Drosophila melanogaster

133 known processes

Dfd (Dmel_CG2189)

Deformed

(Aliases: CG2189,Dmel\CG2189,l(3)84Ae,BG:DS00276.5,DmDfd,dfd,EbR11)

Dfd biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
regionalizationGO:00030024160.887
motor neuron axon guidanceGO:0008045580.875
head segmentationGO:0035287130.810
positive regulation of transcription from rna polymerase ii promoterGO:00459442040.807
nephron tubule morphogenesisGO:007207830.786
positive regulation of transcription dna templatedGO:00458932660.762
transcription from rna polymerase ii promoterGO:00063663680.760
homeostatic processGO:00425921990.753
renal tubule developmentGO:0061326640.719
neuron projection guidanceGO:00974852410.696
dendrite developmentGO:00163582040.669
segment specificationGO:0007379330.631
eye antennal disc developmentGO:0035214600.553
anatomical structure homeostasisGO:0060249970.546
epithelial cell differentiationGO:00308553220.527
axon guidanceGO:00074112330.512
terminal region determinationGO:0007362250.497
chemotaxisGO:00069352490.478
positive regulation of biosynthetic processGO:00098913160.478
axonogenesisGO:00074092900.466
positive regulation of macromolecule metabolic processGO:00106044050.451
positive regulation of gene expressionGO:00106282900.437
regulation of transcription from rna polymerase ii promoterGO:00063573780.425
positive regulation of nucleic acid templated transcriptionGO:19035082660.413
kidney morphogenesisGO:006099330.397
segmentationGO:00352822070.396
positive regulation of macromolecule biosynthetic processGO:00105572830.363
negative regulation of nucleic acid templated transcriptionGO:19035072400.361
programmed cell deathGO:00125012570.360
ocellus developmentGO:000805640.353
embryonic morphogenesisGO:00485982060.352
Mouse
positive regulation of rna biosynthetic processGO:19026802660.350
positive regulation of nucleobase containing compound metabolic processGO:00459353320.350
specification of segmental identity headGO:0007380110.339
embryonic development via the syncytial blastodermGO:00017001480.335
regulation of cell developmentGO:00602842150.331
negative regulation of rna biosynthetic processGO:19026792400.321
zygotic determination of anterior posterior axis embryoGO:0007354270.319
regulation of neurogenesisGO:00507671580.312
torso signaling pathwayGO:0008293210.299
regulation of multicellular organism growthGO:0040014400.296
embryonic organ developmentGO:0048568500.296
Mouse
anterior posterior pattern specificationGO:00099521360.283
Mouse
blastoderm segmentationGO:00073501590.278
endocytosisGO:00068973100.271
axon developmentGO:00615642970.268
cell fate determinationGO:0001709910.258
muscle structure developmentGO:00610612240.253
regulation of nervous system developmentGO:00519602480.247
nephron epithelium morphogenesisGO:007208830.246
renal tubule morphogenesisGO:0061333440.246
positive regulation of rna metabolic processGO:00512542710.245
embryo development ending in birth or egg hatchingGO:00097921520.244
Mouse
imaginal disc derived appendage developmentGO:00487373990.228
skin developmentGO:0043588650.227
nephron developmentGO:007200630.218
neuron fate specificationGO:0048665120.218
regulation of cell differentiationGO:00455953020.218
stem cell differentiationGO:00488631170.218
Human Mouse
nephron morphogenesisGO:007202830.216
nephron epithelium developmentGO:007200930.209
enteroendocrine cell differentiationGO:003588310.205
somatic muscle developmentGO:0007525660.203
epidermis developmentGO:0008544650.202
cellular component assembly involved in morphogenesisGO:00109271510.199
tissue morphogenesisGO:00487292970.198
Mouse
appendage morphogenesisGO:00351073970.192
response to external biotic stimulusGO:00432072930.188
post embryonic appendage morphogenesisGO:00351203850.185
camera type eye developmentGO:004301040.184
