Drosophila melanogaster

38 known processes

PGRP-SC1a (Dmel_CG14746)

CG14746 gene product from transcript CG14746-RA

(Aliases: Dmel\CG14746,CG14746,PGRP-SC,PGRP SC,PGRP-SC1A,PGRP-SC1,picky)

PGRP-SC1a biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
defense response to gram positive bacteriumGO:0050830410.867
Human Fly
defense responseGO:00069523000.771
regulation of biosynthetic process of antibacterial peptides active against gram positive bacteriaGO:000281630.705
Fly
defense response to other organismGO:00985422250.682
Human Fly
immune system processGO:00023763470.642
response to external biotic stimulusGO:00432072930.625
Human Fly
defense response to bacteriumGO:00427421780.602
Human Fly
innate immune responseGO:00450871440.560
defense response to gram negative bacteriumGO:0050829940.557
Fly
lipopolysaccharide mediated signaling pathwayGO:003166310.449
Fly
pattern recognition receptor signaling pathwayGO:000222120.445
Human Fly
response to biotic stimulusGO:00096072940.437
Human Fly
antimicrobial humoral responseGO:0019730990.431
Fly
humoral immune responseGO:00069591170.430
Fly
defense response to fungusGO:0050832480.409
peptidoglycan catabolic processGO:000925330.338
peptide metabolic processGO:0006518800.321
Fly
regulation of antimicrobial humoral responseGO:0002759500.308
Fly
regulation of defense responseGO:00313471020.299
response to bacteriumGO:00096171980.296
Human Fly
biosynthetic process of antibacterial peptides active against gram negative bacteriaGO:0002812140.292
Fly
regulation of antibacterial peptide productionGO:0002786220.275
Fly
response to other organismGO:00517072930.267
Human Fly
positive regulation of biosynthetic process of antibacterial peptides active against gram negative bacteriaGO:0006964120.253
Fly
regulation of defense response to bacteriumGO:1900424300.247
Fly
regulation of immune responseGO:00507761180.246
antimicrobial peptide productionGO:0002775460.228
Fly
defense response to virusGO:0051607230.228
Fly
regulation of response to external stimulusGO:00321011150.222
Fly
peptidoglycan metabolic processGO:000027030.221
secondary metabolic processGO:0019748750.221
Fly
positive regulation of defense response to bacteriumGO:1900426230.220
Fly
regulation of multi organism processGO:00439001310.217
Fly
regulation of humoral immune responseGO:0002920510.213
Fly
immune response activating signal transductionGO:000275720.211
Human Fly
peptidoglycan recognition protein signaling pathwayGO:0061057160.203
Fly
cellular amide metabolic processGO:0043603800.202
Fly
pigment metabolic processGO:0042440840.194
Fly
response to fungusGO:0009620500.191
phenol containing compound metabolic processGO:0018958570.186
Fly
immune responseGO:00069552460.185
positive regulation of multi organism processGO:0043902400.176
Fly
immune response regulating signaling pathwayGO:000276420.163
Human Fly
positive regulation of response to biotic stimulusGO:0002833310.156
Fly
glycosaminoglycan catabolic processGO:000602730.155
organonitrogen compound biosynthetic processGO:19015661170.148
Fly
antibacterial peptide productionGO:0002778220.143
Fly
regulation of peptidoglycan recognition protein signaling pathwayGO:006105840.142
Fly
negative regulation of response to stimulusGO:00485852580.141
regulation of immune effector processGO:0002697520.139
Mouse Fly
regulation of multicellular organismal developmentGO:20000264140.134
Mouse
antibacterial peptide biosynthetic processGO:0002780220.133
Fly
positive regulation of biosynthetic process of antibacterial peptides active against gram positive bacteriaGO:000696530.130
Fly
negative regulation of peptidoglycan recognition protein signaling pathwayGO:006106030.129
Fly
regulation of antimicrobial peptide biosynthetic processGO:0002805380.123
Fly
positive regulation of production of molecular mediator of immune responseGO:0002702280.123
Fly
negative regulation of cell communicationGO:00106482230.120
Fly
