IMP: Integrative Multi-species Prediction

Drosophila melanogaster

75 known processes

Rm62 (Dmel_CG10279)

CG10279 gene product from transcript CG10279-RD

(Aliases: dmP68,Dmel\CG10279,l(3)rG338,rm62,l(3)01086,p68,DmRH8,4136,l(3)j3D5,Dmp68,l(3)s5196,CG10279,RM62,Lip,l(3)j3D2)

FLYBASE: FBgn0003261
Entrez: 40739
UniProtKB: E1JJ68
UniProtKB: P19109
UniProtKB: C7LAE4

Process Predictions
Disease Predictions

Rm62 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
posttranscriptional gene silencing	GO:0016441	46	0.969
posttranscriptional gene silencing by rna	GO:0035194	45	0.876
gene silencing by rna	GO:0031047	57	0.821
sex differentiation	GO:0007548	81	0.809
cell death	GO:0008219	279	0.788	Human
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.754	Human
chromatin organization	GO:0006325	207	0.727
translation	GO:0006412	69	0.724
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.700	Human
chromosome organization	GO:0051276	360	0.643
regulation of gene expression epigenetic	GO:0040029	128	0.584
negative regulation of rna metabolic process	GO:0051253	251	0.581	Human
positive regulation of gene expression	GO:0010628	290	0.519	Human Mouse
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.515	Human
nuclear division	GO:0000280	332	0.509
histone modification	GO:0016570	106	0.488
programmed cell death	GO:0012501	257	0.476	Human
dna metabolic process	GO:0006259	227	0.436
spermatogenesis	GO:0007283	200	0.384
death	GO:0016265	284	0.381	Human
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.371	Human
methylation	GO:0032259	47	0.368
reproductive system development	GO:0061458	74	0.363
regulation of meiosis	GO:0040020	3	0.357
negative regulation of gene expression	GO:0010629	387	0.335
protein alkylation	GO:0008213	43	0.330
meiotic nuclear division	GO:0007126	151	0.330
positive regulation of macromolecule metabolic process	GO:0010604	405	0.318	Human Mouse
gene silencing	GO:0016458	138	0.294
positive regulation of signal transduction	GO:0009967	223	0.294	Human
mitotic spindle organization	GO:0007052	220	0.291
response to abiotic stimulus	GO:0009628	341	0.276
appendage morphogenesis	GO:0035107	397	0.264
positive regulation of response to stimulus	GO:0048584	323	0.252	Human
amine metabolic process	GO:0009308	12	0.249
taxis	GO:0042330	304	0.225
response to oxygen containing compound	GO:1901700	200	0.222
cell motility	GO:0048870	251	0.218
chromatin modification	GO:0016568	147	0.209
ribonucleoprotein complex subunit organization	GO:0071826	28	0.207	Yeast
negative regulation of transcription dna templated	GO:0045892	237	0.206	Human
gene silencing by mirna	GO:0035195	22	0.202
posttranscriptional regulation of gene expression	GO:0010608	145	0.176
regulation of cell cycle	GO:0051726	291	0.171
response to radiation	GO:0009314	155	0.162
macromolecule methylation	GO:0043414	45	0.161
regulation of apoptotic process	GO:0042981	130	0.161
lipid storage	GO:0019915	38	0.158
actin cytoskeleton organization	GO:0030036	206	0.149
regulation of programmed cell death	GO:0043067	152	0.147
oocyte dorsal ventral axis specification	GO:0007310	34	0.144
vesicle mediated transport	GO:0016192	381	0.143
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.143	Human Mouse
positive regulation of cell communication	GO:0010647	250	0.141	Human
apoptotic process	GO:0006915	159	0.138	Human
positive regulation of protein metabolic process	GO:0051247	128	0.138
organelle fission	GO:0048285	340	0.135
cellular response to oxygen containing compound	GO:1901701	79	0.135
cellular response to chemical stimulus	GO:0070887	199	0.133
regulation of multicellular organismal development	GO:2000026	414	0.129	Human Mouse
gonad development	GO:0008406	50	0.126
negative regulation of cellular biosynthetic process	GO:0031327	277	0.123	Human
neuron projection guidance	GO:0097485	241	0.123
cellular response to dna damage stimulus	GO:0006974	223	0.123	Human
protein modification process	GO:0036211	438	0.121
dna biosynthetic process	GO:0071897	24	0.117
cellular response to radiation	GO:0071478	52	0.116
positive regulation of signaling	GO:0023056	243	0.115	Human
histone lysine methylation	GO:0034968	32	0.111