negative regulation of multicellular organismal processGO:00512411420.179
phagocytosisGO:00069092150.171
embryonic pattern specificationGO:00098801740.170
negative regulation of transcription from rna polymerase ii promoterGO:00001221190.170
response to biotic stimulusGO:00096072940.166
cell motilityGO:00488702510.164
regulation of epithelial cell differentiationGO:003085640.163
negative regulation of nitrogen compound metabolic processGO:00511722650.163
regulation of neuron differentiationGO:00456641030.162
nephron tubule developmentGO:007208030.161
regulation of multicellular organismal developmentGO:20000264140.157
regulation of r7 cell differentiationGO:0045676150.152
positive regulation of multicellular organismal processGO:00512401430.149
body morphogenesisGO:001017120.146
tube formationGO:0035148210.144
forebrain developmentGO:003090020.143
negative regulation of transcription dna templatedGO:00458922370.140
positive regulation of developmental processGO:00510941430.130
morphogenesis of embryonic epitheliumGO:0016331940.129
central nervous system segmentationGO:003528350.127
hindbrain developmentGO:003090220.126
epidermal cell differentiationGO:0009913510.125
kidney epithelium developmentGO:007207330.123
imaginal disc derived wing morphogenesisGO:00074763370.122
neuron recognitionGO:00080381010.121
imaginal disc derived female genitalia developmentGO:000748660.119
negative regulation of developmental processGO:00510932010.119
muscle cell fate commitmentGO:0042693140.118
nephron tubule formationGO:007207930.115
taxisGO:00423303040.114
positive regulation of nitrogen compound metabolic processGO:00511733540.112
cell adhesionGO:00071551360.110
dendrite morphogenesisGO:00488131990.110
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691160.106
negative regulation of nucleobase containing compound metabolic processGO:00459342610.105
negative regulation of macromolecule biosynthetic processGO:00105582700.104
wing disc morphogenesisGO:00074723440.104
positive regulation of cellular biosynthetic processGO:00313283160.103
apoptotic processGO:00069151590.103
sensory perceptionGO:00076001960.102
gliogenesisGO:0042063800.101
mesodermal cell differentiationGO:004833370.100
circulatory system developmentGO:0072359820.099
defense responseGO:00069523000.097
embryonic hemopoiesisGO:0035162260.097
regulation of neuron projection developmentGO:0010975690.096
morphogenesis of an epitheliumGO:00020092760.094
Mouse
antennal developmentGO:0007469250.094
axis specificationGO:00097981670.094
hair cell differentiationGO:0035315470.093
eye antennal disc morphogenesisGO:0007455340.092
retinal cone cell differentiationGO:004267020.092
reproductive system developmentGO:0061458740.091
appendage developmentGO:00487364010.090
camera type eye photoreceptor cell differentiationGO:006021920.090
imaginal disc derived appendage morphogenesisGO:00351143950.089
developmental programmed cell deathGO:00106231380.089
negative regulation of programmed cell deathGO:0043069720.087
dendrite guidanceGO:0070983210.087
neuroblast differentiationGO:0014016290.086
sensory perception of chemical stimulusGO:00076061160.085
retina development in camera type eyeGO:006004140.084
cell type specific apoptotic processGO:0097285380.084
digestive tract morphogenesisGO:00485461270.081
respiratory system developmentGO:00605412130.081
adult behaviorGO:00305341370.081
regulation of epithelial cell proliferationGO:005067840.081
developmental growthGO:00485892800.081
neurological system processGO:00508773580.080
germ cell migrationGO:0008354430.080
tube morphogenesisGO:00352391910.080
regulation of photoreceptor cell differentiationGO:0046532340.078
eye developmentGO:00016543230.078
epithelial tube morphogenesisGO:0060562880.078
neuroblast fate commitmentGO:0014017190.077
regulation of anatomical structure morphogenesisGO:00226032420.075
