Drosophila melanogaster

73 known processes

Spn1 (Dmel_CG9456)

Serine protease inhibitor 1

(Aliases: Dmel\CG9456,Spn42Dd,CG9456,sp1)

Spn1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
defense responseGO:00069523000.859
response to fungusGO:0009620500.854
defense response to other organismGO:00985422250.808
immune responseGO:00069552460.801
antifungal humoral responseGO:0019732120.796
Fly
response to external biotic stimulusGO:00432072930.746
regulation of response to biotic stimulusGO:0002831630.741
humoral immune responseGO:00069591170.740
immune system processGO:00023763470.710
defense response to fungusGO:0050832480.694
regulation of biosynthetic process of antibacterial peptides active against gram positive bacteriaGO:000281630.683
antimicrobial humoral responseGO:0019730990.679
innate immune responseGO:00450871440.671
defense response to gram positive bacteriumGO:0050830410.660
response to other organismGO:00517072930.630
defense response to bacteriumGO:00427421780.614
Fly
regulation of response to external stimulusGO:00321011150.594
regulation of defense response to bacteriumGO:1900424300.586
regulation of multi organism processGO:00439001310.558
positive regulation of response to external stimulusGO:0032103440.552
immune effector processGO:0002252980.465
production of molecular mediator of immune responseGO:0002440460.455
secondary metabolic processGO:0019748750.397
negative regulation of peptidoglycan recognition protein signaling pathwayGO:006106030.392
regulation of cellular amide metabolic processGO:0034248390.384
Fly
regulation of immune system processGO:00026821760.379
antimicrobial peptide productionGO:0002775460.379
positive regulation of response to biotic stimulusGO:0002833310.372
positive regulation of defense responseGO:0031349590.366
peptidoglycan recognition protein signaling pathwayGO:0061057160.363
organic hydroxy compound metabolic processGO:1901615830.363
response to biotic stimulusGO:00096072940.352
regulation of peptidoglycan recognition protein signaling pathwayGO:006105840.328
positive regulation of antimicrobial peptide productionGO:0002225280.321
pigment metabolic processGO:0042440840.310
pattern recognition receptor signaling pathwayGO:000222120.302
positive regulation of antimicrobial peptide biosynthetic processGO:0002807260.301
regulation of defense responseGO:00313471020.283
Rat
positive regulation of antimicrobial humoral responseGO:0002760280.282
regulation of antimicrobial peptide productionGO:0002784440.278
regulation of immune effector processGO:0002697520.266
antibacterial humoral responseGO:0019731440.264
peptide metabolic processGO:0006518800.260
Fly
phenol containing compound metabolic processGO:0018958570.259
melanization defense responseGO:0035006450.239
positive regulation of multi organism processGO:0043902400.239
biosynthetic process of antibacterial peptides active against gram positive bacteriaGO:000281530.237
regulation of antimicrobial humoral responseGO:0002759500.235
immune response activating signal transductionGO:000275720.229
regulation of antimicrobial peptide biosynthetic processGO:0002805380.223
cellular amide metabolic processGO:0043603800.219
Fly
innate immune response activating signal transductionGO:000275820.208
activation of innate immune responseGO:000221840.203
response to bacteriumGO:00096171980.201
Fly
regulation of innate immune responseGO:0045088710.189
peptidoglycan catabolic processGO:000925330.187
regulation of humoral immune responseGO:0002920510.185
regionalizationGO:00030024160.179
amide biosynthetic processGO:0043604420.178
antimicrobial peptide biosynthetic processGO:0002777380.175
regulation of immune responseGO:00507761180.170
melanin metabolic processGO:0006582470.169
positive regulation of response to stimulusGO:00485843230.164
positive regulation of biosynthetic process of antibacterial peptides active against gram positive bacteriaGO:000696530.154
organonitrogen compound metabolic processGO:19015643180.152
Fly
organonitrogen compound biosynthetic processGO:19015661170.150
positive regulation of melanization defense responseGO:003500810.150
endocytosisGO:00068973100.146
