IMP: Integrative Multi-species Prediction

Drosophila melanogaster

161 known processes

Dcr-1 (Dmel_CG4792)

Dicer-1

(Aliases: dicer,dcr 1,Dicer1,Dmel\CG4792,DCR1,dcr1,dicer-1,CG4792,Dcr1,dicer1,Dicer,cg4792,DICER,dcr-1,Dcr)

Entrez: 42693
FLYBASE: FBgn0039016
UniProtKB: Q9VCU9

Process Predictions
Disease Predictions

Dcr-1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
germarium derived oocyte fate determination	GO:0007294	26	0.973
oocyte fate determination	GO:0030716	27	0.924
germarium derived oocyte differentiation	GO:0030706	29	0.904
germ line cyst formation	GO:0048134	44	0.883
cell fate determination	GO:0001709	91	0.809
axonogenesis	GO:0007409	290	0.769
axon development	GO:0061564	297	0.685
dendrite morphogenesis	GO:0048813	199	0.677
establishment of localization in cell	GO:0051649	402	0.623
negative regulation of response to stimulus	GO:0048585	258	0.614
negative regulation of signaling	GO:0023057	219	0.578
endocytosis	GO:0006897	310	0.574
negative regulation of rna biosynthetic process	GO:1902679	240	0.548	Mouse Fly
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.531	Mouse
regulation of protein metabolic process	GO:0051246	256	0.453	Mouse
regulation of cell development	GO:0060284	215	0.438	Mouse
female germ line cyst formation	GO:0048135	42	0.427
transcription from rna polymerase ii promoter	GO:0006366	368	0.377	Mouse
wing disc morphogenesis	GO:0007472	344	0.362
negative regulation of gene expression	GO:0010629	387	0.355
cellular response to organic substance	GO:0071310	132	0.344
taxis	GO:0042330	304	0.323
positive regulation of cellular protein metabolic process	GO:0032270	118	0.321
cellular response to chemical stimulus	GO:0070887	199	0.317
negative regulation of biosynthetic process	GO:0009890	277	0.316	Mouse Fly
germarium derived female germ line cyst formation	GO:0030727	42	0.298
dendrite development	GO:0016358	204	0.298
negative regulation of signal transduction	GO:0009968	206	0.296
intracellular signal transduction	GO:0035556	300	0.296
post embryonic appendage morphogenesis	GO:0035120	385	0.283
regulation of cellular response to stress	GO:0080135	89	0.281
negative regulation of cellular metabolic process	GO:0031324	382	0.274	Mouse Fly
neuron projection guidance	GO:0097485	241	0.271
production of mirnas involved in gene silencing by mirna	GO:0035196	10	0.269
regulation of localization	GO:0032879	275	0.262
immune system process	GO:0002376	347	0.247	Mouse Fly
synapse organization	GO:0050808	196	0.237
axon guidance	GO:0007411	233	0.227
chemotaxis	GO:0006935	249	0.222
single organism biosynthetic process	GO:0044711	206	0.222
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.222	Mouse Worm
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.210	Mouse Fly
circadian rhythm	GO:0007623	105	0.203
production of small rna involved in gene silencing by rna	GO:0070918	15	0.202
oocyte microtubule cytoskeleton organization	GO:0016325	35	0.194
regulation of cell death	GO:0010941	173	0.193	Mouse
regulation of multicellular organismal development	GO:2000026	414	0.192	Mouse
small gtpase mediated signal transduction	GO:0007264	88	0.189
regulation of response to stress	GO:0080134	200	0.188	Fly
muscle organ development	GO:0007517	127	0.184
positive regulation of molecular function	GO:0044093	136	0.179
positive regulation of rna metabolic process	GO:0051254	271	0.178	Mouse Worm
appendage morphogenesis	GO:0035107	397	0.177	Mouse
phosphorylation	GO:0016310	294	0.176	Mouse
regulation of anatomical structure size	GO:0090066	163	0.174
oocyte microtubule cytoskeleton polarization	GO:0008103	22	0.172
germarium derived egg chamber formation	GO:0007293	101	0.172
positive regulation of protein metabolic process	GO:0051247	128	0.170
negative regulation of cell communication	GO:0010648	223	0.168
negative regulation of wnt signaling pathway	GO:0030178	28	0.165
