IMP: Integrative Multi-species Prediction

Drosophila melanogaster

0 known processes

Yp1 (Dmel_CG2985)

Yolk protein 1

(Aliases: VIT1Dm,YP1,YP-1,fs(1)1163,YP[[1]],DmYP1,VG1,CG2985,yp1,yp,YP,yp-1,YPI,Dmel\CG2985,fs(1)A1163)

Entrez: 31939
FLYBASE: FBgn0004045
UniProtKB: X2JD55
UniProtKB: P02843

Process Predictions
Disease Predictions

Yp1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
phospholipid homeostasis	GO:0055091	1	0.998	Human
lipid homeostasis	GO:0055088	33	0.716	Human
phosphatidylethanolamine metabolic process	GO:0046337	1	0.677
triglyceride homeostasis	GO:0070328	18	0.671	Human
anion homeostasis	GO:0055081	3	0.666	Human
neutral lipid biosynthetic process	GO:0046460	2	0.621	Rat
sterol homeostasis	GO:0055092	4	0.571	Human
acylglycerol homeostasis	GO:0055090	19	0.477	Human
triglyceride biosynthetic process	GO:0019432	2	0.456	Rat
cellular catabolic process	GO:0044248	372	0.448	Human
acylglycerol biosynthetic process	GO:0046463	2	0.433	Rat
triglyceride catabolic process	GO:0019433	3	0.416	Human
glycerolipid catabolic process	GO:0046503	3	0.402	Human
regulation of sequestering of triglyceride	GO:0010889	3	0.398
neutral lipid catabolic process	GO:0046461	3	0.370	Human
acylglycerol catabolic process	GO:0046464	3	0.352	Human
positive regulation of lipid storage	GO:0010884	4	0.331
fatty acid metabolic process	GO:0006631	20	0.317	Human
lipid catabolic process	GO:0016042	21	0.314	Human Rat
cholesterol homeostasis	GO:0042632	3	0.305	Human
cholesterol transport	GO:0030301	2	0.288	Human
organic substance catabolic process	GO:1901575	308	0.282	Human Rat
regulation of lipid storage	GO:0010883	22	0.270
response to oxygen containing compound	GO:1901700	200	0.251
ethanolamine containing compound metabolic process	GO:0042439	4	0.246
regulation of sterol transport	GO:0032371	1	0.242	Human
catabolic process	GO:0009056	409	0.236	Human Rat
phosphatidic acid metabolic process	GO:0046473	1	0.224
cellular lipid catabolic process	GO:0044242	16	0.223	Human
imaginal disc derived wing morphogenesis	GO:0007476	337	0.215
cellular response to chemical stimulus	GO:0070887	199	0.201
organic substance transport	GO:0071702	257	0.193	Human
oxoacid metabolic process	GO:0043436	103	0.186	Human
amine metabolic process	GO:0009308	12	0.169
establishment of localization in cell	GO:0051649	402	0.168
protein transport	GO:0015031	155	0.165
regulation of lipid transport	GO:0032368	3	0.157	Human
glycerolipid metabolic process	GO:0046486	34	0.155	Human Rat
protein localization	GO:0008104	284	0.142
cellular amine metabolic process	GO:0044106	12	0.139
imaginal disc derived appendage development	GO:0048737	399	0.136
immune system process	GO:0002376	347	0.128
acylglycerol metabolic process	GO:0006639	12	0.128	Human Rat
regulation of cholesterol transport	GO:0032374	1	0.119	Human
homeostatic process	GO:0042592	199	0.117	Human
intracellular transport	GO:0046907	228	0.098
microtubule organizing center organization	GO:0031023	168	0.097
cell proliferation	GO:0008283	299	0.097
appendage morphogenesis	GO:0035107	397	0.094
response to cold	GO:0009409	13	0.093	Rat
lipid metabolic process	GO:0006629	121	0.093	Human Rat
positive regulation of sequestering of triglyceride	GO:0010890	1	0.090
post embryonic appendage morphogenesis	GO:0035120	385	0.089
endocytosis	GO:0006897	310	0.088	Fly
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.086
circadian rhythm	GO:0007623	105	0.083
intracellular protein transport	GO:0006886	104	0.082
regulation of catabolic process	GO:0009894	170	0.081
appendage development	GO:0048736	401	0.080
organophosphate metabolic process	GO:0019637	195	0.078
triglyceride metabolic process	GO:0006641	12	0.077	Human Rat
lipid localization	GO:0010876	54	0.076	Human
wing disc morphogenesis	GO:0007472	344	0.075
protein import	GO:0017038	55	0.075
cellular response to organic substance	GO:0071310	132	0.074
carboxylic acid metabolic process	GO:0019752	92	0.073	Human
response to organonitrogen compound	GO:0010243	75	0.073
small molecule metabolic process	GO:0044281	305	0.071	Human
regulation of cell cycle	GO:0051726	291	0.071
response to abiotic stimulus	GO:0009628	341	0.071	Rat
proteolysis	GO:0006508	192	0.069
cellular response to endogenous stimulus	GO:0071495	80	0.065
establishment of protein localization	GO:0045184	163	0.065
cellular protein localization	GO:0034613	160	0.064
single organism cellular localization	GO:1902580	180	0.063
regulation of catalytic activity	GO:0050790	185	0.060
regulation of localization	GO:0032879	275	0.058	Human
chemical homeostasis	GO:0048878	92	0.058	Human
positive regulation of transport	GO:0051050	92	0.056	Human
cellular response to hormone stimulus	GO:0032870	44	0.055
regulation of multicellular organismal development	GO:2000026	414	0.055
regulation of molecular function	GO:0065009	217	0.054
positive regulation of molecular function	GO:0044093	136	0.054
establishment of protein localization to organelle	GO:0072594	62	0.053
single organism intracellular transport	GO:1902582	207	0.053
cellular lipid metabolic process	GO:0044255	83	0.053	Human Rat
protein complex biogenesis	GO:0070271	201	0.052
response to organic substance	GO:0010033	284	0.052
alditol phosphate metabolic process	GO:0052646	2	0.051
