IMP: Integrative Multi-species Prediction

Drosophila melanogaster

67 known processes

MAPk-Ak2 (Dmel_CG3086)

MAP kinase activated protein-kinase-2

(Aliases: DmMAPKAPK-2,MAPKAP,MAPKAPK-2,CG3086,Dmel\CG3086,MK2)

FLYBASE: FBgn0013987
Entrez: 44573
UniProtKB: P49071
UniProtKB: A4V402

Process Predictions
Disease Predictions

MAPk-Ak2 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
ion transmembrane transport	GO:0034220	122	0.414
transmembrane transport	GO:0055085	139	0.359
membrane fusion	GO:0061025	42	0.256
single organism membrane fusion	GO:0044801	42	0.239
neurological system process	GO:0050877	358	0.202
axonogenesis	GO:0007409	290	0.172
membrane organization	GO:0061024	112	0.157
negative regulation of response to stimulus	GO:0048585	258	0.129
single organism behavior	GO:0044708	391	0.120
regulation of organelle organization	GO:0033043	196	0.114
regulation of cellular component size	GO:0032535	98	0.114
organelle fusion	GO:0048284	46	0.112
cell motility	GO:0048870	251	0.111
actin filament based process	GO:0030029	220	0.102
single organism membrane organization	GO:0044802	93	0.096
endocytosis	GO:0006897	310	0.094	Mouse
regulation of intracellular signal transduction	GO:1902531	236	0.090
regulation of localization	GO:0032879	275	0.088
intracellular signal transduction	GO:0035556	300	0.084
ion transport	GO:0006811	145	0.084
cell adhesion	GO:0007155	136	0.084
multi organism behavior	GO:0051705	175	0.080
regulation of cell projection organization	GO:0031344	92	0.078
sensory perception of mechanical stimulus	GO:0050954	72	0.078
negative regulation of signal transduction	GO:0009968	206	0.077
cell migration	GO:0016477	238	0.076
regulation of anatomical structure size	GO:0090066	163	0.076
negative regulation of cell communication	GO:0010648	223	0.075
regulation of nervous system development	GO:0051960	248	0.074
immune response regulating signaling pathway	GO:0002764	2	0.069	Mouse
purine ribonucleoside monophosphate metabolic process	GO:0009167	50	0.068
positive regulation of cellular component organization	GO:0051130	156	0.068
organelle fission	GO:0048285	340	0.068
anion transmembrane transport	GO:0098656	26	0.067
cellular macromolecular complex assembly	GO:0034622	153	0.066
cation transmembrane transport	GO:0098655	88	0.066
synaptic transmission	GO:0007268	288	0.063
regulation of phosphate metabolic process	GO:0019220	210	0.062
regulation of anatomical structure morphogenesis	GO:0022603	242	0.060
response to other organism	GO:0051707	293	0.059	Mouse
positive regulation of cellular biosynthetic process	GO:0031328	316	0.058
neural precursor cell proliferation	GO:0061351	75	0.057
regulation of neurogenesis	GO:0050767	158	0.057
regulation of multicellular organismal development	GO:2000026	414	0.057
negative regulation of cellular metabolic process	GO:0031324	382	0.057
immune system process	GO:0002376	347	0.055	Mouse
negative regulation of cellular component organization	GO:0051129	108	0.054
regulation of phosphorylation	GO:0042325	147	0.052
cellular macromolecule localization	GO:0070727	220	0.052
cation transport	GO:0006812	110	0.051
regulation of cellular component biogenesis	GO:0044087	201	0.051
signal transduction by phosphorylation	GO:0023014	107	0.051
actin cytoskeleton organization	GO:0030036	206	0.051
regulation of growth	GO:0040008	233	0.051
regulation of cell development	GO:0060284	215	0.050
pigmentation	GO:0043473	75	0.050
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.049	Human
regulation of cell shape	GO:0008360	113	0.047
response to radiation	GO:0009314	155	0.046
anion transport	GO:0006820	41	0.045
developmental growth	GO:0048589	280	0.045
adult behavior	GO:0030534	137	0.044
cell junction organization	GO:0034330	57	0.044
ameboidal type cell migration	GO:0001667	151	0.043
response to biotic stimulus	GO:0009607	294	0.043	Mouse
imaginal disc derived appendage development	GO:0048737	399	0.043
localization of cell	GO:0051674	257	0.043
negative regulation of gene expression	GO:0010629	387	0.042
cellular catabolic process	GO:0044248	372	0.042
response to light stimulus	GO:0009416	124	0.041
defense response	GO:0006952	300	0.041	Mouse
response to bacterium	GO:0009617	198	0.040	Mouse
appendage development	GO:0048736	401	0.039
carboxylic acid metabolic process	GO:0019752	92	0.039
single organism biosynthetic process	GO:0044711	206	0.039
amine metabolic process	GO:0009308	12	0.039
regulation of developmental growth	GO:0048638	174	0.039