negative regulation of transcription dna templated	GO:0045892	237	0.161	Mouse Fly
appendage development	GO:0048736	401	0.161	Mouse
regulation of phosphate metabolic process	GO:0019220	210	0.161	Mouse
regulation of cell morphogenesis	GO:0022604	163	0.157
ribonucleoprotein complex biogenesis	GO:0022613	31	0.155
cell division	GO:0051301	248	0.150
organophosphate metabolic process	GO:0019637	195	0.149	Fly
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.145	Mouse
positive regulation of developmental growth	GO:0048639	62	0.143
response to organic substance	GO:0010033	284	0.142
chromosome localization	GO:0050000	20	0.141
ncrna processing	GO:0034470	30	0.135
regulation of programmed cell death	GO:0043067	152	0.133	Mouse
posttranscriptional regulation of gene expression	GO:0010608	145	0.132
gliogenesis	GO:0042063	80	0.130	Mouse
negative regulation of multicellular organismal process	GO:0051241	142	0.127	Mouse
cellular macromolecular complex assembly	GO:0034622	153	0.124
homeostatic process	GO:0042592	199	0.124
defense response to other organism	GO:0098542	225	0.122	Mouse Fly
response to nitrogen compound	GO:1901698	90	0.122
regulation of response to gamma radiation	GO:2001228	4	0.122
sister chromatid segregation	GO:0000819	92	0.121
regulation of developmental growth	GO:0048638	174	0.120
response to biotic stimulus	GO:0009607	294	0.120	Mouse Fly
negative regulation of cellular biosynthetic process	GO:0031327	277	0.119	Mouse Fly
posttranscriptional gene silencing	GO:0016441	46	0.116
gene silencing by mirna	GO:0035195	22	0.115
regulation of wnt signaling pathway	GO:0030111	68	0.114
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.112
regulation of neuron projection development	GO:0010975	69	0.106
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	54	0.106
organic cyclic compound catabolic process	GO:1901361	168	0.105	Worm Fly
regulation of cellular component biogenesis	GO:0044087	201	0.103
cell proliferation	GO:0008283	299	0.103
embryo development ending in birth or egg hatching	GO:0009792	152	0.100
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.099	Mouse Fly
posttranscriptional gene silencing by rna	GO:0035194	45	0.098
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.097	Mouse
developmental growth	GO:0048589	280	0.094	Mouse
organ growth	GO:0035265	56	0.094
regulation of cellular protein metabolic process	GO:0032268	243	0.093	Mouse
imaginal disc derived wing morphogenesis	GO:0007476	337	0.092
response to oxygen containing compound	GO:1901700	200	0.091
ncrna metabolic process	GO:0034660	43	0.090
organonitrogen compound metabolic process	GO:1901564	318	0.089	Fly
positive regulation of response to stimulus	GO:0048584	323	0.088	Worm
positive regulation of phosphate metabolic process	GO:0045937	139	0.085
wnt signaling pathway	GO:0016055	98	0.083
carbohydrate derivative metabolic process	GO:1901135	217	0.082	Fly
organic substance catabolic process	GO:1901575	308	0.082	Worm Fly
protein complex assembly	GO:0006461	200	0.081	Mouse
positive regulation of rna biosynthetic process	GO:1902680	266	0.080	Mouse
outflow tract morphogenesis	GO:0003151	4	0.078	Mouse
protein modification process	GO:0036211	438	0.077	Mouse
regulation of anatomical structure morphogenesis	GO:0022603	242	0.076	Mouse
response to organonitrogen compound	GO:0010243	75	0.076
nucleobase containing compound catabolic process	GO:0034655	165	0.076	Worm Fly
protein localization	GO:0008104	284	0.075
regulation of mitotic cell cycle	GO:0007346	190	0.075
positive regulation of growth	GO:0045927	75	0.075
nucleoside phosphate catabolic process	GO:1901292	110	0.074	Fly
positive regulation of cellular biosynthetic process	GO:0031328	316	0.074	Mouse
camera type eye morphogenesis	GO:0048593	2	0.074
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.074	Fly
biological adhesion	GO:0022610	138	0.072
