IMP: Integrative Multi-species Prediction

Drosophila melanogaster

0 known processes

Pak (Dmel_CG10295)

PAK-kinase

(Aliases: DPak,dPAK,PaK,pak1,pak,D-Pak,p65[PAK],Dpak1,CG10295,Dmel\CG10295,Pak1,DPAK,dPAK1,dpak,PAK2,Dpak,dPak,PAK,dpak1,PAK1,DmPAK1)

Entrez: 44039
FLYBASE: FBgn0014001
UniProtKB: Q9VI13
UniProtKB: B7Z0W0

Process Predictions
Disease Predictions

Pak biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
axonogenesis	GO:0007409	290	0.998	Mouse
regulation of nervous system development	GO:0051960	248	0.992	Rat Fly
regulation of synaptic growth at neuromuscular junction	GO:0008582	89	0.988
chemotaxis	GO:0006935	249	0.986
axon development	GO:0061564	297	0.979	Mouse
establishment of localization in cell	GO:0051649	402	0.976	Yeast
developmental growth involved in morphogenesis	GO:0060560	65	0.975
synaptic growth at neuromuscular junction	GO:0051124	119	0.974
taxis	GO:0042330	304	0.946
neuromuscular junction development	GO:0007528	149	0.922	Mouse
regulation of neurogenesis	GO:0050767	158	0.907	Rat
regulation of synapse structure and activity	GO:0050803	128	0.903	Fly
actin filament bundle organization	GO:0061572	28	0.896	Human
death	GO:0016265	284	0.891	Human Yeast Rat
negative regulation of synaptic growth at neuromuscular junction	GO:0045886	39	0.890
regulation of phosphate metabolic process	GO:0019220	210	0.888	Human Yeast
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.879
vesicle mediated transport	GO:0016192	381	0.866
protein modification process	GO:0036211	438	0.858	Human Yeast Mouse Rat Worm
axon guidance	GO:0007411	233	0.856
regulation of anatomical structure morphogenesis	GO:0022603	242	0.846	Rat
appendage development	GO:0048736	401	0.825
axis specification	GO:0009798	167	0.818
regulation of cell development	GO:0060284	215	0.816	Rat
cellular protein modification process	GO:0006464	438	0.814	Human Yeast Mouse Rat Worm
axon extension involved in axon guidance	GO:0048846	10	0.810
regulation of programmed cell death	GO:0043067	152	0.810	Human Yeast Rat
phosphorylation	GO:0016310	294	0.801	Human Yeast Mouse Rat Worm
tube development	GO:0035295	244	0.798	Human
neuron projection extension	GO:1990138	32	0.786
regulation of neuron differentiation	GO:0045664	103	0.786	Rat
regulation of multicellular organismal development	GO:2000026	414	0.784	Rat Fly
regulation of cell morphogenesis involved in differentiation	GO:0010769	61	0.777	Rat
gland development	GO:0048732	191	0.773
positive regulation of molecular function	GO:0044093	136	0.744	Human Yeast
tissue morphogenesis	GO:0048729	297	0.741	Human
morphogenesis of an epithelium	GO:0002009	276	0.741	Human
positive regulation of cell projection organization	GO:0031346	29	0.736	Rat
appendage morphogenesis	GO:0035107	397	0.726
cell death	GO:0008219	279	0.711	Human Yeast Rat
regulation of localization	GO:0032879	275	0.691	Yeast
dendrite development	GO:0016358	204	0.688	Mouse Rat
regulation of synapse assembly	GO:0051963	94	0.674	Fly
imaginal disc derived appendage development	GO:0048737	399	0.656
eye development	GO:0001654	323	0.654
positive regulation of cellular component organization	GO:0051130	156	0.653	Human Rat Fly
regulation of cell projection organization	GO:0031344	92	0.649	Rat
regulation of molecular function	GO:0065009	217	0.622	Human Yeast
organelle localization	GO:0051640	148	0.607
regulation of cell differentiation	GO:0045595	302	0.602	Rat
developmental programmed cell death	GO:0010623	138	0.594
regulation of cell morphogenesis	GO:0022604	163	0.593	Rat
positive regulation of macromolecule metabolic process	GO:0010604	405	0.590	Human Yeast Rat
non sensory hair organization	GO:0035316	47	0.585
negative regulation of response to stimulus	GO:0048585	258	0.576