positive regulation of growth	GO:0045927	75	0.039
nucleotide metabolic process	GO:0009117	161	0.039
regulation of transport	GO:0051049	181	0.039
intracellular transport	GO:0046907	228	0.038
oxoacid metabolic process	GO:0043436	103	0.038
adult locomotory behavior	GO:0008344	76	0.037
cellular ketone metabolic process	GO:0042180	24	0.037
negative regulation of phosphate metabolic process	GO:0045936	45	0.036
response to external biotic stimulus	GO:0043207	293	0.035	Mouse
protein localization	GO:0008104	284	0.034
response to endogenous stimulus	GO:0009719	119	0.034
protein modification process	GO:0036211	438	0.033	Human Mouse
nuclear division	GO:0000280	332	0.033
cellular response to organic substance	GO:0071310	132	0.033	Human
cell cell junction organization	GO:0045216	55	0.032
phosphorylation	GO:0016310	294	0.032
actin filament organization	GO:0007015	126	0.032
taxis	GO:0042330	304	0.032
purine ribonucleotide metabolic process	GO:0009150	145	0.032
macromolecular complex assembly	GO:0065003	256	0.032
negative regulation of organelle organization	GO:0010639	56	0.031
positive regulation of biosynthetic process	GO:0009891	316	0.031
heterocycle catabolic process	GO:0046700	166	0.031
nucleoside phosphate metabolic process	GO:0006753	162	0.030
single organism intracellular transport	GO:1902582	207	0.030
renal tubule morphogenesis	GO:0061333	44	0.030
cellular nitrogen compound catabolic process	GO:0044270	165	0.030
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.029	Human
negative regulation of phosphorylation	GO:0042326	35	0.029
negative regulation of nervous system development	GO:0051961	92	0.029
establishment of localization in cell	GO:0051649	402	0.029
atp metabolic process	GO:0046034	49	0.028
cellular response to endogenous stimulus	GO:0071495	80	0.028
response to organic substance	GO:0010033	284	0.028	Human Mouse
negative regulation of cellular biosynthetic process	GO:0031327	277	0.028
regulation of cell morphogenesis	GO:0022604	163	0.028
post embryonic appendage morphogenesis	GO:0035120	385	0.027
embryonic development via the syncytial blastoderm	GO:0001700	148	0.027
regulation of response to stress	GO:0080134	200	0.027
single organism catabolic process	GO:0044712	228	0.027
catabolic process	GO:0009056	409	0.027
tissue migration	GO:0090130	155	0.026
organelle assembly	GO:0070925	198	0.026
developmental cell growth	GO:0048588	52	0.026
positive regulation of developmental process	GO:0051094	143	0.026
lipid localization	GO:0010876	54	0.025
regulation of molecular function	GO:0065009	217	0.025
regulation of cellular ketone metabolic process	GO:0010565	3	0.025
store operated calcium entry	GO:0002115	3	0.025
mapk cascade	GO:0000165	107	0.025
axon development	GO:0061564	297	0.025
positive regulation of lipid biosynthetic process	GO:0046889	3	0.024
growth	GO:0040007	359	0.024
regulation of cytoskeleton organization	GO:0051493	89	0.024
body morphogenesis	GO:0010171	2	0.024
negative regulation of cytoskeleton organization	GO:0051494	30	0.024
regulation of response to external stimulus	GO:0032101	115	0.024
phagocytosis	GO:0006909	215	0.024
organic substance transport	GO:0071702	257	0.024
positive regulation of developmental growth	GO:0048639	62	0.024
glycosyl compound metabolic process	GO:1901657	127	0.024
cardiovascular system development	GO:0072358	82	0.023
axon guidance	GO:0007411	233	0.023
aromatic compound catabolic process	GO:0019439	166	0.023
small molecule metabolic process	GO:0044281	305	0.023
nucleoside triphosphate metabolic process	GO:0009141	120	0.023
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.023
vesicle mediated transport	GO:0016192	381	0.022	Mouse
purine ribonucleoside metabolic process	GO:0046128	127	0.022
cellular response to radiation	GO:0071478	52	0.022
heart development	GO:0007507	82	0.022
aging	GO:0007568	143	0.022	Worm
transforming growth factor beta receptor signaling pathway	GO:0007179	16	0.022
small gtpase mediated signal transduction	GO:0007264	88	0.022
cellular protein complex assembly	GO:0043623	71	0.022
organic acid metabolic process	GO:0006082	103	0.022
establishment of protein localization	GO:0045184	163	0.022
metal ion transport	GO:0030001	74	0.022
purine nucleoside monophosphate catabolic process	GO:0009128	38	0.021
nucleobase containing small molecule metabolic process	GO:0055086	174	0.021
very long chain fatty acid catabolic process	GO:0042760	2	0.021
