Drosophila melanogaster

85 known processes

Npc1a (Dmel_CG5722)

Niemann-Pick type C-1a

(Aliases: DmNPC,dmNPC1,NPC1a,dnpc1a,NPC1,CG5722,dNPC1a,Npc1,Npc1_Dm,npc1,dNPC1,npc1a,Dmel\CG5722,dncp1a)

Npc1a biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
male gamete generationGO:00482322010.922
establishment of localization in cellGO:00516494020.905
Mouse
spermatogenesisGO:00072832000.892
metal ion homeostasisGO:0055065440.858
cellularizationGO:0007349900.839
cation homeostasisGO:0055080510.816
cation transportGO:00068121100.796
taxisGO:00423303040.756
intracellular transportGO:00469072280.728
Mouse
spermatid differentiationGO:00485151140.720
protein complex assemblyGO:00064612000.620
chemical homeostasisGO:0048878920.616
Human Mouse Worm
ion homeostasisGO:0050801550.594
morphogenesis of an epitheliumGO:00020092760.559
sperm individualizationGO:0007291480.558
cellular macromolecule localizationGO:00707272200.544
Human
spermatid developmentGO:0007286980.535
axon developmentGO:00615642970.507
cation transmembrane transportGO:0098655880.503
organonitrogen compound metabolic processGO:19015643180.470
regulation of multicellular organismal developmentGO:20000264140.463
cellular protein modification processGO:00064644380.426
Human Mouse
steroid biosynthetic processGO:0006694160.416
regulation of cellular protein metabolic processGO:00322682430.405
ion transportGO:00068111450.399
developmental growthGO:00485892800.398
protein complex biogenesisGO:00702712010.393
cell maturationGO:00484691440.367
sensory perception of mechanical stimulusGO:0050954720.367
epithelial cell differentiationGO:00308553220.356
single organism membrane organizationGO:0044802930.336
Human
agingGO:00075681430.332
metal ion transportGO:0030001740.327
endomembrane system organizationGO:00102561190.316
regulation of localizationGO:00328792750.315
regulation of microtubule cytoskeleton organizationGO:0070507410.308
homeostatic processGO:00425921990.302
Human Mouse Worm
regulation of microtubule based processGO:0032886490.295
mitotic g2 dna damage checkpointGO:0007095690.292
growthGO:00400073590.285
Worm
protein modification processGO:00362114380.261
Human Mouse
regulation of synapse structure and activityGO:00508031280.257
positive regulation of response to stimulusGO:00485843230.256
ion transmembrane transportGO:00342201220.249
central nervous system developmentGO:00074172010.248
defense responseGO:00069523000.244
peptidyl amino acid modificationGO:00181931050.238
cellular response to chemical stimulusGO:00708871990.235
Mouse
protein localizationGO:00081042840.219
Human
open tracheal system developmentGO:00074242040.208
lateral inhibitionGO:00463312060.203
locomotory behaviorGO:00076261760.195
Mouse
negative regulation of cell cycle phase transitionGO:19019881030.195
regulation of cellular component biogenesisGO:00440872010.193
microtubule organizing center organizationGO:00310231680.193
cellular protein localizationGO:00346131600.190
Human
detection of stimulusGO:00516061560.187
respiratory system developmentGO:00605412130.185
germarium derived egg chamber formationGO:00072931010.185
positive regulation of signalingGO:00230562430.184
establishment of organelle localizationGO:00516561220.181
response to abiotic stimulusGO:00096283410.178
axonogenesisGO:00074092900.176
single organism intracellular transportGO:19025822070.173
Mouse
anterior posterior axis specificationGO:00099481090.170
axon guidanceGO:00074112330.168
ribonucleotide metabolic processGO:00092591450.166
cell cycle checkpointGO:0000075950.163
endocytosisGO:00068973100.162
Mouse
developmental maturationGO:00217001720.160
macromolecular complex assemblyGO:00650032560.160
chemotaxisGO:00069352490.159
cell migrationGO:00164772380.158
membrane organizationGO:00610241120.157
Human
embryonic morphogenesisGO:00485982060.157
immune system processGO:00023763470.155
purine nucleoside triphosphate metabolic processGO:00091441190.152
regulation of transportGO:00510491810.151
protein localization to organelleGO:0033365820.149
