IMP: Integrative Multi-species Prediction

Drosophila melanogaster

47 known processes

Lhr (Dmel_CG18468)

Lethal hybrid rescue

(Aliases: HP3,Dmel\CG18468,CG18468)

Entrez: 36957
FLYBASE: FBgn0034217
UniProtKB: Q95RV3

Process Predictions
Disease Predictions

Lhr biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
negative regulation of gene expression	GO:0010629	387	0.050
anatomical structure homeostasis	GO:0060249	97	0.048
chromosome organization	GO:0051276	360	0.046
appendage morphogenesis	GO:0035107	397	0.037
catabolic process	GO:0009056	409	0.035
appendage development	GO:0048736	401	0.032
nuclear division	GO:0000280	332	0.032
dna metabolic process	GO:0006259	227	0.032
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.031
telomere maintenance	GO:0000723	21	0.030
positive regulation of response to stimulus	GO:0048584	323	0.029
gene silencing	GO:0016458	138	0.029
histone mrna metabolic process	GO:0008334	8	0.028
positive regulation of signal transduction	GO:0009967	223	0.028
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.026
ras protein signal transduction	GO:0007265	88	0.025
regulation of gene expression epigenetic	GO:0040029	128	0.024
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.024
regionalization	GO:0003002	416	0.024
response to abiotic stimulus	GO:0009628	341	0.024
heterochromatin organization	GO:0070828	25	0.023
oxoacid metabolic process	GO:0043436	103	0.023
multi organism behavior	GO:0051705	175	0.023
dna conformation change	GO:0071103	105	0.023
mitotic sister chromatid segregation	GO:0000070	87	0.022
embryonic development via the syncytial blastoderm	GO:0001700	148	0.022
negative regulation of cellular metabolic process	GO:0031324	382	0.021
developmental growth	GO:0048589	280	0.020
organic substance catabolic process	GO:1901575	308	0.020
positive regulation of signaling	GO:0023056	243	0.020
regulation of organelle organization	GO:0033043	196	0.020
wing disc morphogenesis	GO:0007472	344	0.020
macromolecular complex assembly	GO:0065003	256	0.020
positive regulation of cell communication	GO:0010647	250	0.019
organelle fission	GO:0048285	340	0.019
regulation of cellular component biogenesis	GO:0044087	201	0.019
homeostatic process	GO:0042592	199	0.019
mitotic nuclear division	GO:0007067	213	0.019
carboxylic acid metabolic process	GO:0019752	92	0.019
stem cell division	GO:0017145	69	0.019
cilium morphogenesis	GO:0060271	39	0.018
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.018
cellular nitrogen compound catabolic process	GO:0044270	165	0.018
gene silencing by rna	GO:0031047	57	0.018
epithelial cell differentiation	GO:0030855	322	0.018
salivary gland development	GO:0007431	162	0.018
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.017
macromolecule catabolic process	GO:0009057	161	0.017
negative regulation of rna metabolic process	GO:0051253	251	0.017
cell proliferation	GO:0008283	299	0.017
positive regulation of gene expression	GO:0010628	290	0.017
phagocytosis	GO:0006909	215	0.017
aromatic compound catabolic process	GO:0019439	166	0.016
embryonic morphogenesis	GO:0048598	206	0.016
cellular macromolecule catabolic process	GO:0044265	136	0.016
cell projection assembly	GO:0030031	94	0.016
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.016
cellular amino acid metabolic process	GO:0006520	61	0.016
tissue morphogenesis	GO:0048729	297	0.016
cellular macromolecular complex assembly	GO:0034622	153	0.016
neurological system process	GO:0050877	358	0.016
heterocycle catabolic process	GO:0046700	166	0.016
exocrine system development	GO:0035272	162	0.015
compound eye photoreceptor cell differentiation	GO:0001751	140	0.015
regulation of multicellular organismal development	GO:2000026	414	0.015
regulation of cellular amine metabolic process	GO:0033238	3	0.015
protein complex biogenesis	GO:0070271	201	0.015
centrosome cycle	GO:0007098	137	0.015
cellular catabolic process	GO:0044248	372	0.015
regulation of cell differentiation	GO:0045595	302	0.015
central nervous system development	GO:0007417	201	0.015
positive regulation of cellular biosynthetic process	GO:0031328	316	0.015
negative regulation of developmental process	GO:0051093	201	0.015
small gtpase mediated signal transduction	GO:0007264	88	0.015
chromatin organization	GO:0006325	207	0.015
cellular component assembly involved in morphogenesis	GO:0010927	151	0.015
protein dna complex subunit organization	GO:0071824	86	0.014
chromosome segregation	GO:0007059	157	0.014