hemolymph coagulationGO:0042381100.145
defense response to gram negative bacteriumGO:0050829940.138
Fly
biosynthetic process of antibacterial peptides active against gram negative bacteriaGO:0002812140.137
regulation of response to stressGO:00801342000.136
Rat
positive regulation of cellular amide metabolic processGO:0034250260.128
dorsal ventral pattern formationGO:00099531330.127
positive regulation of humoral immune responseGO:0002922280.127
positive regulation of defense response to bacteriumGO:1900426230.121
response to virusGO:0009615280.119
regulation of biosynthetic process of antibacterial peptides active against gram negative bacteriaGO:0002813140.116
dorsal ventral axis specificationGO:0009950660.109
positive regulation of immune responseGO:0050778630.109
antibacterial peptide biosynthetic processGO:0002780220.103
positive regulation of antibacterial peptide productionGO:0002803200.102
regulation of secondary metabolic processGO:004345570.102
axis specificationGO:00097981670.100
antibacterial peptide productionGO:0002778220.096
positive regulation of nitrogen compound metabolic processGO:00511733540.094
immune response regulating signaling pathwayGO:000276420.094
vesicle mediated transportGO:00161923810.093
positive regulation of immune effector processGO:0002699280.092
wound healingGO:0042060750.091
Rat
positive regulation of production of molecular mediator of immune responseGO:0002702280.090
organic substance catabolic processGO:19015753080.089
positive regulation of biosynthetic process of antibacterial peptides active against gram negative bacteriaGO:0006964120.087
regulation of melanization defense responseGO:003500760.086
negative regulation of defense response to bacteriumGO:190042570.084
positive regulation of antibacterial peptide biosynthetic processGO:0006963200.084
regulation of production of molecular mediator of immune responseGO:0002700440.084
positive regulation of cellular biosynthetic processGO:00313283160.083
regulation of antibacterial peptide productionGO:0002786220.080
positive regulation of biosynthetic processGO:00098913160.080
agingGO:00075681430.078
catabolic processGO:00090564090.077
negative regulation of signal transductionGO:00099682060.073
Fly
response to organic substanceGO:00100332840.069
response to radiationGO:00093141550.068
protein maturationGO:0051604710.067
Fly
positive regulation of immune system processGO:0002684680.066
positive regulation of cell communicationGO:00106472500.065
response to light stimulusGO:00094161240.064
zymogen activationGO:0031638200.064
response to peptidoglycanGO:003249420.064
small molecule metabolic processGO:00442813050.063
pigment metabolic process involved in pigmentationGO:0043474330.063
response to woundingGO:0009611940.062
Rat
pigment biosynthetic processGO:0046148360.061
positive regulation of signalingGO:00230562430.060
peptidoglycan metabolic processGO:000027030.060
peptide biosynthetic processGO:0043043420.060
lipopolysaccharide mediated signaling pathwayGO:003166310.060
phagocytosisGO:00069092150.058
regulation of antibacterial peptide biosynthetic processGO:0002808220.057
organonitrogen compound catabolic processGO:19015651280.056
cellular catabolic processGO:00442483720.056
glycosaminoglycan catabolic processGO:000602730.055
response to oxygen containing compoundGO:19017002000.054
carbohydrate derivative metabolic processGO:19011352170.054
cellular amino acid metabolic processGO:0006520610.053
appendage morphogenesisGO:00351073970.052
multicellular organismal agingGO:00102591400.052
biological adhesionGO:00226101380.050
Rat
defense response to virusGO:0051607230.048
lateral inhibitionGO:00463312060.048
single organism biosynthetic processGO:00447112060.047
regulation of toll signaling pathwayGO:0008592170.044
Fly
cellular response to organic substanceGO:00713101320.044
cellular response to lipopolysaccharideGO:007122230.042
chemical homeostasisGO:0048878920.042
response to abiotic stimulusGO:00096283410.041
gland developmentGO:00487321910.041
carboxylic acid metabolic processGO:0019752920.038
negative regulation of signalingGO:00230572190.037
Fly
aminoglycan catabolic processGO:000602660.036