positive regulation of wnt signaling pathway	GO:0030177	25	0.071
positive regulation of protein modification process	GO:0031401	58	0.069
blastoderm segmentation	GO:0007350	159	0.065
positive regulation of chromosome segregation	GO:0051984	10	0.065
regulation of mitosis	GO:0007088	56	0.064
regulation of cell morphogenesis involved in differentiation	GO:0010769	61	0.064
negative regulation of g1 s transition of mitotic cell cycle	GO:2000134	13	0.063
regulation of cell projection organization	GO:0031344	92	0.062
protein modification by small protein conjugation	GO:0032446	79	0.061
negative regulation of cell cycle g1 s phase transition	GO:1902807	13	0.061
regulation of neural precursor cell proliferation	GO:2000177	35	0.061
heterocycle catabolic process	GO:0046700	166	0.060	Worm Fly
regulation of kinase activity	GO:0043549	53	0.060
cellular response to nitrogen compound	GO:1901699	51	0.059
cardiovascular system development	GO:0072358	82	0.059	Mouse
regulation of cellular catabolic process	GO:0031329	157	0.057
response to external biotic stimulus	GO:0043207	293	0.056	Mouse Fly
nucleoside triphosphate metabolic process	GO:0009141	120	0.056	Fly
response to endogenous stimulus	GO:0009719	119	0.056
stem cell differentiation	GO:0048863	117	0.055	Mouse
tissue morphogenesis	GO:0048729	297	0.055	Mouse
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.054
imaginal disc derived leg morphogenesis	GO:0007480	80	0.054
imaginal disc derived appendage development	GO:0048737	399	0.054
positive regulation of biosynthetic process	GO:0009891	316	0.053	Mouse
cellular macromolecule localization	GO:0070727	220	0.052
positive regulation of transcription dna templated	GO:0045893	266	0.052	Mouse
cell cycle phase transition	GO:0044770	140	0.052
protein ubiquitination	GO:0016567	70	0.052
mushroom body development	GO:0016319	70	0.051
sex differentiation	GO:0007548	81	0.050	Worm
protein modification by small protein conjugation or removal	GO:0070647	106	0.050
mitotic sister chromatid segregation	GO:0000070	87	0.049
lamellipodium assembly	GO:0030032	21	0.049
response to wounding	GO:0009611	94	0.048	Mouse
gene silencing by rna	GO:0031047	57	0.047
cellular nitrogen compound catabolic process	GO:0044270	165	0.047	Worm Fly
peptidyl amino acid modification	GO:0018193	105	0.046
positive regulation of canonical wnt signaling pathway	GO:0090263	7	0.046
negative regulation of developmental process	GO:0051093	201	0.045	Mouse
catabolic process	GO:0009056	409	0.045	Worm Fly
regulation of intracellular signal transduction	GO:1902531	236	0.045
retinal ganglion cell axon guidance	GO:0031290	12	0.045
positive regulation of signal transduction	GO:0009967	223	0.044
development of primary sexual characteristics	GO:0045137	50	0.044	Worm
regulation of protein modification process	GO:0031399	112	0.044	Mouse
leg disc morphogenesis	GO:0007478	80	0.044
vesicle organization	GO:0016050	44	0.044
positive regulation of phosphorylation	GO:0042327	87	0.043
muscle structure development	GO:0061061	224	0.043	Mouse
adherens junction assembly	GO:0034333	11	0.043
regulation of transferase activity	GO:0051338	58	0.042
regulation of protein kinase activity	GO:0045859	51	0.042
sensory organ morphogenesis	GO:0090596	260	0.042
endosomal transport	GO:0016197	44	0.042
regulation of phosphorylation	GO:0042325	147	0.041	Mouse
regulation of metaphase anaphase transition of cell cycle	GO:1902099	26	0.041
purine ribonucleoside catabolic process	GO:0046130	112	0.041	Fly
regionalization	GO:0003002	416	0.041
response to extracellular stimulus	GO:0009991	116	0.040
circulatory system development	GO:0072359	82	0.040	Mouse
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.040
regulation of cellular localization	GO:0060341	136	0.039
regulation of cell differentiation	GO:0045595	302	0.038	Mouse