regulation of cell death	GO:0010941	173	0.575	Human Yeast Rat
embryonic development via the syncytial blastoderm	GO:0001700	148	0.561
embryonic morphogenesis	GO:0048598	206	0.552	Worm
catabolic process	GO:0009056	409	0.550
actin filament organization	GO:0007015	126	0.545	Human Fly
regulation of cell shape	GO:0008360	113	0.530
cell migration	GO:0016477	238	0.525	Worm
neuron projection guidance	GO:0097485	241	0.509
positive regulation of synaptic growth at neuromuscular junction	GO:0045887	26	0.505
lipid localization	GO:0010876	54	0.499	Yeast
small molecule metabolic process	GO:0044281	305	0.496
negative regulation of cell communication	GO:0010648	223	0.478
growth	GO:0040007	359	0.475	Yeast
regulation of axon extension	GO:0030516	8	0.462
retinal ganglion cell axon guidance	GO:0031290	12	0.459
developmental cell growth	GO:0048588	52	0.459
regulation of cytoskeleton organization	GO:0051493	89	0.456	Human Rat
positive regulation of nervous system development	GO:0051962	69	0.454	Rat Fly
regulation of cellular component size	GO:0032535	98	0.447	Human
regulation of axon extension involved in axon guidance	GO:0048841	4	0.439
cell growth	GO:0016049	108	0.436	Yeast
imaginal disc derived wing morphogenesis	GO:0007476	337	0.430
regulation of endopeptidase activity	GO:0052548	36	0.425	Human
negative regulation of growth	GO:0045926	84	0.418
negative regulation of developmental process	GO:0051093	201	0.418
dorsal closure	GO:0007391	79	0.411
wing disc morphogenesis	GO:0007472	344	0.407
axon extension	GO:0048675	32	0.405
wnt signaling pathway	GO:0016055	98	0.403
negative regulation of cell differentiation	GO:0045596	143	0.403
positive regulation of multicellular organismal process	GO:0051240	143	0.401	Rat Fly
synapse assembly	GO:0007416	143	0.400	Fly
developmental growth	GO:0048589	280	0.393
protein phosphorylation	GO:0006468	169	0.390	Human Yeast Mouse Rat Worm
negative regulation of signaling	GO:0023057	219	0.386
apoptotic process	GO:0006915	159	0.386	Human Yeast Rat
negative regulation of signal transduction	GO:0009968	206	0.381
regulation of axon guidance	GO:1902667	10	0.379
endocytosis	GO:0006897	310	0.378
regulation of actin filament polymerization	GO:0030833	25	0.377	Human
actin filament bundle assembly	GO:0051017	26	0.376	Human
regulation of cell size	GO:0008361	63	0.376
regulation of actin filament length	GO:0030832	27	0.372	Human
actin filament based process	GO:0030029	220	0.369	Human Rat Fly
dendrite morphogenesis	GO:0048813	199	0.367	Rat
cell proliferation	GO:0008283	299	0.361	Human
localization of cell	GO:0051674	257	0.356	Worm
regulation of vesicle mediated transport	GO:0060627	59	0.354
negative regulation of developmental growth	GO:0048640	64	0.348
actin filament polymerization	GO:0030041	27	0.348	Human
positive regulation of hydrolase activity	GO:0051345	78	0.345
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.343
regulation of synapse organization	GO:0050807	110	0.341	Fly
regulation of endocytosis	GO:0030100	37	0.331
organic substance catabolic process	GO:1901575	308	0.329
regulation of growth	GO:0040008	233	0.318
positive regulation of response to stimulus	GO:0048584	323	0.316	Human Yeast
negative regulation of synapse assembly	GO:0051964	39	0.316
regulation of phosphorylation	GO:0042325	147	0.315	Human Yeast
salivary gland morphogenesis	GO:0007435	145	0.309
nucleotide catabolic process	GO:0009166	109	0.307
ribonucleoside catabolic process	GO:0042454	112	0.298
asymmetric cell division	GO:0008356	37	0.295
stem cell proliferation	GO:0072089	88	0.292
larval development	GO:0002164	104	0.289	Worm
sensory organ morphogenesis	GO:0090596	260	0.288
regionalization	GO:0003002	416	0.282
