IMP: Integrative Multi-species Prediction

Drosophila melanogaster

50 known processes

Ir (Dmel_CG6747)

Inwardly rectifying potassium channel

(Aliases: irk1,CG6747,ir,Dmel\CG6747,Dir,DIR,dKirI)

Entrez: 42742
FLYBASE: FBgn0039061
UniProtKB: E1JIU2
UniProtKB: Q9VCQ0
UniProtKB: A8JR87

Process Predictions
Disease Predictions

Ir biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
circadian rhythm	GO:0007623	105	0.596
circadian behavior	GO:0048512	76	0.363
rhythmic behavior	GO:0007622	76	0.284
rhythmic process	GO:0048511	106	0.224
locomotor rhythm	GO:0045475	56	0.189
intracellular signal transduction	GO:0035556	300	0.113
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.102
single organism behavior	GO:0044708	391	0.100
ion transmembrane transport	GO:0034220	122	0.100
locomotory behavior	GO:0007626	176	0.098
appendage morphogenesis	GO:0035107	397	0.096
negative regulation of cell communication	GO:0010648	223	0.091	Human Fly
positive regulation of response to stimulus	GO:0048584	323	0.090
regulation of intracellular signal transduction	GO:1902531	236	0.089
response to organonitrogen compound	GO:0010243	75	0.078	Human Rat
negative regulation of rna biosynthetic process	GO:1902679	240	0.076
regulation of protein metabolic process	GO:0051246	256	0.073
negative regulation of gene expression	GO:0010629	387	0.073
negative regulation of signaling	GO:0023057	219	0.065	Human Fly
neurological system process	GO:0050877	358	0.065	Human Rat
positive regulation of signal transduction	GO:0009967	223	0.064
organonitrogen compound metabolic process	GO:1901564	318	0.062
positive regulation of signaling	GO:0023056	243	0.058
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.058
negative regulation of cellular metabolic process	GO:0031324	382	0.057
defense response to bacterium	GO:0042742	178	0.056
regulation of cellular protein metabolic process	GO:0032268	243	0.052
negative regulation of rna metabolic process	GO:0051253	251	0.051
response to organic cyclic compound	GO:0014070	89	0.050	Human Rat
small molecule metabolic process	GO:0044281	305	0.049
innate immune response	GO:0045087	144	0.048
positive regulation of cell communication	GO:0010647	250	0.047
compound eye morphogenesis	GO:0001745	249	0.047
response to organophosphorus	GO:0046683	2	0.046	Human
immune system process	GO:0002376	347	0.046
developmental growth	GO:0048589	280	0.046
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.045
negative regulation of transcription dna templated	GO:0045892	237	0.045
immune response	GO:0006955	246	0.044
response to nitrogen compound	GO:1901698	90	0.044	Human Rat
regulation of phosphate metabolic process	GO:0019220	210	0.044
response to other organism	GO:0051707	293	0.043
response to lipopolysaccharide	GO:0032496	4	0.043
regulation of catalytic activity	GO:0050790	185	0.042
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.042
regulation of molecular function	GO:0065009	217	0.041	Rat
cell death	GO:0008219	279	0.040
tissue morphogenesis	GO:0048729	297	0.040
negative regulation of cellular biosynthetic process	GO:0031327	277	0.040
cellular protein modification process	GO:0006464	438	0.039
imaginal disc derived appendage development	GO:0048737	399	0.039
regulation of phosphorylation	GO:0042325	147	0.039
protein modification process	GO:0036211	438	0.039
positive regulation of phosphorus metabolic process	GO:0010562	139	0.039
transmembrane transport	GO:0055085	139	0.038
regulation of cell differentiation	GO:0045595	302	0.038
regionalization	GO:0003002	416	0.037
photoreceptor cell differentiation	GO:0046530	170	0.037
positive regulation of biosynthetic process	GO:0009891	316	0.037
regulation of circadian rhythm	GO:0042752	49	0.037
