IMP: Integrative Multi-species Prediction

Drosophila melanogaster

134 known processes

14-3-3zeta (Dmel_CG17870)

CG17870 gene product from transcript CG17870-RB

(Aliases: 4-3-3 zeta,2G1,l(2)46CFe,CG17870,par-5,14-3-3,D14-3-3,Leo,549,K,D14-3-3zeta,leo,5.11,PAR-5,d14-3-3zeta,l(2)07103,BEST:GH05075,Dmel\CG17870,PAR5,14-3-3 zeta,l(2)46Ee,Par-5)

FLYBASE: FBgn0004907
Entrez: 36059
UniProtKB: P29310

Process Predictions
Disease Predictions

14-3-3zeta biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
learning or memory	GO:0007611	141	0.992
phototransduction	GO:0007602	52	0.978
memory	GO:0007613	94	0.965
ameboidal type cell migration	GO:0001667	151	0.963
ovarian follicle cell migration	GO:0007297	121	0.954
cell migration	GO:0016477	238	0.952	Fly
border follicle cell migration	GO:0007298	113	0.950
columnar cuboidal epithelial cell development	GO:0002066	249	0.946
actin cytoskeleton organization	GO:0030036	206	0.929
post embryonic appendage morphogenesis	GO:0035120	385	0.893
epithelial cell migration	GO:0010631	148	0.891
axis specification	GO:0009798	167	0.873
molting cycle	GO:0042303	56	0.870
tube development	GO:0035295	244	0.853
establishment of localization in cell	GO:0051649	402	0.852	Mouse Worm
epithelial cell differentiation	GO:0030855	322	0.843	Mouse
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.827
regionalization	GO:0003002	416	0.819	Worm Fly
cell motility	GO:0048870	251	0.809	Fly
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.747
sensory organ morphogenesis	GO:0090596	260	0.745
wing disc morphogenesis	GO:0007472	344	0.711
establishment or maintenance of cell polarity	GO:0007163	167	0.667
localization of cell	GO:0051674	257	0.658	Fly
appendage morphogenesis	GO:0035107	397	0.650
tissue migration	GO:0090130	155	0.646
cell cell junction organization	GO:0045216	55	0.641
organelle localization	GO:0051640	148	0.630	Worm
cognition	GO:0050890	141	0.622
imaginal disc derived wing hair organization	GO:0035317	45	0.602
ovarian follicle cell development	GO:0030707	248	0.583
embryo development ending in birth or egg hatching	GO:0009792	152	0.581	Worm
cellular protein modification process	GO:0006464	438	0.576	Human Yeast Mouse
imaginal disc derived wing morphogenesis	GO:0007476	337	0.575
digestive system development	GO:0055123	149	0.572
single organism behavior	GO:0044708	391	0.564
long term memory	GO:0007616	62	0.561
regulation of localization	GO:0032879	275	0.553	Human Mouse
oocyte development	GO:0048599	124	0.552
germarium derived egg chamber formation	GO:0007293	101	0.545
cuticle development	GO:0042335	86	0.543
establishment of organelle localization	GO:0051656	122	0.524	Worm
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.511	Human
olfactory behavior	GO:0042048	97	0.506
epithelium migration	GO:0090132	148	0.497
neurological system process	GO:0050877	358	0.487
protein complex biogenesis	GO:0070271	201	0.455
oocyte differentiation	GO:0009994	145	0.448
response to light stimulus	GO:0009416	124	0.448	Fly
regulation of rhodopsin mediated signaling pathway	GO:0022400	17	0.446
epithelial cell development	GO:0002064	274	0.441	Mouse
secretion	GO:0046903	109	0.416
asymmetric protein localization	GO:0008105	33	0.410	Worm
digestive tract morphogenesis	GO:0048546	127	0.403
regulation of cellular ph	GO:0030641	7	0.399
morphogenesis of an epithelium	GO:0002009	276	0.390
appendage development	GO:0048736	401	0.382
deactivation of rhodopsin mediated signaling	GO:0016059	17	0.381
single organism biosynthetic process	GO:0044711	206	0.379	Yeast
