IMP: Integrative Multi-species Prediction

Drosophila melanogaster

36 known processes

cyc (Dmel_CG8727)

cycle

(Aliases: Bmal1,CG8727,CYC,dCYC,Cyc,dBma1,dbmal,dBMAL1,dBmal,dBMAL,bmal1,MOP3,BMAL1,Dmel\CG8727,bMAL1,bHLHe7,Mop3,Cycle,dbmal1,CYCLE)

Entrez: 40162
FLYBASE: FBgn0023094
UniProtKB: O61734

Process Predictions
Disease Predictions

cyc biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
rhythmic process	GO:0048511	106	0.998
circadian behavior	GO:0048512	76	0.998
circadian rhythm	GO:0007623	105	0.987
regulation of circadian rhythm	GO:0042752	49	0.936
single organism behavior	GO:0044708	391	0.933
rhythmic behavior	GO:0007622	76	0.895
locomotory behavior	GO:0007626	176	0.814
circadian sleep wake cycle sleep	GO:0050802	23	0.509
locomotor rhythm	GO:0045475	56	0.465
circadian sleep wake cycle process	GO:0022410	24	0.232
negative regulation of rna metabolic process	GO:0051253	251	0.221	Zebrafish Mouse Fly
chromatin modification	GO:0016568	147	0.208
organelle fission	GO:0048285	340	0.185
sleep	GO:0030431	49	0.182
protein acetylation	GO:0006473	39	0.178
negative regulation of gene expression	GO:0010629	387	0.172	Zebrafish Mouse Fly
response to light stimulus	GO:0009416	124	0.151	Zebrafish
response to radiation	GO:0009314	155	0.149	Zebrafish
dna metabolic process	GO:0006259	227	0.140
negative regulation of transcription dna templated	GO:0045892	237	0.138	Zebrafish Mouse Fly
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.130	Human Mouse Fly
histone acetylation	GO:0016573	38	0.129
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.123	Zebrafish Mouse Fly
circadian sleep wake cycle	GO:0042745	28	0.123
peptidyl lysine acetylation	GO:0018394	39	0.123
regulation of behavior	GO:0050795	75	0.112
transcription from rna polymerase ii promoter	GO:0006366	368	0.106	Human Mouse Fly
mitotic cell cycle phase transition	GO:0044772	138	0.102
protein modification process	GO:0036211	438	0.102
chromatin organization	GO:0006325	207	0.100
gene silencing	GO:0016458	138	0.098
regulation of circadian sleep wake cycle sleep	GO:0045187	21	0.097
dna integrity checkpoint	GO:0031570	81	0.086
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.086	Zebrafish Mouse Fly
cell cycle checkpoint	GO:0000075	95	0.076
regulation of circadian sleep wake cycle	GO:0042749	25	0.070
male gamete generation	GO:0048232	201	0.067	Mouse
positive regulation of cellular biosynthetic process	GO:0031328	316	0.066	Human Zebrafish Mouse Rat Fly
epithelial cell differentiation	GO:0030855	322	0.063	Mouse
negative regulation of cell communication	GO:0010648	223	0.062	Mouse
olfactory learning	GO:0008355	56	0.061
nuclear division	GO:0000280	332	0.060
meiotic cell cycle	GO:0051321	171	0.059
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.059	Zebrafish Mouse Fly
multi organism behavior	GO:0051705	175	0.059
negative regulation of cellular biosynthetic process	GO:0031327	277	0.056	Zebrafish Mouse Fly
negative regulation of signal transduction	GO:0009968	206	0.056	Mouse
positive regulation of biosynthetic process	GO:0009891	316	0.055	Human Zebrafish Mouse Rat Fly
meiotic nuclear division	GO:0007126	151	0.053
negative regulation of cellular metabolic process	GO:0031324	382	0.052	Zebrafish Mouse Fly
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.048	Human Zebrafish Mouse Rat Fly
response to temperature stimulus	GO:0009266	106	0.048
chromosome organization	GO:0051276	360	0.046
cellular response to dna damage stimulus	GO:0006974	223	0.045
taxis	GO:0042330	304	0.045
peptidyl lysine modification	GO:0018205	57	0.045
positive regulation of behavior	GO:0048520	19	0.044
meiotic cell cycle process	GO:1903046	132	0.043
protein dna complex subunit organization	GO:0071824	86	0.043
muscle organ development	GO:0007517	127	0.042	Mouse Fly
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.042	Zebrafish Mouse Fly
cellular protein modification process	GO:0006464	438	0.038
learning or memory	GO:0007611	141	0.038
spermatogenesis	GO:0007283	200	0.038	Mouse
negative regulation of biosynthetic process	GO:0009890	277	0.037	Zebrafish Mouse Fly
regulation of intracellular signal transduction	GO:1902531	236	0.037	Mouse
response to organophosphorus	GO:0046683	2	0.037
regulation of phosphorylation	GO:0042325	147	0.037
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.035	Zebrafish Mouse Fly
positive regulation of defense response	GO:0031349	59	0.035
regulation of mitotic cell cycle	GO:0007346	190	0.033
posttranscriptional gene silencing	GO:0016441	46	0.032