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.281	Rat
neuron projection extension involved in neuron projection guidance	GO:1902284	10	0.279
eye morphogenesis	GO:0048592	260	0.275
regulation of neuron projection development	GO:0010975	69	0.274	Rat
cellular nitrogen compound catabolic process	GO:0044270	165	0.265
regulation of catalytic activity	GO:0050790	185	0.264	Human Yeast
positive regulation of signal transduction	GO:0009967	223	0.263	Human Yeast
maintenance of location	GO:0051235	73	0.248
positive regulation of catalytic activity	GO:0043085	118	0.248	Human Yeast
positive regulation of axon guidance	GO:1902669	1	0.244
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.242
guanosine containing compound metabolic process	GO:1901068	74	0.242
biological adhesion	GO:0022610	138	0.242
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.242
positive regulation of phosphorus metabolic process	GO:0010562	139	0.241	Human Yeast
embryo development ending in birth or egg hatching	GO:0009792	152	0.238	Worm
morphogenesis of embryonic epithelium	GO:0016331	94	0.236
purine nucleotide catabolic process	GO:0006195	109	0.236
regulation of cell proliferation involved in imaginal disc derived wing morphogenesis	GO:0090256	2	0.232
tube morphogenesis	GO:0035239	191	0.231	Human
programmed cell death	GO:0012501	257	0.231	Human Yeast Rat
regulation of anatomical structure size	GO:0090066	163	0.228	Human
aromatic compound catabolic process	GO:0019439	166	0.225
mapk cascade	GO:0000165	107	0.223	Human Yeast
heterocycle catabolic process	GO:0046700	166	0.220
establishment of organelle localization	GO:0051656	122	0.220
regulation of hydrolase activity	GO:0051336	97	0.220	Human
regulation of developmental growth	GO:0048638	174	0.218
regulation of cell proliferation	GO:0042127	163	0.218	Human
regulation of apoptotic process	GO:0042981	130	0.216	Human Yeast Rat
intracellular signal transduction	GO:0035556	300	0.208	Human Yeast
regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043281	25	0.207	Human
regulation of proteolysis	GO:0030162	87	0.202	Human
carbohydrate derivative catabolic process	GO:1901136	118	0.201
negative regulation of cellular component organization	GO:0051129	108	0.201
regulation of intracellular signal transduction	GO:1902531	236	0.200	Human Yeast
regulation of cellular component movement	GO:0051270	42	0.197
imaginal disc derived wing hair organization	GO:0035317	45	0.193
gland morphogenesis	GO:0022612	145	0.190
post embryonic appendage morphogenesis	GO:0035120	385	0.184
negative regulation of cell development	GO:0010721	62	0.184
purine ribonucleotide catabolic process	GO:0009154	109	0.182
positive regulation of developmental process	GO:0051094	143	0.182	Rat Fly
cellular protein complex assembly	GO:0043623	71	0.173	Human
salivary gland development	GO:0007431	162	0.173
negative regulation of cell death	GO:0060548	81	0.173	Human
synapse organization	GO:0050808	196	0.171	Mouse Fly
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	65	0.171
mushroom body development	GO:0016319	70	0.170
cell fate specification	GO:0001708	71	0.166
retina morphogenesis in camera type eye	GO:0060042	2	0.165
negative regulation of cellular metabolic process	GO:0031324	382	0.162	Human
positive regulation of axonogenesis	GO:0050772	2	0.162
regulation of axonogenesis	GO:0050770	32	0.160
tissue death	GO:0016271	102	0.159
regulation of protein modification process	GO:0031399	112	0.157	Human Yeast
epithelial cell migration	GO:0010631	148	0.157
glycosyl compound catabolic process	GO:1901658	112	0.157
ribonucleotide catabolic process	GO:0009261	109	0.155
imaginal disc derived leg morphogenesis	GO:0007480	80	0.154
