IMP: Integrative Multi-species Prediction

Drosophila melanogaster

0 known processes

Traf-like (Dmel_CG4394)

TNF-receptor-associated factor-like

(Aliases: Traf3,Traf-related,TRAF3,dTRAF3,Dmel\CG4394,CG4394)

FLYBASE: FBgn0030748
Entrez: 32611
UniProtKB: Q9VXG5
UniProtKB: Q960H6
UniProtKB: Q8IR14

Process Predictions
Disease Predictions

Traf-like biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
microtubule organizing center organization	GO:0031023	168	0.665
growth	GO:0040007	359	0.278
centrosome organization	GO:0051297	163	0.240
negative regulation of developmental process	GO:0051093	201	0.196
negative regulation of cellular biosynthetic process	GO:0031327	277	0.185
centrosome duplication	GO:0051298	121	0.173
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.162
purine containing compound metabolic process	GO:0072521	155	0.158
organic substance catabolic process	GO:1901575	308	0.150
small molecule metabolic process	GO:0044281	305	0.138
ribonucleoside metabolic process	GO:0009119	127	0.125
cellular catabolic process	GO:0044248	372	0.117
centrosome cycle	GO:0007098	137	0.116
catabolic process	GO:0009056	409	0.113
negative regulation of cellular metabolic process	GO:0031324	382	0.109
negative regulation of signal transduction	GO:0009968	206	0.107
positive regulation of response to stimulus	GO:0048584	323	0.100
positive regulation of gene expression	GO:0010628	290	0.097
regulation of growth	GO:0040008	233	0.095
ribose phosphate metabolic process	GO:0019693	145	0.095
protein modification by small protein conjugation or removal	GO:0070647	106	0.089
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.081
intracellular transport	GO:0046907	228	0.078
nuclear division	GO:0000280	332	0.072
death	GO:0016265	284	0.071
single organism catabolic process	GO:0044712	228	0.067
positive regulation of signaling	GO:0023056	243	0.067
purine nucleotide metabolic process	GO:0006163	146	0.067
stem cell maintenance	GO:0019827	67	0.066
organelle assembly	GO:0070925	198	0.066
purine ribonucleotide metabolic process	GO:0009150	145	0.065
hematopoietic or lymphoid organ development	GO:0048534	57	0.065
cellular macromolecule catabolic process	GO:0044265	136	0.064
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.062
positive regulation of reactive oxygen species metabolic process	GO:2000379	0	0.060
cellular response to external stimulus	GO:0071496	66	0.059
carbohydrate derivative metabolic process	GO:1901135	217	0.059
regulation of reactive oxygen species metabolic process	GO:2000377	8	0.058
stem cell differentiation	GO:0048863	117	0.058
negative regulation of cell communication	GO:0010648	223	0.058
digestive tract morphogenesis	GO:0048546	127	0.056
cellular protein modification process	GO:0006464	438	0.054
negative regulation of biosynthetic process	GO:0009890	277	0.053
ubiquitin dependent protein catabolic process	GO:0006511	78	0.053
nucleotide metabolic process	GO:0009117	161	0.053
protein ubiquitination	GO:0016567	70	0.053
negative regulation of rna biosynthetic process	GO:1902679	240	0.053
negative regulation of signaling	GO:0023057	219	0.053
protein modification by small protein conjugation	GO:0032446	79	0.052
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.052
purine ribonucleotide biosynthetic process	GO:0009152	28	0.051
negative regulation of transcription dna templated	GO:0045892	237	0.050
cyclic nucleotide metabolic process	GO:0009187	28	0.050
cell maturation	GO:0048469	144	0.050
imaginal disc derived wing morphogenesis	GO:0007476	337	0.050
organelle fusion	GO:0048284	46	0.048
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.048
single organism membrane organization	GO:0044802	93	0.048
response to reactive oxygen species	GO:0000302	24	0.048
negative regulation of response to stimulus	GO:0048585	258	0.047
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.045
intracellular signal transduction	GO:0035556	300	0.045
cellular protein catabolic process	GO:0044257	83	0.044
single organism biosynthetic process	GO:0044711	206	0.044
muscle structure development	GO:0061061	224	0.044