lipid localizationGO:0010876540.149
segmentationGO:00352822070.146
epithelial cell migrationGO:00106311480.145
protein catabolic processGO:00301631010.145
developmental growth involved in morphogenesisGO:0060560650.144
sensory perceptionGO:00076001960.140
cellular ion homeostasisGO:0006873390.136
regulation of secretion by cellGO:1903530390.135
positive regulation of cellular component organizationGO:00511301560.133
regulation of endopeptidase activityGO:0052548360.130
regulation of cell deathGO:00109411730.130
tissue morphogenesisGO:00487292970.128
protein maturationGO:0051604710.127
synaptic transmissionGO:00072682880.126
secretionGO:00469031090.126
macromolecule catabolic processGO:00090571610.125
circulatory system developmentGO:0072359820.121
lipid metabolic processGO:00066291210.119
negative regulation of nervous system developmentGO:0051961920.119
cellular cation homeostasisGO:0030003380.116
small molecule metabolic processGO:00442813050.115
centrosome organizationGO:00512971630.111
cell deathGO:00082192790.111
regionalizationGO:00030024160.109
organelle localizationGO:00516401480.109
regulation of synapse organizationGO:00508071100.109
neurological system processGO:00508773580.107
organophosphate metabolic processGO:00196371950.107
golgi organizationGO:0007030660.103
g2 dna damage checkpointGO:0031572690.102
mitotic g2 m transition checkpointGO:0044818700.098
sensory perception of chemical stimulusGO:00076061160.098
protein transportGO:00150311550.098
cellular hormone metabolic processGO:0034754230.097
negative regulation of mitotic cell cycle phase transitionGO:19019911030.094
establishment or maintenance of apical basal cell polarityGO:0035088340.094
regulation of cysteine type endopeptidase activityGO:2000116270.092
purine containing compound metabolic processGO:00725211550.092
multicellular organismal agingGO:00102591400.090
neuron projection guidanceGO:00974852410.090
protein localization to nucleusGO:0034504550.088
anatomical structure homeostasisGO:0060249970.085
organic substance transportGO:00717022570.083
single organism cellular localizationGO:19025801800.083
Human
positive regulation of catalytic activityGO:00430851180.083
response to woundingGO:0009611940.081
microtubule based movementGO:0007018510.081
defense response to other organismGO:00985422250.079
establishment or maintenance of cell polarityGO:00071631670.078
regulation of molecular functionGO:00650092170.078
regulation of protein transportGO:0051223570.077
catabolic processGO:00090564090.076
Human Mouse
positive regulation of protein metabolic processGO:00512471280.074
immune responseGO:00069552460.072
lipid biosynthetic processGO:0008610460.072
purine ribonucleoside metabolic processGO:00461281270.072
inorganic ion transmembrane transportGO:0098660730.071
purine nucleotide metabolic processGO:00061631460.070
steroid metabolic processGO:0008202200.069
glycosyl compound metabolic processGO:19016571270.069
body morphogenesisGO:001017120.069
mitotic dna damage checkpointGO:0044773740.068
deathGO:00162652840.068
negative regulation of cellular metabolic processGO:00313243820.067
Mouse
positive regulation of cellular protein metabolic processGO:00322701180.066
positive regulation of cell communicationGO:00106472500.065
cellular catabolic processGO:00442483720.064
Human Mouse
epithelium migrationGO:00901321480.064
organic cyclic compound catabolic processGO:19013611680.063
regulation of synapse assemblyGO:0051963940.063
regulation of cell differentiationGO:00455953020.062
cell junction organizationGO:0034330570.062
regulation of proteolysisGO:0030162870.062
regulation of cell cycleGO:00517262910.062
cytoplasmic transportGO:00164821300.062
retina development in camera type eyeGO:006004140.062
maintenance of locationGO:0051235730.061
regulation of nervous system developmentGO:00519602480.061
spindle organizationGO:00070512530.060
dendrite developmentGO:00163582040.059
negative regulation of mitotic cell cycleGO:00459301090.058
regulation of cellular localizationGO:00603411360.058