response to abiotic stimulus	GO:0009628	341	0.037
cell projection assembly	GO:0030031	94	0.037
positive regulation of cellular component organization	GO:0051130	156	0.036
morphogenesis of an epithelium	GO:0002009	276	0.036	Mouse
cell growth	GO:0016049	108	0.036
dna methylation or demethylation	GO:0044728	4	0.036
negative regulation of nervous system development	GO:0051961	92	0.035	Mouse
cellular protein modification process	GO:0006464	438	0.035	Mouse
regulation of gliogenesis	GO:0014013	11	0.035	Mouse
regulation of epidermal cell differentiation	GO:0045604	3	0.035
purine nucleotide metabolic process	GO:0006163	146	0.035	Fly
positive regulation of phosphorus metabolic process	GO:0010562	139	0.034
regulation of canonical wnt signaling pathway	GO:0060828	15	0.034
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.034	Mouse
positive regulation of intracellular signal transduction	GO:1902533	116	0.034
regulation of molecular function	GO:0065009	217	0.034
regulation of phosphorus metabolic process	GO:0051174	210	0.033	Mouse
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.033
positive regulation of gliogenesis	GO:0014015	5	0.033	Mouse
regulation of dendrite development	GO:0050773	37	0.033
regulation of cell shape	GO:0008360	113	0.032
eye morphogenesis	GO:0048592	260	0.032
eye photoreceptor cell differentiation	GO:0001754	145	0.032
purine nucleoside catabolic process	GO:0006152	112	0.032	Fly
larval development	GO:0002164	104	0.032	Worm
regulation of protein phosphorylation	GO:0001932	64	0.032	Mouse
regulation of stem cell proliferation	GO:0072091	40	0.032
nucleosome positioning	GO:0016584	3	0.031
cellular lipid metabolic process	GO:0044255	83	0.031
protein phosphorylation	GO:0006468	169	0.031	Mouse
rhythmic process	GO:0048511	106	0.031
camera type eye development	GO:0043010	4	0.031
secretion	GO:0046903	109	0.031
cell death	GO:0008219	279	0.031	Mouse Worm
positive regulation of signaling	GO:0023056	243	0.031
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.031	Mouse
establishment of rna localization	GO:0051236	47	0.030
stem cell proliferation	GO:0072089	88	0.030
reproductive system development	GO:0061458	74	0.030	Mouse Worm
defense response to bacterium	GO:0042742	178	0.030
ribonucleotide metabolic process	GO:0009259	145	0.030	Fly
regulation of nucleotide metabolic process	GO:0006140	62	0.030
wound healing	GO:0042060	75	0.029	Mouse
heart development	GO:0007507	82	0.029	Mouse
developmental maturation	GO:0021700	172	0.029
ribose phosphate metabolic process	GO:0019693	145	0.029	Fly
regulation of purine nucleotide metabolic process	GO:1900542	62	0.029
organic substance transport	GO:0071702	257	0.029
cellular response to dsrna	GO:0071359	15	0.029
negative regulation of neurogenesis	GO:0050768	53	0.028	Mouse
cellular amine metabolic process	GO:0044106	12	0.028
cellular response to endogenous stimulus	GO:0071495	80	0.028
purine nucleoside metabolic process	GO:0042278	127	0.028	Fly
vesicle mediated transport	GO:0016192	381	0.028
gene silencing	GO:0016458	138	0.028
ubiquitin dependent protein catabolic process	GO:0006511	78	0.028
regulation of growth	GO:0040008	233	0.028
positive regulation of cell communication	GO:0010647	250	0.027
positive regulation of cell cycle	GO:0045787	43	0.027
ras protein signal transduction	GO:0007265	88	0.026
single organism catabolic process	GO:0044712	228	0.026	Fly
cuticle development	GO:0042335	86	0.026
negative regulation of apoptotic process	GO:0043066	63	0.026
multicellular organismal reproductive behavior	GO:0033057	110	0.026	Worm
rna processing	GO:0006396	147	0.026
negative regulation of developmental growth	GO:0048640	64	0.025
regulation of system process	GO:0044057	36	0.025	Mouse
purine nucleotide catabolic process	GO:0006195	109	0.025	Fly
molting cycle chitin based cuticle	GO:0007591	56	0.025
apoptotic process	GO:0006915	159	0.025	Mouse Worm
