Drosophila melanogaster

115 known processes

Ide (Dmel_CG5517)

Insulin degrading metalloproteinase

(Aliases: dIDE,CG5517,IDE,Dmel\CG5517)

Ide biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
positive regulation of growthGO:0045927750.858
regulation of growthGO:00400082330.824
positive regulation of developmental growthGO:0048639620.812
regulation of multicellular organism growthGO:0040014400.748
growthGO:00400073590.475
positive regulation of multicellular organism growthGO:0040018210.409
agingGO:00075681430.383
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691160.366
enzyme linked receptor protein signaling pathwayGO:00071671790.316
regulation of cellular response to insulin stimulusGO:1900076170.303
multicellular organism growthGO:0035264460.303
response to abiotic stimulusGO:00096283410.284
carboxylic acid metabolic processGO:0019752920.265
developmental growthGO:00485892800.263
regulation of cell growthGO:0001558430.260
positive regulation of cellular response to insulin stimulusGO:190007840.256
regulation of insulin receptor signaling pathwayGO:0046626170.249
sulfur compound metabolic processGO:0006790590.236
regulation of developmental growthGO:00486381740.230
positive regulation of nitrogen compound metabolic processGO:00511733540.224
cellular response to insulin stimulusGO:0032869280.212
autophagic vacuole assemblyGO:000004520.206
positive regulation of macromolecule metabolic processGO:00106044050.186
locomotory behaviorGO:00076261760.179
regulation of protein metabolic processGO:00512462560.172
Rat
regulation of localizationGO:00328792750.163
fatty acid homeostasisGO:005508920.148
programmed cell deathGO:00125012570.140
determination of adult lifespanGO:00083401370.137
phosphorylationGO:00163102940.134
cell type specific apoptotic processGO:0097285380.132
response to organic substanceGO:00100332840.131
positive regulation of developmental processGO:00510941430.128
regulation of transcription from rna polymerase ii promoterGO:00063573780.125
insulin receptor signaling pathwayGO:0008286250.125
cellular response to chemical stimulusGO:00708871990.124
cell proliferationGO:00082832990.120
response to nutrient levelsGO:00316671140.114
small molecule metabolic processGO:00442813050.114
Rat
monocarboxylic acid catabolic processGO:0072329100.108
apoptotic processGO:00069151590.105
organic acid catabolic processGO:0016054160.102
protein modification processGO:00362114380.102
alditol phosphate metabolic processGO:005264620.099
thioester metabolic processGO:003538330.098
protein phosphorylationGO:00064681690.096
locomotor rhythmGO:0045475560.096
chemotaxisGO:00069352490.095
regulation of nervous system developmentGO:00519602480.095
organic acid metabolic processGO:00060821030.095
protein maturationGO:0051604710.094
Yeast Rat
taxisGO:00423303040.094
dna metabolic processGO:00062592270.092
positive regulation of cellular biosynthetic processGO:00313283160.091
transmembrane receptor protein serine threonine kinase signaling pathwayGO:0007178650.090
negative regulation of cell cycle phase transitionGO:19019881030.087
regulation of catabolic processGO:00098941700.085
embryonic pattern specificationGO:00098801740.080
cellular protein modification processGO:00064644380.079
single organism catabolic processGO:00447122280.078
Rat
deathGO:00162652840.075
response to starvationGO:0042594970.075
forebrain developmentGO:003090020.074
regulation of protein modification processGO:00313991120.074
cellular amino acid metabolic processGO:0006520610.074
regulation of programmed cell deathGO:00430671520.073
carbohydrate derivative metabolic processGO:19011352170.072
Rat
positive regulation of phosphate metabolic processGO:00459371390.070
positive regulation of multicellular organismal processGO:00512401430.069
monovalent inorganic cation transportGO:0015672400.068
protein localizationGO:00081042840.068
negative regulation of nervous system developmentGO:0051961920.068
organonitrogen compound metabolic processGO:19015643180.066
Human Rat
cellular response to nitrogen compoundGO:1901699510.066
single organism biosynthetic processGO:00447112060.066
acyl coa metabolic processGO:000663730.065
positive regulation of nucleic acid templated transcriptionGO:19035082660.065
positive regulation of nucleobase containing compound metabolic processGO:00459353320.064
positive regulation of biosynthetic processGO:00098913160.064
embryo development ending in birth or egg hatchingGO:00097921520.063
negative regulation of cell differentiationGO:00455961430.063
larval developmentGO:00021641040.063
negative regulation of insulin receptor signaling pathwayGO:0046627110.062
ribonucleoside triphosphate catabolic processGO:00092031080.061
Rat
response to oxygen containing compoundGO:19017002000.061