regulation of intracellular signal transductionGO:19025312360.117
Fly
positive regulation of response to stimulusGO:00485843230.117
Human Fly
negative regulation of defense responseGO:0031348350.116
regulation of biosynthetic process of antibacterial peptides active against gram negative bacteriaGO:0002813140.115
Fly
production of molecular mediator of immune responseGO:0002440460.115
Fly
positive regulation of defense responseGO:0031349590.112
Human Fly
positive regulation of antibacterial peptide biosynthetic processGO:0006963200.111
Fly
response to peptidoglycanGO:003249420.109
Fly
response to lipopolysaccharideGO:003249640.109
Fly
melanin metabolic processGO:0006582470.109
Fly
positive regulation of response to external stimulusGO:0032103440.109
Fly
phosphorylationGO:00163102940.106
Fly
circadian behaviorGO:0048512760.106
Rat
single organism behaviorGO:00447083910.105
Rat
regulation of response to stressGO:00801342000.104
immune effector processGO:0002252980.103
Mouse Fly
regulation of antimicrobial peptide productionGO:0002784440.102
Fly
intracellular signal transductionGO:00355563000.100
Fly
positive regulation of signalingGO:00230562430.100
carbohydrate derivative metabolic processGO:19011352170.099
cellular response to molecule of bacterial originGO:007121930.097
Fly
cellular response to lipopolysaccharideGO:007122230.095
Fly
positive regulation of signal transductionGO:00099672230.095
positive regulation of immune effector processGO:0002699280.092
Fly
response to virusGO:0009615280.090
Fly
rhythmic processGO:00485111060.090
Rat
positive regulation of nitrogen compound metabolic processGO:00511733540.089
Fly
regulation of circadian rhythmGO:0042752490.087
Rat
growthGO:00400073590.086
Mouse
regulation of immune system processGO:00026821760.085
peptide biosynthetic processGO:0043043420.085
Fly
regulation of cellular response to stressGO:0080135890.084
Fly
negative regulation of immune system processGO:0002683500.082
rhythmic behaviorGO:0007622760.082
Rat
regulation of innate immune responseGO:0045088710.079
signal transduction by phosphorylationGO:00230141070.078
Fly
negative regulation of cellular metabolic processGO:00313243820.073
Fly
detection of stimulusGO:00516061560.073
Human
amide biosynthetic processGO:0043604420.070
Fly
catabolic processGO:00090564090.070
negative regulation of signal transductionGO:00099682060.068
Fly
positive regulation of biosynthetic processGO:00098913160.066
Fly
circadian sleep wake cycle processGO:0022410240.065
Rat
regulation of secondary metabolic processGO:004345570.064
Fly
organonitrogen compound metabolic processGO:19015643180.064
negative regulation of signalingGO:00230572190.063
Fly
positive regulation of cell communicationGO:00106472500.063
positive regulation of humoral immune responseGO:0002922280.062
Fly
organic substance catabolic processGO:19015753080.061
regulation of response to biotic stimulusGO:0002831630.060
Fly
regulation of phosphorylationGO:00423251470.057
Fly
stress activated mapk cascadeGO:0051403520.057
Fly
positive regulation of cellular biosynthetic processGO:00313283160.056
Fly
response to organonitrogen compoundGO:0010243750.055
Fly
organonitrogen compound catabolic processGO:19015651280.055
negative regulation of developmental processGO:00510932010.055
Mouse
vesicle mediated transportGO:00161923810.055
determination of adult lifespanGO:00083401370.054
Fly
regulation of phosphate metabolic processGO:00192202100.053
Fly
negative regulation of immune responseGO:0050777390.052
sleepGO:0030431490.051
Rat
glycosaminoglycan metabolic processGO:0030203110.051
negative regulation of stress activated protein kinase signaling cascadeGO:0070303200.050
Fly
imaginal disc derived appendage developmentGO:00487373990.049
activation of innate immune responseGO:000221840.048
Human Fly
negative regulation of cell differentiationGO:00455961430.047
Mouse
regulation of toll signaling pathwayGO:0008592170.046
response to organic substanceGO:00100332840.046
Fly