ion transport	GO:0006811	145	0.036
gene silencing	GO:0016458	138	0.035
nitrogen compound transport	GO:0071705	85	0.035	Human Rat
oxoacid metabolic process	GO:0043436	103	0.035
columnar cuboidal epithelial cell development	GO:0002066	249	0.035
regulation of response to stress	GO:0080134	200	0.035
negative regulation of response to stimulus	GO:0048585	258	0.034	Fly
compound eye photoreceptor cell differentiation	GO:0001751	140	0.033
response to oxygen containing compound	GO:1901700	200	0.033	Human Rat
imaginal disc derived wing morphogenesis	GO:0007476	337	0.033
wing disc morphogenesis	GO:0007472	344	0.033
organic substance transport	GO:0071702	257	0.033	Human Rat
establishment of localization in cell	GO:0051649	402	0.033	Human
sensory perception	GO:0007600	196	0.032	Rat
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.032
positive regulation of catalytic activity	GO:0043085	118	0.032
mapk cascade	GO:0000165	107	0.032
positive regulation of defense response	GO:0031349	59	0.031
cellular amino acid metabolic process	GO:0006520	61	0.031
positive regulation of intracellular signal transduction	GO:1902533	116	0.031
regulation of cell death	GO:0010941	173	0.031
immune response activating signal transduction	GO:0002757	2	0.031
regulation of phosphorus metabolic process	GO:0051174	210	0.030
cellular response to dna damage stimulus	GO:0006974	223	0.030
regulation of immune response	GO:0050776	118	0.030
carboxylic acid metabolic process	GO:0019752	92	0.030
appendage development	GO:0048736	401	0.030
regulation of transport	GO:0051049	181	0.030
organic substance catabolic process	GO:1901575	308	0.030
single organism cellular localization	GO:1902580	180	0.030
catabolic process	GO:0009056	409	0.030
humoral immune response	GO:0006959	117	0.029
regulation of multi organism process	GO:0043900	131	0.029
organic acid metabolic process	GO:0006082	103	0.029
defense response to other organism	GO:0098542	225	0.029
regulation of catabolic process	GO:0009894	170	0.029
regulation of anatomical structure morphogenesis	GO:0022603	242	0.029
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.029
positive regulation of phosphate metabolic process	GO:0045937	139	0.029
homeostatic process	GO:0042592	199	0.029	Rat
negative regulation of signal transduction	GO:0009968	206	0.029	Fly
regulation of organelle organization	GO:0033043	196	0.028
compound eye development	GO:0048749	307	0.028
protein phosphorylation	GO:0006468	169	0.028
carbohydrate derivative metabolic process	GO:1901135	217	0.028
purine containing compound metabolic process	GO:0072521	155	0.027
response to biotic stimulus	GO:0009607	294	0.027
negative regulation of biosynthetic process	GO:0009890	277	0.027
jnk cascade	GO:0007254	50	0.027
response to external biotic stimulus	GO:0043207	293	0.027
organelle fission	GO:0048285	340	0.027
regulation of cellular localization	GO:0060341	136	0.027	Human
positive regulation of protein metabolic process	GO:0051247	128	0.026
signal transduction by phosphorylation	GO:0023014	107	0.026
cuticle development	GO:0042335	86	0.026
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.026
sensory perception of chemical stimulus	GO:0007606	116	0.026
innate immune response activating signal transduction	GO:0002758	2	0.026
response to abiotic stimulus	GO:0009628	341	0.025	Rat
regulation of cellular ketone metabolic process	GO:0010565	3	0.025
response to endogenous stimulus	GO:0009719	119	0.025	Human Rat
single organism biosynthetic process	GO:0044711	206	0.025
l amino acid import	GO:0043092	2	0.025	Rat
nucleoside phosphate metabolic process	GO:0006753	162	0.025
regulation of localization	GO:0032879	275	0.024
