IMP: Integrative Multi-species Prediction

Drosophila melanogaster

45 known processes

Orc1 (Dmel_CG10667)

Origin recognition complex subunit 1

(Aliases: DmOrc1p,dORC1,CG10667,ORC1,DmORC1,Dmel\CG10667,orc1,ORC,rDmORC)

FLYBASE: FBgn0022772
Entrez: 35686
UniProtKB: O16810

Process Predictions
Disease Predictions

Orc1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

Filter by process size:

Biological process	GO term ID	Process size	Probability	Func Analog Org
dna metabolic process	GO:0006259	227	0.956
organelle fission	GO:0048285	340	0.927
positive regulation of macromolecule metabolic process	GO:0010604	405	0.613
microtubule organizing center organization	GO:0031023	168	0.568
dna biosynthetic process	GO:0071897	24	0.553
nuclear division	GO:0000280	332	0.532
dna amplification	GO:0006277	11	0.515
chromosome organization	GO:0051276	360	0.470
regulation of neurogenesis	GO:0050767	158	0.420
eye development	GO:0001654	323	0.388
negative regulation of transcription dna templated	GO:0045892	237	0.339
negative regulation of rna biosynthetic process	GO:1902679	240	0.286
eggshell chorion gene amplification	GO:0007307	9	0.278
macromolecular complex assembly	GO:0065003	256	0.262
sister chromatid segregation	GO:0000819	92	0.252
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.248
cell cycle phase transition	GO:0044770	140	0.244
regulation of mitotic cell cycle	GO:0007346	190	0.243
regulation of cell cycle process	GO:0010564	181	0.242
regulation of cell death	GO:0010941	173	0.234
cellular component assembly involved in morphogenesis	GO:0010927	151	0.223
epithelial cell differentiation	GO:0030855	322	0.220
cell proliferation	GO:0008283	299	0.217
cell cycle dna replication	GO:0044786	23	0.215
negative regulation of gene expression	GO:0010629	387	0.211
regulation of cell cycle	GO:0051726	291	0.202
mitotic nuclear division	GO:0007067	213	0.192
programmed cell death	GO:0012501	257	0.176
dna conformation change	GO:0071103	105	0.170
dna packaging	GO:0006323	91	0.166
cellular response to dna damage stimulus	GO:0006974	223	0.160
negative regulation of biosynthetic process	GO:0009890	277	0.159
photoreceptor cell differentiation	GO:0046530	170	0.157
epithelial cell development	GO:0002064	274	0.157
spindle organization	GO:0007051	253	0.151
gene silencing	GO:0016458	138	0.148
regulation of apoptotic process	GO:0042981	130	0.144
brain development	GO:0007420	120	0.143
centrosome organization	GO:0051297	163	0.142
growth	GO:0040007	359	0.141	Zebrafish
regulation of multicellular organismal development	GO:2000026	414	0.141
intracellular signal transduction	GO:0035556	300	0.140
protein dna complex subunit organization	GO:0071824	86	0.137
regulation of nervous system development	GO:0051960	248	0.136
positive regulation of rna metabolic process	GO:0051254	271	0.133
cell death	GO:0008219	279	0.132
compound eye morphogenesis	GO:0001745	249	0.127
chorion containing eggshell formation	GO:0007304	105	0.127
nuclear dna replication	GO:0033260	1	0.123
head development	GO:0060322	135	0.118
nucleosome organization	GO:0034728	59	0.117
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.115
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.113
negative regulation of rna metabolic process	GO:0051253	251	0.111
protein complex assembly	GO:0006461	200	0.110
embryonic pattern specification	GO:0009880	174	0.110
positive regulation of cellular biosynthetic process	GO:0031328	316	0.110
positive regulation of biosynthetic process	GO:0009891	316	0.106
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.105
regulation of programmed cell death	GO:0043067	152	0.105
developmental growth	GO:0048589	280	0.105	Zebrafish
compound eye photoreceptor cell differentiation	GO:0001751	140	0.102
regulation of cell development	GO:0060284	215	0.102
segmentation	GO:0035282	207	0.099
compound eye development	GO:0048749	307	0.099
eye photoreceptor cell differentiation	GO:0001754	145	0.098
gliogenesis	GO:0042063	80	0.095
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.095
positive regulation of gene expression	GO:0010628	290	0.093
proteolysis	GO:0006508	192	0.093
cell adhesion	GO:0007155	136	0.090
cellular catabolic process	GO:0044248	372	0.088