positive regulation of signal transductionGO:00099672230.035
imaginal disc derived appendage morphogenesisGO:00351143950.034
response to nitrogen compoundGO:1901698900.034
response to lipopolysaccharideGO:003249640.034
regulation of phosphorus metabolic processGO:00511742100.034
oxoacid metabolic processGO:00434361030.033
cell adhesionGO:00071551360.033
Rat
cellular response to molecule of bacterial originGO:007121930.032
developmental pigmentationGO:0048066680.032
detection of stimulusGO:00516061560.032
cellular response to biotic stimulusGO:007121640.032
intracellular signal transductionGO:00355563000.031
protein processingGO:0016485680.031
Fly
regulation of phosphate metabolic processGO:00192202100.031
regulation of intracellular signal transductionGO:19025312360.030
hormone catabolic processGO:004244730.030
negative regulation of cell communicationGO:00106482230.030
Fly
regulation of body fluid levelsGO:0050878140.029
cell cell signaling involved in cell fate commitmentGO:00451682100.029
single organism cell adhesionGO:0098602470.028
salivary gland developmentGO:00074311620.028
cell deathGO:00082192790.028
response to endogenous stimulusGO:00097191190.027
pigmentationGO:0043473750.027
cation homeostasisGO:0055080510.027
cell recognitionGO:00080371020.026
detection of abiotic stimulusGO:0009582660.026
negative regulation of cellular metabolic processGO:00313243820.026
killing of cells of other organismGO:003164010.026
positive regulation of innate immune responseGO:0045089380.026
regulation of cell cycleGO:00517262910.026
negative regulation of response to stimulusGO:00485852580.026
Rat Fly
response to organophosphorusGO:004668320.025
toll signaling pathwayGO:0008063250.025
Fly
lipid metabolic processGO:00066291210.025
proteolysisGO:00065081920.025
homeostatic processGO:00425921990.025
post embryonic appendage morphogenesisGO:00351203850.025
phosphorylationGO:00163102940.025
imaginal disc derived wing morphogenesisGO:00074763370.024
signal transduction by phosphorylationGO:00230141070.024
cellular ketone metabolic processGO:0042180240.024
single organism behaviorGO:00447083910.024
regulation of cellular response to stressGO:0080135890.024
organic substance transportGO:00717022570.024
multi organism behaviorGO:00517051750.023
single organism catabolic processGO:00447122280.023
organelle fissionGO:00482853400.023
appendage developmentGO:00487364010.023
coagulationGO:0050817100.023
organophosphate metabolic processGO:00196371950.023
deathGO:00162652840.023
columnar cuboidal epithelial cell differentiationGO:00020652560.023
body morphogenesisGO:001017120.022
epithelial cell differentiationGO:00308553220.022
cellular amine metabolic processGO:0044106120.022
neurotransmitter metabolic processGO:004213320.022
eye pigment biosynthetic processGO:0006726320.022
pigment metabolic process involved in developmental pigmentationGO:0043324330.022
regulation of molecular functionGO:00650092170.021
cellular response to chemical stimulusGO:00708871990.021
response to organonitrogen compoundGO:0010243750.021
glycosaminoglycan metabolic processGO:0030203110.021
response to nutrient levelsGO:00316671140.021
Rat
growthGO:00400073590.021
Rat
stress activated mapk cascadeGO:0051403520.020
developmental programmed cell deathGO:00106231380.020
cellular homeostasisGO:0019725800.020
mapk cascadeGO:00001651070.020
negative regulation of growthGO:0045926840.020
exocrine system developmentGO:00352721620.020
synaptic transmissionGO:00072682880.020
detection of chemical stimulusGO:0009593930.020
gland morphogenesisGO:00226121450.020
cellular protein modification processGO:00064644380.020
negative regulation of defense responseGO:0031348350.019
Rat
stress activated protein kinase signaling cascadeGO:0031098550.019
regulation of localizationGO:00328792750.019
protein modification processGO:00362114380.019
regulation of transportGO:00510491810.019
nuclear divisionGO:00002803320.019
regulation of mapk cascadeGO:0043408920.019
cellular response to lipidGO:0071396200.019
negative regulation of nitrogen compound metabolic processGO:00511722650.019
Fly
regulation of jnk cascadeGO:0046328400.019
macromolecule catabolic processGO:00090571610.019