regulation of cell death	GO:0010941	173	0.110
growth	GO:0040007	359	0.109
positive regulation of cellular biosynthetic process	GO:0031328	316	0.107	Human Mouse
intracellular transport	GO:0046907	228	0.105
development of primary sexual characteristics	GO:0045137	50	0.103
regulation of localization	GO:0032879	275	0.101
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.100	Human
positive regulation of hydrolase activity	GO:0051345	78	0.100
cell division	GO:0051301	248	0.098
response to light stimulus	GO:0009416	124	0.097
maintenance of location	GO:0051235	73	0.094
response to organic cyclic compound	GO:0014070	89	0.092
regulation of developmental growth	GO:0048638	174	0.091
cell cycle g1 s phase transition	GO:0044843	31	0.091
aromatic compound catabolic process	GO:0019439	166	0.090	Yeast
response to uv	GO:0009411	24	0.089
chemotaxis	GO:0006935	249	0.089
response to organic substance	GO:0010033	284	0.087
oocyte differentiation	GO:0009994	145	0.087
organelle assembly	GO:0070925	198	0.087
cellular homeostasis	GO:0019725	80	0.086
response to external biotic stimulus	GO:0043207	293	0.083
rna processing	GO:0006396	147	0.081
regulation of molecular function	GO:0065009	217	0.081
regulation of response to stress	GO:0080134	200	0.081	Human
positive regulation of cellular protein metabolic process	GO:0032270	118	0.081
stem cell development	GO:0048864	79	0.079
regulation of cellular protein metabolic process	GO:0032268	243	0.078
response to biotic stimulus	GO:0009607	294	0.076
imaginal disc derived appendage development	GO:0048737	399	0.075
germarium derived egg chamber formation	GO:0007293	101	0.072
stem cell maintenance	GO:0019827	67	0.070
cellular response to organic substance	GO:0071310	132	0.070
peptidyl amino acid modification	GO:0018193	105	0.068
regulation of protein metabolic process	GO:0051246	256	0.066
chorion containing eggshell formation	GO:0007304	105	0.064
regionalization	GO:0003002	416	0.063
axon guidance	GO:0007411	233	0.062
meiotic cell cycle	GO:0051321	171	0.061
histolysis	GO:0007559	102	0.060
ribonucleoprotein complex biogenesis	GO:0022613	31	0.059	Yeast
positive regulation of programmed cell death	GO:0043068	62	0.059
cell cycle phase transition	GO:0044770	140	0.059
regulation of cellular ketone metabolic process	GO:0010565	3	0.057
cellular amine metabolic process	GO:0044106	12	0.056
purine ribonucleoside metabolic process	GO:0046128	127	0.056	Yeast
protein localization	GO:0008104	284	0.055
covalent chromatin modification	GO:0016569	106	0.054
regulation of embryonic development	GO:0045995	68	0.053
regulation of phosphatase activity	GO:0010921	3	0.052
regulation of cell cycle process	GO:0010564	181	0.052
developmental programmed cell death	GO:0010623	138	0.051
regulation of cellular amine metabolic process	GO:0033238	3	0.051
regulation of growth	GO:0040008	233	0.050
histone methylation	GO:0016571	40	0.050
cellular component disassembly	GO:0022411	46	0.050
cell maturation	GO:0048469	144	0.048
developmental maturation	GO:0021700	172	0.047
anatomical structure homeostasis	GO:0060249	97	0.046
regulation of cellular amino acid metabolic process	GO:0006521	0	0.046
regulation of immune system process	GO:0002682	176	0.046
g1 s transition of mitotic cell cycle	GO:0000082	31	0.045
dna packaging	GO:0006323	91	0.045
transcription from rna polymerase ii promoter	GO:0006366	368	0.045	Human
negative regulation of cellular metabolic process	GO:0031324	382	0.044	Human
mrna splicing via spliceosome	GO:0000398	73	0.043
negative regulation of cell communication	GO:0010648	223	0.043
axis specification	GO:0009798	167	0.042
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.042	Yeast
regulation of protein complex disassembly	GO:0043244	29	0.041
negative regulation of cell death	GO:0060548	81	0.041
positive regulation of biosynthetic process	GO:0009891	316	0.041	Human Mouse
positive regulation of cell death	GO:0010942	69	0.040
regulation of hemocyte proliferation	GO:0035206	37	0.040
mrna metabolic process	GO:0016071	124	0.040
regulation of cellular localization	GO:0060341	136	0.040
rna splicing	GO:0008380	83	0.039
organonitrogen compound metabolic process	GO:1901564	318	0.039	Yeast
