Drosophila melanogaster

50 known processes

Ir (Dmel_CG6747)

Inwardly rectifying potassium channel

(Aliases: irk1,CG6747,ir,Dmel\CG6747,Dir,DIR,dKirI)

Ir biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
circadian rhythmGO:00076231050.596
circadian behaviorGO:0048512760.363
rhythmic behaviorGO:0007622760.284
rhythmic processGO:00485111060.224
locomotor rhythmGO:0045475560.189
intracellular signal transductionGO:00355563000.113
negative regulation of nitrogen compound metabolic processGO:00511722650.102
single organism behaviorGO:00447083910.100
ion transmembrane transportGO:00342201220.100
locomotory behaviorGO:00076261760.098
appendage morphogenesisGO:00351073970.096
negative regulation of cell communicationGO:00106482230.091
Human Fly
positive regulation of response to stimulusGO:00485843230.090
regulation of intracellular signal transductionGO:19025312360.089
response to organonitrogen compoundGO:0010243750.078
Human Rat
negative regulation of rna biosynthetic processGO:19026792400.076
regulation of protein metabolic processGO:00512462560.073
negative regulation of gene expressionGO:00106293870.073
negative regulation of signalingGO:00230572190.065
Human Fly
neurological system processGO:00508773580.065
Human Rat
positive regulation of signal transductionGO:00099672230.064
organonitrogen compound metabolic processGO:19015643180.062
positive regulation of signalingGO:00230562430.058
negative regulation of nucleic acid templated transcriptionGO:19035072400.058
negative regulation of cellular metabolic processGO:00313243820.057
defense response to bacteriumGO:00427421780.056
regulation of cellular protein metabolic processGO:00322682430.052
negative regulation of rna metabolic processGO:00512532510.051
response to organic cyclic compoundGO:0014070890.050
Human Rat
small molecule metabolic processGO:00442813050.049
innate immune responseGO:00450871440.048
positive regulation of cell communicationGO:00106472500.047
compound eye morphogenesisGO:00017452490.047
response to organophosphorusGO:004668320.046
Human
immune system processGO:00023763470.046
developmental growthGO:00485892800.046
negative regulation of cellular macromolecule biosynthetic processGO:20001132670.045
negative regulation of transcription dna templatedGO:00458922370.045
immune responseGO:00069552460.044
response to nitrogen compoundGO:1901698900.044
Human Rat
regulation of phosphate metabolic processGO:00192202100.044
response to other organismGO:00517072930.043
response to lipopolysaccharideGO:003249640.043
regulation of catalytic activityGO:00507901850.042
negative regulation of nucleobase containing compound metabolic processGO:00459342610.042
regulation of molecular functionGO:00650092170.041
Rat
cell deathGO:00082192790.040
tissue morphogenesisGO:00487292970.040
negative regulation of cellular biosynthetic processGO:00313272770.040
cellular protein modification processGO:00064644380.039
imaginal disc derived appendage developmentGO:00487373990.039
regulation of phosphorylationGO:00423251470.039
protein modification processGO:00362114380.039
positive regulation of phosphorus metabolic processGO:00105621390.039
transmembrane transportGO:00550851390.038
regulation of cell differentiationGO:00455953020.038
regionalizationGO:00030024160.037
photoreceptor cell differentiationGO:00465301700.037
positive regulation of biosynthetic processGO:00098913160.037
regulation of circadian rhythmGO:0042752490.037
ion transportGO:00068111450.036
gene silencingGO:00164581380.035
nitrogen compound transportGO:0071705850.035
Human Rat
oxoacid metabolic processGO:00434361030.035
columnar cuboidal epithelial cell developmentGO:00020662490.035
regulation of response to stressGO:00801342000.035
negative regulation of response to stimulusGO:00485852580.034
Fly
compound eye photoreceptor cell differentiationGO:00017511400.033
response to oxygen containing compoundGO:19017002000.033
Human Rat
imaginal disc derived wing morphogenesisGO:00074763370.033
wing disc morphogenesisGO:00074723440.033
organic substance transportGO:00717022570.033
Human Rat
establishment of localization in cellGO:00516494020.033
Human
sensory perceptionGO:00076001960.032