purine containing compound metabolic process	GO:0072521	155	0.021
regulation of immune response	GO:0050776	118	0.021	Mouse
lipid metabolic process	GO:0006629	121	0.020
salivary gland development	GO:0007431	162	0.020
divalent metal ion transport	GO:0070838	26	0.020
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.020
regulation of immune system process	GO:0002682	176	0.020	Mouse
cellular response to peptide hormone stimulus	GO:0071375	28	0.020
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.019
cellular response to nitrogen compound	GO:1901699	51	0.019
regionalization	GO:0003002	416	0.019
purine nucleoside monophosphate metabolic process	GO:0009126	50	0.019
regulation of ras protein signal transduction	GO:0046578	93	0.019
androgen metabolic process	GO:0008209	1	0.019
compound eye development	GO:0048749	307	0.019
positive regulation of macromolecule metabolic process	GO:0010604	405	0.019
negative regulation of molecular function	GO:0044092	51	0.018
negative regulation of phosphatase activity	GO:0010923	3	0.018
regulation of cell differentiation	GO:0045595	302	0.018
purine nucleotide metabolic process	GO:0006163	146	0.018
regulation of cellular amine metabolic process	GO:0033238	3	0.018
asymmetric stem cell division	GO:0098722	49	0.017
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.017
regulation of phosphorus metabolic process	GO:0051174	210	0.017
epithelial cell differentiation	GO:0030855	322	0.017
protein complex assembly	GO:0006461	200	0.017
monovalent inorganic cation transport	GO:0015672	40	0.017
atp catabolic process	GO:0006200	38	0.017
locomotory behavior	GO:0007626	176	0.017
negative regulation of phosphorus metabolic process	GO:0010563	45	0.017
positive regulation of intracellular signal transduction	GO:1902533	116	0.017
plasma membrane organization	GO:0007009	26	0.017
response to abiotic stimulus	GO:0009628	341	0.017
regulation of neuron differentiation	GO:0045664	103	0.017
appendage morphogenesis	GO:0035107	397	0.017
regulation of multi organism process	GO:0043900	131	0.017
heart morphogenesis	GO:0003007	32	0.017
positive regulation of lipid metabolic process	GO:0045834	4	0.017
cellular amine metabolic process	GO:0044106	12	0.017
ras protein signal transduction	GO:0007265	88	0.017
positive regulation of cell communication	GO:0010647	250	0.017
ovarian follicle cell development	GO:0030707	248	0.016
open tracheal system development	GO:0007424	204	0.016
regulation of mapk cascade	GO:0043408	92	0.016
wing disc morphogenesis	GO:0007472	344	0.016
positive regulation of cellular component biogenesis	GO:0044089	80	0.016
regulation of cellular localization	GO:0060341	136	0.016
homeostatic process	GO:0042592	199	0.016
regulation of cell cycle process	GO:0010564	181	0.016
purine containing compound catabolic process	GO:0072523	112	0.016
chromosome organization	GO:0051276	360	0.016
nucleoside catabolic process	GO:0009164	112	0.016
rac protein signal transduction	GO:0016601	3	0.016
chemotaxis	GO:0006935	249	0.016
peptidyl amino acid modification	GO:0018193	105	0.016	Human
organophosphate metabolic process	GO:0019637	195	0.016
endomembrane system organization	GO:0010256	119	0.016
chloride transport	GO:0006821	10	0.015
organic substance catabolic process	GO:1901575	308	0.015
positive regulation of signal transduction	GO:0009967	223	0.015
ribose phosphate metabolic process	GO:0019693	145	0.015
nucleotide catabolic process	GO:0009166	109	0.015
positive regulation of molecular function	GO:0044093	136	0.015
developmental growth involved in morphogenesis	GO:0060560	65	0.015
negative regulation of signaling	GO:0023057	219	0.015
positive regulation of response to stimulus	GO:0048584	323	0.015	Mouse
eye development	GO:0001654	323	0.015
cellular protein localization	GO:0034613	160	0.015
regulation of phosphatase activity	GO:0010921	3	0.015
regulation of actin filament based process	GO:0032970	42	0.014
neuronal stem cell division	GO:0036445	35	0.014
biological adhesion	GO:0022610	138	0.014
regulation of immune effector process	GO:0002697	52	0.014
ribonucleotide metabolic process	GO:0009259	145	0.014
purine nucleoside metabolic process	GO:0042278	127	0.014
imaginal disc derived wing morphogenesis	GO:0007476	337	0.014
regulation of cellular catabolic process	GO:0031329	157	0.014
response to nitrogen compound	GO:1901698	90	0.014
response to oxygen containing compound	GO:1901700	200	0.014	Mouse
regulation of hemocyte proliferation	GO:0035206	37	0.014