monocarboxylic acid metabolic processGO:0032787290.060
cell growthGO:00160491080.057
cell divisionGO:00513012480.057
cellular response to endogenous stimulusGO:0071495800.057
response to radiationGO:00093141550.056
vesicle mediated transportGO:00161923810.056
positive regulation of protein metabolic processGO:00512471280.055
positive regulation of signal transductionGO:00099672230.055
regulation of cellular protein metabolic processGO:00322682430.054
Rat
endocytosisGO:00068973100.053
body morphogenesisGO:001017120.053
regulation of tor signalingGO:0032006210.053
neuron projection guidanceGO:00974852410.052
positive regulation of mitochondrion organizationGO:001082280.052
establishment of localization in cellGO:00516494020.050
regulation of cellular ketone metabolic processGO:001056530.049
organophosphate metabolic processGO:00196371950.049
Rat
oxoacid metabolic processGO:00434361030.049
cellular amine metabolic processGO:0044106120.048
regulation of macroautophagyGO:0016241150.048
macromolecular complex assemblyGO:00650032560.048
Human Rat
cellular response to organonitrogen compoundGO:0071417360.048
negative regulation of cellular biosynthetic processGO:00313272770.047
negative regulation of response to stimulusGO:00485852580.046
transcription from rna polymerase ii promoterGO:00063663680.046
purine containing compound metabolic processGO:00725211550.046
Rat
amine metabolic processGO:0009308120.044
cell deathGO:00082192790.044
purine ribonucleoside metabolic processGO:00461281270.043
Rat
phagocytosisGO:00069092150.043
regulation of apoptotic processGO:00429811300.042
multicellular organismal agingGO:00102591400.041
positive regulation of cell growthGO:0030307190.041
regulation of cell differentiationGO:00455953020.040
negative regulation of mitotic cell cycle phase transitionGO:19019911030.040
axonogenesisGO:00074092900.040
negative regulation of macromolecule biosynthetic processGO:00105582700.039
circadian rhythmGO:00076231050.039
positive regulation of rna metabolic processGO:00512542710.039
organonitrogen compound catabolic processGO:19015651280.038
Human Rat
regulation of establishment of protein localizationGO:0070201610.038
cellular response to organic substanceGO:00713101320.037
regulation of phosphorylationGO:00423251470.037
ribonucleoside triphosphate metabolic processGO:00091991190.037
Rat
negative regulation of apoptotic processGO:0043066630.037
response to external biotic stimulusGO:00432072930.037
nucleoside metabolic processGO:00091161270.037
Rat
regulation of membrane potentialGO:0042391350.036
blastoderm segmentationGO:00073501590.036
regulation of multicellular organismal developmentGO:20000264140.036
cellular response to peptideGO:1901653280.036
pigmentationGO:0043473750.036
purine ribonucleotide catabolic processGO:00091541090.035
Rat
positive regulation of catabolic processGO:00098961050.035
rhythmic behaviorGO:0007622760.034
intracellular transportGO:00469072280.034
protein complex assemblyGO:00064612000.034
Human Rat
regulation of cell sizeGO:0008361630.034
regulation of organelle organizationGO:00330431960.033
response to biotic stimulusGO:00096072940.033
regulation of small gtpase mediated signal transductionGO:0051056930.033
tor signalingGO:0031929320.033
establishment of protein localizationGO:00451841630.033
response to endogenous stimulusGO:00097191190.032
organonitrogen compound biosynthetic processGO:19015661170.032
regulation of mitotic cell cycleGO:00073461900.032
purine ribonucleoside triphosphate metabolic processGO:00092051190.032
Rat
reproductive behaviorGO:00190981220.032
positive regulation of signalingGO:00230562430.032
autophagyGO:00069141080.032
regulation of phosphorus metabolic processGO:00511742100.031
organic substance transportGO:00717022570.031
cellular response to external stimulusGO:0071496660.031
purine ribonucleoside catabolic processGO:00461301120.031
Rat
regulation of anatomical structure sizeGO:00900661630.030
regulation of cellular component biogenesisGO:00440872010.029
Human
regulation of protein phosphorylationGO:0001932640.029
positive regulation of phosphorus metabolic processGO:00105621390.029
translational initiationGO:0006413110.028
axon guidanceGO:00074112330.028
regulation of glial cell proliferationGO:0060251110.028
oocyte differentiationGO:00099941450.028
negative regulation of developmental growthGO:0048640640.027
guanosine containing compound catabolic processGO:1901069740.027
regulation of cellular catabolic processGO:00313291570.027
guanosine containing compound metabolic processGO:1901068740.026
single organism behaviorGO:00447083910.026
protein processingGO:0016485680.026
Rat
cellular homeostasisGO:0019725800.026
Human
negative regulation of biosynthetic processGO:00098902770.026