nucleoside metabolic process	GO:0009116	127	0.038	Yeast
cellular macromolecular complex assembly	GO:0034622	153	0.038	Yeast
negative regulation of response to stimulus	GO:0048585	258	0.037
regulation of protein modification process	GO:0031399	112	0.037
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.036	Human
cellular response to abiotic stimulus	GO:0071214	58	0.035
negative regulation of rna biosynthetic process	GO:1902679	240	0.035	Human
regulation of cellular component biogenesis	GO:0044087	201	0.035
nucleoside phosphate metabolic process	GO:0006753	162	0.034	Yeast
positive regulation of apoptotic process	GO:0043065	47	0.033
imaginal disc derived wing morphogenesis	GO:0007476	337	0.033
negative regulation of developmental process	GO:0051093	201	0.032
cellular response to light stimulus	GO:0071482	37	0.032
response to temperature stimulus	GO:0009266	106	0.031
purine containing compound catabolic process	GO:0072523	112	0.031	Yeast
germline ring canal formation	GO:0030725	13	0.031
endocytosis	GO:0006897	310	0.031
regulation of catalytic activity	GO:0050790	185	0.030
mesenchymal cell development	GO:0014031	1	0.030
mrna processing	GO:0006397	104	0.029
muscle structure development	GO:0061061	224	0.029	Human Mouse
determination of adult lifespan	GO:0008340	137	0.029
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.028
rna splicing via transesterification reactions	GO:0000375	73	0.028
cellular component assembly involved in morphogenesis	GO:0010927	151	0.028
nucleosome organization	GO:0034728	59	0.028
dna conformation change	GO:0071103	105	0.028
negative regulation of intracellular signal transduction	GO:1902532	57	0.028
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.027	Human Mouse
negative regulation of signal transduction	GO:0009968	206	0.027
rna splicing via transesterification reactions with bulged adenosine as nucleophile	GO:0000377	73	0.027
positive regulation of transcription dna templated	GO:0045893	266	0.027	Human Mouse
cellular macromolecule localization	GO:0070727	220	0.027
reproductive structure development	GO:0048608	74	0.027
neuroblast proliferation	GO:0007405	74	0.027
appendage development	GO:0048736	401	0.026
eggshell chorion assembly	GO:0007306	66	0.026
nucleoside triphosphate metabolic process	GO:0009141	120	0.026	Yeast
cardiovascular system development	GO:0072358	82	0.026	Mouse
organic acid metabolic process	GO:0006082	103	0.025
nucleobase containing compound catabolic process	GO:0034655	165	0.025	Yeast
negative regulation of biosynthetic process	GO:0009890	277	0.024	Human
ribonucleoprotein complex assembly	GO:0022618	23	0.024	Yeast
protein methylation	GO:0006479	43	0.024
male gamete generation	GO:0048232	201	0.024
embryo development ending in birth or egg hatching	GO:0009792	152	0.023	Mouse Worm
rna interference	GO:0016246	27	0.023
central nervous system development	GO:0007417	201	0.023
dorsal ventral axis specification	GO:0009950	66	0.023
rna 3 end processing	GO:0031123	45	0.023
actin filament based process	GO:0030029	220	0.022
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.022	Yeast
dendrite development	GO:0016358	204	0.022
tissue morphogenesis	GO:0048729	297	0.022
cellular protein modification process	GO:0006464	438	0.022
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.021	Human
positive regulation of developmental growth	GO:0048639	62	0.021
regulation of organelle organization	GO:0033043	196	0.021
brain development	GO:0007420	120	0.021
immune system process	GO:0002376	347	0.021
glycosyl compound metabolic process	GO:1901657	127	0.020	Yeast
oocyte axis specification	GO:0007309	108	0.020
cellular amino acid metabolic process	GO:0006520	61	0.020
negative regulation of cellular component organization	GO:0051129	108	0.020
autophagic cell death	GO:0048102	83	0.020
single organism behavior	GO:0044708	391	0.019
small gtpase mediated signal transduction	GO:0007264	88	0.019
regulation of meiotic cell cycle	GO:0051445	9	0.019
regulation of chromatin organization	GO:1902275	32	0.019
wing disc morphogenesis	GO:0007472	344	0.018
salivary gland cell autophagic cell death	GO:0035071	83	0.018