purine containing compound catabolic process	GO:0072523	112	0.153
positive regulation of axon extension	GO:0045773	2	0.152
ameboidal type cell migration	GO:0001667	151	0.148
cell proliferation involved in imaginal disc derived wing morphogenesis	GO:0090255	2	0.147
cellular catabolic process	GO:0044248	372	0.140
rho protein signal transduction	GO:0007266	14	0.139
apoptotic cell clearance	GO:0043277	14	0.138
regulation of phosphorus metabolic process	GO:0051174	210	0.138	Human Yeast
cell maturation	GO:0048469	144	0.138
regulation of cysteine type endopeptidase activity	GO:2000116	27	0.137	Human
purine ribonucleoside catabolic process	GO:0046130	112	0.132
protein complex assembly	GO:0006461	200	0.131	Human
defense response to other organism	GO:0098542	225	0.131
positive regulation of cell migration	GO:0030335	2	0.130
regulation of stress activated protein kinase signaling cascade	GO:0070302	42	0.125	Human
guanosine containing compound catabolic process	GO:1901069	74	0.124
adherens junction organization	GO:0034332	27	0.122
cell motility	GO:0048870	251	0.120	Worm
unidimensional cell growth	GO:0009826	15	0.117
negative regulation of multicellular organismal process	GO:0051241	142	0.114
muscle structure development	GO:0061061	224	0.114	Fly
regulation of actin filament based process	GO:0032970	42	0.114	Human Rat
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.114
oocyte development	GO:0048599	124	0.113
instar larval development	GO:0002168	55	0.112
protein polymerization	GO:0051258	42	0.111	Human
developmental maturation	GO:0021700	172	0.111
cell cycle checkpoint	GO:0000075	95	0.111
regulation of multi organism process	GO:0043900	131	0.109
purine nucleoside catabolic process	GO:0006152	112	0.109
positive regulation of catabolic process	GO:0009896	105	0.108
compound eye development	GO:0048749	307	0.108
regulation of cellular localization	GO:0060341	136	0.106	Yeast
positive regulation of cell morphogenesis involved in differentiation	GO:0010770	12	0.106	Rat
organic cyclic compound catabolic process	GO:1901361	168	0.105
negative regulation of gene expression	GO:0010629	387	0.104	Human Yeast
nucleoside triphosphate catabolic process	GO:0009143	108	0.103
ribonucleoside metabolic process	GO:0009119	127	0.103
organophosphate metabolic process	GO:0019637	195	0.101
phagocytosis	GO:0006909	215	0.100
negative regulation of nervous system development	GO:0051961	92	0.100
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.100
exocrine system development	GO:0035272	162	0.099
cell division	GO:0051301	248	0.099	Yeast
positive regulation of synapse assembly	GO:0051965	29	0.098	Fly
nucleobase containing compound catabolic process	GO:0034655	165	0.095
regulation of protein polymerization	GO:0032271	28	0.093	Human
positive regulation of peptidase activity	GO:0010952	29	0.093
cellular response to organic substance	GO:0071310	132	0.092	Yeast Rat
organonitrogen compound catabolic process	GO:1901565	128	0.091
response to organic substance	GO:0010033	284	0.091	Yeast Rat
oocyte axis specification	GO:0007309	108	0.090
purine ribonucleoside metabolic process	GO:0046128	127	0.088
notch signaling pathway	GO:0007219	120	0.088
single organism intracellular transport	GO:1902582	207	0.088	Yeast
cellular amine metabolic process	GO:0044106	12	0.087
response to external biotic stimulus	GO:0043207	293	0.084
organic substance transport	GO:0071702	257	0.082	Yeast
regulation of actin cytoskeleton organization	GO:0032956	42	0.081	Human Rat
negative regulation of cellular protein metabolic process	GO:0032269	85	0.081	Human
ovarian follicle cell development	GO:0030707	248	0.080
positive regulation of jun kinase activity	GO:0043507	4	0.080	Human