mitotic g2 dna damage checkpointGO:0007095690.026
purine nucleotide catabolic processGO:00061951090.026
Rat
mitochondrion organizationGO:0007005650.025
anatomical structure homeostasisGO:0060249970.025
lipid metabolic processGO:00066291210.025
nucleoside phosphate catabolic processGO:19012921100.025
Rat
gtp metabolic processGO:0046039720.025
cellular protein localizationGO:00346131600.024
macromolecular complex disassemblyGO:0032984370.024
carbohydrate derivative catabolic processGO:19011361180.024
Rat
nucleobase containing compound catabolic processGO:00346551650.024
Rat
regulation of phosphate metabolic processGO:00192202100.024
negative regulation of multicellular organismal processGO:00512411420.024
axis specificationGO:00097981670.023
purine nucleoside metabolic processGO:00422781270.023
Rat
negative regulation of mitotic cell cycleGO:00459301090.022
regulation of ras protein signal transductionGO:0046578930.022
segmentationGO:00352822070.022
response to other organismGO:00517072930.022
brain developmentGO:00074201200.022
response to monosaccharideGO:003428440.022
cellular ketone metabolic processGO:0042180240.022
negative regulation of signal transductionGO:00099682060.022
chromatin modificationGO:00165681470.022
neuronal action potentialGO:0019228100.021
positive regulation of transcription from rna polymerase ii promoterGO:00459442040.021
synapse organizationGO:00508081960.021
single organism cellular localizationGO:19025801800.021
purine nucleoside triphosphate metabolic processGO:00091441190.021
Rat
purine ribonucleoside triphosphate catabolic processGO:00092071080.020
Rat
negative regulation of signalingGO:00230572190.020
response to ionizing radiationGO:0010212320.020
mitotic cell cycle checkpointGO:0007093880.020
positive regulation of cell communicationGO:00106472500.020
response to light stimulusGO:00094161240.020
humoral immune responseGO:00069591170.020
fatty acid catabolic processGO:000906290.020
cellular response to oxygen containing compoundGO:1901701790.020
ion transportGO:00068111450.019
ensheathment of neuronsGO:0007272100.019
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090092380.019
adult behaviorGO:00305341370.019
purine nucleoside triphosphate catabolic processGO:00091461080.019
Rat
positive regulation of gene expressionGO:00106282900.019
peptidyl threonine phosphorylationGO:001810720.019
cellular response to starvationGO:0009267610.019
regulation of chemotaxisGO:0050920120.018
positive regulation of macromolecule biosynthetic processGO:00105572830.018
response to heatGO:0009408630.018
negative regulation of cell deathGO:0060548810.018
circadian behaviorGO:0048512760.018
cellular macromolecule localizationGO:00707272200.018
homeostatic processGO:00425921990.017
Human
single organism carbohydrate metabolic processGO:0044723720.017
positive regulation of protein modification processGO:0031401580.017
response to bacteriumGO:00096171980.017
imaginal disc derived wing morphogenesisGO:00074763370.017
regulation of cell deathGO:00109411730.017
carbohydrate derivative biosynthetic processGO:1901137850.017
multicellular organismal reproductive behaviorGO:00330571100.017
cellular catabolic processGO:00442483720.017
Human Rat
maintenance of locationGO:0051235730.017
cellular response to peptide hormone stimulusGO:0071375280.017
negative regulation of programmed cell deathGO:0043069720.016
regulation of cellular amine metabolic processGO:003323830.016
nucleoside phosphate metabolic processGO:00067531620.016
Rat
spinal cord developmentGO:002151010.016
cellular carbohydrate metabolic processGO:0044262220.016
positive regulation of response to stimulusGO:00485843230.016
cell migrationGO:00164772380.016
axon ensheathmentGO:0008366100.016
defense responseGO:00069523000.016
positive regulation of cellular protein metabolic processGO:00322701180.016
lipid homeostasisGO:0055088330.016
metal ion transportGO:0030001740.016
protein catabolic processGO:00301631010.016
defense response to other organismGO:00985422250.016
regulation of anatomical structure morphogenesisGO:00226032420.016
thioester biosynthetic processGO:003538420.016
negative regulation of cellular metabolic processGO:00313243820.016
Rat
ion homeostasisGO:0050801550.015
response to decreased oxygen levelsGO:0036293580.015
cell maturationGO:00484691440.015
multicellular organismal signalingGO:0035637120.015
response to hexoseGO:000974630.015
regulation of adult chitin containing cuticle pigmentationGO:0048082130.015
response to peptideGO:1901652290.015
response to organonitrogen compoundGO:0010243750.015
negative regulation of nucleobase containing compound metabolic processGO:00459342610.015
nucleoside catabolic processGO:00091641120.015
Rat
single organism intracellular transportGO:19025822070.015
axon developmentGO:00615642970.015