tissue migrationGO:00901301550.057
positive regulation of hydrolase activityGO:0051345780.057
organic acid metabolic processGO:00060821030.056
Mouse
regulation of programmed cell deathGO:00430671520.056
programmed cell deathGO:00125012570.055
organic substance catabolic processGO:19015753080.055
regulation of intracellular transportGO:0032386640.055
negative regulation of multicellular organismal processGO:00512411420.054
tube developmentGO:00352952440.054
determination of adult lifespanGO:00083401370.054
oocyte differentiationGO:00099941450.053
response to radiationGO:00093141550.052
carbohydrate derivative metabolic processGO:19011352170.051
Human Mouse
asymmetric protein localizationGO:0008105330.051
regulation of apoptotic processGO:00429811300.051
ameboidal type cell migrationGO:00016671510.051
axis specificationGO:00097981670.051
embryonic development via the syncytial blastodermGO:00017001480.050
embryonic pattern specificationGO:00098801740.050
cellular homeostasisGO:0019725800.050
intracellular protein transportGO:00068861040.050
positive regulation of molecular functionGO:00440931360.050
cytoplasm organizationGO:0007028640.049
positive regulation of apoptotic signaling pathwayGO:200123540.049
peptidyl tyrosine phosphorylationGO:0018108240.048
positive regulation of signal transductionGO:00099672230.047
protein processingGO:0016485680.047
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043281250.047
dendrite morphogenesisGO:00488131990.047
positive regulation of programmed cell deathGO:0043068620.047
regulation of catalytic activityGO:00507901850.046
regulation of hormone levelsGO:0010817400.046
blastoderm segmentationGO:00073501590.046
cellular macromolecular complex assemblyGO:00346221530.046
protein targeting to nucleusGO:0044744510.045
establishment of protein localizationGO:00451841630.045
Human
organic hydroxy compound metabolic processGO:1901615830.045
sleepGO:0030431490.045
regulation of phosphate metabolic processGO:00192202100.045
forebrain developmentGO:003090020.044
lipid storageGO:0019915380.044
nucleoside triphosphate metabolic processGO:00091411200.044
negative regulation of growthGO:0045926840.043
negative regulation of synaptic growth at neuromuscular junctionGO:0045886390.043
cellular amine metabolic processGO:0044106120.043
proteolysisGO:00065081920.043
regulation of secretionGO:0051046440.042
epithelial cell developmentGO:00020642740.042
circadian rhythmGO:00076231050.042
regulation of growthGO:00400082330.042
Worm
mitotic cell cycle checkpointGO:0007093880.041
cellular ketone metabolic processGO:0042180240.041
glycosyl compound catabolic processGO:19016581120.041
cellular metal ion homeostasisGO:0006875310.040
nucleoside phosphate catabolic processGO:19012921100.040
neuromuscular junction developmentGO:00075281490.040
regulation of intracellular signal transductionGO:19025312360.040
regulation of organelle organizationGO:00330431960.040
tube morphogenesisGO:00352391910.039
regulation of protein metabolic processGO:00512462560.039
eye developmentGO:00016543230.038
imaginal disc derived appendage developmentGO:00487373990.038
cell cycle phase transitionGO:00447701400.038
inorganic cation transmembrane transportGO:0098662610.038
cellular response to dna damage stimulusGO:00069742230.038
cell motilityGO:00488702510.037
regulation of cell developmentGO:00602842150.037
single organism nuclear importGO:1902593510.037
head developmentGO:00603221350.036
positive regulation of cell deathGO:0010942690.036
regulation of protein localizationGO:0032880760.035
nuclear importGO:0051170510.035
purine nucleotide catabolic processGO:00061951090.035
pigmentationGO:0043473750.034
cell proliferationGO:00082832990.034
detection of chemical stimulusGO:0009593930.034
cell growthGO:00160491080.034
terminal branching open tracheal systemGO:0007430170.034
branching involved in open tracheal system developmentGO:0060446450.033
activation of cysteine type endopeptidase activityGO:0097202170.033
negative regulation of synapse assemblyGO:0051964390.033