telencephalon developmentGO:002153720.075
camera type eye morphogenesisGO:004859320.074
spiracle morphogenesis open tracheal systemGO:0035277220.074
retina morphogenesis in camera type eyeGO:006004220.072
response to other organismGO:00517072930.070
muscle tissue developmentGO:0060537300.068
negative regulation of biosynthetic processGO:00098902770.067
skeletal muscle organ developmentGO:0060538480.066
brain segmentationGO:003528450.066
cell deathGO:00082192790.065
negative regulation of neurogenesisGO:0050768530.064
proximal distal pattern formationGO:0009954150.064
negative regulation of rna metabolic processGO:00512532510.063
immune responseGO:00069552460.063
open tracheal system developmentGO:00074242040.062
cardiac cell fate determinationGO:006091330.062
kidney developmentGO:000182230.062
extrinsic apoptotic signaling pathwayGO:009719110.062
single organismal cell cell adhesionGO:0016337450.061
ectodermal placode morphogenesisGO:007169740.060
gland developmentGO:00487321910.060
regulation of cell deathGO:00109411730.060
locomotory behaviorGO:00076261760.058
mesodermal cell fate commitmentGO:000171070.057
response to fibroblast growth factorGO:0071774100.057
embryonic epithelial tube formationGO:000183860.056
developmental maturationGO:00217001720.055
striated muscle cell differentiationGO:0051146900.055
anterior posterior axis specificationGO:00099481090.055
cell migrationGO:00164772380.055
internal protein amino acid acetylationGO:0006475380.054
negative regulation of nervous system developmentGO:0051961920.054
cell recognitionGO:00080371020.053
hindgut developmentGO:0061525580.052
antennal morphogenesisGO:0048800140.051
apoptotic process involved in morphogenesisGO:006056130.051
spinal cord developmentGO:002151010.051
regulation of response to external stimulusGO:00321011150.050
heart morphogenesisGO:0003007320.050
regulation of cell fate specificationGO:0042659270.050
neuroblast developmentGO:0014019130.048
reproductive structure developmentGO:0048608740.048
agingGO:00075681430.047
cell fate specificationGO:0001708710.046
cation transmembrane transportGO:0098655880.046
heart developmentGO:0007507820.046
cellular response to chemical stimulusGO:00708871990.044
leg disc developmentGO:0035218920.043
chorion containing eggshell formationGO:00073041050.042
synaptic growth at neuromuscular junctionGO:00511241190.042
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043281250.042
positive regulation of cell communicationGO:00106472500.041
innate immune responseGO:00450871440.041
carboxylic acid metabolic processGO:0019752920.041
regulation of response to stressGO:00801342000.040
ectodermal placode formationGO:006078840.040
positive regulation of protein metabolic processGO:00512471280.040
posterior head segmentationGO:003528960.040
sensory organ morphogenesisGO:00905962600.040
regulation of developmental growthGO:00486381740.039
epithelial cell developmentGO:00020642740.039
synaptic target recognitionGO:0008039450.038
regulation of cell cycle phase transitionGO:19019871300.038
imaginal disc derived leg segmentationGO:0036011260.038
eye photoreceptor cell differentiationGO:00017541450.038
regulation of embryonic developmentGO:0045995680.038
regulation of endopeptidase activityGO:0052548360.037
regulation of programmed cell deathGO:00430671520.037
cellular response to growth factor stimulusGO:0071363300.037
deathGO:00162652840.037
mesenchymal cell differentiationGO:004876210.037
multicellular organismal agingGO:00102591400.037
digestive system developmentGO:00551231490.037
central nervous system developmentGO:00074172010.037
regulation of anatomical structure sizeGO:00900661630.037
reproductive behaviorGO:00190981220.036
bolwig s organ developmentGO:005503480.036
localization of cellGO:00516742570.036
tripartite regional subdivisionGO:00073511030.035