cell proliferation	GO:0008283	299	0.377	Mouse
response to ethanol	GO:0045471	59	0.371
skin development	GO:0043588	65	0.366	Mouse
macromolecular complex assembly	GO:0065003	256	0.359	Yeast
aging	GO:0007568	143	0.352	Worm Fly
non sensory hair organization	GO:0035316	47	0.349
asymmetric protein localization involved in cell fate determination	GO:0045167	9	0.349	Worm
transcription from rna polymerase ii promoter	GO:0006366	368	0.348	Yeast
cell junction organization	GO:0034330	57	0.341
regulation of cell cycle	GO:0051726	291	0.341	Yeast Mouse Worm Fly
actin filament based process	GO:0030029	220	0.341
chorion containing eggshell formation	GO:0007304	105	0.334
cuticle pattern formation	GO:0035017	27	0.332
oocyte construction	GO:0007308	112	0.329
protein modification by small protein conjugation	GO:0032446	79	0.327	Yeast
germ line cyst formation	GO:0048134	44	0.325
small molecule metabolic process	GO:0044281	305	0.308
eye morphogenesis	GO:0048592	260	0.304
neural precursor cell proliferation	GO:0061351	75	0.301
protein transport	GO:0015031	155	0.297	Human Mouse
protein complex assembly	GO:0006461	200	0.296
negative regulation of gene expression	GO:0010629	387	0.293	Human Yeast
olfactory learning	GO:0008355	56	0.286
stem cell proliferation	GO:0072089	88	0.285
positive regulation of cellular biosynthetic process	GO:0031328	316	0.284	Human
detection of light stimulus	GO:0009583	58	0.284
cellular macromolecular complex assembly	GO:0034622	153	0.282	Yeast
ph reduction	GO:0045851	7	0.278
eye development	GO:0001654	323	0.274
exocytosis	GO:0006887	28	0.272
heart development	GO:0007507	82	0.266	Zebrafish
associative learning	GO:0008306	65	0.265
cell division	GO:0051301	248	0.260	Yeast Mouse Worm Fly
establishment of planar polarity	GO:0001736	87	0.255
negative regulation of multicellular organismal process	GO:0051241	142	0.253	Mouse
detection of external stimulus	GO:0009581	66	0.246
detection of abiotic stimulus	GO:0009582	66	0.245
single organism intracellular transport	GO:1902582	207	0.239	Mouse
compound eye photoreceptor fate commitment	GO:0001752	36	0.239
germarium derived female germ line cyst formation	GO:0030727	42	0.238
secretion by cell	GO:0032940	101	0.238
imaginal disc derived appendage development	GO:0048737	399	0.237
mitotic spindle organization	GO:0007052	220	0.237
actin filament organization	GO:0007015	126	0.234
regulation of notch signaling pathway	GO:0008593	100	0.231
synaptic transmission	GO:0007268	288	0.231	Human
oocyte microtubule cytoskeleton organization	GO:0016325	35	0.228
positive regulation of biosynthetic process	GO:0009891	316	0.226	Human
blastoderm segmentation	GO:0007350	159	0.224
regulation of cell differentiation	GO:0045595	302	0.220	Human Mouse
phototransduction visible light	GO:0007603	27	0.220
single organism cellular localization	GO:1902580	180	0.216	Worm
cell maturation	GO:0048469	144	0.213
rhodopsin mediated signaling pathway	GO:0016056	21	0.213
response to abiotic stimulus	GO:0009628	341	0.210
instar larval development	GO:0002168	55	0.209
chitin based cuticle development	GO:0040003	49	0.209
oocyte axis specification	GO:0007309	108	0.209
striated muscle cell differentiation	GO:0051146	90	0.206
learning	GO:0007612	75	0.205
signal release	GO:0023061	49	0.202
single organism catabolic process	GO:0044712	228	0.194	Human
positive regulation of cellular component biogenesis	GO:0044089	80	0.193
respiratory system development	GO:0060541	213	0.190
oxoacid metabolic process	GO:0043436	103	0.189
hair cell differentiation	GO:0035315	47	0.186