sensory organ morphogenesis	GO:0090596	260	0.024
negative regulation of multicellular organismal process	GO:0051241	142	0.024
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.024
eye development	GO:0001654	323	0.023
transcription from rna polymerase ii promoter	GO:0006366	368	0.023
epithelial cell development	GO:0002064	274	0.023
stress activated protein kinase signaling cascade	GO:0031098	55	0.023
nucleobase containing small molecule metabolic process	GO:0055086	174	0.023
secondary metabolic process	GO:0019748	75	0.023
cellular catabolic process	GO:0044248	372	0.022
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.022
phosphorylation	GO:0016310	294	0.022
response to organic substance	GO:0010033	284	0.022	Human Rat
post embryonic appendage morphogenesis	GO:0035120	385	0.022
positive regulation of gene expression	GO:0010628	290	0.022
regulation of immune system process	GO:0002682	176	0.022
regulation of protein modification process	GO:0031399	112	0.022
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.022
response to monosaccharide	GO:0034284	4	0.022	Rat
cellular amine metabolic process	GO:0044106	12	0.022
amine metabolic process	GO:0009308	12	0.022
cellular macromolecule localization	GO:0070727	220	0.022
defense response	GO:0006952	300	0.022	Rat
ras protein signal transduction	GO:0007265	88	0.022
secretion by cell	GO:0032940	101	0.021	Human
cellular response to organic substance	GO:0071310	132	0.021	Rat
peptide metabolic process	GO:0006518	80	0.021
negative regulation of cellular protein metabolic process	GO:0032269	85	0.021
gliogenesis	GO:0042063	80	0.021
positive regulation of mapk cascade	GO:0043410	63	0.021
response to light stimulus	GO:0009416	124	0.021	Rat
response to purine containing compound	GO:0014074	12	0.021	Human
response to alkaloid	GO:0043279	26	0.021	Rat
positive regulation of phosphorylation	GO:0042327	87	0.021
proteolysis	GO:0006508	192	0.021
negative regulation of phosphate metabolic process	GO:0045936	45	0.021
immune response regulating signaling pathway	GO:0002764	2	0.021
response to hexose	GO:0009746	3	0.021	Rat
body morphogenesis	GO:0010171	2	0.021
negative regulation of protein metabolic process	GO:0051248	85	0.021
organic hydroxy compound metabolic process	GO:1901615	83	0.021
cellular response to lipopolysaccharide	GO:0071222	3	0.021
small gtpase mediated signal transduction	GO:0007264	88	0.020
regulation of cell cycle	GO:0051726	291	0.020
ribonucleotide metabolic process	GO:0009259	145	0.020
regulation of smoothened signaling pathway	GO:0008589	28	0.020
macromolecule catabolic process	GO:0009057	161	0.020
regulation of defense response	GO:0031347	102	0.020
protein complex assembly	GO:0006461	200	0.020	Human Rat
taxis	GO:0042330	304	0.020
chaeta development	GO:0022416	97	0.020
response to radiation	GO:0009314	155	0.020	Rat
monocarboxylic acid transport	GO:0015718	3	0.020
positive regulation of cellular biosynthetic process	GO:0031328	316	0.020
stress activated mapk cascade	GO:0051403	52	0.020
growth	GO:0040007	359	0.019
nuclear division	GO:0000280	332	0.019
positive regulation of macromolecule metabolic process	GO:0010604	405	0.019
intracellular transport	GO:0046907	228	0.019
regulation of neurogenesis	GO:0050767	158	0.019
cellular response to biotic stimulus	GO:0071216	4	0.019
regulation of protein phosphorylation	GO:0001932	64	0.019
chromosome segregation	GO:0007059	157	0.018
secretion	GO:0046903	109	0.018	Human
chromosome organization	GO:0051276	360	0.018
epithelial cell differentiation	GO:0030855	322	0.018
cell proliferation	GO:0008283	299	0.018
inorganic ion transmembrane transport	GO:0098660	73	0.018
metal ion transport	GO:0030001	74	0.018