hematopoietic or lymphoid organ development	GO:0048534	57	0.024	Mouse
signal transduction by phosphorylation	GO:0023014	107	0.024
regulation of cellular component size	GO:0032535	98	0.024
positive regulation of cell cycle process	GO:0090068	28	0.024
negative regulation of cell cycle phase transition	GO:1901988	103	0.024
growth	GO:0040007	359	0.024	Mouse
glial cell differentiation	GO:0010001	35	0.023	Mouse
defense response	GO:0006952	300	0.023	Mouse Worm Fly
ribonucleoprotein complex subunit organization	GO:0071826	28	0.023
retina development in camera type eye	GO:0060041	4	0.023
negative regulation of gene expression epigenetic	GO:0045814	77	0.023	Fly
aromatic compound catabolic process	GO:0019439	166	0.023	Worm Fly
positive regulation of rho gtpase activity	GO:0032321	19	0.023
regulation of cell growth	GO:0001558	43	0.023
regulation of cell size	GO:0008361	63	0.022
modification dependent macromolecule catabolic process	GO:0043632	79	0.022
regulation of catalytic activity	GO:0050790	185	0.022
immune response	GO:0006955	246	0.022
cellular catabolic process	GO:0044248	372	0.022	Worm Fly
actin filament organization	GO:0007015	126	0.022
response to other organism	GO:0051707	293	0.022	Mouse Fly
multi multicellular organism process	GO:0044706	123	0.022	Worm
regulation of cell cycle phase transition	GO:1901987	130	0.021
regulation of cellular amino acid metabolic process	GO:0006521	0	0.021
positive regulation of nucleotide catabolic process	GO:0030813	46	0.021
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.021	Fly
positive regulation of developmental process	GO:0051094	143	0.021	Mouse
dna methylation	GO:0006306	4	0.021
protein complex biogenesis	GO:0070271	201	0.021	Mouse
regulation of protein stability	GO:0031647	43	0.020
phagocytosis	GO:0006909	215	0.020
regulation of ras protein signal transduction	GO:0046578	93	0.020
macromolecule catabolic process	GO:0009057	161	0.020	Worm
embryonic pattern specification	GO:0009880	174	0.020
cystoblast division	GO:0007282	10	0.020
regulation of epithelial cell proliferation	GO:0050678	4	0.020
positive regulation of metaphase anaphase transition of cell cycle	GO:1902101	10	0.020
regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032434	37	0.019
nucleotide metabolic process	GO:0009117	161	0.019	Fly
specification of symmetry	GO:0009799	13	0.019
forebrain development	GO:0030900	2	0.019	Mouse
positive regulation of cell development	GO:0010720	61	0.019	Mouse
regulation of catabolic process	GO:0009894	170	0.019
regulation of mitotic sister chromatid segregation	GO:0033047	28	0.019
positive regulation of nervous system development	GO:0051962	69	0.019	Mouse
chromosome separation	GO:0051304	42	0.019
response to dsrna	GO:0043331	15	0.019
regulation of cellular response to insulin stimulus	GO:1900076	17	0.019
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.019	Mouse Fly
positive regulation of nucleotide metabolic process	GO:0045981	55	0.019
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.019
gonad development	GO:0008406	50	0.019	Worm
cell cycle g1 s phase transition	GO:0044843	31	0.019
positive regulation of purine nucleotide metabolic process	GO:1900544	55	0.018
body morphogenesis	GO:0010171	2	0.018
molting cycle	GO:0042303	56	0.018	Mouse
connective tissue development	GO:0061448	3	0.018	Mouse
multicellular organismal aging	GO:0010259	140	0.018
cellular amino acid metabolic process	GO:0006520	61	0.018
positive regulation of protein phosphorylation	GO:0001934	34	0.018
retina morphogenesis in camera type eye	GO:0060042	2	0.018
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.018	Fly
neuroblast proliferation	GO:0007405	74	0.018
mitotic cell cycle phase transition	GO:0044772	138	0.018
respiratory system development	GO:0060541	213	0.018	Mouse
tube development	GO:0035295	244	0.017	Mouse
