IMP: Integrative Multi-species Prediction

Drosophila melanogaster

46 known processes

Kmn1 (Dmel_CG1558)

kinetochore Mis12-Ndc80 network component 1

(Aliases: Nsl1,l(1)G0237,CT4038,CG1558,anon-WO03040301.201,Dmel\CG1558,dmNsl1R)

Entrez: 32102
FLYBASE: FBgn0027259
UniProtKB: Q9VYX4

Process Predictions
Disease Predictions

Kmn1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
sister chromatid segregation	GO:0000819	92	0.984
chromosome segregation	GO:0007059	157	0.946
mitotic sister chromatid segregation	GO:0000070	87	0.943
mitotic metaphase plate congression	GO:0007080	13	0.942
mitotic spindle organization	GO:0007052	220	0.866
mitotic nuclear division	GO:0007067	213	0.832
chromosome localization	GO:0050000	20	0.798
chromosome organization	GO:0051276	360	0.762
nuclear division	GO:0000280	332	0.646
spindle assembly involved in mitosis	GO:0090307	50	0.641
cell cycle phase transition	GO:0044770	140	0.623
spindle assembly	GO:0051225	80	0.603
establishment of localization in cell	GO:0051649	402	0.532
negative regulation of rna biosynthetic process	GO:1902679	240	0.504
regulation of neurogenesis	GO:0050767	158	0.487
metaphase plate congression	GO:0051310	19	0.463
establishment of chromosome localization	GO:0051303	20	0.455
regulation of cell cycle phase transition	GO:1901987	130	0.448
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.421
dendrite development	GO:0016358	204	0.411
mitotic spindle elongation	GO:0000022	81	0.405
mitotic sister chromatid separation	GO:0051306	30	0.371
dendrite morphogenesis	GO:0048813	199	0.367
spindle organization	GO:0007051	253	0.358
muscle structure development	GO:0061061	224	0.358
regulation of cell differentiation	GO:0045595	302	0.317
positive regulation of mitotic cell cycle	GO:0045931	34	0.313
cellular response to dna damage stimulus	GO:0006974	223	0.304
intracellular signal transduction	GO:0035556	300	0.288
microtubule cytoskeleton organization involved in mitosis	GO:1902850	52	0.282
organelle fission	GO:0048285	340	0.270
negative regulation of gene expression	GO:0010629	387	0.254
establishment of organelle localization	GO:0051656	122	0.249
negative regulation of cellular metabolic process	GO:0031324	382	0.248
positive regulation of mitotic cell cycle phase transition	GO:1901992	20	0.248
rna processing	GO:0006396	147	0.240
regulation of mitotic sister chromatid segregation	GO:0033047	28	0.239
organelle localization	GO:0051640	148	0.229
mitotic cell cycle phase transition	GO:0044772	138	0.195
cell proliferation	GO:0008283	299	0.192
metaphase anaphase transition of cell cycle	GO:0044784	28	0.188
dna conformation change	GO:0071103	105	0.165
positive regulation of cell cycle process	GO:0090068	28	0.157
negative regulation of cell cycle process	GO:0010948	109	0.157
meiotic chromosome segregation	GO:0045132	59	0.151
kinetochore organization	GO:0051383	9	0.143
recombinational repair	GO:0000725	13	0.138
protein complex assembly	GO:0006461	200	0.138
meiotic cell cycle process	GO:1903046	132	0.136
macromolecule catabolic process	GO:0009057	161	0.133
organic substance transport	GO:0071702	257	0.131
negative regulation of mitotic cell cycle	GO:0045930	109	0.130
protein complex biogenesis	GO:0070271	201	0.130
exocrine system development	GO:0035272	162	0.130
regulation of mitotic cell cycle	GO:0007346	190	0.127
muscle organ development	GO:0007517	127	0.126
cellular protein catabolic process	GO:0044257	83	0.123
dna damage checkpoint	GO:0000077	78	0.123
neuroblast proliferation	GO:0007405	74	0.122
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.121
cell death	GO:0008219	279	0.118
positive regulation of phosphate metabolic process	GO:0045937	139	0.117