regulation of protein metabolic process	GO:0051246	256	0.043
organonitrogen compound metabolic process	GO:1901564	318	0.043
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.042
developmental maturation	GO:0021700	172	0.042
purine nucleoside metabolic process	GO:0042278	127	0.042
nucleoside triphosphate metabolic process	GO:0009141	120	0.042
digestive tract development	GO:0048565	149	0.042
secretion	GO:0046903	109	0.041
endosomal transport	GO:0016197	44	0.041
asymmetric neuroblast division	GO:0055059	33	0.041
negative regulation of molecular function	GO:0044092	51	0.041
negative regulation of multicellular organismal process	GO:0051241	142	0.041
protein modification process	GO:0036211	438	0.041
hemopoiesis	GO:0030097	46	0.040
nucleoside phosphate metabolic process	GO:0006753	162	0.039
organelle fission	GO:0048285	340	0.039
glial cell migration	GO:0008347	31	0.038
immune system development	GO:0002520	57	0.038
localization of cell	GO:0051674	257	0.038
carbohydrate derivative catabolic process	GO:1901136	118	0.038
positive regulation of immune system process	GO:0002684	68	0.037
modification dependent macromolecule catabolic process	GO:0043632	79	0.037
positive regulation of cell communication	GO:0010647	250	0.036
cellular response to nutrient levels	GO:0031669	62	0.036
defense response	GO:0006952	300	0.035
chaeta development	GO:0022416	97	0.035
regulation of nervous system development	GO:0051960	248	0.034
stem cell development	GO:0048864	79	0.034
positive regulation of signal transduction	GO:0009967	223	0.034
cell migration	GO:0016477	238	0.033
organophosphate metabolic process	GO:0019637	195	0.032
cellular response to dna damage stimulus	GO:0006974	223	0.032
regulation of catalytic activity	GO:0050790	185	0.031
stem cell division	GO:0017145	69	0.031
ribonucleotide metabolic process	GO:0009259	145	0.031
organonitrogen compound catabolic process	GO:1901565	128	0.031
aromatic compound catabolic process	GO:0019439	166	0.031
membrane fusion	GO:0061025	42	0.030
protein catabolic process	GO:0030163	101	0.030
sensory organ morphogenesis	GO:0090596	260	0.030
regulation of intracellular signal transduction	GO:1902531	236	0.030
cell motility	GO:0048870	251	0.029
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.029
nucleoside triphosphate catabolic process	GO:0009143	108	0.029
immune response regulating signaling pathway	GO:0002764	2	0.029
programmed cell death	GO:0012501	257	0.029
response to lipopolysaccharide	GO:0032496	4	0.029
appendage morphogenesis	GO:0035107	397	0.028
protein phosphorylation	GO:0006468	169	0.028
modification dependent protein catabolic process	GO:0019941	78	0.028
synaptic transmission	GO:0007268	288	0.027
regulation of cellular protein metabolic process	GO:0032268	243	0.027
forebrain development	GO:0030900	2	0.027
phosphorylation	GO:0016310	294	0.027
multicellular organismal aging	GO:0010259	140	0.027
immune system process	GO:0002376	347	0.026
ethanolamine containing compound metabolic process	GO:0042439	4	0.026
appendage development	GO:0048736	401	0.026
trachea development	GO:0060438	29	0.026
regulation of cell differentiation	GO:0045595	302	0.026
limb development	GO:0060173	1	0.025
reactive oxygen species metabolic process	GO:0072593	22	0.025
cell division	GO:0051301	248	0.025
membrane organization	GO:0061024	112	0.025
regulation of phosphorylation	GO:0042325	147	0.025
negative regulation of rna metabolic process	GO:0051253	251	0.025
transcription from rna polymerase ii promoter	GO:0006366	368	0.025
regulation of immune system process	GO:0002682	176	0.025
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.025
purine nucleotide catabolic process	GO:0006195	109	0.025
cell fate determination	GO:0001709	91	0.024
regulation of cell substrate adhesion	GO:0010810	2	0.024
immune effector process	GO:0002252	98	0.024
negative regulation of cell differentiation	GO:0045596	143	0.024
mitotic nuclear division	GO:0007067	213	0.024
ribonucleoside monophosphate metabolic process	GO:0009161	51	0.024
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.024