regulation of secretion	GO:0051046	44	0.185
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.185	Human
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.184	Yeast
molting cycle chitin based cuticle	GO:0007591	56	0.184
multicellular organismal aging	GO:0010259	140	0.183	Worm Fly
determination of adult lifespan	GO:0008340	137	0.180	Worm Fly
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.180	Human Yeast
catabolic process	GO:0009056	409	0.179	Human
body morphogenesis	GO:0010171	2	0.176
cellular response to chemical stimulus	GO:0070887	199	0.175
eggshell formation	GO:0030703	105	0.175
organelle assembly	GO:0070925	198	0.170
muscle cell differentiation	GO:0042692	103	0.170
female germ line cyst formation	GO:0048135	42	0.169
chromosome organization	GO:0051276	360	0.161
embryonic development via the syncytial blastoderm	GO:0001700	148	0.160
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.160	Human
tissue morphogenesis	GO:0048729	297	0.159
segmentation	GO:0035282	207	0.159
protein modification process	GO:0036211	438	0.156	Human Yeast Mouse
anterior posterior pattern specification	GO:0009952	136	0.155	Worm
regulation of tube architecture open tracheal system	GO:0035152	68	0.154
intracellular ph reduction	GO:0051452	7	0.153
asymmetric neuroblast division	GO:0055059	33	0.150
g protein coupled receptor signaling pathway	GO:0007186	136	0.147
regulation of neurotransmitter levels	GO:0001505	38	0.145
negative regulation of cellular biosynthetic process	GO:0031327	277	0.140	Human Yeast
gland development	GO:0048732	191	0.138
positive regulation of transcription dna templated	GO:0045893	266	0.137	Human
neurotransmitter secretion	GO:0007269	35	0.137
notch signaling pathway	GO:0007219	120	0.137
cellular protein localization	GO:0034613	160	0.137	Human Mouse
digestive tract development	GO:0048565	149	0.137
positive regulation of rna metabolic process	GO:0051254	271	0.134	Human
positive regulation of cell migration	GO:0030335	2	0.132
regulation of stem cell proliferation	GO:0072091	40	0.129
epidermis development	GO:0008544	65	0.128	Mouse
intracellular protein transport	GO:0006886	104	0.127	Mouse
response to organic substance	GO:0010033	284	0.127
regulation of secretion by cell	GO:1903530	39	0.126
positive regulation of macromolecule metabolic process	GO:0010604	405	0.125	Human
negative regulation of developmental process	GO:0051093	201	0.125	Mouse
compound eye development	GO:0048749	307	0.124
protein modification by small protein conjugation or removal	GO:0070647	106	0.123	Yeast
protein localization	GO:0008104	284	0.122	Human Mouse Worm
peptidyl amino acid modification	GO:0018193	105	0.122
nuclear division	GO:0000280	332	0.121	Yeast Worm Fly
cellular macromolecule localization	GO:0070727	220	0.120	Human Mouse
sevenless signaling pathway	GO:0045500	4	0.120
tube morphogenesis	GO:0035239	191	0.119
cell fate determination	GO:0001709	91	0.118
cellular response to organic substance	GO:0071310	132	0.118
sensory perception	GO:0007600	196	0.116
cellular catabolic process	GO:0044248	372	0.116
regulation of ph	GO:0006885	7	0.112
establishment or maintenance of apical basal cell polarity	GO:0035088	34	0.110
negative regulation of cell differentiation	GO:0045596	143	0.109	Mouse
regulation of protein polymerization	GO:0032271	28	0.109
regulation of protein localization	GO:0032880	76	0.109	Human Mouse
response to biotic stimulus	GO:0009607	294	0.107
neurotransmitter transport	GO:0006836	37	0.107
dorsal appendage formation	GO:0046843	47	0.106
response to alcohol	GO:0097305	95	0.105