small molecule metabolic processGO:00442813050.045
negative regulation of multicellular organismal processGO:00512411420.045
Mouse
circadian sleep wake cycle sleepGO:0050802230.043
Rat
response to nitrogen compoundGO:1901698900.043
Fly
post embryonic appendage morphogenesisGO:00351203850.043
multicellular organismal agingGO:00102591400.042
Fly
stress activated protein kinase signaling cascadeGO:0031098550.042
Fly
regulation of circadian sleep wake cycleGO:0042749250.041
Rat
innate immune response activating signal transductionGO:000275820.040
Human Fly
cell cell signaling involved in cell fate commitmentGO:00451682100.038
negative regulation of phosphate metabolic processGO:0045936450.038
Fly
anatomical structure homeostasisGO:0060249970.037
l amino acid importGO:004309220.037
toll signaling pathwayGO:0008063250.037
response to endogenous stimulusGO:00097191190.036
Fly
regulation of stress activated mapk cascadeGO:0032872410.036
Fly
negative regulation of intracellular signal transductionGO:1902532570.036
Fly
intracellular transportGO:00469072280.035
regulation of jnk cascadeGO:0046328400.034
Fly
cellular response to biotic stimulusGO:007121640.034
Fly
negative regulation of mapk cascadeGO:0043409230.034
Fly
negative regulation of innate immune responseGO:0045824300.034
eye developmentGO:00016543230.032
organic substance transportGO:00717022570.031
Fly
imaginal disc derived wing morphogenesisGO:00074763370.031
regulation of growthGO:00400082330.030
compound eye morphogenesisGO:00017452490.030
compound eye developmentGO:00487493070.030
response to oxygen containing compoundGO:19017002000.029
Fly
positive regulation of immune system processGO:0002684680.029
Human Fly
appendage developmentGO:00487364010.029
segmentationGO:00352822070.029
positive regulation of innate immune responseGO:0045089380.029
Human Fly
ovarian follicle cell developmentGO:00307072480.029
hemopoiesisGO:0030097460.029
Mouse
body morphogenesisGO:001017120.029
appendage morphogenesisGO:00351073970.029
homeostatic processGO:00425921990.028
cellular catabolic processGO:00442483720.028
phagocytosisGO:00069092150.028
interspecies interaction between organismsGO:0044419160.027
Mouse
protein modification processGO:00362114380.027
epithelial cell differentiationGO:00308553220.027
carboxylic acid metabolic processGO:0019752920.027
regionalizationGO:00030024160.026
biosynthetic process of antibacterial peptides active against gram positive bacteriaGO:000281530.025
Fly
endocytosisGO:00068973100.025
morphogenesis of an epitheliumGO:00020092760.025
negative regulation of phosphorus metabolic processGO:0010563450.024
Fly
developmental growthGO:00485892800.023
columnar cuboidal epithelial cell differentiationGO:00020652560.023
gland morphogenesisGO:00226121450.022
wing disc morphogenesisGO:00074723440.022
camera type eye developmentGO:004301040.022
regulation of localizationGO:00328792750.022
establishment of localization in cellGO:00516494020.022
epithelial cell developmentGO:00020642740.022
cuticle developmentGO:0042335860.022
organelle fissionGO:00482853400.022
single organism intracellular transportGO:19025822070.022
protein localizationGO:00081042840.022
positive regulation of intracellular signal transductionGO:19025331160.021
macromolecule catabolic processGO:00090571610.021
regulation of cellular component biogenesisGO:00440872010.021
regulation of cellular amine metabolic processGO:003323830.021
cellular protein modification processGO:00064644380.021
imaginal disc derived appendage morphogenesisGO:00351143950.021
organophosphate metabolic processGO:00196371950.021
regulation of phosphorus metabolic processGO:00511742100.021
Fly
negative regulation of gene expressionGO:00106293870.021
epithelial structure maintenanceGO:0010669170.021
salivary gland developmentGO:00074311620.020
cellular amino acid metabolic processGO:0006520610.020
dorsal ventral pattern formationGO:00099531330.020
negative regulation of multi organism processGO:0043901290.020