negative regulation of transcription dna templated	GO:0045892	237	0.117
cellular catabolic process	GO:0044248	372	0.117
dna metabolic process	GO:0006259	227	0.116
proteolysis	GO:0006508	192	0.112
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.110
cellular macromolecule catabolic process	GO:0044265	136	0.108
negative regulation of cellular biosynthetic process	GO:0031327	277	0.097
positive regulation of r7 cell differentiation	GO:0045678	7	0.095
regulation of phosphate metabolic process	GO:0019220	210	0.092
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.092
positive regulation of phosphorus metabolic process	GO:0010562	139	0.088
regulation of proteasomal protein catabolic process	GO:0061136	39	0.082
positive regulation of neurogenesis	GO:0050769	41	0.081
regulation of mitotic sister chromatid separation	GO:0010965	28	0.080
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.077
single organism catabolic process	GO:0044712	228	0.077
negative regulation of cell differentiation	GO:0045596	143	0.076
photoreceptor cell differentiation	GO:0046530	170	0.071
cell cycle checkpoint	GO:0000075	95	0.070
regulation of mitotic metaphase anaphase transition	GO:0030071	26	0.068
modification dependent macromolecule catabolic process	GO:0043632	79	0.067
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.066
body morphogenesis	GO:0010171	2	0.066
response to abiotic stimulus	GO:0009628	341	0.065
regulation of cell division	GO:0051302	72	0.065
regulation of chromosome segregation	GO:0051983	32	0.065
protein localization	GO:0008104	284	0.062
negative regulation of gene expression epigenetic	GO:0045814	77	0.062
proteasomal protein catabolic process	GO:0010498	59	0.061
positive regulation of cell cycle	GO:0045787	43	0.061
rna localization	GO:0006403	115	0.060
cellular protein modification process	GO:0006464	438	0.058
microtubule based movement	GO:0007018	51	0.057
regulation of metaphase anaphase transition of cell cycle	GO:1902099	26	0.057
ras protein signal transduction	GO:0007265	88	0.056
negative regulation of biosynthetic process	GO:0009890	277	0.056
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	54	0.055
metaphase anaphase transition of mitotic cell cycle	GO:0007091	28	0.055
mitotic cell cycle checkpoint	GO:0007093	88	0.054
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.054
organic substance catabolic process	GO:1901575	308	0.054
chromosome movement towards spindle pole	GO:0051305	4	0.053
regulation of mapk cascade	GO:0043408	92	0.053
regulation of phosphorylation	GO:0042325	147	0.052
regulation of multicellular organismal development	GO:2000026	414	0.051
modification dependent protein catabolic process	GO:0019941	78	0.051
gliogenesis	GO:0042063	80	0.051
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.051
small gtpase mediated signal transduction	GO:0007264	88	0.051
embryo development ending in birth or egg hatching	GO:0009792	152	0.051
negative regulation of meiotic cell cycle	GO:0051447	2	0.049
protein localization to organelle	GO:0033365	82	0.047
atp dependent chromatin remodeling	GO:0043044	22	0.047
regulation of cellular protein metabolic process	GO:0032268	243	0.046
cardiovascular system development	GO:0072358	82	0.045
ubiquitin dependent protein catabolic process	GO:0006511	78	0.043
establishment of rna localization	GO:0051236	47	0.043
positive regulation of phosphorylation	GO:0042327	87	0.042
regulation of cellular catabolic process	GO:0031329	157	0.042
positive regulation of molecular function	GO:0044093	136	0.041
regulation of phosphorus metabolic process	GO:0051174	210	0.041
lateral inhibition	GO:0046331	206	0.041