developmental growth	GO:0048589	280	0.051
cellular macromolecule localization	GO:0070727	220	0.050
dna metabolic process	GO:0006259	227	0.049
defense response to other organism	GO:0098542	225	0.048
protein complex assembly	GO:0006461	200	0.046
growth	GO:0040007	359	0.046
regulation of phosphate metabolic process	GO:0019220	210	0.046
monocarboxylic acid metabolic process	GO:0032787	29	0.045	Human
hematopoietic or lymphoid organ development	GO:0048534	57	0.044
single organism catabolic process	GO:0044712	228	0.044	Human Rat
dna conformation change	GO:0071103	105	0.044
positive regulation of cellular catabolic process	GO:0031331	95	0.044
protein transmembrane transport	GO:0071806	4	0.041
generation of precursor metabolites and energy	GO:0006091	42	0.041
protein targeting	GO:0006605	64	0.039
organic acid metabolic process	GO:0006082	103	0.038	Human
single organism biosynthetic process	GO:0044711	206	0.038	Human Rat
macromolecular complex assembly	GO:0065003	256	0.037
single organism behavior	GO:0044708	391	0.037
positive regulation of catabolic process	GO:0009896	105	0.037
response to temperature stimulus	GO:0009266	106	0.036	Rat
response to nitrogen compound	GO:1901698	90	0.035
regulation of protein metabolic process	GO:0051246	256	0.035
regulation of phosphorus metabolic process	GO:0051174	210	0.035
nuclear transport	GO:0051169	72	0.035
vesicle mediated transport	GO:0016192	381	0.034	Fly
negative regulation of cell proliferation	GO:0008285	69	0.034
regulation of transport	GO:0051049	181	0.034	Human
regulation of cell cycle phase transition	GO:1901987	130	0.034
regulation of cellular amine metabolic process	GO:0033238	3	0.033
regulation of mitotic cell cycle	GO:0007346	190	0.032
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.032
hemopoiesis	GO:0030097	46	0.031
intracellular protein transmembrane transport	GO:0065002	4	0.031
fatty acid biosynthetic process	GO:0006633	6	0.031	Human
organonitrogen compound metabolic process	GO:1901564	318	0.031
centrosome organization	GO:0051297	163	0.031
hematopoietic progenitor cell differentiation	GO:0002244	1	0.030
lipid biosynthetic process	GO:0008610	46	0.030	Human Rat
oxidation reduction process	GO:0055114	123	0.029
cellular amino acid metabolic process	GO:0006520	61	0.029
regulation of cellular ketone metabolic process	GO:0010565	3	0.028
imaginal disc growth	GO:0007446	37	0.028
rhythmic process	GO:0048511	106	0.028
regulation of protein transport	GO:0051223	57	0.027
positive regulation of signal transduction	GO:0009967	223	0.027
negative regulation of response to stimulus	GO:0048585	258	0.027
positive regulation of catalytic activity	GO:0043085	118	0.027
cellular response to oxygen containing compound	GO:1901701	79	0.027
regulation of cellular amino acid metabolic process	GO:0006521	0	0.026
regulation of intracellular signal transduction	GO:1902531	236	0.026
eggshell formation	GO:0030703	105	0.026
organic hydroxy compound metabolic process	GO:1901615	83	0.026
compound eye development	GO:0048749	307	0.025
maintenance of location	GO:0051235	73	0.025
glycoprotein biosynthetic process	GO:0009101	41	0.025
adult behavior	GO:0030534	137	0.025
positive regulation of macromolecule metabolic process	GO:0010604	405	0.025
eggshell chorion assembly	GO:0007306	66	0.025
organophosphate catabolic process	GO:0046434	112	0.025
regulation of growth	GO:0040008	233	0.024
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.024
cytoplasmic transport	GO:0016482	130	0.023
ion homeostasis	GO:0050801	55	0.023	Human
small molecule biosynthetic process	GO:0044283	37	0.023	Human
positive regulation of multicellular organismal process	GO:0051240	143	0.022	Human
negative regulation of developmental process	GO:0051093	201	0.022
protein modification process	GO:0036211	438	0.022
chorion containing eggshell formation	GO:0007304	105	0.022
protein localization to organelle	GO:0033365	82	0.022
cellular response to ethanol	GO:0071361	4	0.021
neuropeptide signaling pathway	GO:0007218	45	0.021
centrosome cycle	GO:0007098	137	0.021
sulfur compound biosynthetic process	GO:0044272	16	0.021
response to endogenous stimulus	GO:0009719	119	0.021
response to peptide hormone	GO:0043434	29	0.021
response to copper ion	GO:0046688	4	0.021
organelle fission	GO:0048285	340	0.020
cellular ketone metabolic process	GO:0042180	24	0.020
protein catabolic process	GO:0030163	101	0.020
carbohydrate derivative metabolic process	GO:1901135	217	0.019
regulation of protein modification process	GO:0031399	112	0.019
positive regulation of cell communication	GO:0010647	250	0.019
acetaldehyde metabolic process	GO:0006117	5	0.019
positive regulation of mitotic cell cycle	GO:0045931	34	0.019
regulation of cell cycle process	GO:0010564	181	0.019
cell cycle phase transition	GO:0044770	140	0.019
positive regulation of signaling	GO:0023056	243	0.018
intracellular protein transmembrane import	GO:0044743	4	0.018
positive regulation of i kappab kinase nf kappab signaling	GO:0043123	1	0.018
negative regulation of cell communication	GO:0010648	223	0.018
phosphorylation	GO:0016310	294	0.018
immune system development	GO:0002520	57	0.017
nucleocytoplasmic transport	GO:0006913	72	0.017