sensory organ morphogenesis	GO:0090596	260	0.087
negative regulation of cellular biosynthetic process	GO:0031327	277	0.086
spermatogenesis	GO:0007283	200	0.083
regulation of cell proliferation	GO:0042127	163	0.082
apoptotic signaling pathway	GO:0097190	27	0.081
regulation of dna metabolic process	GO:0051052	34	0.081
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.080
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.079
mitotic dna damage checkpoint	GO:0044773	74	0.077
protein complex biogenesis	GO:0070271	201	0.076
eggshell chorion assembly	GO:0007306	66	0.076
regionalization	GO:0003002	416	0.075
cellular protein modification process	GO:0006464	438	0.075
single organism biosynthetic process	GO:0044711	206	0.075
eye morphogenesis	GO:0048592	260	0.073
regulation of anatomical structure morphogenesis	GO:0022603	242	0.071
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.071
tube morphogenesis	GO:0035239	191	0.068
negative regulation of developmental process	GO:0051093	201	0.068
protein targeting to nucleus	GO:0044744	51	0.067
morphogenesis of an epithelium	GO:0002009	276	0.066
positive regulation of protein metabolic process	GO:0051247	128	0.066
protein dna complex assembly	GO:0065004	63	0.065
mitotic chromosome condensation	GO:0007076	22	0.065
mitotic sister chromatid segregation	GO:0000070	87	0.065
protein modification process	GO:0036211	438	0.064
eggshell formation	GO:0030703	105	0.064
protein modification by small protein conjugation or removal	GO:0070647	106	0.063
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.063
positive regulation of cellular protein metabolic process	GO:0032270	118	0.063
mitotic g2 dna damage checkpoint	GO:0007095	69	0.062
negative regulation of programmed cell death	GO:0043069	72	0.061
dna dependent dna replication	GO:0006261	17	0.060
phosphorylation	GO:0016310	294	0.057
centrosome cycle	GO:0007098	137	0.057
organic substance catabolic process	GO:1901575	308	0.057
regulation of cell division	GO:0051302	72	0.057
regulation of growth	GO:0040008	233	0.057	Zebrafish
protein localization to nucleus	GO:0034504	55	0.055
death	GO:0016265	284	0.055
regulation of gene expression epigenetic	GO:0040029	128	0.055
dendrite development	GO:0016358	204	0.055
regulation of localization	GO:0032879	275	0.054
regulation of neuron differentiation	GO:0045664	103	0.053
male gamete generation	GO:0048232	201	0.053
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.053
regulation of intracellular signal transduction	GO:1902531	236	0.052
positive regulation of neurogenesis	GO:0050769	41	0.052
cellular macromolecule localization	GO:0070727	220	0.052
protein import into nucleus	GO:0006606	51	0.052
negative regulation of cell cycle process	GO:0010948	109	0.051
organophosphate metabolic process	GO:0019637	195	0.050
meiotic nuclear division	GO:0007126	151	0.049
carbohydrate derivative metabolic process	GO:1901135	217	0.049
regulation of mitosis	GO:0007088	56	0.048
axon development	GO:0061564	297	0.048
dna replication	GO:0006260	48	0.048
negative regulation of cell death	GO:0060548	81	0.048
nuclear import	GO:0051170	51	0.047
mitotic cell cycle checkpoint	GO:0007093	88	0.047
small molecule metabolic process	GO:0044281	305	0.046
positive regulation of multicellular organismal process	GO:0051240	143	0.046
regulation of transport	GO:0051049	181	0.045
ubiquitin dependent protein catabolic process	GO:0006511	78	0.044
cell fate determination	GO:0001709	91	0.043
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.043
ribonucleotide metabolic process	GO:0009259	145	0.043
small gtpase mediated signal transduction	GO:0007264	88	0.042
cell motility	GO:0048870	251	0.042
positive regulation of developmental process	GO:0051094	143	0.042
positive regulation of phosphate metabolic process	GO:0045937	139	0.041
carboxylic acid metabolic process	GO:0019752	92	0.041
regulation of nuclear division	GO:0051783	58	0.041
positive regulation of rna biosynthetic process	GO:1902680	266	0.041
cell cycle checkpoint	GO:0000075	95	0.041
gene silencing by rna	GO:0031047	57	0.039
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.039
positive regulation of cellular amine metabolic process	GO:0033240	0	0.038
negative regulation of cellular metabolic process	GO:0031324	382	0.038