Rat
positive regulation of nitrogen compound metabolic processGO:00511733540.032
positive regulation of catalytic activityGO:00430851180.032
mapk cascadeGO:00001651070.032
positive regulation of defense responseGO:0031349590.031
cellular amino acid metabolic processGO:0006520610.031
positive regulation of intracellular signal transductionGO:19025331160.031
regulation of cell deathGO:00109411730.031
immune response activating signal transductionGO:000275720.031
regulation of phosphorus metabolic processGO:00511742100.030
cellular response to dna damage stimulusGO:00069742230.030
regulation of immune responseGO:00507761180.030
carboxylic acid metabolic processGO:0019752920.030
appendage developmentGO:00487364010.030
regulation of transportGO:00510491810.030
organic substance catabolic processGO:19015753080.030
single organism cellular localizationGO:19025801800.030
catabolic processGO:00090564090.030
humoral immune responseGO:00069591170.029
regulation of multi organism processGO:00439001310.029
organic acid metabolic processGO:00060821030.029
defense response to other organismGO:00985422250.029
regulation of catabolic processGO:00098941700.029
regulation of anatomical structure morphogenesisGO:00226032420.029
negative regulation of macromolecule biosynthetic processGO:00105582700.029
positive regulation of phosphate metabolic processGO:00459371390.029
homeostatic processGO:00425921990.029
Rat
negative regulation of signal transductionGO:00099682060.029
Fly
regulation of organelle organizationGO:00330431960.028
compound eye developmentGO:00487493070.028
protein phosphorylationGO:00064681690.028
carbohydrate derivative metabolic processGO:19011352170.028
purine containing compound metabolic processGO:00725211550.027
response to biotic stimulusGO:00096072940.027
negative regulation of biosynthetic processGO:00098902770.027
jnk cascadeGO:0007254500.027
response to external biotic stimulusGO:00432072930.027
organelle fissionGO:00482853400.027
regulation of cellular localizationGO:00603411360.027
Human
positive regulation of protein metabolic processGO:00512471280.026
signal transduction by phosphorylationGO:00230141070.026
cuticle developmentGO:0042335860.026
imaginal disc derived appendage morphogenesisGO:00351143950.026
sensory perception of chemical stimulusGO:00076061160.026
innate immune response activating signal transductionGO:000275820.026
response to abiotic stimulusGO:00096283410.025
Rat
regulation of cellular ketone metabolic processGO:001056530.025
response to endogenous stimulusGO:00097191190.025
Human Rat
single organism biosynthetic processGO:00447112060.025
l amino acid importGO:004309220.025
Rat
nucleoside phosphate metabolic processGO:00067531620.025
regulation of localizationGO:00328792750.024
sensory organ morphogenesisGO:00905962600.024
negative regulation of multicellular organismal processGO:00512411420.024
regulation of transcription from rna polymerase ii promoterGO:00063573780.024
eye developmentGO:00016543230.023
transcription from rna polymerase ii promoterGO:00063663680.023
epithelial cell developmentGO:00020642740.023
stress activated protein kinase signaling cascadeGO:0031098550.023
nucleobase containing small molecule metabolic processGO:00550861740.023
secondary metabolic processGO:0019748750.023
cellular catabolic processGO:00442483720.022
columnar cuboidal epithelial cell differentiationGO:00020652560.022
phosphorylationGO:00163102940.022
response to organic substanceGO:00100332840.022
Human Rat
post embryonic appendage morphogenesisGO:00351203850.022
positive regulation of gene expressionGO:00106282900.022
regulation of immune system processGO:00026821760.022
regulation of protein modification processGO:00313991120.022
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691160.022
response to monosaccharideGO:003428440.022
Rat
cellular amine metabolic processGO:0044106120.022
amine metabolic processGO:0009308120.022
cellular macromolecule localizationGO:00707272200.022
defense responseGO:00069523000.022
Rat
ras protein signal transductionGO:0007265880.022
secretion by cellGO:00329401010.021
Human
cellular response to organic substanceGO:00713101320.021
Rat