secretion by cell	GO:0032940	101	0.079
immune system process	GO:0002376	347	0.079
negative regulation of programmed cell death	GO:0043069	72	0.079	Human
oocyte construction	GO:0007308	112	0.078
regulation of purine nucleotide catabolic process	GO:0033121	48	0.078
positive regulation of biosynthetic process	GO:0009891	316	0.077	Rat
muscle organ development	GO:0007517	127	0.076
response to growth factor	GO:0070848	31	0.075
gastrulation	GO:0007369	70	0.074
organonitrogen compound metabolic process	GO:1901564	318	0.074
epithelial cell development	GO:0002064	274	0.074
leg disc development	GO:0035218	92	0.073
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.073
regulation of protein metabolic process	GO:0051246	256	0.073	Human Yeast
regulation of cell cycle process	GO:0010564	181	0.072	Yeast
fatty acid metabolic process	GO:0006631	20	0.072
response to other organism	GO:0051707	293	0.072
muscle cell differentiation	GO:0042692	103	0.070	Fly
central nervous system development	GO:0007417	201	0.070
initiation of dorsal closure	GO:0007392	12	0.069
protein complex biogenesis	GO:0070271	201	0.069	Human
secretion	GO:0046903	109	0.069
regulation of locomotion	GO:0040012	42	0.068
regulation of peptidase activity	GO:0052547	39	0.068	Human
oxidation reduction process	GO:0055114	123	0.066
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.066
response to extracellular stimulus	GO:0009991	116	0.066
positive regulation of filopodium assembly	GO:0051491	15	0.066
positive regulation of endopeptidase activity	GO:0010950	26	0.065
regulation of dendrite morphogenesis	GO:0048814	28	0.064	Rat
macromolecular complex assembly	GO:0065003	256	0.063	Human Yeast
cellular response to growth factor stimulus	GO:0071363	30	0.063
regulation of stress activated mapk cascade	GO:0032872	41	0.063	Human
negative regulation of apoptotic process	GO:0043066	63	0.062	Human
establishment of imaginal disc derived wing hair orientation	GO:0001737	24	0.061
positive regulation of immune system process	GO:0002684	68	0.061
salivary gland histolysis	GO:0035070	88	0.060
peripheral nervous system development	GO:0007422	52	0.059
camera type eye morphogenesis	GO:0048593	2	0.058
dorsal ventral axon guidance	GO:0033563	2	0.058
regulation of protein modification by small protein conjugation or removal	GO:1903320	25	0.058
collateral sprouting	GO:0048668	3	0.058
cholesterol homeostasis	GO:0042632	3	0.058
regulation of cell motility	GO:2000145	23	0.057
anterior posterior axis specification	GO:0009948	109	0.057
positive regulation of cellular biosynthetic process	GO:0031328	316	0.057	Rat
regulation of cellular catabolic process	GO:0031329	157	0.057
response to biotic stimulus	GO:0009607	294	0.056
oocyte differentiation	GO:0009994	145	0.056
epithelium migration	GO:0090132	148	0.055
positive regulation of protein metabolic process	GO:0051247	128	0.053	Human Yeast
spindle organization	GO:0007051	253	0.053
actin polymerization or depolymerization	GO:0008154	31	0.052	Human
negative regulation of phosphorus metabolic process	GO:0010563	45	0.052
nucleobase containing small molecule metabolic process	GO:0055086	174	0.052
regulation of wnt signaling pathway	GO:0030111	68	0.051
nucleoside catabolic process	GO:0009164	112	0.051
establishment of synaptic vesicle localization	GO:0097480	50	0.051
retina development in camera type eye	GO:0060041	4	0.050
ribonucleotide metabolic process	GO:0009259	145	0.049
cellular macromolecular complex assembly	GO:0034622	153	0.047	Human Yeast
positive regulation of cellular component biogenesis	GO:0044089	80	0.047	Human Fly
regulation of stress fiber assembly	GO:0051492	6	0.047	Human
branching morphogenesis of an epithelial tube	GO:0048754	45	0.046	Human