cell division	GO:0051301	248	0.014
negative regulation of intracellular signal transduction	GO:1902532	57	0.014
inorganic ion transmembrane transport	GO:0098660	73	0.014
carbohydrate derivative metabolic process	GO:1901135	217	0.014
positive regulation of transport	GO:0051050	92	0.013
regulation of protein transport	GO:0051223	57	0.013
positive regulation of phosphorus metabolic process	GO:0010562	139	0.013
dna metabolic process	GO:0006259	227	0.013
spindle organization	GO:0007051	253	0.013
positive regulation of phosphate metabolic process	GO:0045937	139	0.013
stress activated protein kinase signaling cascade	GO:0031098	55	0.013
cellular protein modification process	GO:0006464	438	0.013	Human Mouse
regulation of actin cytoskeleton organization	GO:0032956	42	0.013
regulation of cellular protein metabolic process	GO:0032268	243	0.013
fatty acid catabolic process	GO:0009062	9	0.013
positive regulation of catalytic activity	GO:0043085	118	0.013
cell aging	GO:0007569	2	0.013
negative regulation of protein metabolic process	GO:0051248	85	0.013
organic acid catabolic process	GO:0016054	16	0.012
neuron projection guidance	GO:0097485	241	0.012
cellular response to hormone stimulus	GO:0032870	44	0.012
purine ribonucleoside monophosphate catabolic process	GO:0009169	38	0.012
muscle cell differentiation	GO:0042692	103	0.012
sensory perception	GO:0007600	196	0.012
embryonic morphogenesis	GO:0048598	206	0.012	Zebrafish
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.012
regulation of cell size	GO:0008361	63	0.012
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.012
regulation of catalytic activity	GO:0050790	185	0.012
septate junction assembly	GO:0019991	26	0.012
regulation of protein modification process	GO:0031399	112	0.012
cell growth	GO:0016049	108	0.012
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	65	0.012
nucleoside triphosphate catabolic process	GO:0009143	108	0.012
organonitrogen compound catabolic process	GO:1901565	128	0.012
organic cyclic compound catabolic process	GO:1901361	168	0.012
small molecule catabolic process	GO:0044282	21	0.012
cuticle development	GO:0042335	86	0.012
positive regulation of signaling	GO:0023056	243	0.012
negative regulation of multicellular organismal process	GO:0051241	142	0.012
negative regulation of cell death	GO:0060548	81	0.012
stress activated mapk cascade	GO:0051403	52	0.012
regulation of synapse assembly	GO:0051963	94	0.012
muscle structure development	GO:0061061	224	0.012
cellular response to abiotic stimulus	GO:0071214	58	0.011
organonitrogen compound metabolic process	GO:1901564	318	0.011
gland development	GO:0048732	191	0.011
gliogenesis	GO:0042063	80	0.011
dendrite development	GO:0016358	204	0.011
establishment or maintenance of cell polarity	GO:0007163	167	0.011
collateral sprouting	GO:0048668	3	0.011
response to growth factor	GO:0070848	31	0.011	Human
regulation of adult chitin containing cuticle pigmentation	GO:0048082	13	0.011
purine nucleoside catabolic process	GO:0006152	112	0.011
transcription from rna polymerase ii promoter	GO:0006366	368	0.011
regulation of hydrolase activity	GO:0051336	97	0.011
regulation of synapse organization	GO:0050807	110	0.011
negative regulation of cell differentiation	GO:0045596	143	0.011
internal peptidyl lysine acetylation	GO:0018393	38	0.011
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.011
regulation of protein polymerization	GO:0032271	28	0.011
negative regulation of cellular protein metabolic process	GO:0032269	85	0.011
nucleocytoplasmic transport	GO:0006913	72	0.011
developmental pigmentation	GO:0048066	68	0.011
nucleoside monophosphate metabolic process	GO:0009123	52	0.011
nucleoside metabolic process	GO:0009116	127	0.011
regulation of synapse structure and activity	GO:0050803	128	0.010
death	GO:0016265	284	0.010
monocarboxylic acid catabolic process	GO:0072329	10	0.010
protein phosphorylation	GO:0006468	169	0.010	Human Mouse
egg activation	GO:0007343	9	0.010
organophosphate catabolic process	GO:0046434	112	0.010
regulation of response to biotic stimulus	GO:0002831	63	0.010
defense response to other organism	GO:0098542	225	0.010
ribonucleoside catabolic process	GO:0042454	112	0.010

MAPk-Ak2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.041
disease of metabolism	DOID:0014667	0.014
inherited metabolic disorder	DOID:655	0.013
musculoskeletal system disease	DOID:17	0.010

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