central nervous system development	GO:0007417	201	0.024
purine ribonucleoside catabolic process	GO:0046130	112	0.024
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.024
response to oxidative stress	GO:0006979	86	0.024
regulation of synapse organization	GO:0050807	110	0.024
positive regulation of programmed cell death	GO:0043068	62	0.024
regulation of cell cycle	GO:0051726	291	0.023
apoptotic process	GO:0006915	159	0.023
multicellular organism growth	GO:0035264	46	0.023
digestive system development	GO:0055123	149	0.023
cyclic purine nucleotide metabolic process	GO:0052652	25	0.023
tube development	GO:0035295	244	0.023
proteasomal protein catabolic process	GO:0010498	59	0.022
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.022
connective tissue development	GO:0061448	3	0.022
phototaxis	GO:0042331	21	0.022
embryonic morphogenesis	GO:0048598	206	0.022
organic substance transport	GO:0071702	257	0.022
proteolysis	GO:0006508	192	0.022
nucleotide biosynthetic process	GO:0009165	34	0.022
positive regulation of macromolecule metabolic process	GO:0010604	405	0.022
somatic stem cell division	GO:0048103	37	0.021
phosphatidylethanolamine metabolic process	GO:0046337	1	0.021
g protein coupled receptor signaling pathway	GO:0007186	136	0.021
ribonucleotide biosynthetic process	GO:0009260	28	0.021
wing disc morphogenesis	GO:0007472	344	0.021
secretion by cell	GO:0032940	101	0.021
positive regulation of cell migration	GO:0030335	2	0.021
macromolecule catabolic process	GO:0009057	161	0.021
guanosine containing compound catabolic process	GO:1901069	74	0.021
carbohydrate metabolic process	GO:0005975	82	0.021
phagocytosis	GO:0006909	215	0.020
gland development	GO:0048732	191	0.020
regulation of cell cycle process	GO:0010564	181	0.020
heterocycle catabolic process	GO:0046700	166	0.020
regulation of cell proliferation	GO:0042127	163	0.020
amine metabolic process	GO:0009308	12	0.019
regulation of catabolic process	GO:0009894	170	0.019
biological adhesion	GO:0022610	138	0.019
lipid localization	GO:0010876	54	0.019
purine ribonucleoside metabolic process	GO:0046128	127	0.019
post embryonic appendage morphogenesis	GO:0035120	385	0.019
oocyte development	GO:0048599	124	0.019
response to hexose	GO:0009746	3	0.019
negative regulation of cell proliferation	GO:0008285	69	0.019
nucleoside phosphate biosynthetic process	GO:1901293	34	0.019
actin filament based process	GO:0030029	220	0.019
negative regulation of sequence specific dna binding transcription factor activity	GO:0043433	4	0.019
gliogenesis	GO:0042063	80	0.019
negative regulation of developmental growth	GO:0048640	64	0.019
cellular response to hexose stimulus	GO:0071331	1	0.019
maintenance of location	GO:0051235	73	0.018
purine containing compound biosynthetic process	GO:0072522	30	0.018
regulation of multicellular organismal development	GO:2000026	414	0.018
positive regulation of apoptotic process	GO:0043065	47	0.018
centriole replication	GO:0007099	24	0.018
cgmp metabolic process	GO:0046068	11	0.018
regulation of anatomical structure morphogenesis	GO:0022603	242	0.018
regulation of synaptic growth at neuromuscular junction	GO:0008582	89	0.018
regulation of cell morphogenesis	GO:0022604	163	0.018
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	54	0.018
cellular response to lipopolysaccharide	GO:0071222	3	0.018
cell cell junction organization	GO:0045216	55	0.018
synapse organization	GO:0050808	196	0.017
mesenchymal cell development	GO:0014031	1	0.017
regulation of synapse structure and activity	GO:0050803	128	0.017
regulation of molecular function	GO:0065009	217	0.017
response to wounding	GO:0009611	94	0.017
regulation of hydrolase activity	GO:0051336	97	0.017
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.017
cell proliferation	GO:0008283	299	0.017
regulation of rna splicing	GO:0043484	69	0.017
organic cyclic compound catabolic process	GO:1901361	168	0.016
regulation of translation	GO:0006417	56	0.016
energy taxis	GO:0009453	21	0.016
germ line stem cell maintenance	GO:0030718	50	0.016
positive regulation of phosphorylation	GO:0042327	87	0.016