peptide metabolic processGO:0006518800.021
negative regulation of cellular protein metabolic processGO:0032269850.021
gliogenesisGO:0042063800.021
positive regulation of mapk cascadeGO:0043410630.021
response to light stimulusGO:00094161240.021
Rat
response to purine containing compoundGO:0014074120.021
Human
response to alkaloidGO:0043279260.021
Rat
positive regulation of phosphorylationGO:0042327870.021
proteolysisGO:00065081920.021
negative regulation of phosphate metabolic processGO:0045936450.021
immune response regulating signaling pathwayGO:000276420.021
response to hexoseGO:000974630.021
Rat
body morphogenesisGO:001017120.021
negative regulation of protein metabolic processGO:0051248850.021
organic hydroxy compound metabolic processGO:1901615830.021
cellular response to lipopolysaccharideGO:007122230.021
small gtpase mediated signal transductionGO:0007264880.020
regulation of cell cycleGO:00517262910.020
ribonucleotide metabolic processGO:00092591450.020
regulation of smoothened signaling pathwayGO:0008589280.020
macromolecule catabolic processGO:00090571610.020
regulation of defense responseGO:00313471020.020
protein complex assemblyGO:00064612000.020
Human Rat
taxisGO:00423303040.020
chaeta developmentGO:0022416970.020
response to radiationGO:00093141550.020
Rat
monocarboxylic acid transportGO:001571830.020
positive regulation of cellular biosynthetic processGO:00313283160.020
stress activated mapk cascadeGO:0051403520.020
growthGO:00400073590.019
nuclear divisionGO:00002803320.019
positive regulation of macromolecule metabolic processGO:00106044050.019
intracellular transportGO:00469072280.019
regulation of neurogenesisGO:00507671580.019
cellular response to biotic stimulusGO:007121640.019
regulation of protein phosphorylationGO:0001932640.019
chromosome segregationGO:00070591570.018
secretionGO:00469031090.018
Human
chromosome organizationGO:00512763600.018
epithelial cell differentiationGO:00308553220.018
cell proliferationGO:00082832990.018
inorganic ion transmembrane transportGO:0098660730.018
metal ion transportGO:0030001740.018
cellular response to chemical stimulusGO:00708871990.018
Rat
kidney developmentGO:000182230.018
Rat
regulation of protein kinase activityGO:0045859510.018
positive regulation of catabolic processGO:00098961050.018
pigmentationGO:0043473750.018
positive regulation of molecular functionGO:00440931360.018
Rat
regulation of gene expression epigeneticGO:00400291280.018
organophosphate metabolic processGO:00196371950.018
positive regulation of rna biosynthetic processGO:19026802660.018
defense response to gram negative bacteriumGO:0050829940.017
regulation of small gtpase mediated signal transductionGO:0051056930.017
cell motilityGO:00488702510.017
negative regulation of phosphorus metabolic processGO:0010563450.017
positive regulation of transcription dna templatedGO:00458932660.017
cellular response to carbohydrate stimulusGO:007132240.017
Rat
positive regulation of programmed cell deathGO:0043068620.017
response to glucoseGO:000974920.017
Rat
single organism intracellular transportGO:19025822070.017
positive regulation of nucleobase containing compound metabolic processGO:00459353320.017
defense response to fungusGO:0050832480.017
antimicrobial humoral responseGO:0019730990.017
morphogenesis of an epitheliumGO:00020092760.016
regulation of multicellular organismal developmentGO:20000264140.016
actin filament based processGO:00300292200.016
Rat
chemosensory behaviorGO:00076351060.016
cognitionGO:00508901410.016
multi organism behaviorGO:00517051750.016
regulation of secretion by cellGO:1903530390.016
Human
eye photoreceptor cell fate commitmentGO:0042706370.016
imaginal disc pattern formationGO:0007447910.016
negative regulation of insulin secretionGO:004667610.016
Human
positive regulation of ion transmembrane transporter activityGO:003241440.016
Rat
cellular response to endogenous stimulusGO:0071495800.016
Rat
cellular homeostasisGO:0019725800.016
Rat
regulation of cellular response to stressGO:0080135890.016
eye morphogenesisGO:00485922600.016
positive regulation of cellular catabolic processGO:0031331950.016
detection of stimulus involved in sensory perceptionGO:0050906920.016