intracellular receptor signaling pathway	GO:0030522	19	0.018	Human
spliceosomal complex assembly	GO:0000245	1	0.018
carboxylic acid metabolic process	GO:0019752	92	0.018
homeostatic process	GO:0042592	199	0.018
stem cell differentiation	GO:0048863	117	0.018
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.017
single organism intracellular transport	GO:1902582	207	0.017
chromatin assembly	GO:0031497	48	0.017
immune response	GO:0006955	246	0.017
organic substance transport	GO:0071702	257	0.016
regulation of transferase activity	GO:0051338	58	0.016
mesenchymal cell differentiation	GO:0048762	1	0.016
larval development	GO:0002164	104	0.016	Worm
regulation of oocyte development	GO:0060281	27	0.016
oocyte construction	GO:0007308	112	0.015
positive regulation of intracellular signal transduction	GO:1902533	116	0.015	Human
regulation of intracellular signal transduction	GO:1902531	236	0.015	Human
mrna splice site selection	GO:0006376	1	0.015
positive regulation of immune system process	GO:0002684	68	0.015
organelle localization	GO:0051640	148	0.015
protein modification by small protein removal	GO:0070646	28	0.015
asymmetric stem cell division	GO:0098722	49	0.015
centrosome organization	GO:0051297	163	0.014
single organism cellular localization	GO:1902580	180	0.014
regulation of nuclear division	GO:0051783	58	0.014
salivary gland histolysis	GO:0035070	88	0.014
response to lipid	GO:0033993	38	0.014
head development	GO:0060322	135	0.014
alternative mrna splicing via spliceosome	GO:0000380	60	0.014
regulation of mitotic cell cycle	GO:0007346	190	0.014
cellular ketone metabolic process	GO:0042180	24	0.014
receptor mediated endocytosis	GO:0006898	21	0.014
oxoacid metabolic process	GO:0043436	103	0.014
negative regulation of nucleotide metabolic process	GO:0045980	4	0.014
heterocycle catabolic process	GO:0046700	166	0.013	Yeast
negative regulation of cell differentiation	GO:0045596	143	0.013
meiotic g2 mi transition	GO:0008315	3	0.013
regulation of translation	GO:0006417	56	0.013
dorsal ventral axis specification ovarian follicular epithelium	GO:0008069	13	0.013
cytoplasmic transport	GO:0016482	130	0.013
regulation of reactive oxygen species biosynthetic process	GO:1903426	0	0.012
stem cell division	GO:0017145	69	0.012
positive regulation of cellular component organization	GO:0051130	156	0.012
germ line stem cell maintenance	GO:0030718	50	0.012
proteolysis	GO:0006508	192	0.012
regulation of multi organism process	GO:0043900	131	0.012
regulation of nucleobase containing compound transport	GO:0032239	4	0.012
tissue death	GO:0016271	102	0.012
imaginal disc pattern formation	GO:0007447	91	0.012
regulation of mrna processing	GO:0050684	71	0.011
regulation of endopeptidase activity	GO:0052548	36	0.011
axonogenesis	GO:0007409	290	0.011
cell migration	GO:0016477	238	0.011
oocyte development	GO:0048599	124	0.011
negative regulation of gene expression epigenetic	GO:0045814	77	0.011
negative regulation of intrinsic apoptotic signaling pathway	GO:2001243	1	0.011
post embryonic appendage morphogenesis	GO:0035120	385	0.011
spermatid differentiation	GO:0048515	114	0.011
localization of cell	GO:0051674	257	0.011
morphogenesis of a branching structure	GO:0001763	45	0.011
cellular nitrogen compound catabolic process	GO:0044270	165	0.011	Yeast
response to ketone	GO:1901654	34	0.011
positive regulation of cellular amine metabolic process	GO:0033240	0	0.010
regulation of hydrolase activity	GO:0051336	97	0.010
regulation of signal transduction by p53 class mediator	GO:1901796	1	0.010	Human
neurological system process	GO:0050877	358	0.010
positive regulation of proteolysis	GO:0045862	52	0.010
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.010
protein dephosphorylation	GO:0006470	27	0.010
chromatin remodeling	GO:0006338	72	0.010
lipid metabolic process	GO:0006629	121	0.010
response to alcohol	GO:0097305	95	0.010
macromolecular complex assembly	GO:0065003	256	0.010	Yeast
regulation of protein deacetylation	GO:0090311	2	0.010
embryonic axis specification	GO:0000578	107	0.010

Rm62 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org

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