cellular protein catabolic process	GO:0044257	83	0.017
single organism nuclear import	GO:1902593	51	0.017
protein targeting to nucleus	GO:0044744	51	0.017
death	GO:0016265	284	0.017
monocarboxylic acid transport	GO:0015718	3	0.016
positive regulation of response to stimulus	GO:0048584	323	0.016
positive regulation of phosphorus metabolic process	GO:0010562	139	0.016
positive regulation of intracellular signal transduction	GO:1902533	116	0.016
mitotic cell cycle phase transition	GO:0044772	138	0.016
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.016
regulation of i kappab kinase nf kappab signaling	GO:0043122	2	0.016
transmembrane transport	GO:0055085	139	0.016
nad metabolic process	GO:0019674	1	0.016
phagocytosis	GO:0006909	215	0.016	Fly
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.016
endomembrane system organization	GO:0010256	119	0.015
defense response to fungus	GO:0050832	48	0.015
negative regulation of cell cycle phase transition	GO:1901988	103	0.015
regulation of cellular catabolic process	GO:0031329	157	0.015
sensory organ morphogenesis	GO:0090596	260	0.015
cellular response to lipopolysaccharide	GO:0071222	3	0.015
negative regulation of multicellular organismal process	GO:0051241	142	0.015
ubiquitin dependent protein catabolic process	GO:0006511	78	0.015
phosphatidylcholine metabolic process	GO:0046470	3	0.015
positive regulation of protein metabolic process	GO:0051247	128	0.015
regulation of protein localization	GO:0032880	76	0.015
cellular response to biotic stimulus	GO:0071216	4	0.015
regulation of cellular protein metabolic process	GO:0032268	243	0.014
spindle organization	GO:0007051	253	0.014
body morphogenesis	GO:0010171	2	0.014
nucleobase containing compound catabolic process	GO:0034655	165	0.014
positive regulation of lipid metabolic process	GO:0045834	4	0.014
response to nutrient levels	GO:0031667	114	0.014
macromolecule catabolic process	GO:0009057	161	0.014
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.014
positive regulation of phosphate metabolic process	GO:0045937	139	0.014
response to carbohydrate	GO:0009743	15	0.014
response to calcium ion	GO:0051592	1	0.014
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.014
g protein coupled receptor signaling pathway	GO:0007186	136	0.013
peptidyl tyrosine modification	GO:0018212	24	0.013
carbohydrate derivative biosynthetic process	GO:1901137	85	0.013
rna processing	GO:0006396	147	0.013
dna dependent dna replication	GO:0006261	17	0.013
regulation of cellular localization	GO:0060341	136	0.013
mitochondrion organization	GO:0007005	65	0.013
nuclear import	GO:0051170	51	0.013
protein import into nucleus	GO:0006606	51	0.013
ion transport	GO:0006811	145	0.013
organic acid biosynthetic process	GO:0016053	15	0.012	Human
alcohol metabolic process	GO:0006066	25	0.012
modification dependent protein catabolic process	GO:0019941	78	0.012
protein localization to nucleus	GO:0034504	55	0.012
mitotic nuclear division	GO:0007067	213	0.012
cellular response to molecule of bacterial origin	GO:0071219	3	0.012
regulation of cell differentiation	GO:0045595	302	0.012
compound eye morphogenesis	GO:0001745	249	0.012
regulation of synapse structure and activity	GO:0050803	128	0.012
melanotic encapsulation of foreign target	GO:0035011	30	0.012
extrinsic apoptotic signaling pathway	GO:0097191	1	0.012
organic anion transport	GO:0015711	28	0.012
dorsal appendage formation	GO:0046843	47	0.012
encapsulation of foreign target	GO:0035010	38	0.011
dna replication	GO:0006260	48	0.011
cellular protein modification process	GO:0006464	438	0.011
carboxylic acid biosynthetic process	GO:0046394	15	0.011	Human
regulation of phosphorylation	GO:0042325	147	0.011
immune effector process	GO:0002252	98	0.011
negative regulation of protein metabolic process	GO:0051248	85	0.011
negative regulation of cellular metabolic process	GO:0031324	382	0.011
wnt signaling pathway	GO:0016055	98	0.011
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.011
immune response regulating signaling pathway	GO:0002764	2	0.011
regulation of response to stress	GO:0080134	200	0.011
kidney development	GO:0001822	3	0.011
positive regulation of phosphorylation	GO:0042327	87	0.011
negative regulation of signaling	GO:0023057	219	0.011
regulation of establishment of protein localization	GO:0070201	61	0.011
intracellular signal transduction	GO:0035556	300	0.011
cellular macromolecule catabolic process	GO:0044265	136	0.011
modification dependent macromolecule catabolic process	GO:0043632	79	0.011
centrosome duplication	GO:0051298	121	0.011
regulation of immune response	GO:0050776	118	0.011
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.010
positive regulation of cellular biosynthetic process	GO:0031328	316	0.010
regulation of cell proliferation	GO:0042127	163	0.010
rna localization	GO:0006403	115	0.010
purine containing compound metabolic process	GO:0072521	155	0.010
positive regulation of hydrolase activity	GO:0051345	78	0.010
phospholipid metabolic process	GO:0006644	23	0.010
detection of chemical stimulus	GO:0009593	93	0.010
mrna processing	GO:0006397	104	0.010
transcription from rna polymerase ii promoter	GO:0006366	368	0.010
protein phosphorylation	GO:0006468	169	0.010