positive regulation of response to stimulus	GO:0048584	323	0.041
chromatin modification	GO:0016568	147	0.040
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.040
cellular macromolecule localization	GO:0070727	220	0.040
regulation of dendrite development	GO:0050773	37	0.040
mitotic g2 m transition checkpoint	GO:0044818	70	0.039
nitrogen compound transport	GO:0071705	85	0.039
regulation of intracellular signal transduction	GO:1902531	236	0.038
eye photoreceptor cell differentiation	GO:0001754	145	0.037
cellular amino acid metabolic process	GO:0006520	61	0.036
dna packaging	GO:0006323	91	0.036
regulation of sister chromatid segregation	GO:0033045	28	0.035
protein modification by small protein conjugation or removal	GO:0070647	106	0.035
negative regulation of cell cycle phase transition	GO:1901988	103	0.035
dna integrity checkpoint	GO:0031570	81	0.034
chromatin remodeling	GO:0006338	72	0.034
regulation of neuroblast proliferation	GO:1902692	34	0.033
rho protein signal transduction	GO:0007266	14	0.033
regulation of response to stress	GO:0080134	200	0.033
histone exchange	GO:0043486	21	0.033
dna endoreduplication	GO:0042023	22	0.032
chromatin silencing	GO:0006342	76	0.032
regulation of r7 cell differentiation	GO:0045676	15	0.032
mitotic chromosome condensation	GO:0007076	22	0.032
regulation of neuron differentiation	GO:0045664	103	0.032
catabolic process	GO:0009056	409	0.032
regulation of chromosome organization	GO:0033044	64	0.031
regulation of catalytic activity	GO:0050790	185	0.031
organic acid metabolic process	GO:0006082	103	0.031
regulation of nervous system development	GO:0051960	248	0.031
protein phosphorylation	GO:0006468	169	0.030
regulation of molecular function	GO:0065009	217	0.030
regulation of meiosis	GO:0040020	3	0.030
positive regulation of cellular protein metabolic process	GO:0032270	118	0.029
regulation of gene silencing	GO:0060968	63	0.029
positive regulation of protein modification process	GO:0031401	58	0.029
regulation of cell proliferation	GO:0042127	163	0.029
gene silencing	GO:0016458	138	0.029
regulation of gene expression epigenetic	GO:0040029	128	0.029
protein modification process	GO:0036211	438	0.029
organonitrogen compound metabolic process	GO:1901564	318	0.029
compound eye photoreceptor cell differentiation	GO:0001751	140	0.029
signal transduction by phosphorylation	GO:0023014	107	0.029
purine ribonucleotide catabolic process	GO:0009154	109	0.028
phagocytosis	GO:0006909	215	0.028
positive regulation of gtpase activity	GO:0043547	43	0.028
centrosome cycle	GO:0007098	137	0.028
positive regulation of cellular component organization	GO:0051130	156	0.027
regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032434	37	0.027
positive regulation of cell proliferation	GO:0008284	47	0.027
carboxylic acid metabolic process	GO:0019752	92	0.027
positive regulation of catalytic activity	GO:0043085	118	0.026
regulation of cellular amine metabolic process	GO:0033238	3	0.026
regulation of ras protein signal transduction	GO:0046578	93	0.026
positive regulation of cellular amine metabolic process	GO:0033240	0	0.026
centromere complex assembly	GO:0034508	7	0.025
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.025
regulation of cellular amino acid metabolic process	GO:0006521	0	0.025
positive regulation of photoreceptor cell differentiation	GO:0046534	12	0.025
female meiosis i	GO:0007144	8	0.024
macromolecular complex assembly	GO:0065003	256	0.023
germarium derived female germ line cyst formation	GO:0030727	42	0.023
meiotic spindle organization	GO:0000212	36	0.023
negative regulation of organelle organization	GO:0010639	56	0.023
regulation of catabolic process	GO:0009894	170	0.023
