GO:0045471	59	0.015
growth	GO:0040007	359	0.015
protein complex assembly	GO:0006461	200	0.015
phagocytosis	GO:0006909	215	0.015
positive regulation of cell development	GO:0010720	61	0.015
regulation of neurogenesis	GO:0050767	158	0.014
xenobiotic catabolic process	GO:0042178	1	0.014
salivary gland morphogenesis	GO:0007435	145	0.014
regulation of synapse structure and activity	GO:0050803	128	0.014
heterocycle catabolic process	GO:0046700	166	0.014
regulation of hormone levels	GO:0010817	40	0.014
tissue morphogenesis	GO:0048729	297	0.014	Human Zebrafish Fly
protein ubiquitination	GO:0016567	70	0.014	Human
purine containing compound metabolic process	GO:0072521	155	0.014
protein catabolic process	GO:0030163	101	0.014	Human
intracellular signal transduction	GO:0035556	300	0.014
single organism biosynthetic process	GO:0044711	206	0.013
positive regulation of catalytic activity	GO:0043085	118	0.013
regulation of proteolysis	GO:0030162	87	0.013	Human
positive regulation of biosynthetic process	GO:0009891	316	0.013
columnar cuboidal epithelial cell development	GO:0002066	249	0.013
negative regulation of signaling	GO:0023057	219	0.013	Human Fly
rna splicing via transesterification reactions	GO:0000375	73	0.013
extracellular structure organization	GO:0043062	46	0.013
nucleobase containing small molecule metabolic process	GO:0055086	174	0.013
regulation of protein metabolic process	GO:0051246	256	0.013	Human
regulation of synapse organization	GO:0050807	110	0.012
protein modification process	GO:0036211	438	0.012	Human
nuclear division	GO:0000280	332	0.012
macromolecular complex assembly	GO:0065003	256	0.012
regulation of hydrolase activity	GO:0051336	97	0.012
nucleoside catabolic process	GO:0009164	112	0.012
single organism catabolic process	GO:0044712	228	0.012
protein phosphorylation	GO:0006468	169	0.012
positive regulation of exocytosis	GO:0045921	4	0.012
cell death	GO:0008219	279	0.012
regulation of mrna processing	GO:0050684	71	0.012
cell motility	GO:0048870	251	0.012	Zebrafish
ion transmembrane transport	GO:0034220	122	0.011
cellular response to chemical stimulus	GO:0070887	199	0.011
mating	GO:0007618	120	0.011
respiratory system development	GO:0060541	213	0.011
nucleocytoplasmic transport	GO:0006913	72	0.011	Human Rat
organonitrogen compound metabolic process	GO:1901564	318	0.011
embryo development ending in birth or egg hatching	GO:0009792	152	0.011	Human
regulation of phosphate metabolic process	GO:0019220	210	0.011
limb development	GO:0060173	1	0.011
regulation of synapse assembly	GO:0051963	94	0.011
nucleoside phosphate metabolic process	GO:0006753	162	0.011
inorganic cation transmembrane transport	GO:0098662	61	0.011
cellular protein localization	GO:0034613	160	0.011	Human Rat
regulation of transport	GO:0051049	181	0.011
regulation of cellular response to stress	GO:0080135	89	0.011
inorganic ion transmembrane transport	GO:0098660	73	0.011
dna packaging	GO:0006323	91	0.011
regulation of mrna splicing via spliceosome	GO:0048024	64	0.010
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.010
urogenital system development	GO:0001655	72	0.010
positive regulation of phosphorus metabolic process	GO:0010562	139	0.010
positive regulation of programmed cell death	GO:0043068	62	0.010
compound eye morphogenesis	GO:0001745	249	0.010	Fly
programmed cell death	GO:0012501	257	0.010
neuron recognition	GO:0008038	101	0.010
response to organic cyclic compound	GO:0014070	89	0.010
blastoderm segmentation	GO:0007350	159	0.010
meiotic cell cycle	GO:0051321	171	0.010
regulation of catabolic process	GO:0009894	170	0.010	Human
positive regulation of phosphate metabolic process	GO:0045937	139	0.010
organic substance catabolic process	GO:1901575	308	0.010	Human

esn disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability	Func Analog Org
disease of anatomical entity	DOID:7	0.022	Human
nervous system disease	DOID:863	0.017	Human
disease of metabolism	DOID:0014667	0.014

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