negative regulation of response to external stimulusGO:0032102220.019
Rat
amine metabolic processGO:0009308120.019
positive regulation of cellular component organizationGO:00511301560.019
eye pigmentationGO:0048069430.018
negative regulation of innate immune responseGO:0045824300.018
neurological system processGO:00508773580.018
negative regulation of stress activated protein kinase signaling cascadeGO:0070303200.018
imaginal disc derived appendage developmentGO:00487373990.018
cellular cation homeostasisGO:0030003380.018
actin filament based processGO:00300292200.018
salivary gland morphogenesisGO:00074351450.018
negative regulation of immune responseGO:0050777390.017
wing disc morphogenesisGO:00074723440.017
protein localizationGO:00081042840.017
detection of external stimulusGO:0009581660.017
columnar cuboidal epithelial cell developmentGO:00020662490.017
chemotaxisGO:00069352490.017
male gamete generationGO:00482322010.017
ethanolamine containing compound metabolic processGO:004243940.017
cytolysisGO:001983510.017
regulation of behaviorGO:0050795750.017
organic acid metabolic processGO:00060821030.017
regulation of cell deathGO:00109411730.017
multi multicellular organism processGO:00447061230.017
regulation of cell adhesionGO:0030155270.017
Rat
regulation of multicellular organismal developmentGO:20000264140.017
matingGO:00076181200.017
regulation of catalytic activityGO:00507901850.017
determination of adult lifespanGO:00083401370.016
spermatogenesisGO:00072832000.016
aromatic compound catabolic processGO:00194391660.016
response to extracellular stimulusGO:00099911160.016
Rat
salivary gland histolysisGO:0035070880.016
open tracheal system developmentGO:00074242040.016
septate junction assemblyGO:0019991260.016
negative regulation of developmental processGO:00510932010.015
organic cyclic compound catabolic processGO:19013611680.015
positive regulation of catalytic activityGO:00430851180.015
benzene containing compound metabolic processGO:004253730.015
cell motilityGO:00488702510.015
spermatid differentiationGO:00485151140.015
negative regulation of intracellular signal transductionGO:1902532570.015
localization of cellGO:00516742570.015
cell cell junction organizationGO:0045216550.015
positive regulation of cell migrationGO:003033520.015
kidney developmentGO:000182230.015
negative regulation of gene expressionGO:00106293870.014
macromolecular complex assemblyGO:00650032560.014
tissue deathGO:00162711020.014
cellular ion homeostasisGO:0006873390.014
glycerolipid catabolic processGO:004650330.014
negative regulation of phosphorylationGO:0042326350.014
ameboidal type cell migrationGO:00016671510.014
multi organism reproductive behaviorGO:00447051210.014
establishment of localization in cellGO:00516494020.014
cellularizationGO:0007349900.014
androgen metabolic processGO:000820910.014
regulation of cellular catabolic processGO:00313291570.014
cellular response to dna damage stimulusGO:00069742230.014
protein complex assemblyGO:00064612000.014
epithelial cell developmentGO:00020642740.014
autophagic cell deathGO:0048102830.014
aminoglycan metabolic processGO:0006022180.014
programmed cell deathGO:00125012570.014
positive regulation of macromolecule metabolic processGO:00106044050.014
cell proliferationGO:00082832990.014
gene silencingGO:00164581380.014
positive regulation of cell motilityGO:200014730.014
rhodopsin biosynthetic processGO:001606390.014
jnk cascadeGO:0007254500.013
retina development in camera type eyeGO:006004140.013
spindle organizationGO:00070512530.013
connective tissue developmentGO:006144830.013
posttranscriptional regulation of gene expressionGO:00106081450.013
embryonic pattern specificationGO:00098801740.013
regulation of i kappab kinase nf kappab signalingGO:004312220.013
axon developmentGO:00615642970.013
maintenance of locationGO:0051235730.013
regulation of phosphorylationGO:00423251470.013
regulation of phGO:000688570.013
taxisGO:00423303040.013
endomembrane system organizationGO:00102561190.013
cellular response to oxygen containing compoundGO:1901701790.013
regulation of cellular ketone metabolic processGO:001056530.013