Fly
oxoacid metabolic processGO:00434361030.020
regulation of anatomical structure sizeGO:00900661630.020
cell deathGO:00082192790.020
cell divisionGO:00513012480.020
regulation of circadian sleep wake cycle sleepGO:0045187210.020
Rat
single organism biosynthetic processGO:00447112060.020
forebrain developmentGO:003090020.020
lateral inhibitionGO:00463312060.019
developmental programmed cell deathGO:00106231380.019
response to molecule of bacterial originGO:000223770.019
Fly
negative regulation of nitrogen compound metabolic processGO:00511722650.019
nitrogen compound transportGO:0071705850.019
Fly
cellular response to chemical stimulusGO:00708871990.019
Fly
cellular ketone metabolic processGO:0042180240.018
single organism cellular localizationGO:19025801800.018
regulation of cellular ketone metabolic processGO:001056530.018
programmed cell deathGO:00125012570.018
neurological system processGO:00508773580.018
regulation of catabolic processGO:00098941700.018
regulation of cell cycleGO:00517262910.018
cytoplasmic transportGO:00164821300.018
antimicrobial peptide biosynthetic processGO:0002777380.018
Fly
imaginal disc pattern formationGO:0007447910.017
single organism catabolic processGO:00447122280.017
rna localizationGO:00064031150.017
response to organophosphorusGO:004668320.017
response to lipidGO:0033993380.017
Fly
somatic muscle developmentGO:0007525660.017
neutral lipid biosynthetic processGO:004646020.017
organic acid metabolic processGO:00060821030.017
nuclear divisionGO:00002803320.017
organic hydroxy compound metabolic processGO:1901615830.017
Fly
exocrine system developmentGO:00352721620.017
stem cell divisionGO:0017145690.017
regulation of transportGO:00510491810.017
response to woundingGO:0009611940.017
wnt signaling pathwayGO:0016055980.017
developmental maturationGO:00217001720.017
hematopoietic or lymphoid organ developmentGO:0048534570.016
Mouse
axon developmentGO:00615642970.016
negative regulation of nucleic acid templated transcriptionGO:19035072400.016
nucleobase containing compound catabolic processGO:00346551650.016
positive regulation of cellular amide metabolic processGO:0034250260.016
Fly
cellular macromolecule localizationGO:00707272200.016
chemotaxisGO:00069352490.016
positive regulation of nucleobase containing compound metabolic processGO:00459353320.016
macromolecular complex assemblyGO:00650032560.016
gland developmentGO:00487321910.016
positive regulation of multicellular organismal processGO:00512401430.016
multicellular organismal homeostasisGO:0048871410.016
molting cycle chitin based cuticleGO:0007591560.016
columnar cuboidal epithelial cell developmentGO:00020662490.016
synapse organizationGO:00508081960.016
cell proliferationGO:00082832990.016
regulation of mapk cascadeGO:0043408920.016
Fly
cell recognitionGO:00080371020.015
embryonic pattern specificationGO:00098801740.015
limb developmentGO:006017310.015
deathGO:00162652840.015
jak stat cascadeGO:0007259490.015
response to abiotic stimulusGO:00096283410.015
positive regulation of cell migrationGO:003033520.015
chaeta developmentGO:0022416970.015
mapk cascadeGO:00001651070.015
Fly
axis specificationGO:00097981670.015
matingGO:00076181200.015
cellular nitrogen compound catabolic processGO:00442701650.015
regulation of cellular amino acid metabolic processGO:000652100.015
kidney developmentGO:000182230.015
sensory organ morphogenesisGO:00905962600.014
cellular response to lipidGO:0071396200.014
Fly
aromatic compound catabolic processGO:00194391660.014
establishment of planar polarityGO:0001736870.014
synaptic target recognitionGO:0008039450.014
long term memoryGO:0007616620.014
response to hexoseGO:000974630.014
encapsulation of foreign targetGO:0035010380.014
amine metabolic processGO:0009308120.014
cellular component assembly involved in morphogenesisGO:00109271510.014
glycosyl compound metabolic processGO:19016571270.014
eye morphogenesisGO:00485922600.014