gene silencing by rna	GO:0031047	57	0.031
response to abiotic stimulus	GO:0009628	341	0.031	Zebrafish Fly
columnar cuboidal epithelial cell development	GO:0002066	249	0.031	Mouse
negative regulation of rna biosynthetic process	GO:1902679	240	0.030	Zebrafish Mouse Fly
regulation of cell cycle	GO:0051726	291	0.030	Mouse
photoperiodism	GO:0009648	10	0.030	Zebrafish
developmental maturation	GO:0021700	172	0.029
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.029	Human Zebrafish Mouse Rat Fly
positive regulation of rna biosynthetic process	GO:1902680	266	0.029	Human Zebrafish Mouse Rat Fly
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.029	Human Mouse Fly
covalent chromatin modification	GO:0016569	106	0.028
cognition	GO:0050890	141	0.028
determination of adult lifespan	GO:0008340	137	0.027
regulation of defense response	GO:0031347	102	0.027
mitotic nuclear division	GO:0007067	213	0.026
positive regulation of rna metabolic process	GO:0051254	271	0.025	Human Zebrafish Mouse Rat Fly
internal protein amino acid acetylation	GO:0006475	38	0.025
entrainment of circadian clock	GO:0009649	16	0.024
internal peptidyl lysine acetylation	GO:0018393	38	0.024
cellular catabolic process	GO:0044248	372	0.024	Mouse
neuroblast division	GO:0055057	35	0.024
negative regulation of cell death	GO:0060548	81	0.024
oocyte differentiation	GO:0009994	145	0.024
regulation of multicellular organismal development	GO:2000026	414	0.024	Zebrafish Mouse Fly
negative regulation of signaling	GO:0023057	219	0.024	Mouse
neurological system process	GO:0050877	358	0.023
macromolecule catabolic process	GO:0009057	161	0.023	Mouse
appendage morphogenesis	GO:0035107	397	0.022
response to nutrient levels	GO:0031667	114	0.022
negative regulation of small gtpase mediated signal transduction	GO:0051058	13	0.022
positive regulation of transcription dna templated	GO:0045893	266	0.022	Human Zebrafish Mouse Rat Fly
positive regulation of macromolecule metabolic process	GO:0010604	405	0.022	Human Zebrafish Mouse Rat Fly
response to bacterium	GO:0009617	198	0.021
regulation of cellular response to stress	GO:0080135	89	0.021	Mouse
response to oxygen containing compound	GO:1901700	200	0.021	Fly
peptidyl amino acid modification	GO:0018193	105	0.021
adult locomotory behavior	GO:0008344	76	0.020
regulation of epithelial cell differentiation	GO:0030856	4	0.020	Mouse
regulation of gene expression epigenetic	GO:0040029	128	0.020
cell cycle phase transition	GO:0044770	140	0.019
intracellular receptor signaling pathway	GO:0030522	19	0.019	Mouse
learning	GO:0007612	75	0.019
regulation of cellular protein metabolic process	GO:0032268	243	0.019
peptidyl threonine phosphorylation	GO:0018107	2	0.019
dna repair	GO:0006281	54	0.019
asymmetric stem cell division	GO:0098722	49	0.018
secretion	GO:0046903	109	0.018	Mouse
defense response to gram negative bacterium	GO:0050829	94	0.018
cell maturation	GO:0048469	144	0.018
oocyte axis specification	GO:0007309	108	0.017
camera type eye development	GO:0043010	4	0.017
endocytosis	GO:0006897	310	0.017
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.017
positive regulation of gene expression	GO:0010628	290	0.017	Human Zebrafish Mouse Rat Fly
histone modification	GO:0016570	106	0.017
detection of external stimulus	GO:0009581	66	0.017
catabolic process	GO:0009056	409	0.017	Mouse
muscle structure development	GO:0061061	224	0.017	Mouse Fly
phagocytosis	GO:0006909	215	0.017
rna interference	GO:0016246	27	0.017
protein catabolic process	GO:0030163	101	0.016	Mouse
detection of abiotic stimulus	GO:0009582	66	0.016
positive regulation of response to stimulus	GO:0048584	323	0.016	Mouse
ubiquitin dependent protein catabolic process	GO:0006511	78	0.016	Mouse
regulation of localization	GO:0032879	275	0.016	Mouse
multicellular organismal reproductive behavior	GO:0033057	110	0.016
positive regulation of response to external stimulus	GO:0032103	44	0.016
modification dependent macromolecule catabolic process	GO:0043632	79	0.016	Mouse
male mating behavior	GO:0060179	70	0.016
vesicle mediated transport	GO:0016192	381	0.016
organic substance catabolic process	GO:1901575	308	0.016	Mouse
associative learning	GO:0008306	65	0.016
modification dependent protein catabolic process	GO:0019941	78	0.015	Mouse
rna processing	GO:0006396	147	0.015
phototransduction	GO:0007602	52	0.015
negative regulation of intracellular signal transduction	GO:1902532	57	0.015	Mouse
detection of stimulus	GO:0051606	156	0.015
cellular homeostasis	GO:0019725	80	0.015