dorsal ventral pattern formation	GO:0009953	133	0.046
negative regulation of molecular function	GO:0044092	51	0.046	Human
protein ubiquitination	GO:0016567	70	0.045
mesoderm development	GO:0007498	78	0.045
regulation of cellular response to stress	GO:0080135	89	0.045	Human
epithelial cell differentiation	GO:0030855	322	0.045
regulation of nucleotide metabolic process	GO:0006140	62	0.044
proteolysis	GO:0006508	192	0.044	Human
salivary gland cell autophagic cell death	GO:0035071	83	0.044
digestive tract morphogenesis	GO:0048546	127	0.044
organophosphate catabolic process	GO:0046434	112	0.044
positive regulation of intracellular signal transduction	GO:1902533	116	0.043	Human Yeast
regulation of mapk cascade	GO:0043408	92	0.043	Human Yeast
regulation of dendrite development	GO:0050773	37	0.042	Rat
glycosyl compound metabolic process	GO:1901657	127	0.041
positive regulation of cellular catabolic process	GO:0031331	95	0.040
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.040
detection of stimulus	GO:0051606	156	0.040
actomyosin structure organization	GO:0031032	56	0.039	Human
vesicle organization	GO:0016050	44	0.039
nucleoside phosphate metabolic process	GO:0006753	162	0.039
neural precursor cell proliferation	GO:0061351	75	0.039
endosomal transport	GO:0016197	44	0.039
regulation of protein phosphorylation	GO:0001932	64	0.039	Human Yeast
regulation of extent of cell growth	GO:0061387	8	0.039
nucleoside phosphate catabolic process	GO:1901292	110	0.038
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.038
positive regulation of lamellipodium organization	GO:1902745	7	0.037
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.037
dorsal closure elongation of leading edge cells	GO:0007394	10	0.037
cellular response to chemical stimulus	GO:0070887	199	0.037	Yeast Rat
stem cell maintenance	GO:0019827	67	0.037
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.037	Rat
membrane tubulation	GO:0097320	4	0.037
oxoacid metabolic process	GO:0043436	103	0.037
regulation of cellular amine metabolic process	GO:0033238	3	0.037
negative regulation of epithelial cell proliferation	GO:0050680	4	0.036
regulation of mitotic cell cycle	GO:0007346	190	0.036	Yeast
camera type eye development	GO:0043010	4	0.036
positive regulation of rna biosynthetic process	GO:1902680	266	0.035
regulation of immune system process	GO:0002682	176	0.035
ion transmembrane transport	GO:0034220	122	0.035
response to organic cyclic compound	GO:0014070	89	0.035
positive regulation of establishment of protein localization to plasma membrane	GO:0090004	3	0.035
positive regulation of cellular protein metabolic process	GO:0032270	118	0.035	Human Yeast
organelle assembly	GO:0070925	198	0.035	Yeast
positive regulation of cell development	GO:0010720	61	0.034	Rat
regulation of actin polymerization or depolymerization	GO:0008064	27	0.034	Human
signal release	GO:0023061	49	0.034
response to insulin	GO:0032868	29	0.034	Rat
anterior posterior axis specification embryo	GO:0008595	103	0.033
protein localization	GO:0008104	284	0.033	Yeast Mouse
transcription from rna polymerase ii promoter	GO:0006366	368	0.033
regulation of cell cycle	GO:0051726	291	0.033	Yeast
regulation of neuron death	GO:1901214	26	0.033	Rat
transmembrane transport	GO:0055085	139	0.033	Yeast
histolysis	GO:0007559	102	0.033
receptor clustering	GO:0043113	3	0.032	Mouse
defense response to virus	GO:0051607	23	0.032
motor neuron axon guidance	GO:0008045	58	0.031
regulation of lamellipodium organization	GO:1902743	15	0.031
organelle fission	GO:0048285	340	0.031	Yeast
gtp catabolic process	GO:0006184	72	0.030
response to unfolded protein	GO:0006986	9	0.030