positive regulation of rna metabolic processGO:00512542710.016
immune effector processGO:0002252980.016
ribose phosphate metabolic processGO:00196931450.016
nucleotide metabolic processGO:00091171610.016
pattern recognition receptor signaling pathwayGO:000222120.016
negative regulation of catalytic activityGO:0043086420.016
regulation of cell developmentGO:00602842150.015
regulation of response to external stimulusGO:00321011150.015
response to starvationGO:0042594970.015
negative regulation of intracellular signal transductionGO:1902532570.015
eye photoreceptor cell differentiationGO:00017541450.015
positive regulation of apoptotic signaling pathwayGO:200123540.015
regulation of innate immune responseGO:0045088710.015
long term memoryGO:0007616620.015
protein localizationGO:00081042840.015
l glutamate importGO:005193810.015
Rat
learning or memoryGO:00076111410.015
photoreceptor cell fate commitmentGO:0046552410.015
phagocytosisGO:00069092150.015
single organism catabolic processGO:00447122280.015
enzyme linked receptor protein signaling pathwayGO:00071671790.015
Fly
positive regulation of cellular protein metabolic processGO:00322701180.015
regulation of kinase activityGO:0043549530.015
cellular ketone metabolic processGO:0042180240.015
morphogenesis of a polarized epitheliumGO:0001738930.015
cellular nitrogen compound catabolic processGO:00442701650.015
cellular response to hexose stimulusGO:007133110.014
Rat
regulation of cellular amino acid metabolic processGO:000652100.014
regulation of nervous system developmentGO:00519602480.014
regulation of transmembrane transportGO:0034762270.014
lipopolysaccharide mediated signaling pathwayGO:003166310.014
protein processingGO:0016485680.014
positive regulation of immune responseGO:0050778630.014
apoptotic processGO:00069151590.014
epithelial cell migrationGO:00106311480.014
regulation of transferase activityGO:0051338580.014
organonitrogen compound catabolic processGO:19015651280.014
regulation of mapk cascadeGO:0043408920.014
vesicle mediated transportGO:00161923810.014
cell cell signaling involved in cell fate commitmentGO:00451682100.014
purine nucleotide metabolic processGO:00061631460.014
regulation of growthGO:00400082330.014
regulation of proteolysisGO:0030162870.014
establishment of tissue polarityGO:0007164870.014
macromolecular complex assemblyGO:00650032560.014
Human Rat
cellular response to monosaccharide stimulusGO:007132620.014
Rat
deathGO:00162652840.013
muscle organ developmentGO:00075171270.013
intracellular protein transportGO:00068861040.013
positive regulation of apoptotic processGO:0043065470.013
ameboidal type cell migrationGO:00016671510.013
gene silencing by rnaGO:0031047570.013
cytoplasmic transportGO:00164821300.013
hippo signalingGO:0035329200.013
mitotic nuclear divisionGO:00070672130.013
spermatogenesisGO:00072832000.013
response to bacteriumGO:00096171980.013
erbb signaling pathwayGO:0038127580.013
regulation of humoral immune responseGO:0002920510.013
protein complex biogenesisGO:00702712010.013
Human Rat
negative regulation of kinase activityGO:0033673160.013
organonitrogen compound biosynthetic processGO:19015661170.013
ovarian follicle cell developmentGO:00307072480.013
posttranscriptional regulation of gene expressionGO:00106081450.013
reproductive behaviorGO:00190981220.013
epithelium migrationGO:00901321480.013
male gamete generationGO:00482322010.013
dna integrity checkpointGO:0031570810.013
cation transportGO:00068121100.013
response to extracellular stimulusGO:00099911160.013
cell divisionGO:00513012480.013
extrinsic apoptotic signaling pathwayGO:009719110.013
chemical homeostasisGO:0048878920.012
Rat
cell adhesionGO:00071551360.012
wnt signaling pathwayGO:0016055980.012
anion transportGO:0006820410.012
Rat
regulation of cellular amine metabolic processGO:003323830.012
neuron projection guidanceGO:00974852410.012
melanization defense responseGO:0035006450.012
negative regulation of phosphorylationGO:0042326350.012
cell cell junction organizationGO:0045216550.012
segmentationGO:00352822070.012
carbohydrate derivative biosynthetic processGO:1901137850.012
eggshell chorion assemblyGO:0007306660.012