adult behavior	GO:0030534	137	0.104
cell cell junction assembly	GO:0007043	38	0.102
chromatin modification	GO:0016568	147	0.101
membrane organization	GO:0061024	112	0.100	Zebrafish
cell junction assembly	GO:0034329	42	0.100
regulation of phosphorus metabolic process	GO:0051174	210	0.099
negative regulation of response to stimulus	GO:0048585	258	0.098
protein catabolic process	GO:0030163	101	0.098
chemosensory behavior	GO:0007635	106	0.096
proteolysis	GO:0006508	192	0.095	Human
establishment of protein localization	GO:0045184	163	0.094	Human Mouse
positive regulation of neurotransmitter secretion	GO:0001956	2	0.093
cell projection assembly	GO:0030031	94	0.092
regulation of cellular protein metabolic process	GO:0032268	243	0.091	Human Yeast Mouse
gliogenesis	GO:0042063	80	0.091
response to oxygen containing compound	GO:1901700	200	0.091
behavioral response to ethanol	GO:0048149	49	0.091
neuroblast division	GO:0055057	35	0.090
initiation of dorsal closure	GO:0007392	12	0.090
establishment of imaginal disc derived wing hair orientation	GO:0001737	24	0.087
regulation of organelle organization	GO:0033043	196	0.087	Yeast Fly
establishment or maintenance of cytoskeleton polarity	GO:0030952	44	0.087
guanosine containing compound metabolic process	GO:1901068	74	0.086
macromolecule catabolic process	GO:0009057	161	0.085
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.085
establishment of vesicle localization	GO:0051650	51	0.084
organophosphate metabolic process	GO:0019637	195	0.084
neuron fate commitment	GO:0048663	50	0.082
vacuolar acidification	GO:0007035	4	0.080
carboxylic acid metabolic process	GO:0019752	92	0.080
filopodium assembly	GO:0046847	33	0.080
regulation of protein complex assembly	GO:0043254	42	0.079
regulation of cellular localization	GO:0060341	136	0.079	Mouse
small gtpase mediated signal transduction	GO:0007264	88	0.079
negative regulation of transcription dna templated	GO:0045892	237	0.079	Human Yeast
negative regulation of biosynthetic process	GO:0009890	277	0.078	Human Yeast
regulation of actin filament length	GO:0030832	27	0.078
purine ribonucleoside catabolic process	GO:0046130	112	0.078
detection of stimulus	GO:0051606	156	0.076
developmental maturation	GO:0021700	172	0.076
maternal determination of anterior posterior axis embryo	GO:0008358	74	0.075
organonitrogen compound metabolic process	GO:1901564	318	0.075	Yeast
metarhodopsin inactivation	GO:0016060	5	0.075
establishment or maintenance of microtubule cytoskeleton polarity	GO:0030951	41	0.073
cardiovascular system development	GO:0072358	82	0.073	Zebrafish
regulation of actin polymerization or depolymerization	GO:0008064	27	0.073
cellular response to lipopolysaccharide	GO:0071222	3	0.073
embryonic pattern specification	GO:0009880	174	0.072
positive regulation of signal transduction	GO:0009967	223	0.072
anterior posterior axis specification	GO:0009948	109	0.071	Worm
rna processing	GO:0006396	147	0.071
cytoplasm organization	GO:0007028	64	0.070
stem cell differentiation	GO:0048863	117	0.069
positive regulation of feeding behavior	GO:2000253	8	0.069
response to lipopolysaccharide	GO:0032496	4	0.069
dna metabolic process	GO:0006259	227	0.068	Yeast
regulation of molecular function	GO:0065009	217	0.068	Human Yeast Mouse
regulation of cell projection assembly	GO:0060491	30	0.068
intracellular signal transduction	GO:0035556	300	0.068
cellular response to light stimulus	GO:0071482	37	0.066
response to carbon dioxide	GO:0010037	4	0.065
cellular protein complex assembly	GO:0043623	71	0.064