positive regulation of apoptotic signaling pathway	GO:2001235	4	0.015
nucleoside phosphate biosynthetic process	GO:1901293	34	0.015
protein complex assembly	GO:0006461	200	0.014
negative regulation of homeostatic process	GO:0032845	2	0.014
negative regulation of cell cycle process	GO:0010948	109	0.014
response to organic substance	GO:0010033	284	0.014	Fly
immune response activating signal transduction	GO:0002757	2	0.014
single organism biosynthetic process	GO:0044711	206	0.014
negative regulation of cell cycle phase transition	GO:1901988	103	0.014
heart contraction	GO:0060047	26	0.014
rna splicing via transesterification reactions	GO:0000375	73	0.014
ion transport	GO:0006811	145	0.013
mitotic cell cycle checkpoint	GO:0007093	88	0.013
regulation of mapk cascade	GO:0043408	92	0.013
regulation of phosphate metabolic process	GO:0019220	210	0.013
trna modification	GO:0006400	2	0.013
axon development	GO:0061564	297	0.013
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.013
posttranscriptional regulation of gene expression	GO:0010608	145	0.013
cellular protein catabolic process	GO:0044257	83	0.013	Mouse
regulation of catabolic process	GO:0009894	170	0.013	Mouse
regulation of mrna metabolic process	GO:1903311	72	0.013
multicellular organismal aging	GO:0010259	140	0.013
eye development	GO:0001654	323	0.012	Fly
dna conformation change	GO:0071103	105	0.012
adult behavior	GO:0030534	137	0.012
cell death	GO:0008219	279	0.012
multicellular organismal homeostasis	GO:0048871	41	0.012
organonitrogen compound metabolic process	GO:1901564	318	0.012
regulation of molecular function	GO:0065009	217	0.012
response to other organism	GO:0051707	293	0.012
response to organonitrogen compound	GO:0010243	75	0.012	Fly
memory	GO:0007613	94	0.012
eye morphogenesis	GO:0048592	260	0.012	Fly
protein acylation	GO:0043543	42	0.012
response to lipopolysaccharide	GO:0032496	4	0.012
negative regulation of developmental process	GO:0051093	201	0.012	Mouse
positive regulation of signaling	GO:0023056	243	0.012	Mouse
cellular amino acid metabolic process	GO:0006520	61	0.012
regulation of insulin secretion	GO:0050796	5	0.012	Mouse
regulation of sequence specific dna binding transcription factor activity	GO:0051090	12	0.012
phosphorylation	GO:0016310	294	0.012
developmental growth	GO:0048589	280	0.012
oocyte dorsal ventral axis specification	GO:0007310	34	0.012
regulation of cell cycle process	GO:0010564	181	0.012
cellular response to ionizing radiation	GO:0071479	15	0.012
detection of light stimulus	GO:0009583	58	0.012
regulation of catalytic activity	GO:0050790	185	0.012
regulation of response to stress	GO:0080134	200	0.012	Mouse
dopamine receptor signaling pathway	GO:0007212	4	0.012
chemotaxis	GO:0006935	249	0.012
regulation of embryonic development	GO:0045995	68	0.011
branching morphogenesis of an epithelial tube	GO:0048754	45	0.011
oocyte development	GO:0048599	124	0.011
female meiotic division	GO:0007143	70	0.011
chromosome segregation	GO:0007059	157	0.011
oocyte construction	GO:0007308	112	0.011
striated muscle myosin thick filament assembly	GO:0071688	3	0.011
mrna processing	GO:0006397	104	0.011
embryo development ending in birth or egg hatching	GO:0009792	152	0.011
respiratory system development	GO:0060541	213	0.011
positive regulation of signal transduction	GO:0009967	223	0.011	Mouse
negative regulation of mitotic cell cycle	GO:0045930	109	0.011
proteolysis	GO:0006508	192	0.011	Mouse
response to ionizing radiation	GO:0010212	32	0.011
immune response regulating signaling pathway	GO:0002764	2	0.011
spermatid differentiation	GO:0048515	114	0.011
regulation of response to external stimulus	GO:0032101	115	0.011
secretion by cell	GO:0032940	101	0.011	Mouse
negative regulation of multicellular organismal process	GO:0051241	142	0.011
protein dna complex assembly	GO:0065004	63	0.011
posttranscriptional gene silencing by rna	GO:0035194	45	0.010
dorsal ventral pattern formation	GO:0009953	133	0.010
regulation of immune response	GO:0050776	118	0.010
spinal cord development	GO:0021510	1	0.010
small gtpase mediated signal transduction	GO:0007264	88	0.010
regulation of heart contraction	GO:0008016	21	0.010
regulation of phosphorus metabolic process	GO:0051174	210	0.010
cellular response to chemical stimulus	GO:0070887	199	0.010	Mouse Fly

cyc disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	disease of anatomical entity	DOID:7	0	0.030
	nervous system disease	DOID:863	0	0.019

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