endocytosis	GO:0006897	310	0.022
positive regulation of cellular catabolic process	GO:0031331	95	0.022
nucleobase containing compound transport	GO:0015931	56	0.022
negative regulation of neuroblast proliferation	GO:0007406	27	0.022
regulation of protein metabolic process	GO:0051246	256	0.022
chromosome condensation	GO:0030261	41	0.022
positive regulation of protein metabolic process	GO:0051247	128	0.022
regulation of cellular protein catabolic process	GO:1903362	44	0.022
mitotic dna damage checkpoint	GO:0044773	74	0.022
regulation of cell cycle	GO:0051726	291	0.022
gland morphogenesis	GO:0022612	145	0.021
negative regulation of neurogenesis	GO:0050768	53	0.021
sarcomere organization	GO:0045214	26	0.021
salivary gland development	GO:0007431	162	0.021
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process	GO:0031145	30	0.020
regulation of cell death	GO:0010941	173	0.020
regulation of cell cycle process	GO:0010564	181	0.020
positive regulation of gliogenesis	GO:0014015	5	0.020
positive regulation of chromatin silencing	GO:0031937	16	0.019
intracellular transport	GO:0046907	228	0.019
positive regulation of metaphase anaphase transition of cell cycle	GO:1902101	10	0.019
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.019
positive regulation of hydrolase activity	GO:0051345	78	0.019
negative regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032435	16	0.019
aging	GO:0007568	143	0.019
axon development	GO:0061564	297	0.018
protein catabolic process	GO:0030163	101	0.018
striated muscle tissue development	GO:0014706	27	0.018
cellular protein localization	GO:0034613	160	0.018
negative regulation of developmental process	GO:0051093	201	0.018
circulatory system development	GO:0072359	82	0.018
regulation of photoreceptor cell differentiation	GO:0046532	34	0.018
positive regulation of erk1 and erk2 cascade	GO:0070374	36	0.018
gland development	GO:0048732	191	0.018
axonogenesis	GO:0007409	290	0.018
positive regulation of mitotic sister chromatid separation	GO:1901970	10	0.017
regulation of proteolysis	GO:0030162	87	0.017
regulation of organelle organization	GO:0033043	196	0.017
cell cycle dna replication	GO:0044786	23	0.017
g2 dna damage checkpoint	GO:0031572	69	0.017
positive regulation of dna endoreduplication	GO:0032877	4	0.017
regulation of chromatin silencing	GO:0031935	36	0.017
dorsal ventral pattern formation	GO:0009953	133	0.016
phosphorylation	GO:0016310	294	0.016
regulation of cellular ketone metabolic process	GO:0010565	3	0.016
regulation of nucleotide metabolic process	GO:0006140	62	0.016
chromosome separation	GO:0051304	42	0.016
nuclear transport	GO:0051169	72	0.015
rna transport	GO:0050658	46	0.015
muscle cell differentiation	GO:0042692	103	0.015
stem cell maintenance	GO:0019827	67	0.015
death	GO:0016265	284	0.015
posttranscriptional regulation of gene expression	GO:0010608	145	0.015
chemosensory behavior	GO:0007635	106	0.015
r7 cell differentiation	GO:0045466	43	0.014
erk1 and erk2 cascade	GO:0070371	39	0.014
response to organic substance	GO:0010033	284	0.014
protein localization to nucleus	GO:0034504	55	0.014
regulation of cellular component biogenesis	GO:0044087	201	0.014
histolysis	GO:0007559	102	0.014
regulation of erk1 and erk2 cascade	GO:0070372	39	0.014
negative regulation of mitotic sister chromatid separation	GO:2000816	13	0.014
synapse organization	GO:0050808	196	0.014
negative regulation of cellular catabolic process	GO:0031330	34	0.014
positive regulation of catabolic process	GO:0009896	105	0.014
mitotic g2 dna damage checkpoint	GO:0007095	69	0.014
stem cell development	GO:0048864	79	0.014
positive regulation of multicellular organismal process	GO:0051240	143	0.014