rna phosphodiester bond hydrolysis	GO:0090501	17	0.017
oocyte development	GO:0048599	124	0.017
modification dependent protein catabolic process	GO:0019941	78	0.017
purine containing compound metabolic process	GO:0072521	155	0.017	Fly
positive regulation of transport	GO:0051050	92	0.017
small molecule metabolic process	GO:0044281	305	0.017	Fly
stem cell maintenance	GO:0019827	67	0.017	Mouse
negative regulation of response to gamma radiation	GO:2001229	4	0.017
canonical wnt signaling pathway	GO:0060070	21	0.017
response to ionizing radiation	GO:0010212	32	0.017
embryonic morphogenesis	GO:0048598	206	0.017	Mouse
cellular macromolecule catabolic process	GO:0044265	136	0.017	Worm
embryonic organ development	GO:0048568	50	0.017
regulation of cell cycle g1 s phase transition	GO:1902806	23	0.017
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.017	Fly
regulation of transport	GO:0051049	181	0.017
positive regulation of cellular amine metabolic process	GO:0033240	0	0.017
actin cytoskeleton organization	GO:0030036	206	0.016
regulation of dendrite morphogenesis	GO:0048814	28	0.016
pole cell development	GO:0007277	26	0.016
carboxylic acid metabolic process	GO:0019752	92	0.016
negative regulation of cellular component organization	GO:0051129	108	0.016
cellular response to dna damage stimulus	GO:0006974	223	0.016
regulation of cellular ketone metabolic process	GO:0010565	3	0.016
epidermal cell differentiation	GO:0009913	51	0.016
neural precursor cell proliferation	GO:0061351	75	0.016
negative regulation of programmed cell death	GO:0043069	72	0.016
stem cell division	GO:0017145	69	0.016
hindbrain development	GO:0030902	2	0.016
proteasomal protein catabolic process	GO:0010498	59	0.016
pharynx development	GO:0060465	1	0.016
positive regulation of kinase activity	GO:0033674	25	0.016
histone ubiquitination	GO:0016574	4	0.016
cell aging	GO:0007569	2	0.016
regulation of cell proliferation	GO:0042127	163	0.016	Mouse
anterior posterior pattern specification	GO:0009952	136	0.016
cellular response to peptide	GO:1901653	28	0.015
single organism behavior	GO:0044708	391	0.015	Worm
cellular response to organic cyclic compound	GO:0071407	32	0.015
primary mirna processing	GO:0031053	5	0.015	Worm
positive regulation of mitotic sister chromatid separation	GO:1901970	10	0.015
compound eye photoreceptor cell differentiation	GO:0001751	140	0.015
determination of bilateral symmetry	GO:0009855	13	0.015
cell adhesion	GO:0007155	136	0.015
nucleoside triphosphate catabolic process	GO:0009143	108	0.015	Fly
regulation of translation	GO:0006417	56	0.015
mitotic sister chromatid cohesion	GO:0007064	6	0.015
regulation of gene expression epigenetic	GO:0040029	128	0.015
anatomical structure homeostasis	GO:0060249	97	0.015
pigmentation	GO:0043473	75	0.015
negative regulation of cell death	GO:0060548	81	0.015
positive regulation of cellular catabolic process	GO:0031331	95	0.015
negative regulation of dendrite morphogenesis	GO:0050774	2	0.014
eye photoreceptor cell development	GO:0042462	81	0.014
regulation of epithelial cell differentiation	GO:0030856	4	0.014
nucleoside phosphate metabolic process	GO:0006753	162	0.014	Fly
positive regulation of cell death	GO:0010942	69	0.014
asymmetric protein localization	GO:0008105	33	0.014
protein catabolic process	GO:0030163	101	0.014
negative regulation of protein metabolic process	GO:0051248	85	0.014
cellular protein catabolic process	GO:0044257	83	0.014
positive regulation of multicellular organismal process	GO:0051240	143	0.014	Mouse
positive regulation of ras gtpase activity	GO:0032320	36	0.014
positive regulation of catabolic process	GO:0009896	105	0.014
compound eye development	GO:0048749	307	0.014
cell substrate adhesion	GO:0031589	10	0.014
regulation of axonogenesis	GO:0050770	32	0.014
regulation of nervous system development	GO:0051960	248	0.014	Mouse