cellular response to chemical stimulus	GO:0070887	199	0.018	Rat
kidney development	GO:0001822	3	0.018	Rat
regulation of protein kinase activity	GO:0045859	51	0.018
positive regulation of catabolic process	GO:0009896	105	0.018
pigmentation	GO:0043473	75	0.018
positive regulation of molecular function	GO:0044093	136	0.018	Rat
regulation of gene expression epigenetic	GO:0040029	128	0.018
organophosphate metabolic process	GO:0019637	195	0.018
positive regulation of rna biosynthetic process	GO:1902680	266	0.018
defense response to gram negative bacterium	GO:0050829	94	0.017
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.017
cell motility	GO:0048870	251	0.017
negative regulation of phosphorus metabolic process	GO:0010563	45	0.017
positive regulation of transcription dna templated	GO:0045893	266	0.017
cellular response to carbohydrate stimulus	GO:0071322	4	0.017	Rat
positive regulation of programmed cell death	GO:0043068	62	0.017
response to glucose	GO:0009749	2	0.017	Rat
single organism intracellular transport	GO:1902582	207	0.017
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.017
defense response to fungus	GO:0050832	48	0.017
antimicrobial humoral response	GO:0019730	99	0.017
morphogenesis of an epithelium	GO:0002009	276	0.016
regulation of multicellular organismal development	GO:2000026	414	0.016
actin filament based process	GO:0030029	220	0.016	Rat
chemosensory behavior	GO:0007635	106	0.016
cognition	GO:0050890	141	0.016
multi organism behavior	GO:0051705	175	0.016
regulation of secretion by cell	GO:1903530	39	0.016	Human
eye photoreceptor cell fate commitment	GO:0042706	37	0.016
imaginal disc pattern formation	GO:0007447	91	0.016
negative regulation of insulin secretion	GO:0046676	1	0.016	Human
positive regulation of ion transmembrane transporter activity	GO:0032414	4	0.016	Rat
cellular response to endogenous stimulus	GO:0071495	80	0.016	Rat
cellular homeostasis	GO:0019725	80	0.016	Rat
regulation of cellular response to stress	GO:0080135	89	0.016
eye morphogenesis	GO:0048592	260	0.016
positive regulation of cellular catabolic process	GO:0031331	95	0.016
detection of stimulus involved in sensory perception	GO:0050906	92	0.016
positive regulation of rna metabolic process	GO:0051254	271	0.016
immune effector process	GO:0002252	98	0.016
ribose phosphate metabolic process	GO:0019693	145	0.016
nucleotide metabolic process	GO:0009117	161	0.016
pattern recognition receptor signaling pathway	GO:0002221	2	0.016
negative regulation of catalytic activity	GO:0043086	42	0.016
regulation of cell development	GO:0060284	215	0.015
regulation of response to external stimulus	GO:0032101	115	0.015
response to starvation	GO:0042594	97	0.015
negative regulation of intracellular signal transduction	GO:1902532	57	0.015
eye photoreceptor cell differentiation	GO:0001754	145	0.015
positive regulation of apoptotic signaling pathway	GO:2001235	4	0.015
regulation of innate immune response	GO:0045088	71	0.015
long term memory	GO:0007616	62	0.015
protein localization	GO:0008104	284	0.015
l glutamate import	GO:0051938	1	0.015	Rat
learning or memory	GO:0007611	141	0.015
photoreceptor cell fate commitment	GO:0046552	41	0.015
phagocytosis	GO:0006909	215	0.015
single organism catabolic process	GO:0044712	228	0.015
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.015	Fly
positive regulation of cellular protein metabolic process	GO:0032270	118	0.015
regulation of kinase activity	GO:0043549	53	0.015
cellular ketone metabolic process	GO:0042180	24	0.015
morphogenesis of a polarized epithelium	GO:0001738	93	0.015
cellular nitrogen compound catabolic process	GO:0044270	165	0.015
cellular response to hexose stimulus	GO:0071331	1	0.014	Rat