protein modification by small protein conjugation	GO:0032446	79	0.013
meiotic cell cycle	GO:0051321	171	0.013
regulation of cell development	GO:0060284	215	0.013
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.013
response to temperature stimulus	GO:0009266	106	0.013
single organism behavior	GO:0044708	391	0.013
regulation of dna metabolic process	GO:0051052	34	0.013
acylglycerol catabolic process	GO:0046464	3	0.013
germ line cyst formation	GO:0048134	44	0.013
positive regulation of intracellular signal transduction	GO:1902533	116	0.013
purine ribonucleotide metabolic process	GO:0009150	145	0.013
mitotic cell cycle embryonic	GO:0045448	38	0.013
regulation of cellular response to stress	GO:0080135	89	0.013
developmental programmed cell death	GO:0010623	138	0.013
oxoacid metabolic process	GO:0043436	103	0.013
regulation of double strand break repair	GO:2000779	3	0.013
aromatic compound catabolic process	GO:0019439	166	0.013
organelle assembly	GO:0070925	198	0.013
maintenance of protein location in cell	GO:0032507	26	0.013
regulation of nucleotide catabolic process	GO:0030811	48	0.013
regulation of transcription by chromatin organization	GO:0034401	3	0.013
regulation of purine nucleotide catabolic process	GO:0033121	48	0.012
poly a mrna export from nucleus	GO:0016973	5	0.012
mapk cascade	GO:0000165	107	0.012
regulation of triglyceride catabolic process	GO:0010896	1	0.012
camera type eye morphogenesis	GO:0048593	2	0.012
intracellular protein transport	GO:0006886	104	0.012
cellular response to endogenous stimulus	GO:0071495	80	0.012
positive regulation of macromolecule metabolic process	GO:0010604	405	0.012
neuron recognition	GO:0008038	101	0.012
positive regulation of nucleotide catabolic process	GO:0030813	46	0.012
response to biotic stimulus	GO:0009607	294	0.012
chromatin organization	GO:0006325	207	0.012
vesicle mediated transport	GO:0016192	381	0.012
response to uv	GO:0009411	24	0.012
positive regulation of mapk cascade	GO:0043410	63	0.012
wing disc morphogenesis	GO:0007472	344	0.011
negative regulation of wnt signaling pathway	GO:0030178	28	0.011
negative regulation of cellular component organization	GO:0051129	108	0.011
positive regulation of cell differentiation	GO:0045597	64	0.011
single organism biosynthetic process	GO:0044711	206	0.011
macromolecular complex disassembly	GO:0032984	37	0.011
regulation of protein processing	GO:0070613	32	0.011
positive regulation of organelle organization	GO:0010638	65	0.011
negative regulation of cell communication	GO:0010648	223	0.011
mitotic dna integrity checkpoint	GO:0044774	75	0.011
negative regulation of catabolic process	GO:0009895	36	0.011
response to organic cyclic compound	GO:0014070	89	0.011
heterocycle catabolic process	GO:0046700	166	0.011
mrna processing	GO:0006397	104	0.011
negative regulation of cellular protein metabolic process	GO:0032269	85	0.011
negative regulation of response to stimulus	GO:0048585	258	0.011
positive regulation of binding	GO:0051099	4	0.010
purine ribonucleoside metabolic process	GO:0046128	127	0.010
regulation of transferase activity	GO:0051338	58	0.010
response to radiation	GO:0009314	155	0.010
nucleus localization	GO:0051647	34	0.010
actomyosin structure organization	GO:0031032	56	0.010
oocyte maturation	GO:0001556	3	0.010
larval development	GO:0002164	104	0.010
synaptic transmission	GO:0007268	288	0.010
positive regulation of cellular component biogenesis	GO:0044089	80	0.010

Kmn1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	disease of anatomical entity	DOID:7	0	0.027
	nervous system disease	DOID:863	0	0.018

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