cellular protein modification processGO:00064644380.035
epithelial tube formationGO:007217570.035
maintenance of locationGO:0051235730.035
multi organism behaviorGO:00517051750.035
pigment metabolic processGO:0042440840.034
regulation of dendrite morphogenesisGO:0048814280.034
larval developmentGO:00021641040.033
dorsal closureGO:0007391790.033
protein modification processGO:00362114380.033
adult locomotory behaviorGO:0008344760.032
organonitrogen compound metabolic processGO:19015643180.032
positive regulation of autophagyGO:0010508210.032
salivary gland morphogenesisGO:00074351450.032
vesicle mediated transportGO:00161923810.032
negative regulation of cell deathGO:0060548810.031
renal system developmentGO:0072001720.031
negative regulation of cellular macromolecule biosynthetic processGO:20001132670.031
positive regulation of signal transductionGO:00099672230.031
cardiovascular system developmentGO:0072358820.031
positive regulation of neurogenesisGO:0050769410.031
germ band shorteningGO:0007390190.030
negative regulation of gene expressionGO:00106293870.030
positive regulation of multicellular organism growthGO:0040018210.030
regulation of immune system processGO:00026821760.029
regulation of dendrite developmentGO:0050773370.029
regulation of molecular functionGO:00650092170.029
response to extracellular stimulusGO:00099911160.029
digestive tract developmentGO:00485651490.029
cell cycle phase transitionGO:00447701400.029
regulation of defense responseGO:00313471020.029
female genitalia developmentGO:003054060.029
cardioblast cell fate determinationGO:000751030.029
gastrulationGO:0007369700.028
cardioblast differentiationGO:0010002200.028
single organism behaviorGO:00447083910.028
immune system processGO:00023763470.027
Human Mouse
cell fate commitment involved in formation of primary germ layerGO:0060795100.027
compound eye photoreceptor developmentGO:0042051780.027
cell maturationGO:00484691440.026
malpighian tubule morphogenesisGO:0007443440.026
response to woundingGO:0009611940.026
compound eye developmentGO:00487493070.026
mesenchyme developmentGO:006048590.026
positive regulation of epithelial cell differentiationGO:003085810.025
embryonic axis specificationGO:00005781070.025
defense response to bacteriumGO:00427421780.025
r7 cell differentiationGO:0045466430.025
regulation of organ morphogenesisGO:2000027780.025
cellular response to fibroblast growth factor stimulusGO:0044344100.025
columnar cuboidal epithelial cell developmentGO:00020662490.025
tube developmentGO:00352952440.025
specification of segmental identity trunkGO:003529270.024
response to organic substanceGO:00100332840.024
regulation of neuroblast proliferationGO:1902692340.024
negative regulation of neural precursor cell proliferationGO:2000178270.024
sex differentiationGO:0007548810.023
head involutionGO:0008258350.023
chromosome organizationGO:00512763600.023
bolwig s organ morphogenesisGO:000174680.023
gland morphogenesisGO:00226121450.023
cellular homeostasisGO:0019725800.023
biological adhesionGO:00226101380.023
regulation of multi organism processGO:00439001310.023
single organism cell adhesionGO:0098602470.023
cellular ketone metabolic processGO:0042180240.023
multi multicellular organism processGO:00447061230.023
ectodermal placode developmentGO:007169640.023
brain morphogenesisGO:0048854160.023
regulation of cell morphogenesis involved in differentiationGO:0010769610.023
establishment of protein localizationGO:00451841630.023
dna templated transcription elongationGO:0006354180.022
regulation of cell cycle processGO:00105641810.022
response to oxygen containing compoundGO:19017002000.022
negative regulation of sequence specific dna binding transcription factor activityGO:004343340.022
regulation of immune responseGO:00507761180.022
dorsal ventral pattern formationGO:00099531330.022