developmental growth involved in morphogenesis	GO:0060560	65	0.064
open tracheal system development	GO:0007424	204	0.064
negative regulation of catabolic process	GO:0009895	36	0.064
compound eye morphogenesis	GO:0001745	249	0.064
chromatin remodeling	GO:0006338	72	0.062
muscle system process	GO:0003012	21	0.062
regulation of cellular component biogenesis	GO:0044087	201	0.062
regulation of actin cytoskeleton organization	GO:0032956	42	0.062
negative regulation of rna biosynthetic process	GO:1902679	240	0.060	Human Yeast
single organismal cell cell adhesion	GO:0016337	45	0.059
regulation of reactive oxygen species metabolic process	GO:2000377	8	0.059
photoreceptor cell development	GO:0042461	96	0.059
anatomical structure homeostasis	GO:0060249	97	0.058
muscle cell development	GO:0055001	50	0.058
retinal cell programmed cell death	GO:0046666	25	0.058
gastrulation	GO:0007369	70	0.058
regulation of g protein coupled receptor protein signaling pathway	GO:0008277	23	0.057
positive regulation of reactive oxygen species metabolic process	GO:2000379	0	0.057
multicellular organismal homeostasis	GO:0048871	41	0.057
cellular response to carbon dioxide	GO:0071244	2	0.057
protein polymerization	GO:0051258	42	0.056
organic substance transport	GO:0071702	257	0.056	Human Mouse
pseudocleavage involved in syncytial blastoderm formation	GO:0030589	9	0.056
cellular component assembly involved in morphogenesis	GO:0010927	151	0.055
purine containing compound metabolic process	GO:0072521	155	0.055
developmental cell growth	GO:0048588	52	0.054
camera type eye development	GO:0043010	4	0.054
mitotic cytokinesis	GO:0000281	50	0.054
regulation of catabolic process	GO:0009894	170	0.054
apical constriction	GO:0003383	18	0.053
positive regulation of secretion	GO:0051047	22	0.053
neuromuscular junction development	GO:0007528	149	0.052
mitotic nuclear division	GO:0007067	213	0.051	Yeast Fly
exocrine system development	GO:0035272	162	0.051
synaptic vesicle localization	GO:0097479	53	0.051
neuron projection guidance	GO:0097485	241	0.051	Fly
positive regulation of rna biosynthetic process	GO:1902680	266	0.051	Human
organic acid metabolic process	GO:0006082	103	0.050
developmental growth	GO:0048589	280	0.049
negative regulation of epithelial cell proliferation	GO:0050680	4	0.049	Mouse
immune response	GO:0006955	246	0.049
retina development in camera type eye	GO:0060041	4	0.049
tripartite regional subdivision	GO:0007351	103	0.049
nucleus localization	GO:0051647	34	0.049	Worm
neuroblast proliferation	GO:0007405	74	0.049
regulation of locomotion	GO:0040012	42	0.048
regulation of intracellular ph	GO:0051453	7	0.048
actin filament polymerization	GO:0030041	27	0.048
regulation of phosphate metabolic process	GO:0019220	210	0.048
regulation of cell morphogenesis	GO:0022604	163	0.048	Mouse
regulation of cellular component size	GO:0032535	98	0.047
establishment or maintenance of bipolar cell polarity	GO:0061245	34	0.047
establishment of protein localization to organelle	GO:0072594	62	0.047
cellular monovalent inorganic cation homeostasis	GO:0030004	7	0.047
morphogenesis of follicular epithelium	GO:0016333	36	0.047
forebrain development	GO:0030900	2	0.046
eggshell chorion assembly	GO:0007306	66	0.046
regulation of establishment of protein localization	GO:0070201	61	0.046	Human Mouse
mitotic cell cycle phase transition	GO:0044772	138	0.046	Yeast Fly
vesicle localization	GO:0051648	55	0.045
organic cyclic compound catabolic process	GO:1901361	168	0.044	Human
ras protein signal transduction	GO:0007265	88	0.044