positive regulation of cellular catabolic processGO:0031331950.014
proteolysisGO:00065081920.014
wound healingGO:0042060750.014
response to monosaccharideGO:003428440.014
ribonucleotide metabolic processGO:00092591450.014
actin filament based processGO:00300292200.014
regulation of cellular catabolic processGO:00313291570.014
telencephalon developmentGO:002153720.014
nucleobase containing small molecule metabolic processGO:00550861740.013
neuron recognitionGO:00080381010.013
nucleotide catabolic processGO:00091661090.013
retina development in camera type eyeGO:006004140.013
positive regulation of macromolecule metabolic processGO:00106044050.013
carbohydrate derivative catabolic processGO:19011361180.013
segment specificationGO:0007379330.013
long chain fatty acid metabolic processGO:000167630.013
regulation of protein metabolic processGO:00512462560.013
salivary gland cell autophagic cell deathGO:0035071830.013
multi organism behaviorGO:00517051750.013
positive regulation of nucleic acid templated transcriptionGO:19035082660.013
response to nutrient levelsGO:00316671140.013
positive regulation of cell motilityGO:200014730.013
salivary gland morphogenesisGO:00074351450.013
ras protein signal transductionGO:0007265880.013
cellular response to dna damage stimulusGO:00069742230.013
ion transportGO:00068111450.013
histolysisGO:00075591020.013
cellular macromolecular complex assemblyGO:00346221530.013
convergent extensionGO:006002620.013
memoryGO:0007613940.013
connective tissue developmentGO:006144830.013
positive regulation of immune responseGO:0050778630.013
Human Fly
small gtpase mediated signal transductionGO:0007264880.013
convergent extension involved in gastrulationGO:006002720.013
camera type eye morphogenesisGO:004859320.013
positive regulation of catabolic processGO:00098961050.013
organic cyclic compound catabolic processGO:19013611680.013
mitotic nuclear divisionGO:00070672130.013
locomotory behaviorGO:00076261760.012
regulation of cellular protein metabolic processGO:00322682430.012
salivary gland histolysisGO:0035070880.012
endomembrane system organizationGO:00102561190.012
cellular amine metabolic processGO:0044106120.012
tube developmentGO:00352952440.012
localization of cellGO:00516742570.012
cell motilityGO:00488702510.012
eye antennal disc developmentGO:0035214600.012
regulation of cell deathGO:00109411730.012
regulation of embryonic developmentGO:0045995680.012
positive regulation of phosphorus metabolic processGO:00105621390.012
regulation of synapse organizationGO:00508071100.012
establishment of tissue polarityGO:0007164870.012
protein phosphorylationGO:00064681690.012
molting cycle processGO:0022404290.012
hindbrain developmentGO:003090220.012
establishment of protein localizationGO:00451841630.012
maintenance of locationGO:0051235730.012
chromosome organizationGO:00512763600.012
purine nucleotide metabolic processGO:00061631460.012
regulation of developmental growthGO:00486381740.012
gene silencingGO:00164581380.012
response to temperature stimulusGO:00092661060.012
protein complex assemblyGO:00064612000.012
cell activationGO:000177590.012
Mouse
cation transportGO:00068121100.012
aminoglycan catabolic processGO:000602660.012
reproductive behaviorGO:00190981220.012
tissue migrationGO:00901301550.012
melanization defense responseGO:0035006450.012
Fly
regulation of developmental pigmentationGO:0048070240.012
rna processingGO:00063961470.012
purine ribonucleoside metabolic processGO:00461281270.012
anterior posterior pattern specificationGO:00099521360.012
organophosphate catabolic processGO:00464341120.012
neuron projection guidanceGO:00974852410.012
fatty acid elongationGO:003049730.011
purine containing compound catabolic processGO:00725231120.011
ribonucleoside triphosphate metabolic processGO:00091991190.011
regulation of catalytic activityGO:00507901850.011
nucleoside phosphate catabolic processGO:19012921100.011
regulation of cell cycle processGO:00105641810.011