catabolic process	GO:0009056	409	0.038
meiotic cell cycle	GO:0051321	171	0.037
positive regulation of signal transduction	GO:0009967	223	0.037
axonogenesis	GO:0007409	290	0.037
regulation of cellular protein metabolic process	GO:0032268	243	0.037
regulation of catalytic activity	GO:0050790	185	0.036
ribose phosphate metabolic process	GO:0019693	145	0.036
rna localization	GO:0006403	115	0.036
regulation of phosphorus metabolic process	GO:0051174	210	0.036
response to organic substance	GO:0010033	284	0.035
regulation of neuron projection development	GO:0010975	69	0.035
dna damage checkpoint	GO:0000077	78	0.035
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.035
apoptotic process	GO:0006915	159	0.035
positive regulation of proteolysis	GO:0045862	52	0.034
regulation of protein metabolic process	GO:0051246	256	0.034
nucleobase containing compound catabolic process	GO:0034655	165	0.034
negative regulation of cell cycle	GO:0045786	116	0.034
regulation of organelle organization	GO:0033043	196	0.034
positive regulation of phosphorylation	GO:0042327	87	0.033
negative regulation of response to stimulus	GO:0048585	258	0.033
positive regulation of transcription dna templated	GO:0045893	266	0.033
sex differentiation	GO:0007548	81	0.032	Worm
regulation of cellular ketone metabolic process	GO:0010565	3	0.032
meiosis i	GO:0007127	59	0.032
transcription from rna polymerase ii promoter	GO:0006366	368	0.032
eye photoreceptor cell development	GO:0042462	81	0.032
mitotic cell cycle phase transition	GO:0044772	138	0.032
protein import	GO:0017038	55	0.032
cellular ketone metabolic process	GO:0042180	24	0.032
anatomical structure homeostasis	GO:0060249	97	0.031
organonitrogen compound metabolic process	GO:1901564	318	0.031
endocytosis	GO:0006897	310	0.031
purine ribonucleotide metabolic process	GO:0009150	145	0.031
dendrite morphogenesis	GO:0048813	199	0.030
meiotic chromosome segregation	GO:0045132	59	0.030
anterior posterior axis specification	GO:0009948	109	0.030
single organism cellular localization	GO:1902580	180	0.030
positive regulation of phosphorus metabolic process	GO:0010562	139	0.029
cellular nitrogen compound catabolic process	GO:0044270	165	0.029
positive regulation of signaling	GO:0023056	243	0.029
negative regulation of apoptotic process	GO:0043066	63	0.029
regulation of cellular amine metabolic process	GO:0033238	3	0.029
mitotic spindle organization	GO:0007052	220	0.028
regulation of multicellular organism growth	GO:0040014	40	0.027	Zebrafish
positive regulation of mapk cascade	GO:0043410	63	0.027
oocyte differentiation	GO:0009994	145	0.027
response to abiotic stimulus	GO:0009628	341	0.027
neuron death	GO:0070997	27	0.027
germarium derived egg chamber formation	GO:0007293	101	0.026
cellular macromolecule catabolic process	GO:0044265	136	0.026
positive regulation of transport	GO:0051050	92	0.026
negative regulation of signal transduction	GO:0009968	206	0.026
regulation of protein catabolic process	GO:0042176	55	0.026
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.025
erk1 and erk2 cascade	GO:0070371	39	0.025
single organism nuclear import	GO:1902593	51	0.025
cell division	GO:0051301	248	0.025
dna repair	GO:0006281	54	0.025
positive regulation of cell development	GO:0010720	61	0.025
peptidyl amino acid modification	GO:0018193	105	0.025
regulation of ras protein signal transduction	GO:0046578	93	0.024
regulation of cellular localization	GO:0060341	136	0.024
aromatic compound catabolic process	GO:0019439	166	0.024
neuroblast proliferation	GO:0007405	74	0.024
nucleotide metabolic process	GO:0009117	161	0.024
cellular amine metabolic process	GO:0044106	12	0.024
regulation of phosphorylation	GO:0042325	147	0.024
chromatin assembly or disassembly	GO:0006333	52	0.024
regulation of catabolic process	GO:0009894	170	0.024
mitotic g2 m transition checkpoint	GO:0044818	70	0.024
double strand break repair	GO:0006302	26	0.023
recombinational repair	GO:0000725	13	0.023
negative regulation of mitotic cell cycle	GO:0045930	109	0.023
posttranscriptional gene silencing	GO:0016441	46	0.022
regulation of molecular function	GO:0065009	217	0.022
oxoacid metabolic process	GO:0043436	103	0.022