neuromuscular synaptic transmission	GO:0007274	67	0.044
negative regulation of rna metabolic process	GO:0051253	251	0.044	Human Yeast
response to radiation	GO:0009314	155	0.044	Fly
photoreceptor cell fate commitment	GO:0046552	41	0.044
anterior posterior axis specification embryo	GO:0008595	103	0.043
dopamine receptor signaling pathway	GO:0007212	4	0.043
intracellular transport	GO:0046907	228	0.043	Mouse
larval development	GO:0002164	104	0.042	Worm
regulation of lamellipodium organization	GO:1902743	15	0.042
morphogenesis of a polarized epithelium	GO:0001738	93	0.042
regulation of cell cycle process	GO:0010564	181	0.042	Yeast Fly
urogenital system development	GO:0001655	72	0.041
dorsal closure	GO:0007391	79	0.041
cellular response to abiotic stimulus	GO:0071214	58	0.041
chemical homeostasis	GO:0048878	92	0.041	Mouse
detection of visible light	GO:0009584	38	0.041
positive regulation of cellular component organization	GO:0051130	156	0.041
organonitrogen compound biosynthetic process	GO:1901566	117	0.040	Yeast
establishment of cell polarity	GO:0030010	40	0.040	Worm
embryonic axis specification	GO:0000578	107	0.040
hemocyte differentiation	GO:0042386	38	0.040
regulation of adult chitin containing cuticle pigmentation	GO:0048082	13	0.040
actin polymerization or depolymerization	GO:0008154	31	0.039
positive regulation of secretion by cell	GO:1903532	20	0.039
developmental programmed cell death	GO:0010623	138	0.039
regulation of oocyte development	GO:0060281	27	0.039
phosphorylation	GO:0016310	294	0.039
synaptic vesicle exocytosis	GO:0016079	16	0.038
ion homeostasis	GO:0050801	55	0.038
protein ubiquitination	GO:0016567	70	0.038	Yeast
pole plasm protein localization	GO:0007318	10	0.038
regulation of muscle cell differentiation	GO:0051147	8	0.037
carbohydrate derivative metabolic process	GO:1901135	217	0.037	Yeast
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.037	Human Yeast
positive regulation of exocytosis	GO:0045921	4	0.037
embryonic organ development	GO:0048568	50	0.036
growth	GO:0040007	359	0.036	Yeast Mouse Fly
regulation of tube diameter open tracheal system	GO:0035158	11	0.036
positive regulation of cell motility	GO:2000147	3	0.036
regulation of actin filament polymerization	GO:0030833	25	0.035
regulation of multicellular organismal development	GO:2000026	414	0.035	Human Mouse
endomembrane system organization	GO:0010256	119	0.035
actin cytoskeleton reorganization	GO:0031532	22	0.035
regulation of compound eye retinal cell programmed cell death	GO:0046669	18	0.035
eye photoreceptor cell fate commitment	GO:0042706	37	0.035
regulation of hemocyte differentiation	GO:0045610	22	0.035
head development	GO:0060322	135	0.035	Human Zebrafish
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.034
spindle organization	GO:0007051	253	0.034
compound eye photoreceptor cell differentiation	GO:0001751	140	0.034
branching involved in open tracheal system development	GO:0060446	45	0.034
regulation of epithelial cell proliferation	GO:0050678	4	0.034	Mouse
embryonic morphogenesis	GO:0048598	206	0.034
cell adhesion	GO:0007155	136	0.034
cellular protein catabolic process	GO:0044257	83	0.034
circulatory system development	GO:0072359	82	0.033	Zebrafish
maintenance of cell polarity	GO:0030011	18	0.033
apical constriction involved in gastrulation	GO:0003384	7	0.033
regulation of reproductive process	GO:2000241	54	0.032
regulation of vesicle mediated transport	GO:0060627	59	0.032
positive regulation of sequence specific dna binding transcription factor activity	GO:0051091	9	0.032