regulation of growthGO:00400082330.022
specification of organ identityGO:001009230.022
immune effector processGO:0002252980.022
protein complex biogenesisGO:00702712010.021
organic acid metabolic processGO:00060821030.021
positive regulation of cellular protein metabolic processGO:00322701180.021
cellular macromolecular complex assemblyGO:00346221530.020
chromatin modificationGO:00165681470.020
intracellular signal transductionGO:00355563000.020
neural retina developmentGO:000340740.020
eye morphogenesisGO:00485922600.020
energy derivation by oxidation of organic compoundsGO:0015980320.020
limb developmentGO:006017310.020
hematopoietic or lymphoid organ developmentGO:0048534570.020
Human Mouse
muscle cell fate specificationGO:004269470.019
regulation of cell projection organizationGO:0031344920.019
muscle organ developmentGO:00075171270.019
positive regulation of signalingGO:00230562430.019
imaginal disc pattern formationGO:0007447910.019
growthGO:00400073590.019
negative regulation of cell developmentGO:0010721620.019
optic lobe placode formationGO:000174440.019
axonal defasciculationGO:0007414120.019
imaginal disc derived leg morphogenesisGO:0007480800.019
regulation of response to biotic stimulusGO:0002831630.018
gonad developmentGO:0008406500.018
chromatin organizationGO:00063252070.018
neuron fate commitmentGO:0048663500.018
eye photoreceptor cell developmentGO:0042462810.018
positive regulation of protein modification processGO:0031401580.018
response to nutrient levelsGO:00316671140.018
male courtship behaviorGO:0008049630.018
axonal fasciculationGO:0007413120.017
regulation of cell sizeGO:0008361630.017
embryonic hindgut morphogenesisGO:0048619480.017
cellular amino acid metabolic processGO:0006520610.017
negative regulation of cell differentiationGO:00455961430.017
regulation of synapse structure and activityGO:00508031280.017
tissue deathGO:00162711020.017
appendage segmentationGO:0035285260.017
negative regulation of cellular response to oxidative stressGO:190040810.017
dna templated transcription initiationGO:0006352250.017
stem cell fate commitmentGO:0048865250.017
immune response regulating signaling pathwayGO:000276420.017
embryonic foregut morphogenesisGO:004861730.017
negative regulation of cellular biosynthetic processGO:00313272770.017
adipose tissue developmentGO:006061220.016
connective tissue developmentGO:006144830.016
Mouse
cranial nerve developmentGO:002154510.016
leg disc proximal distal pattern formationGO:000747990.016
glial cell migrationGO:0008347310.016
positive regulation of cell differentiationGO:0045597640.016
regulation of apoptotic process involved in morphogenesisGO:190233720.016
negative regulation of apoptotic processGO:0043066630.016
regulation of compound eye cone cell fate specificationGO:004268240.016
single organism biosynthetic processGO:00447112060.016
development of primary sexual characteristicsGO:0045137500.015
neuron fate determinationGO:004866410.015
determination of imaginal disc primordiumGO:0007445110.015
regulation of neuron deathGO:1901214260.015
determination of adult lifespanGO:00083401370.015
salivary gland cell autophagic cell deathGO:0035071830.015
exocrine system developmentGO:00352721620.015
anterior posterior axis specification embryoGO:00085951030.015
genitalia developmentGO:0048806260.015
g1 s transition of mitotic cell cycleGO:0000082310.015
compound eye photoreceptor cell differentiationGO:00017511400.015
lipid storageGO:0019915380.015
cation transportGO:00068121100.014
photoreceptor cell developmentGO:0042461960.014
glial cell differentiationGO:0010001350.014
cell fate commitment involved in pattern specificationGO:0060581310.014
brain developmentGO:00074201200.014
muscle cell differentiationGO:00426921030.014
male mating behaviorGO:0060179700.014
positive regulation of cell migrationGO:003033520.014