regulation of cellular amino acid metabolic process	GO:0006521	0	0.014
regulation of nervous system development	GO:0051960	248	0.014
regulation of transmembrane transport	GO:0034762	27	0.014
lipopolysaccharide mediated signaling pathway	GO:0031663	1	0.014
protein processing	GO:0016485	68	0.014
positive regulation of immune response	GO:0050778	63	0.014
apoptotic process	GO:0006915	159	0.014
epithelial cell migration	GO:0010631	148	0.014
regulation of transferase activity	GO:0051338	58	0.014
organonitrogen compound catabolic process	GO:1901565	128	0.014
regulation of mapk cascade	GO:0043408	92	0.014
vesicle mediated transport	GO:0016192	381	0.014
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.014
purine nucleotide metabolic process	GO:0006163	146	0.014
regulation of growth	GO:0040008	233	0.014
regulation of proteolysis	GO:0030162	87	0.014
establishment of tissue polarity	GO:0007164	87	0.014
macromolecular complex assembly	GO:0065003	256	0.014	Human Rat
cellular response to monosaccharide stimulus	GO:0071326	2	0.014	Rat
death	GO:0016265	284	0.013
muscle organ development	GO:0007517	127	0.013
intracellular protein transport	GO:0006886	104	0.013
positive regulation of apoptotic process	GO:0043065	47	0.013
ameboidal type cell migration	GO:0001667	151	0.013
gene silencing by rna	GO:0031047	57	0.013
cytoplasmic transport	GO:0016482	130	0.013
hippo signaling	GO:0035329	20	0.013
mitotic nuclear division	GO:0007067	213	0.013
spermatogenesis	GO:0007283	200	0.013
response to bacterium	GO:0009617	198	0.013
erbb signaling pathway	GO:0038127	58	0.013
regulation of humoral immune response	GO:0002920	51	0.013
protein complex biogenesis	GO:0070271	201	0.013	Human Rat
negative regulation of kinase activity	GO:0033673	16	0.013
organonitrogen compound biosynthetic process	GO:1901566	117	0.013
ovarian follicle cell development	GO:0030707	248	0.013
posttranscriptional regulation of gene expression	GO:0010608	145	0.013
reproductive behavior	GO:0019098	122	0.013
epithelium migration	GO:0090132	148	0.013
male gamete generation	GO:0048232	201	0.013
dna integrity checkpoint	GO:0031570	81	0.013
cation transport	GO:0006812	110	0.013
response to extracellular stimulus	GO:0009991	116	0.013
cell division	GO:0051301	248	0.013
extrinsic apoptotic signaling pathway	GO:0097191	1	0.013
chemical homeostasis	GO:0048878	92	0.012	Rat
cell adhesion	GO:0007155	136	0.012
wnt signaling pathway	GO:0016055	98	0.012
anion transport	GO:0006820	41	0.012	Rat
regulation of cellular amine metabolic process	GO:0033238	3	0.012
neuron projection guidance	GO:0097485	241	0.012
melanization defense response	GO:0035006	45	0.012
negative regulation of phosphorylation	GO:0042326	35	0.012
cell cell junction organization	GO:0045216	55	0.012
segmentation	GO:0035282	207	0.012
carbohydrate derivative biosynthetic process	GO:1901137	85	0.012
eggshell chorion assembly	GO:0007306	66	0.012
establishment of protein localization	GO:0045184	163	0.012
cellular response to organic cyclic compound	GO:0071407	32	0.012	Rat
photoreceptor cell development	GO:0042461	96	0.012
olfactory behavior	GO:0042048	97	0.012
regulation of response to biotic stimulus	GO:0002831	63	0.012
axon development	GO:0061564	297	0.012
ribonucleotide biosynthetic process	GO:0009260	28	0.012
central nervous system development	GO:0007417	201	0.012
response to temperature stimulus	GO:0009266	106	0.012
notch signaling pathway	GO:0007219	120	0.012
protein transport	GO:0015031	155	0.012
antibacterial humoral response	GO:0019731	44	0.012
meiotic nuclear division	GO:0007126	151	0.012
salivary gland development	GO:0007431	162	0.012
epithelial tube morphogenesis	GO:0060562	88	0.012