glycosyl compound catabolic processGO:19016581120.015
Rat
regulation of synaptic plasticityGO:0048167140.014
ribonucleotide metabolic processGO:00092591450.014
Rat
ribonucleoside metabolic processGO:00091191270.014
Rat
regulation of intracellular signal transductionGO:19025312360.014
developmental maturationGO:00217001720.014
inositol lipid mediated signalingGO:004801740.014
neuromuscular junction developmentGO:00075281490.014
regulation of glial cell differentiationGO:004568510.014
peptidyl amino acid modificationGO:00181931050.014
response to temperature stimulusGO:00092661060.014
cellular response to hormone stimulusGO:0032870440.014
protein modification by small protein conjugation or removalGO:00706471060.014
ribose phosphate biosynthetic processGO:0046390280.014
telencephalon developmentGO:002153720.014
regulation of gliogenesisGO:0014013110.014
catabolic processGO:00090564090.014
negative regulation of cellular response to insulin stimulusGO:1900077110.014
purine nucleoside catabolic processGO:00061521120.014
Rat
negative regulation of epithelial cell proliferationGO:005068040.014
regulation of epithelial cell proliferationGO:005067840.013
positive regulation of cell sizeGO:0045793210.013
regionalizationGO:00030024160.013
negative regulation of rna biosynthetic processGO:19026792400.013
response to hormoneGO:0009725450.013
neurological system processGO:00508773580.013
positive regulation of insulin receptor signaling pathwayGO:004662830.013
transmission of nerve impulseGO:0019226120.013
adult locomotory behaviorGO:0008344760.013
negative regulation of gene expressionGO:00106293870.013
Rat
regulation of cellular component movementGO:0051270420.013
organophosphate catabolic processGO:00464341120.013
Rat
sister chromatid segregationGO:0000819920.013
hindbrain developmentGO:003090220.013
heterocycle catabolic processGO:00467001660.012
Rat
rhythmic processGO:00485111060.012
localization of cellGO:00516742570.012
purine ribonucleotide metabolic processGO:00091501450.012
Rat
positive regulation of phosphorylationGO:0042327870.012
cell cell signaling involved in cell fate commitmentGO:00451682100.012
multi organism reproductive behaviorGO:00447051210.012
nerve developmentGO:002167560.012
positive regulation of cell migrationGO:003033520.012
regulation of cell cycle processGO:00105641810.012
carbohydrate metabolic processGO:0005975820.012
cell motilityGO:00488702510.012
nucleotide biosynthetic processGO:0009165340.012
regulation of protein transportGO:0051223570.012
carboxylic acid catabolic processGO:0046395160.012
organelle fissionGO:00482853400.012
regulation of reproductive processGO:2000241540.012
lipid biosynthetic processGO:0008610460.012
regulation of response to extracellular stimulusGO:0032104180.012
aromatic compound catabolic processGO:00194391660.012
Rat
head developmentGO:00603221350.012
posttranscriptional regulation of gene expressionGO:00106081450.012
positive regulation of neuron apoptotic processGO:004352510.012
positive regulation of protein phosphorylationGO:0001934340.011
nuclear divisionGO:00002803320.011
wing disc morphogenesisGO:00074723440.011
positive regulation of gtpase activityGO:0043547430.011
phototaxisGO:0042331210.011
regulation of imaginal disc growthGO:0045570260.011
nucleoside triphosphate metabolic processGO:00091411200.011
Rat
regulation of growth rateGO:004000930.011
regulation of nucleoside metabolic processGO:0009118500.011
dna integrity checkpointGO:0031570810.011
positive regulation of catalytic activityGO:00430851180.011
regulation of cell developmentGO:00602842150.011
glial cell proliferationGO:0014009130.011
ribonucleotide catabolic processGO:00092611090.011
Rat
regulation of cellular component sizeGO:0032535980.011
protein kinase b signalingGO:004349110.011
regulation of phosphatidylinositol 3 kinase activityGO:004355120.011
regulation of cellular localizationGO:00603411360.011
cellular response to dna damage stimulusGO:00069742230.011
mitotic dna damage checkpointGO:0044773740.011
regulation of neuron differentiationGO:00456641030.011
purine nucleoside monophosphate metabolic processGO:0009126500.010
Rat
spindle organizationGO:00070512530.010
positive regulation of response to nutrient levelsGO:003210980.010
regulation of neuronal synaptic plasticityGO:004816880.010
cell cycle checkpointGO:0000075950.010
regulation of cell proliferationGO:00421271630.010
regulation of mitosisGO:0007088560.010
response to woundingGO:0009611940.010
regulation of hemocyte proliferationGO:0035206370.010

Ide disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of cellular proliferationDOID:1456600.113
cancerDOID:16200.113
organ system cancerDOID:005068600.113
disease of metabolismDOID:001466700.011
thoracic cancerDOID:509300.011