organic acid metabolic process	GO:0006082	103	0.022
positive regulation of response to stimulus	GO:0048584	323	0.022
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.022
regulation of cell morphogenesis	GO:0022604	163	0.021
oocyte anterior posterior axis specification	GO:0007314	72	0.021
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.021
nucleoside phosphate metabolic process	GO:0006753	162	0.021
transposition	GO:0032196	13	0.021
negative regulation of oskar mrna translation	GO:0007319	5	0.021
rna processing	GO:0006396	147	0.021
chromosome segregation	GO:0007059	157	0.021
protein localization	GO:0008104	284	0.021
protein catabolic process	GO:0030163	101	0.020
negative regulation of meiotic cell cycle	GO:0051447	2	0.020
tissue morphogenesis	GO:0048729	297	0.020
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	65	0.020
macromolecule catabolic process	GO:0009057	161	0.020
meiotic cell cycle process	GO:1903046	132	0.020
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.020
protein ubiquitination	GO:0016567	70	0.020
cellular amino acid metabolic process	GO:0006520	61	0.020
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.019
regulation of cellular response to stress	GO:0080135	89	0.019
regulation of cellular amino acid metabolic process	GO:0006521	0	0.019
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.019
protein phosphorylation	GO:0006468	169	0.019
localization of cell	GO:0051674	257	0.019
establishment or maintenance of cell polarity	GO:0007163	167	0.019
chromatin organization	GO:0006325	207	0.019
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.019
dna recombination	GO:0006310	32	0.018
response to biotic stimulus	GO:0009607	294	0.018	Zebrafish
protein modification by small protein conjugation	GO:0032446	79	0.018
negative regulation of signaling	GO:0023057	219	0.018
nucleoside metabolic process	GO:0009116	127	0.018
posttranscriptional gene silencing by rna	GO:0035194	45	0.018
modification dependent macromolecule catabolic process	GO:0043632	79	0.018
respiratory system development	GO:0060541	213	0.018
embryonic axis specification	GO:0000578	107	0.018
biological adhesion	GO:0022610	138	0.018
purine containing compound metabolic process	GO:0072521	155	0.018
posttranscriptional regulation of gene expression	GO:0010608	145	0.018
regulation of phosphate metabolic process	GO:0019220	210	0.018
organic cyclic compound catabolic process	GO:1901361	168	0.018
regulation of apoptotic signaling pathway	GO:2001233	10	0.017
amine metabolic process	GO:0009308	12	0.017
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.017
dna endoreduplication	GO:0042023	22	0.017
regulation of embryonic development	GO:0045995	68	0.017
regulation of response to stress	GO:0080134	200	0.017
positive regulation of protein catabolic process	GO:0045732	34	0.017
purine ribonucleoside metabolic process	GO:0046128	127	0.017
positive regulation of cell cycle	GO:0045787	43	0.017
locomotory behavior	GO:0007626	176	0.017
response to bacterium	GO:0009617	198	0.017
nucleotide catabolic process	GO:0009166	109	0.017
germarium derived oocyte fate determination	GO:0007294	26	0.017
telomere maintenance	GO:0000723	21	0.017
regulation of cell size	GO:0008361	63	0.017
karyosome formation	GO:0030717	22	0.016
purine nucleoside catabolic process	GO:0006152	112	0.016
neurological system process	GO:0050877	358	0.016
cellular protein localization	GO:0034613	160	0.016
phagocytosis	GO:0006909	215	0.016
regulation of cellular catabolic process	GO:0031329	157	0.016
positive regulation of catalytic activity	GO:0043085	118	0.016
purine nucleotide metabolic process	GO:0006163	146	0.015
cell maturation	GO:0048469	144	0.015
oocyte dorsal ventral axis specification	GO:0007310	34	0.015
g2 dna damage checkpoint	GO:0031572	69	0.015
secretion by cell	GO:0032940	101	0.015
ribonucleotide catabolic process	GO:0009261	109	0.015
mitotic sister chromatid separation	GO:0051306	30	0.014
regulation of mitotic sister chromatid segregation	GO:0033047	28	0.014
appendage development	GO:0048736	401	0.014
oocyte maturation	GO:0001556	3	0.014
pole plasm assembly	GO:0007315	61	0.014
dna integrity checkpoint	GO:0031570	81	0.014
negative regulation of cell communication	GO:0010648	223	0.014