cellular protein localization	GO:0034613	160	0.012
carboxylic acid transport	GO:0046942	18	0.012	Rat
regulation of jnk cascade	GO:0046328	40	0.011
positive regulation of hydrolase activity	GO:0051345	78	0.011
protein heterooligomerization	GO:0051291	4	0.011
smoothened signaling pathway	GO:0007224	49	0.011
response to wounding	GO:0009611	94	0.011
posttranscriptional gene silencing by rna	GO:0035194	45	0.011
determination of adult lifespan	GO:0008340	137	0.011
regulation of cell morphogenesis	GO:0022604	163	0.011
negative regulation of developmental growth	GO:0048640	64	0.011
heterocycle catabolic process	GO:0046700	166	0.011
regulation of mitotic cell cycle	GO:0007346	190	0.011
open tracheal system development	GO:0007424	204	0.011
detection of stimulus	GO:0051606	156	0.011
muscle structure development	GO:0061061	224	0.011
programmed cell death	GO:0012501	257	0.011
chromatin organization	GO:0006325	207	0.011
wound healing	GO:0042060	75	0.011
regulation of production of molecular mediator of immune response	GO:0002700	44	0.011
negative regulation of growth	GO:0045926	84	0.011
cell cycle checkpoint	GO:0000075	95	0.011
negative regulation of developmental process	GO:0051093	201	0.011
cell fate determination	GO:0001709	91	0.011
regulation of system process	GO:0044057	36	0.011	Human Rat
nucleoside catabolic process	GO:0009164	112	0.011
melanin metabolic process	GO:0006582	47	0.011
regulation of ras protein signal transduction	GO:0046578	93	0.011
cellular response to nitrogen compound	GO:1901699	51	0.011	Rat
positive regulation of cellular component organization	GO:0051130	156	0.011
phenol containing compound metabolic process	GO:0018958	57	0.011
cellular amide metabolic process	GO:0043603	80	0.011
organic anion transport	GO:0015711	28	0.011	Rat
sensory perception of smell	GO:0007608	80	0.011
positive regulation of transport	GO:0051050	92	0.011	Rat
gene silencing by mirna	GO:0035195	22	0.011
nucleocytoplasmic transport	GO:0006913	72	0.010
regulation of programmed cell death	GO:0043067	152	0.010
posttranscriptional gene silencing	GO:0016441	46	0.010
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	65	0.010	Fly
establishment of planar polarity	GO:0001736	87	0.010
endocytosis	GO:0006897	310	0.010
dendrite development	GO:0016358	204	0.010
ribonucleotide catabolic process	GO:0009261	109	0.010
cellular macromolecular complex assembly	GO:0034622	153	0.010
regulation of antimicrobial humoral response	GO:0002759	50	0.010
response to ketone	GO:1901654	34	0.010	Rat
protein import into nucleus	GO:0006606	51	0.010
response to gravity	GO:0009629	26	0.010
salivary gland histolysis	GO:0035070	88	0.010
organelle assembly	GO:0070925	198	0.010
eye photoreceptor cell development	GO:0042462	81	0.010
respiratory system development	GO:0060541	213	0.010
regulation of ion transmembrane transport	GO:0034765	27	0.010
centrosome organization	GO:0051297	163	0.010
regulation of immune effector process	GO:0002697	52	0.010

Ir disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability	Func Analog Org
disease of metabolism	DOID:0014667	0.079	Human
inherited metabolic disorder	DOID:655	0.042	Human
disease of anatomical entity	DOID:7	0.039	Human
nervous system disease	DOID:863	0.025	Human
acquired metabolic disease	DOID:0060158	0.023	Human
type 2 diabetes mellitus	DOID:9352	0.015	Human
carbohydrate metabolism disease	DOID:0050013	0.015	Human
diabetes mellitus	DOID:9351	0.015	Human
glucose metabolism disease	DOID:4194	0.015	Human
urinary system disease	DOID:18	0.013	Human
eye and adnexa disease	DOID:1492	0.013	Human
sensory system disease	DOID:0050155	0.013	Human
eye disease	DOID:5614	0.012	Human

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