regulation of endocytosisGO:0030100370.033
dna integrity checkpointGO:0031570810.033
amine metabolic processGO:0009308120.032
protein targetingGO:0006605640.032
regulation of cell cycle phase transitionGO:19019871300.032
nucleoside phosphate metabolic processGO:00067531620.032
regulation of mitotic cell cycleGO:00073461900.032
chromatin silencingGO:0006342760.032
transmembrane transportGO:00550851390.032
brain developmentGO:00074201200.032
germarium derived female germ line cyst formationGO:0030727420.031
histolysisGO:00075591020.031
regulation of protein depolymerizationGO:1901879270.031
chaeta developmentGO:0022416970.031
lipid homeostasisGO:0055088330.031
Human Mouse Worm
intracellular mrna localizationGO:0008298660.030
negative regulation of cellular component organizationGO:00511291080.030
aromatic compound catabolic processGO:00194391660.030
mitochondrial fissionGO:000026680.030
cellular component assembly involved in morphogenesisGO:00109271510.030
urogenital system developmentGO:0001655720.030
response to nutrient levelsGO:00316671140.029
Mouse
regulation of cytoskeleton organizationGO:0051493890.029
cell recognitionGO:00080371020.029
regulation of mitotic cell cycle phase transitionGO:19019901300.029
nucleus localizationGO:0051647340.029
cellular lipid metabolic processGO:0044255830.029
protein import into nucleusGO:0006606510.029
cardiovascular system developmentGO:0072358820.028
regulation of vesicle mediated transportGO:0060627590.028
localization of cellGO:00516742570.028
regulation of microtubule polymerization or depolymerizationGO:0031110270.028
regulation of cell cycle processGO:00105641810.028
regulation of hydrolase activityGO:0051336970.028
regulation of cytoplasmic transportGO:1903649470.027
cellular amino acid metabolic processGO:0006520610.027
protein secretionGO:0009306450.027
maintenance of protein locationGO:0045185280.027
purine ribonucleoside triphosphate metabolic processGO:00092051190.027
regulation of hemocyte proliferationGO:0035206370.027
nucleotide metabolic processGO:00091171610.027
eye morphogenesisGO:00485922600.027
post embryonic appendage morphogenesisGO:00351203850.027
maintenance of protein location in cellGO:0032507260.027
positive regulation of macromolecule metabolic processGO:00106044050.026
camera type eye developmentGO:004301040.026
purine nucleoside catabolic processGO:00061521120.026
neuron maturationGO:0042551310.026
calcium ion transportGO:0006816240.026
negative regulation of cellular macromolecule biosynthetic processGO:20001132670.026
regulation of establishment of protein localizationGO:0070201610.026
negative regulation of cell cycle processGO:00109481090.026
response to bacteriumGO:00096171980.026
posttranscriptional regulation of gene expressionGO:00106081450.026
response to organic substanceGO:00100332840.025
Mouse
gland developmentGO:00487321910.025
regulation of intracellular protein transportGO:0033157460.025
negative regulation of developmental processGO:00510932010.025
positive regulation of cellular component biogenesisGO:0044089800.025
protein phosphorylationGO:00064681690.024
intracellular signal transductionGO:00355563000.024
synaptic growth at neuromuscular junctionGO:00511241190.024
regulation of embryonic developmentGO:0045995680.024
positive regulation of apoptotic processGO:0043065470.024
protein heterooligomerizationGO:005129140.024
positive regulation of macromolecule biosynthetic processGO:00105572830.024
regulation of anatomical structure sizeGO:00900661630.024
larval developmentGO:00021641040.024
Worm
positive regulation of nucleobase containing compound metabolic processGO:00459353320.024
telencephalon developmentGO:002153720.023
epithelial tube morphogenesisGO:0060562880.023
oocyte axis specificationGO:00073091080.023
regulation of protein complex disassemblyGO:0043244290.022
cognitionGO:00508901410.022
secretion by cellGO:00329401010.022
immune system developmentGO:0002520570.022
rhythmic behaviorGO:0007622760.022
phototaxisGO:0042331210.021
tissue deathGO:00162711020.021