positive regulation of actin filament polymerization	GO:0030838	11	0.030
positive regulation of phosphorylation	GO:0042327	87	0.030	Human Yeast
regulation of cellular protein metabolic process	GO:0032268	243	0.030	Human Yeast
organic acid metabolic process	GO:0006082	103	0.030
cell cell junction organization	GO:0045216	55	0.030
positive regulation of proteolysis	GO:0045862	52	0.030
regulation of lipid transport	GO:0032368	3	0.029
compound eye morphogenesis	GO:0001745	249	0.029
non canonical wnt signaling pathway	GO:0035567	8	0.029
regulation of ras protein signal transduction	GO:0046578	93	0.029
positive regulation of signaling	GO:0023056	243	0.029	Human Yeast
immune response regulating signaling pathway	GO:0002764	2	0.028
regulation of organ morphogenesis	GO:2000027	78	0.028
single organism catabolic process	GO:0044712	228	0.028
adult locomotory behavior	GO:0008344	76	0.028
chromatin organization	GO:0006325	207	0.028	Yeast
actin cytoskeleton reorganization	GO:0031532	22	0.028	Human
leg disc morphogenesis	GO:0007478	80	0.028
sensory perception of touch	GO:0050975	11	0.028
syncytium formation	GO:0006949	43	0.028	Fly
cell recognition	GO:0008037	102	0.027
monovalent inorganic cation transport	GO:0015672	40	0.027
autophagic cell death	GO:0048102	83	0.027
response to transforming growth factor beta	GO:0071559	18	0.027
regulation of organelle organization	GO:0033043	196	0.027	Human Yeast Rat
regulation of jnk cascade	GO:0046328	40	0.026	Human
cholesterol transport	GO:0030301	2	0.026
positive regulation of gtp catabolic process	GO:0033126	43	0.026
neural retina development	GO:0003407	4	0.025
endoderm formation	GO:0001706	3	0.025
generation of precursor metabolites and energy	GO:0006091	42	0.025
heart morphogenesis	GO:0003007	32	0.025
regulation of transferase activity	GO:0051338	58	0.025	Human Yeast
regulation of cell migration	GO:0030334	22	0.025
purine nucleotide metabolic process	GO:0006163	146	0.025
purine ribonucleotide metabolic process	GO:0009150	145	0.025
positive regulation of phosphate metabolic process	GO:0045937	139	0.024	Human Yeast
homeostatic process	GO:0042592	199	0.024
transforming growth factor beta receptor signaling pathway	GO:0007179	16	0.024
eye photoreceptor cell differentiation	GO:0001754	145	0.024
positive regulation of cell death	GO:0010942	69	0.024	Human Yeast Rat
axon midline choice point recognition	GO:0016199	26	0.024
bmp signaling pathway involved in malpighian tubule cell chemotaxis	GO:0061353	3	0.023
positive regulation of phagocytosis engulfment	GO:0060100	1	0.023
syncytium formation by plasma membrane fusion	GO:0000768	43	0.023	Fly
positive regulation of purine nucleotide metabolic process	GO:1900544	55	0.023
positive regulation of neurogenesis	GO:0050769	41	0.023	Rat
negative regulation of transferase activity	GO:0051348	18	0.023
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.023
negative regulation of protein metabolic process	GO:0051248	85	0.023	Human
regulation of canonical wnt signaling pathway	GO:0060828	15	0.023
mitotic spindle organization	GO:0007052	220	0.023
filopodium assembly	GO:0046847	33	0.023
positive regulation of gtpase activity	GO:0043547	43	0.023
stress fiber assembly	GO:0043149	6	0.022	Human
regulation of behavior	GO:0050795	75	0.022
regulation of chemotaxis	GO:0050920	12	0.022
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	38	0.022
nucleoside triphosphate metabolic process	GO:0009141	120	0.022
positive regulation of transcription dna templated	GO:0045893	266	0.022
negative regulation of cell cycle process	GO:0010948	109	0.022
intracellular transport	GO:0046907	228	0.022	Yeast
ras protein signal transduction	GO:0007265	88	0.022
endodermal cell fate commitment	GO:0001711	3	0.022