establishment of protein localizationGO:00451841630.012
cellular response to organic cyclic compoundGO:0071407320.012
Rat
photoreceptor cell developmentGO:0042461960.012
olfactory behaviorGO:0042048970.012
regulation of response to biotic stimulusGO:0002831630.012
axon developmentGO:00615642970.012
ribonucleotide biosynthetic processGO:0009260280.012
central nervous system developmentGO:00074172010.012
response to temperature stimulusGO:00092661060.012
notch signaling pathwayGO:00072191200.012
protein transportGO:00150311550.012
antibacterial humoral responseGO:0019731440.012
meiotic nuclear divisionGO:00071261510.012
salivary gland developmentGO:00074311620.012
epithelial tube morphogenesisGO:0060562880.012
cellular protein localizationGO:00346131600.012
carboxylic acid transportGO:0046942180.012
Rat
regulation of jnk cascadeGO:0046328400.011
positive regulation of hydrolase activityGO:0051345780.011
protein heterooligomerizationGO:005129140.011
smoothened signaling pathwayGO:0007224490.011
response to woundingGO:0009611940.011
posttranscriptional gene silencing by rnaGO:0035194450.011
determination of adult lifespanGO:00083401370.011
regulation of cell morphogenesisGO:00226041630.011
negative regulation of developmental growthGO:0048640640.011
heterocycle catabolic processGO:00467001660.011
regulation of mitotic cell cycleGO:00073461900.011
open tracheal system developmentGO:00074242040.011
detection of stimulusGO:00516061560.011
muscle structure developmentGO:00610612240.011
programmed cell deathGO:00125012570.011
chromatin organizationGO:00063252070.011
wound healingGO:0042060750.011
regulation of production of molecular mediator of immune responseGO:0002700440.011
negative regulation of growthGO:0045926840.011
cell cycle checkpointGO:0000075950.011
negative regulation of developmental processGO:00510932010.011
cell fate determinationGO:0001709910.011
regulation of system processGO:0044057360.011
Human Rat
nucleoside catabolic processGO:00091641120.011
melanin metabolic processGO:0006582470.011
regulation of ras protein signal transductionGO:0046578930.011
cellular response to nitrogen compoundGO:1901699510.011
Rat
positive regulation of cellular component organizationGO:00511301560.011
phenol containing compound metabolic processGO:0018958570.011
cellular amide metabolic processGO:0043603800.011
organic anion transportGO:0015711280.011
Rat
sensory perception of smellGO:0007608800.011
positive regulation of transportGO:0051050920.011
Rat
gene silencing by mirnaGO:0035195220.011
nucleocytoplasmic transportGO:0006913720.010
regulation of programmed cell deathGO:00430671520.010
posttranscriptional gene silencingGO:0016441460.010
transmembrane receptor protein serine threonine kinase signaling pathwayGO:0007178650.010
Fly
establishment of planar polarityGO:0001736870.010
endocytosisGO:00068973100.010
dendrite developmentGO:00163582040.010
ribonucleotide catabolic processGO:00092611090.010
cellular macromolecular complex assemblyGO:00346221530.010
regulation of antimicrobial humoral responseGO:0002759500.010
response to ketoneGO:1901654340.010
Rat
protein import into nucleusGO:0006606510.010
response to gravityGO:0009629260.010
salivary gland histolysisGO:0035070880.010
organelle assemblyGO:00709251980.010
eye photoreceptor cell developmentGO:0042462810.010
respiratory system developmentGO:00605412130.010
regulation of ion transmembrane transportGO:0034765270.010
centrosome organizationGO:00512971630.010
regulation of immune effector processGO:0002697520.010

Ir disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of metabolismDOID:001466700.079
Human
inherited metabolic disorderDOID:65500.042
Human
disease of anatomical entityDOID:700.039
Human
nervous system diseaseDOID:86300.025
Human
acquired metabolic diseaseDOID:006015800.023
Human
type 2 diabetes mellitusDOID:935200.015
Human
carbohydrate metabolism diseaseDOID:005001300.015
Human
diabetes mellitusDOID:935100.015
Human
glucose metabolism diseaseDOID:419400.015
Human
urinary system diseaseDOID:1800.013
Human
eye and adnexa diseaseDOID:149200.013
Human
sensory system diseaseDOID:005015500.013
Human
eye diseaseDOID:561400.012
Human