rna localizationGO:00064031150.013
negative regulation of cell deathGO:0060548810.013
cellular response to radiationGO:0071478520.013
regulation of stress activated mapk cascadeGO:0032872410.012
ras protein signal transductionGO:0007265880.012
regulation of cellular component biogenesisGO:00440872010.012
epithelial cell migrationGO:00106311480.012
sterol homeostasisGO:005509240.012
positive regulation of nucleobase containing compound metabolic processGO:00459353320.012
positive regulation of catabolic processGO:00098961050.012
cellular macromolecule localizationGO:00707272200.012
small gtpase mediated signal transductionGO:0007264880.012
positive regulation of behaviorGO:0048520190.012
rhythmic behaviorGO:0007622760.012
cellular chemical homeostasisGO:0055082400.012
blastoderm segmentationGO:00073501590.012
negative regulation of cell differentiationGO:00455961430.012
multicellular organismal reproductive behaviorGO:00330571100.012
cytolysis in other organismGO:005171510.012
single organismal cell cell adhesionGO:0016337450.012
monocarboxylic acid transportGO:001571830.012
developmental maturationGO:00217001720.012
carbohydrate derivative catabolic processGO:19011361180.012
response to protozoanGO:000156230.012
negative regulation of immune system processGO:0002683500.012
regulation of cellular amine metabolic processGO:003323830.012
positive regulation of phosphorus metabolic processGO:00105621390.011
heterocycle catabolic processGO:00467001660.011
rhythmic processGO:00485111060.011
drinking behaviorGO:004275620.011
respiratory system developmentGO:00605412130.011
cellular protein localizationGO:00346131600.011
protein complex biogenesisGO:00702712010.011
establishment of protein localizationGO:00451841630.011
chromosome segregationGO:00070591570.011
nucleoside metabolic processGO:00091161270.011
negative regulation of peptide hormone processingGO:006057010.011
Fly
negative regulation of biosynthetic processGO:00098902770.011
positive regulation of intracellular signal transductionGO:19025331160.011
cellular response to nutrient levelsGO:0031669620.011
male mating behaviorGO:0060179700.011
nucleobase containing small molecule metabolic processGO:00550861740.011
cellular lipid metabolic processGO:0044255830.011
protein transportGO:00150311550.011
axonogenesisGO:00074092900.011
telencephalon developmentGO:002153720.011
neuron recognitionGO:00080381010.011
non sensory hair organizationGO:0035316470.011
forebrain developmentGO:003090020.011
actin cytoskeleton organizationGO:00300362060.011
purine nucleoside metabolic processGO:00422781270.011
regulation of vesicle mediated transportGO:0060627590.011
limb developmentGO:006017310.011
histolysisGO:00075591020.011
regulation of proteolysisGO:0030162870.011
mrna metabolic processGO:00160711240.011
g protein coupled receptor signaling pathwayGO:00071861360.010
regulation of cellular protein metabolic processGO:00322682430.010
cell migrationGO:00164772380.010
disruption of cells of other organismGO:004436410.010
circulatory system developmentGO:0072359820.010
regulation of endocytosisGO:0030100370.010
epithelium migrationGO:00901321480.010
negative regulation of multicellular organismal processGO:00512411420.010
salivary gland cell autophagic cell deathGO:0035071830.010
positive regulation of molecular functionGO:00440931360.010
heart developmentGO:0007507820.010
alpha amino acid metabolic processGO:1901605200.010
negative regulation of catalytic activityGO:0043086420.010
nucleoside phosphate metabolic processGO:00067531620.010
segmentationGO:00352822070.010
choline catabolic processGO:004242610.010
regulation of catabolic processGO:00098941700.010
imaginal disc derived wing margin morphogenesisGO:0008587410.010
camera type eye developmentGO:004301040.010
regulation of growthGO:00400082330.010
positive regulation of macromolecule biosynthetic processGO:00105572830.010
compound eye morphogenesisGO:00017452490.010

Spn1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.043
disease of metabolismDOID:001466700.015
nervous system diseaseDOID:86300.014
inherited metabolic disorderDOID:65500.013
disease of cellular proliferationDOID:1456600.010