formation of organ boundary	GO:0010160	30	0.021
meiotic cell cycle process	GO:1903046	132	0.021
pseudocleavage involved in syncytial blastoderm formation	GO:0030589	9	0.021
cellular response to unfolded protein	GO:0034620	9	0.021
negative regulation of rna biosynthetic process	GO:1902679	240	0.021
positive regulation of neuron projection development	GO:0010976	14	0.021	Rat
negative regulation of cellular biosynthetic process	GO:0031327	277	0.021
nucleocytoplasmic transport	GO:0006913	72	0.021	Yeast
brain development	GO:0007420	120	0.021
regulation of filopodium assembly	GO:0051489	24	0.021
positive regulation of protein modification process	GO:0031401	58	0.021	Human Yeast
neuron maturation	GO:0042551	31	0.021
nucleoside metabolic process	GO:0009116	127	0.021
cortical actin cytoskeleton organization	GO:0030866	24	0.021
jnk cascade	GO:0007254	50	0.021	Human
establishment of spindle localization	GO:0051293	22	0.021
regulation of notch signaling pathway	GO:0008593	100	0.020
positive regulation of cell motility	GO:2000147	3	0.020
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.020
cellular response to endogenous stimulus	GO:0071495	80	0.020	Rat
morphogenesis of larval imaginal disc epithelium	GO:0016335	5	0.020
regulation of stem cell proliferation	GO:0072091	40	0.020
forebrain development	GO:0030900	2	0.020
regulation of hemocyte proliferation	GO:0035206	37	0.020
stress activated protein kinase signaling cascade	GO:0031098	55	0.019	Human
cell competition in a multicellular organism	GO:0035212	10	0.019
positive regulation of protein polymerization	GO:0032273	14	0.019
purine containing compound metabolic process	GO:0072521	155	0.019
response to bacterium	GO:0009617	198	0.019
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.019
meiotic cell cycle	GO:0051321	171	0.019
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.018
positive regulation of purine nucleotide catabolic process	GO:0033123	46	0.018
monocarboxylic acid transport	GO:0015718	3	0.018
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.018
cellular macromolecule localization	GO:0070727	220	0.017	Yeast Mouse
extracellular structure organization	GO:0043062	46	0.017
negative regulation of notch signaling pathway	GO:0045746	41	0.017
cellular response to topologically incorrect protein	GO:0035967	10	0.017
regulation of protein localization	GO:0032880	76	0.017	Yeast
dna integrity checkpoint	GO:0031570	81	0.017
response to abiotic stimulus	GO:0009628	341	0.017	Yeast Rat
pupal development	GO:0035209	11	0.017
hair cell differentiation	GO:0035315	47	0.017
negative regulation of neurogenesis	GO:0050768	53	0.017
endodermal cell differentiation	GO:0035987	3	0.016
glutamate secretion	GO:0014047	1	0.016
negative regulation of cellular response to growth factor stimulus	GO:0090288	6	0.016
maintenance of location in cell	GO:0051651	28	0.016
autophagy	GO:0006914	108	0.016
cellular respiration	GO:0045333	26	0.016
response to topologically incorrect protein	GO:0035966	10	0.016
axon choice point recognition	GO:0016198	26	0.016
regulation of kinase activity	GO:0043549	53	0.016	Human Yeast
positive regulation of immune response	GO:0050778	63	0.016
gtp metabolic process	GO:0046039	72	0.016
cytoplasmic microtubule organization	GO:0031122	22	0.015
posttranscriptional gene silencing by rna	GO:0035194	45	0.015
positive regulation of autophagy	GO:0010508	21	0.015
ethanolamine containing compound metabolic process	GO:0042439	4	0.015

Pak disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.025
disease of cellular proliferation	DOID:14566	0.022
cardiovascular system disease	DOID:1287	0.016

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