negative regulation of insulin secretion	GO:0046676	1	0.016
positive regulation of cell death	GO:0010942	69	0.016
synapse assembly	GO:0007416	143	0.016
immune response activating signal transduction	GO:0002757	2	0.016
response to extracellular stimulus	GO:0009991	116	0.016
positive regulation of cell motility	GO:2000147	3	0.016
gland morphogenesis	GO:0022612	145	0.016
camera type eye development	GO:0043010	4	0.015
centriole assembly	GO:0098534	24	0.015
nucleoside metabolic process	GO:0009116	127	0.015
positive regulation of cellular amine metabolic process	GO:0033240	0	0.015
rna processing	GO:0006396	147	0.015
hindbrain development	GO:0030902	2	0.015
neuromuscular junction development	GO:0007528	149	0.015
regulation of epithelial cell proliferation	GO:0050678	4	0.015
determination of adult lifespan	GO:0008340	137	0.015
cellular nitrogen compound catabolic process	GO:0044270	165	0.015
regulation of phosphate metabolic process	GO:0019220	210	0.015
telencephalon development	GO:0021537	2	0.015
cellular response to molecule of bacterial origin	GO:0071219	3	0.015
positive regulation of molecular function	GO:0044093	136	0.015
neuronal stem cell division	GO:0036445	35	0.015
substrate adhesion dependent cell spreading	GO:0034446	2	0.015
negative regulation of catalytic activity	GO:0043086	42	0.015
ras protein signal transduction	GO:0007265	88	0.015
secondary metabolic process	GO:0019748	75	0.015
regulation of autophagy	GO:0010506	62	0.015
protein localization	GO:0008104	284	0.015
positive regulation of cellular biosynthetic process	GO:0031328	316	0.015
leg disc morphogenesis	GO:0007478	80	0.015
gtp metabolic process	GO:0046039	72	0.014
oocyte dorsal ventral axis specification	GO:0007310	34	0.014
eye development	GO:0001654	323	0.014
negative regulation of growth	GO:0045926	84	0.014
kidney development	GO:0001822	3	0.014
peptidyl threonine phosphorylation	GO:0018107	2	0.014
cyclic nucleotide biosynthetic process	GO:0009190	25	0.014
purine containing compound catabolic process	GO:0072523	112	0.014
cell growth	GO:0016049	108	0.014
positive regulation of protein metabolic process	GO:0051247	128	0.014
mesenchymal cell differentiation	GO:0048762	1	0.014
negative regulation of cellular component organization	GO:0051129	108	0.014
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.014
sterol homeostasis	GO:0055092	4	0.014
hair cell differentiation	GO:0035315	47	0.014
glycosyl compound catabolic process	GO:1901658	112	0.014
nucleoside phosphate catabolic process	GO:1901292	110	0.014
positive regulation of catalytic activity	GO:0043085	118	0.014
neuromuscular synaptic transmission	GO:0007274	67	0.014
protein import into nucleus	GO:0006606	51	0.014
salivary gland morphogenesis	GO:0007435	145	0.014
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.014
organophosphate catabolic process	GO:0046434	112	0.013
oocyte construction	GO:0007308	112	0.013
somatic muscle development	GO:0007525	66	0.013
regulation of ras protein signal transduction	GO:0046578	93	0.013
ameboidal type cell migration	GO:0001667	151	0.013
organophosphate biosynthetic process	GO:0090407	46	0.013
regulation of i kappab kinase nf kappab signaling	GO:0043122	2	0.013
homeostatic process	GO:0042592	199	0.013
autophagic cell death	GO:0048102	83	0.013
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.013
cellularization	GO:0007349	90	0.013
male meiosis	GO:0007140	52	0.013
response to decreased oxygen levels	GO:0036293	58	0.013
response to glucose	GO:0009749	2	0.013
genital disc development	GO:0035215	44	0.013
cell death	GO:0008219	279	0.013
epidermis development	GO:0008544	65	0.013
negative regulation of gene expression	GO:0010629	387	0.013
regulation of cellular component biogenesis	GO:0044087	201	0.012
response to radiation	GO:0009314	155	0.012
regulation of secretion by cell	GO:1903530	39	0.012
positive regulation of cellular protein metabolic process	GO:0032270	118	0.012
negative regulation of cellular protein metabolic process	GO:0032269	85	0.012
ribonucleoside catabolic process	GO:0042454	112	0.012
negative regulation of epithelial cell proliferation	GO:0050680	4	0.012