response to biotic stimulusGO:00096072940.021
actin filament based movementGO:0030048260.021
response to external biotic stimulusGO:00432072930.021
endocytic recyclingGO:0032456130.021
negative regulation of gene expressionGO:00106293870.021
oocyte developmentGO:00485991240.021
embryo development ending in birth or egg hatchingGO:00097921520.020
Worm
protein importGO:0017038550.020
regulation of phosphorus metabolic processGO:00511742100.020
purine nucleoside triphosphate catabolic processGO:00091461080.020
imaginal disc derived appendage morphogenesisGO:00351143950.019
detection of light stimulusGO:0009583580.019
hormone biosynthetic processGO:0042446200.019
organonitrogen compound catabolic processGO:19015651280.019
gastrulationGO:0007369700.019
nitrogen compound transportGO:0071705850.019
cellular amide metabolic processGO:0043603800.019
cellular pigmentationGO:0033059120.019
positive regulation of proteolysisGO:0045862520.019
ribose phosphate metabolic processGO:00196931450.019
ribonucleoside catabolic processGO:00424541120.019
myofibril assemblyGO:0030239360.018
regulation of cellular catabolic processGO:00313291570.018
Mouse
regulation of peptidase activityGO:0052547390.018
negative regulation of sequence specific dna binding transcription factor activityGO:004343340.018
regulation of reproductive processGO:2000241540.018
Worm
chromosome organizationGO:00512763600.018
cellular protein complex assemblyGO:0043623710.018
purine containing compound catabolic processGO:00725231120.018
regulation of cellular amino acid metabolic processGO:000652100.018
exocrine system developmentGO:00352721620.018
multicellular organism growthGO:0035264460.018
ribonucleoside metabolic processGO:00091191270.017
regulation of cellular ketone metabolic processGO:001056530.017
vesicle mediated transportGO:00161923810.017
Mouse
developmental programmed cell deathGO:00106231380.017
ribonucleotide catabolic processGO:00092611090.017
regulation of protein import into nucleusGO:0042306280.017
gtp catabolic processGO:0006184720.017
positive regulation of phosphate metabolic processGO:00459371390.017
regulation of actin filament lengthGO:0030832270.017
microtubule depolymerizationGO:0007019250.017
mitotic spindle organizationGO:00070522200.017
carboxylic acid metabolic processGO:0019752920.017
Mouse
oxoacid metabolic processGO:00434361030.017
Mouse
response to decreased oxygen levelsGO:0036293580.016
developmental pigmentationGO:0048066680.016
steroid catabolic processGO:000670610.016
regulation of cell adhesionGO:0030155270.016
regulation of circadian sleep wake cycleGO:0042749250.016
salivary gland cell autophagic cell deathGO:0035071830.016
chromatin organizationGO:00063252070.016
regulation of mitochondrial fissionGO:009014070.016
sarcomere organizationGO:0045214260.016
divalent inorganic cation homeostasisGO:0072507290.016
ribonucleoside triphosphate metabolic processGO:00091991190.016
morphogenesis of a branching structureGO:0001763450.016
molting cycle chitin based cuticleGO:0007591560.015
tripartite regional subdivisionGO:00073511030.015
syncytium formationGO:0006949430.015
cell cell signaling involved in cell fate commitmentGO:00451682100.015
regulation of cellular amine metabolic processGO:003323830.015
purine ribonucleotide metabolic processGO:00091501450.015
immune effector processGO:0002252980.015
morphogenesis of embryonic epitheliumGO:0016331940.015
transition metal ion homeostasisGO:0055076170.015
columnar cuboidal epithelial cell developmentGO:00020662490.014
positive regulation of organelle organizationGO:0010638650.014
positive regulation of phosphorus metabolic processGO:00105621390.014
hemopoiesisGO:0030097460.014
regulation of body fluid levelsGO:0050878140.014
hatchingGO:003518840.014
regulation of translationGO:0006417560.014
hormone metabolic processGO:0042445330.014
regulation of synaptic transmissionGO:0050804690.014
regulation of ion transportGO:0043269390.014
positive regulation of multicellular organismal processGO:00512401430.014