negative regulation of transcription dna templated	GO:0045892	237	0.014
triglyceride catabolic process	GO:0019433	3	0.014
chromatin remodeling	GO:0006338	72	0.014
locomotory behavior	GO:0007626	176	0.014
chromatin assembly	GO:0031497	48	0.014
organophosphate metabolic process	GO:0019637	195	0.014
cell division	GO:0051301	248	0.014
synaptic transmission	GO:0007268	288	0.014
phosphorylation	GO:0016310	294	0.014
regulation of cell cycle process	GO:0010564	181	0.014
organonitrogen compound metabolic process	GO:1901564	318	0.014
rna interference	GO:0016246	27	0.014
establishment or maintenance of cell polarity	GO:0007163	167	0.014
rna processing	GO:0006396	147	0.014
body morphogenesis	GO:0010171	2	0.014
organelle assembly	GO:0070925	198	0.014
negative regulation of rna biosynthetic process	GO:1902679	240	0.013
positive regulation of lipid metabolic process	GO:0045834	4	0.013
imaginal disc derived wing morphogenesis	GO:0007476	337	0.013
positive regulation of biosynthetic process	GO:0009891	316	0.013
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.013
stem cell proliferation	GO:0072089	88	0.013
salivary gland morphogenesis	GO:0007435	145	0.013
negative regulation of cellular biosynthetic process	GO:0031327	277	0.013
cellular metal ion homeostasis	GO:0006875	31	0.013
posttranscriptional gene silencing	GO:0016441	46	0.013
spinal cord development	GO:0021510	1	0.013
organic cyclic compound catabolic process	GO:1901361	168	0.013
cellular response to dna damage stimulus	GO:0006974	223	0.012
determination of adult lifespan	GO:0008340	137	0.012
axis specification	GO:0009798	167	0.012
imaginal disc derived appendage development	GO:0048737	399	0.012
organic acid metabolic process	GO:0006082	103	0.012
cilium organization	GO:0044782	41	0.012
negative regulation of nervous system development	GO:0051961	92	0.012
regulation of dna metabolic process	GO:0051052	34	0.012
regulation of epidermal growth factor receptor signaling pathway	GO:0042058	42	0.012
forebrain development	GO:0030900	2	0.012
posttranscriptional gene silencing by rna	GO:0035194	45	0.012
cellular amine metabolic process	GO:0044106	12	0.012
cellularization	GO:0007349	90	0.012
response to light stimulus	GO:0009416	124	0.012
stem cell development	GO:0048864	79	0.012
spindle organization	GO:0007051	253	0.012
negative regulation of erk1 and erk2 cascade	GO:0070373	3	0.012
regulation of phosphorus metabolic process	GO:0051174	210	0.012
response to extracellular stimulus	GO:0009991	116	0.012
positive regulation of rna biosynthetic process	GO:1902680	266	0.012
endocytosis	GO:0006897	310	0.012
positive regulation of cellular amine metabolic process	GO:0033240	0	0.012
multi multicellular organism process	GO:0044706	123	0.012
cellular protein modification process	GO:0006464	438	0.011
taxis	GO:0042330	304	0.011
regulation of localization	GO:0032879	275	0.011
regulation of cellular amino acid metabolic process	GO:0006521	0	0.011
cellular response to biotic stimulus	GO:0071216	4	0.011
single organism biosynthetic process	GO:0044711	206	0.011
protein modification process	GO:0036211	438	0.011
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.011
learning	GO:0007612	75	0.011
compound eye morphogenesis	GO:0001745	249	0.011
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.011
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.011
chromosome localization	GO:0050000	20	0.011
negative regulation of biosynthetic process	GO:0009890	277	0.011
negative regulation of cell differentiation	GO:0045596	143	0.011
nucleobase containing compound catabolic process	GO:0034655	165	0.011
regulation of neurogenesis	GO:0050767	158	0.011
regulation of immune system process	GO:0002682	176	0.011
regulation of phosphate metabolic process	GO:0019220	210	0.011
telencephalon development	GO:0021537	2	0.011
apoptotic process	GO:0006915	159	0.011
positive regulation of cellular component biogenesis	GO:0044089	80	0.010
regulation of nervous system development	GO:0051960	248	0.010
eye photoreceptor cell differentiation	GO:0001754	145	0.010
lipid metabolic process	GO:0006629	121	0.010
gland morphogenesis	GO:0022612	145	0.010
regulation of developmental growth	GO:0048638	174	0.010
pole cell formation	GO:0007279	19	0.010
regulation of ras protein signal transduction	GO:0046578	93	0.010

Lhr disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	disease of anatomical entity	DOID:7	0	0.019
	nervous system disease	DOID:863	0	0.017

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