Yp1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability	Func Analog Org
familial hypertriglyceridemia	DOID:0050527	1.000	Human
inherited metabolic disorder	DOID:655	1.000	Human
lipid metabolism disorder	DOID:3146	1.000	Human
disease of metabolism	DOID:0014667	1.000	Human
disease of anatomical entity	DOID:7	0.987	Human
hair disease	DOID:421	0.987	Human
integumentary system disease	DOID:16	0.987	Human
hypotrichosis	DOID:4535	0.987	Human
familial hyperlipidemia	DOID:1168	0.956
familial combined hyperlipidemia	DOID:13809	0.903
carbohydrate metabolism disease	DOID:0050013	0.493	Human
diabetes mellitus	DOID:9351	0.493	Human
glucose metabolism disease	DOID:4194	0.493	Human
acquired metabolic disease	DOID:0060158	0.493	Human
familial lipoprotein lipase deficiency	DOID:14118	0.416
type 2 diabetes mellitus	DOID:9352	0.332	Human
nervous system disease	DOID:863	0.027
musculoskeletal system disease	DOID:17	0.015
connective tissue disease	DOID:65	0.015
bone disease	DOID:0080001	0.015
sensory system disease	DOID:0050155	0.012
eye and adnexa disease	DOID:1492	0.012

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