muscle tissue morphogenesisGO:006041520.014
response to growth factorGO:0070848310.014
autophagyGO:00069141080.014
regulation of cellular protein metabolic processGO:00322682430.014
sensory perception of smellGO:0007608800.014
ventral cord developmentGO:0007419160.014
regulation of epithelial cell migration open tracheal systemGO:2000274110.013
cellular response to dna damage stimulusGO:00069742230.013
regulation of transcription elongation from rna polymerase ii promoterGO:0034243150.013
salivary gland developmentGO:00074311620.013
positive regulation of programmed cell deathGO:0043068620.013
regulation of dna templated transcription elongationGO:0032784170.013
positive regulation of catalytic activityGO:00430851180.013
germline ring canal formationGO:0030725130.013
regulation of cell cycleGO:00517262910.013
positive regulation of macroautophagyGO:001623980.013
immune system developmentGO:0002520570.013
Human Mouse
peptidyl lysine modificationGO:0018205570.013
glandular epithelial cell differentiationGO:000206710.013
trunk segmentationGO:003529080.013
anterior commissure morphogenesisGO:002196020.013
positive regulation of peptidyl tyrosine phosphorylationGO:005073140.013
response to inorganic substanceGO:0010035440.013
response to endogenous stimulusGO:00097191190.013
ecdysone mediated induction of salivary gland cell autophagic cell deathGO:0035072120.012
rna splicingGO:0008380830.012
midgut developmentGO:0007494230.012
regulation of innate immune responseGO:0045088710.012
mesenchymal cell developmentGO:001403110.012
outflow tract morphogenesisGO:000315140.012
regulation of body fluid levelsGO:0050878140.012
negative regulation of neuron apoptotic processGO:0043524140.012
macromolecular complex assemblyGO:00650032560.012
wing disc pattern formationGO:0035222660.012
multi organism reproductive behaviorGO:00447051210.012
immune response activating signal transductionGO:000275720.012
establishment or maintenance of cytoskeleton polarityGO:0030952440.011
compound eye morphogenesisGO:00017452490.011
notch signaling pathwayGO:00072191200.011
urogenital system developmentGO:0001655720.011
peptidyl lysine acetylationGO:0018394390.011
cardioblast cell fate commitmentGO:0042684140.011
positive regulation of nervous system developmentGO:0051962690.011
actomyosin structure organizationGO:0031032560.011
regulation of tube diameter open tracheal systemGO:0035158110.011
oxidation reduction processGO:00551141230.011
regulation of imaginal disc derived wing sizeGO:0044719200.011
negative regulation of cellular component organizationGO:00511291080.011
mapk cascadeGO:00001651070.011
cell fate specification involved in pattern specificationGO:006057380.011
genital disc sexually dimorphic developmentGO:003526340.011
positive regulation of cell motilityGO:200014730.011
response to glucoseGO:000974920.011
defense response to other organismGO:00985422250.011
synaptic transmissionGO:00072682880.011
methylationGO:0032259470.011
stem cell proliferationGO:0072089880.011
anterior head developmentGO:009706530.011
positive regulation of response to stimulusGO:00485843230.011
cellular amine metabolic processGO:0044106120.010
neural precursor cell proliferationGO:0061351750.010
central nervous system formationGO:002155650.010
phosphorylationGO:00163102940.010
small molecule metabolic processGO:00442813050.010

Dfd disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.122
disease of cellular proliferationDOID:1456600.060
cancerDOID:16200.033
organ system cancerDOID:005068600.032
cardiovascular system diseaseDOID:128700.029
congenital nervous system abnormalityDOID:249000.017
physical disorderDOID:008001500.017
sensory system diseaseDOID:005015500.015
nervous system diseaseDOID:86300.015
congenital heart diseaseDOID:168200.013
tetralogy of fallotDOID:641900.013
heart diseaseDOID:11400.013