oocyte anterior posterior axis specification	GO:0007314	72	0.032
heart contraction	GO:0060047	26	0.031
regulation of cell junction assembly	GO:1901888	2	0.031
regulation of pole plasm oskar mrna localization	GO:0007317	27	0.031
protein localization to organelle	GO:0033365	82	0.031
response to other organism	GO:0051707	293	0.030
cellular nitrogen compound catabolic process	GO:0044270	165	0.030
striated muscle cell development	GO:0055002	50	0.030
regulation of transport	GO:0051049	181	0.030	Human Mouse
organonitrogen compound catabolic process	GO:1901565	128	0.030
cellular response to dna damage stimulus	GO:0006974	223	0.030	Human Yeast Fly
wnt signaling pathway	GO:0016055	98	0.030
regulation of lamellipodium assembly	GO:0010591	15	0.030
photoreceptor cell differentiation	GO:0046530	170	0.029
response to wounding	GO:0009611	94	0.029
microtubule polymerization	GO:0046785	15	0.029
autophagy	GO:0006914	108	0.029
spindle assembly	GO:0051225	80	0.029
positive regulation of response to stimulus	GO:0048584	323	0.029
lamellipodium assembly	GO:0030032	21	0.028
cellular amino acid metabolic process	GO:0006520	61	0.028
immune system development	GO:0002520	57	0.028
spindle elongation	GO:0051231	83	0.028
positive regulation of cyclase activity	GO:0031281	9	0.028
golgi organization	GO:0007030	66	0.028
regulation of cell morphogenesis involved in differentiation	GO:0010769	61	0.028	Mouse
positive regulation of transport	GO:0051050	92	0.028	Mouse
epithelial cell morphogenesis involved in gastrulation	GO:0003381	7	0.027
imaginal disc growth	GO:0007446	37	0.027
carbohydrate metabolic process	GO:0005975	82	0.027	Yeast
regulation of intracellular transport	GO:0032386	64	0.027	Mouse
organophosphate catabolic process	GO:0046434	112	0.027
regulation of protein modification process	GO:0031399	112	0.027	Human Yeast Mouse
synaptic vesicle transport	GO:0048489	50	0.027
glycosyl compound catabolic process	GO:1901658	112	0.027
peripheral nervous system development	GO:0007422	52	0.026
regulation of gene expression epigenetic	GO:0040029	128	0.026
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.026	Human Yeast
pigmentation	GO:0043473	75	0.026
regulation of cellular catabolic process	GO:0031329	157	0.026
cuticle pigmentation	GO:0048067	22	0.026
cytokinesis	GO:0000910	90	0.026
gtp catabolic process	GO:0006184	72	0.026
nuclear migration	GO:0007097	20	0.026	Worm
signal transduction by phosphorylation	GO:0023014	107	0.025
compound eye retinal cell programmed cell death	GO:0046667	23	0.025
trachea development	GO:0060438	29	0.025
cellular homeostasis	GO:0019725	80	0.025
maintenance of protein location	GO:0045185	28	0.025	Human
nucleoside phosphate metabolic process	GO:0006753	162	0.024
regulation of cell development	GO:0060284	215	0.024	Human Mouse
cytoplasmic transport	GO:0016482	130	0.024	Mouse
purine nucleoside catabolic process	GO:0006152	112	0.024
response to hexose	GO:0009746	3	0.024
asymmetric stem cell division	GO:0098722	49	0.024
nucleotide catabolic process	GO:0009166	109	0.024
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.024	Human Yeast
regulation of embryonic development	GO:0045995	68	0.024
regulation of cuticle pigmentation	GO:0048079	16	0.024
sensory perception of chemical stimulus	GO:0007606	116	0.024
reactive oxygen species metabolic process	GO:0072593	22	0.023
cellular ketone metabolic process	GO:0042180	24	0.023
regulation of cytoskeleton organization	GO:0051493	89	0.023
positive regulation of cell death	GO:0010942	69	0.023
muscle organ development	GO:0007517	127	0.023