regulation of neurogenesis	GO:0050767	158	0.012
anatomical structure homeostasis	GO:0060249	97	0.012
l amino acid import	GO:0043092	2	0.012
single organism carbohydrate metabolic process	GO:0044723	72	0.012
regulation of locomotion	GO:0040012	42	0.012
regulation of blood circulation	GO:1903522	21	0.012
smoothened signaling pathway	GO:0007224	49	0.012
neuroblast division	GO:0055057	35	0.012
germline ring canal formation	GO:0030725	13	0.012
regulation of mitosis	GO:0007088	56	0.012
cellular response to monosaccharide stimulus	GO:0071326	2	0.012
regulation of lipid transport	GO:0032368	3	0.012
translation	GO:0006412	69	0.012
pigmentation	GO:0043473	75	0.012
dorsal ventral pattern formation	GO:0009953	133	0.012
meiotic chromosome segregation	GO:0045132	59	0.012
monocarboxylic acid transport	GO:0015718	3	0.012
regulation of cyclic nucleotide biosynthetic process	GO:0030802	13	0.012
response to monosaccharide	GO:0034284	4	0.012
positive regulation of transcription dna templated	GO:0045893	266	0.012
cholesterol homeostasis	GO:0042632	3	0.011
endosome organization	GO:0007032	9	0.011
glycosyl compound metabolic process	GO:1901657	127	0.011
cellular response to radiation	GO:0071478	52	0.011
hormone catabolic process	GO:0042447	3	0.011
limb morphogenesis	GO:0035108	1	0.011
purine nucleoside catabolic process	GO:0006152	112	0.011
ribose phosphate biosynthetic process	GO:0046390	28	0.011
retina development in camera type eye	GO:0060041	4	0.011
small gtpase mediated signal transduction	GO:0007264	88	0.011
compound eye morphogenesis	GO:0001745	249	0.011
regulation of mrna splicing via spliceosome	GO:0048024	64	0.011
nucleobase containing compound catabolic process	GO:0034655	165	0.011
organic acid metabolic process	GO:0006082	103	0.011
organic hydroxy compound metabolic process	GO:1901615	83	0.011
cellular response to biotic stimulus	GO:0071216	4	0.011
ribonucleotide catabolic process	GO:0009261	109	0.011
glycerolipid catabolic process	GO:0046503	3	0.011
peptidyl tyrosine phosphorylation	GO:0018108	24	0.011
regulation of cellular amine metabolic process	GO:0033238	3	0.011
endocytosis	GO:0006897	310	0.011
melanin metabolic process	GO:0006582	47	0.011
compound eye development	GO:0048749	307	0.011
synaptic vesicle exocytosis	GO:0016079	16	0.011
regulation of cell adhesion	GO:0030155	27	0.011
signal transduction by phosphorylation	GO:0023014	107	0.011
response to oxygen containing compound	GO:1901700	200	0.011
nucleoside monophosphate metabolic process	GO:0009123	52	0.011
regulation of cellular localization	GO:0060341	136	0.011
reproductive structure development	GO:0048608	74	0.011
adherens junction organization	GO:0034332	27	0.011
mrna processing	GO:0006397	104	0.011
regulation of purine nucleotide metabolic process	GO:1900542	62	0.011
response to hypoxia	GO:0001666	53	0.011
negative regulation of immune system process	GO:0002683	50	0.010
response to organophosphorus	GO:0046683	2	0.010
protein k48 linked ubiquitination	GO:0070936	3	0.010
epiboly	GO:0090504	2	0.010
regulation of cell death	GO:0010941	173	0.010
lipid storage	GO:0019915	38	0.010
microtubule based movement	GO:0007018	51	0.010
glandular epithelial cell differentiation	GO:0002067	1	0.010
axonogenesis	GO:0007409	290	0.010
positive regulation of protein modification process	GO:0031401	58	0.010
cellular macromolecule localization	GO:0070727	220	0.010
regulation of microtubule cytoskeleton organization	GO:0070507	41	0.010
skin development	GO:0043588	65	0.010

Traf-like disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.037
disease of metabolism	DOID:0014667	0.032
inherited metabolic disorder	DOID:655	0.028
nervous system disease	DOID:863	0.023
diabetes mellitus	DOID:9351	0.020
type 2 diabetes mellitus	DOID:9352	0.020
carbohydrate metabolism disease	DOID:0050013	0.020
acquired metabolic disease	DOID:0060158	0.020
glucose metabolism disease	DOID:4194	0.020
central nervous system disease	DOID:331	0.015
disease of cellular proliferation	DOID:14566	0.011

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