negative regulation of stress activated mapk cascadeGO:0032873190.011
Fly
purine nucleoside triphosphate catabolic processGO:00091461080.011
synaptic growth at neuromuscular junctionGO:00511241190.011
ethanolamine containing compound metabolic processGO:004243940.011
lipid metabolic processGO:00066291210.011
monocarboxylic acid transportGO:001571830.011
cell adhesionGO:00071551360.011
morphogenesis of a polarized epitheliumGO:0001738930.011
apical constrictionGO:0003383180.011
nucleoside phosphate metabolic processGO:00067531620.011
kidney morphogenesisGO:006099330.011
paracrine signalingGO:003800170.011
regulation of gene expression epigeneticGO:00400291280.011
tissue morphogenesisGO:00487292970.011
nucleotide metabolic processGO:00091171610.011
amino acid transportGO:0006865120.011
vitamin metabolic processGO:000676620.011
regulation of organelle organizationGO:00330431960.011
transcription from rna polymerase ii promoterGO:00063663680.011
negative regulation of biosynthetic processGO:00098902770.011
regulation of programmed cell deathGO:00430671520.011
positive regulation of cellular amino acid metabolic processGO:004576400.011
positive regulation of cellular component biogenesisGO:0044089800.011
vitamin biosynthetic processGO:000911010.011
regulation of cell morphogenesisGO:00226041630.011
regulation of anatomical structure morphogenesisGO:00226032420.011
cellular protein localizationGO:00346131600.011
blastoderm segmentationGO:00073501590.011
epithelial cell migrationGO:00106311480.011
purine nucleotide catabolic processGO:00061951090.011
acid secretionGO:004671710.011
photoreceptor cell developmentGO:0042461960.011
regulation of sequestering of triglycerideGO:001088930.011
regulation of molecular functionGO:00650092170.011
negative regulation of phosphorylationGO:0042326350.011
Fly
chromosome separationGO:0051304420.011
purine ribonucleotide metabolic processGO:00091501450.011
mesenchymal cell differentiationGO:004876210.011
positive regulation of antimicrobial humoral responseGO:0002760280.011
Fly
kidney epithelium developmentGO:007207330.011
purine containing compound metabolic processGO:00725211550.011
anion homeostasisGO:005508130.011
nucleoside triphosphate catabolic processGO:00091431080.011
response to extracellular stimulusGO:00099911160.011
dna methylationGO:000630640.011
synapse assemblyGO:00074161430.011
regulation of cell shapeGO:00083601130.011
multi organism reproductive behaviorGO:00447051210.011
heterocycle catabolic processGO:00467001660.011
cell migrationGO:00164772380.010
negative regulation of macromolecule biosynthetic processGO:00105582700.010
nephron epithelium developmentGO:007200930.010
antibacterial humoral responseGO:0019731440.010
Fly
positive regulation of developmental growthGO:0048639620.010
cellular response to mechanical stimulusGO:007126020.010
chromatin remodelingGO:0006338720.010
negative regulation of nucleobase containing compound metabolic processGO:00459342610.010
protein transportGO:00150311550.010
protein complex biogenesisGO:00702712010.010
tissue deathGO:00162711020.010
non sensory hair organizationGO:0035316470.010
regulation of wnt signaling pathwayGO:0030111680.010
nucleoside triphosphate metabolic processGO:00091411200.010
open tracheal system developmentGO:00074242040.010
taxisGO:00423303040.010
positive regulation of cellular component organizationGO:00511301560.010
positive regulation of transportGO:0051050920.010
mesenchymal cell developmentGO:001403110.010

PGRP-SC1a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of metabolismDOID:001466700.031
acquired metabolic diseaseDOID:006015800.031
disease of anatomical entityDOID:700.030
nervous system diseaseDOID:86300.015
inherited metabolic disorderDOID:65500.012
cardiovascular system diseaseDOID:128700.011
vascular diseaseDOID:17800.010
hypertensionDOID:1076300.010
artery diseaseDOID:005082800.010
cancerDOID:16200.010
disease of cellular proliferationDOID:1456600.010