apoptotic process	GO:0006915	159	0.023	Human Yeast
synaptic growth at neuromuscular junction	GO:0051124	119	0.023
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.023
positive regulation of cell projection organization	GO:0031346	29	0.023
chromatin organization	GO:0006325	207	0.023
taxis	GO:0042330	304	0.023	Fly
positive regulation of cell communication	GO:0010647	250	0.022
imaginal disc derived wing vein specification	GO:0007474	48	0.022
formation of primary germ layer	GO:0001704	24	0.022
establishment or maintenance of polarity of follicular epithelium	GO:0016334	26	0.022
non canonical wnt signaling pathway	GO:0035567	8	0.022
regulation of i kappab kinase nf kappab signaling	GO:0043122	2	0.022
ribonucleoside catabolic process	GO:0042454	112	0.022
regulation of embryonic pattern specification	GO:1902875	27	0.021
establishment of spindle localization	GO:0051293	22	0.021	Worm
positive regulation of epithelial cell differentiation	GO:0030858	1	0.021	Mouse
chorion containing eggshell pattern formation	GO:0030381	11	0.021
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.021	Yeast
nucleobase containing small molecule metabolic process	GO:0055086	174	0.021
circulatory system process	GO:0003013	37	0.021
cell cycle arrest	GO:0007050	4	0.021
mesoderm development	GO:0007498	78	0.021
ribonucleotide catabolic process	GO:0009261	109	0.021
mapk cascade	GO:0000165	107	0.021
positive regulation of cytoskeleton organization	GO:0051495	21	0.020
spindle localization	GO:0051653	22	0.020	Worm
oocyte nucleus localization involved in oocyte dorsal ventral axis specification	GO:0051663	12	0.020
positive regulation of intracellular signal transduction	GO:1902533	116	0.020
positive regulation of notch signaling pathway	GO:0045747	34	0.020
endoderm formation	GO:0001706	3	0.020
regulation of epithelial cell migration	GO:0010632	12	0.020
positive regulation of signaling	GO:0023056	243	0.020
gtp metabolic process	GO:0046039	72	0.020
amine metabolic process	GO:0009308	12	0.020
regulation of epidermal growth factor receptor signaling pathway	GO:0042058	42	0.020
cellular response to nutrient levels	GO:0031669	62	0.020
epithelial tube morphogenesis	GO:0060562	88	0.019
cytoskeleton dependent cytokinesis	GO:0061640	81	0.019
negative regulation of neuroblast proliferation	GO:0007406	27	0.019
positive regulation of protein polymerization	GO:0032273	14	0.019
generation of precursor metabolites and energy	GO:0006091	42	0.019	Yeast
innate immune response	GO:0045087	144	0.019
biological adhesion	GO:0022610	138	0.019
regulation of cell maturation	GO:1903429	27	0.019
regulation of wound healing	GO:0061041	13	0.019
regulation of cellular ketone metabolic process	GO:0010565	3	0.019
organelle fission	GO:0048285	340	0.019	Yeast Worm Fly
renal system development	GO:0072001	72	0.019
regulation of developmental pigmentation	GO:0048070	24	0.019
nucleotide metabolic process	GO:0009117	161	0.019
lamellipodium organization	GO:0097581	21	0.018
positive regulation of neuron apoptotic process	GO:0043525	1	0.018
meiotic chromosome segregation	GO:0045132	59	0.018
synapse organization	GO:0050808	196	0.018
regulation of cell adhesion	GO:0030155	27	0.018
carbohydrate derivative biosynthetic process	GO:1901137	85	0.018	Yeast

14-3-3zeta disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.066
cancer	DOID:162	0.034
organ system cancer	DOID:0050686	0.034
disease of cellular proliferation	DOID:14566	0.034
nervous system disease	DOID:863	0.028

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