compound eye photoreceptor development	GO:0042051	78	0.014
columnar cuboidal epithelial cell development	GO:0002066	249	0.014
positive regulation of cell communication	GO:0010647	250	0.014
neuron recognition	GO:0008038	101	0.014
lateral inhibition	GO:0046331	206	0.014
positive regulation of intracellular signal transduction	GO:1902533	116	0.014
regulation of cell shape	GO:0008360	113	0.014
single organism catabolic process	GO:0044712	228	0.014
nucleobase containing small molecule metabolic process	GO:0055086	174	0.014
positive regulation of catabolic process	GO:0009896	105	0.013
positive regulation of nervous system development	GO:0051962	69	0.013
carbohydrate derivative catabolic process	GO:1901136	118	0.013
positive regulation of neuron differentiation	GO:0045666	26	0.013
ras protein signal transduction	GO:0007265	88	0.013
chromatin silencing	GO:0006342	76	0.013
regulation of hydrolase activity	GO:0051336	97	0.013
regulation of meiosis	GO:0040020	3	0.013
positive regulation of cellular protein catabolic process	GO:1903364	24	0.013
positive regulation of cellular catabolic process	GO:0031331	95	0.013
modification dependent protein catabolic process	GO:0019941	78	0.013
single organism cell adhesion	GO:0098602	47	0.013
double strand break repair via homologous recombination	GO:0000724	13	0.013
regulation of reproductive process	GO:2000241	54	0.013
tube development	GO:0035295	244	0.012
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.012
positive regulation of cell proliferation	GO:0008284	47	0.012
wound healing	GO:0042060	75	0.012
regulation of cell differentiation	GO:0045595	302	0.012
nuclear transport	GO:0051169	72	0.012
mrna processing	GO:0006397	104	0.012
tripartite regional subdivision	GO:0007351	103	0.012
regulation of proteolysis	GO:0030162	87	0.012
regulation of g1 s transition of mitotic cell cycle	GO:2000045	23	0.012
positive regulation of protein phosphorylation	GO:0001934	34	0.012
mitotic dna integrity checkpoint	GO:0044774	75	0.012
regulation of purine nucleotide metabolic process	GO:1900542	62	0.012
blastoderm segmentation	GO:0007350	159	0.011
positive regulation of protein transport	GO:0051222	37	0.011
exocrine system development	GO:0035272	162	0.011
regulation of transcription by chromatin organization	GO:0034401	3	0.011
chromatin assembly	GO:0031497	48	0.011
intracellular mrna localization	GO:0008298	66	0.011
telomere organization	GO:0032200	21	0.011
oocyte construction	GO:0007308	112	0.011
immune system process	GO:0002376	347	0.011
negative regulation of cellular component organization	GO:0051129	108	0.011
wnt signaling pathway	GO:0016055	98	0.011
heterocycle catabolic process	GO:0046700	166	0.011
regulation of cellular component size	GO:0032535	98	0.011
cell fate specification	GO:0001708	71	0.011
maintenance of location	GO:0051235	73	0.011
single organism behavior	GO:0044708	391	0.011
regulation of cellular protein catabolic process	GO:1903362	44	0.011
positive regulation of transcription factor import into nucleus	GO:0042993	19	0.011
developmental maturation	GO:0021700	172	0.011
dorsal appendage formation	GO:0046843	47	0.011
purine containing compound catabolic process	GO:0072523	112	0.011
protein transport	GO:0015031	155	0.011
positive regulation of hydrolase activity	GO:0051345	78	0.010
photoreceptor cell development	GO:0042461	96	0.010
single organismal cell cell adhesion	GO:0016337	45	0.010
anterior posterior pattern specification	GO:0009952	136	0.010
positive regulation of molecular function	GO:0044093	136	0.010
atp metabolic process	GO:0046034	49	0.010
regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032434	37	0.010
response to oxygen containing compound	GO:1901700	200	0.010
positive regulation of nucleocytoplasmic transport	GO:0046824	24	0.010
vesicle mediated transport	GO:0016192	381	0.010
chromatin remodeling	GO:0006338	72	0.010

Orc1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.044
vascular disease	DOID:178	0.023
cardiovascular system disease	DOID:1287	0.023
disease of cellular proliferation	DOID:14566	0.012
cancer	DOID:162	0.010
organ system cancer	DOID:0050686	0.010

Loading network...

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network