positive regulation of transportGO:0051050920.013
embryonic axis specificationGO:00005781070.013
monovalent inorganic cation transportGO:0015672400.013
phosphorylationGO:00163102940.013
guanosine containing compound metabolic processGO:1901068740.013
intracellular mrna localization involved in pattern specification processGO:0060810560.013
detection of stimulus involved in sensory perceptionGO:0050906920.013
nucleoside metabolic processGO:00091161270.013
imaginal disc derived wing morphogenesisGO:00074763370.013
mitotic dna integrity checkpointGO:0044774750.013
regulation of anatomical structure morphogenesisGO:00226032420.013
eye pigmentationGO:0048069430.013
maintenance of location in cellGO:0051651280.012
nucleobase containing small molecule metabolic processGO:00550861740.012
cellular macromolecule catabolic processGO:00442651360.012
neuron deathGO:0070997270.012
single organism behaviorGO:00447083910.012
Mouse
camera type eye morphogenesisGO:004859320.012
mitochondrion organizationGO:0007005650.012
regulation of synaptic growth at neuromuscular junctionGO:0008582890.012
gene silencingGO:00164581380.012
reproductive system developmentGO:0061458740.012
connective tissue developmentGO:006144830.012
anterior posterior pattern specificationGO:00099521360.012
regulation of chromosome organizationGO:0033044640.012
response to inorganic substanceGO:0010035440.012
establishment of nucleus localizationGO:0040023260.012
negative regulation of programmed cell deathGO:0043069720.012
negative regulation of cell cycleGO:00457861160.012
cgmp biosynthetic processGO:000618280.012
imaginal disc pattern formationGO:0007447910.012
peptide metabolic processGO:0006518800.012
actin filament polymerizationGO:0030041270.012
muscle attachmentGO:0016203360.012
negative regulation of neurogenesisGO:0050768530.012
single organismal cell cell adhesionGO:0016337450.012
cellular nitrogen compound catabolic processGO:00442701650.012
regulation of catabolic processGO:00098941700.012
Mouse
negative regulation of cell deathGO:0060548810.011
cell fate determinationGO:0001709910.011
regulation of neurogenesisGO:00507671580.011
negative regulation of cellular protein metabolic processGO:0032269850.011
cellular response to nutrient levelsGO:0031669620.011
Mouse
positive regulation of developmental processGO:00510941430.011
rna localizationGO:00064031150.011
circadian behaviorGO:0048512760.011
autophagic cell deathGO:0048102830.011
wing disc morphogenesisGO:00074723440.011
synapse assemblyGO:00074161430.011
regulation of mitotic sister chromatid separationGO:0010965280.011
substrate adhesion dependent cell spreadingGO:003444620.011
purine ribonucleoside triphosphate catabolic processGO:00092071080.011
response to hexoseGO:000974630.011
tissue homeostasisGO:0001894360.011
protein modification by small protein removalGO:0070646280.011
positive regulation of intracellular signal transductionGO:19025331160.011
phagocytosisGO:00069092150.011
salivary gland developmentGO:00074311620.011
dna packagingGO:0006323910.011
cellular monovalent inorganic cation homeostasisGO:003000470.011
cellular response to oxygen containing compoundGO:1901701790.011
regulation of cell matrix adhesionGO:000195210.011
phosphatidylinositol mediated signalingGO:004801540.011
nucleobase containing compound catabolic processGO:00346551650.011
nucleocytoplasmic transportGO:0006913720.011
nucleoside catabolic processGO:00091641120.010
positive regulation of cellular biosynthetic processGO:00313283160.010
gland morphogenesisGO:00226121450.010
negative regulation of gene expression epigeneticGO:0045814770.010
rhythmic processGO:00485111060.010
sensory organ morphogenesisGO:00905962600.010
salivary gland morphogenesisGO:00074351450.010

Npc1a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.034
Human
cancerDOID:16200.028
disease of cellular proliferationDOID:1456600.028
nervous system diseaseDOID:86300.019
organ system cancerDOID:005068600.018
inherited metabolic disorderDOID:65500.016
Human
disease of metabolismDOID:001466700.016
Human