jak stat cascade	GO:0007259	49	0.014
positive regulation of cellular component biogenesis	GO:0044089	80	0.013
mitotic nuclear division	GO:0007067	213	0.013
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.013
metaphase anaphase transition of mitotic cell cycle	GO:0007091	28	0.013
neuron remodeling	GO:0016322	29	0.013
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.013	Fly
regulation of ras gtpase activity	GO:0032318	38	0.013
purine ribonucleotide catabolic process	GO:0009154	109	0.013	Fly
regulation of neuroblast proliferation	GO:1902692	34	0.013
macromolecular complex assembly	GO:0065003	256	0.013
regulation of cell substrate adhesion	GO:0010810	2	0.013
learning or memory	GO:0007611	141	0.013	Worm
digestive tract development	GO:0048565	149	0.013	Mouse
response to peptide	GO:1901652	29	0.013
oocyte differentiation	GO:0009994	145	0.013
chromosome organization	GO:0051276	360	0.013	Fly
negative regulation of phosphatidylinositol 3 kinase signaling	GO:0014067	4	0.013
eye development	GO:0001654	323	0.012
regulation of dna templated transcription elongation	GO:0032784	17	0.012
regulation of apoptotic process	GO:0042981	130	0.012	Mouse
larval midgut histolysis	GO:0035069	22	0.012
positive regulation of gtp catabolic process	GO:0033126	43	0.012
activation of jun kinase activity	GO:0007257	3	0.012
regulation of neurogenesis	GO:0050767	158	0.012	Mouse
transcription elongation from rna polymerase ii promoter	GO:0006368	18	0.012
positive regulation of organelle organization	GO:0010638	65	0.012
ribonucleotide catabolic process	GO:0009261	109	0.012	Fly
dendrite guidance	GO:0070983	21	0.012
photoreceptor cell differentiation	GO:0046530	170	0.012
stem cell development	GO:0048864	79	0.012	Mouse
regulation of nucleoside metabolic process	GO:0009118	50	0.012
limb morphogenesis	GO:0035108	1	0.012	Mouse
negative regulation of cell proliferation	GO:0008285	69	0.011	Mouse
g1 s transition of mitotic cell cycle	GO:0000082	31	0.011
regulation of cell cycle process	GO:0010564	181	0.011
positive regulation of macromolecule metabolic process	GO:0010604	405	0.011	Mouse Worm
cellular response to oxygen containing compound	GO:1901701	79	0.011
regulation of organelle organization	GO:0033043	196	0.011
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.011
regulation of cellular response to hypoxia	GO:1900037	3	0.011
purine ribonucleotide metabolic process	GO:0009150	145	0.011	Fly
rna splicing	GO:0008380	83	0.011
dna alkylation	GO:0006305	4	0.011
establishment of epithelial cell apical basal polarity	GO:0045198	10	0.011
regulation of mitotic sister chromatid separation	GO:0010965	28	0.011
regulation of protein complex assembly	GO:0043254	42	0.011
intracellular transport	GO:0046907	228	0.011
protein transport	GO:0015031	155	0.011
dsrna fragmentation	GO:0031050	15	0.011
organophosphate biosynthetic process	GO:0090407	46	0.011
ribonucleoprotein complex assembly	GO:0022618	23	0.010
oxoacid metabolic process	GO:0043436	103	0.010
metaphase anaphase transition of cell cycle	GO:0044784	28	0.010
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.010
mesoderm development	GO:0007498	78	0.010
pole plasm mrna localization	GO:0019094	49	0.010
gtp metabolic process	GO:0046039	72	0.010
regulation of protein serine threonine kinase activity	GO:0071900	25	0.010
chaeta development	GO:0022416	97	0.010
regulation of hydrolase activity	GO:0051336	97	0.010
dna templated transcription elongation	GO:0006354	18	0.010
neurological system process	GO:0050877	358	0.010	Mouse Worm
regulation of hippo signaling	GO:0035330	14	0.010
regulation of multi organism process	GO:0043900	131	0.010	Mouse Fly

Dcr-1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	disease of cellular proliferation	DOID:14566	0	0.021	Human
	cancer	DOID:162	0	0.013	Human

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