IMP: Integrative Multi-species Prediction

Drosophila melanogaster

60 known processes

inv (Dmel_CG17835)

invected

(Aliases: Engrailed/Invected,Inv,IV,CG17835,in,Dmel\CG17835,er)

FLYBASE: FBgn0001269
Entrez: 36239
UniProtKB: P05527

Process Predictions
Disease Predictions

inv biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.894
imaginal disc derived appendage development	GO:0048737	399	0.821
negative regulation of rna metabolic process	GO:0051253	251	0.777	Worm Fly
appendage development	GO:0048736	401	0.737
negative regulation of biosynthetic process	GO:0009890	277	0.730	Worm Fly
wing disc morphogenesis	GO:0007472	344	0.701
negative regulation of transcription dna templated	GO:0045892	237	0.686	Worm Fly
appendage morphogenesis	GO:0035107	397	0.627
negative regulation of cellular metabolic process	GO:0031324	382	0.614	Worm Fly
post embryonic appendage morphogenesis	GO:0035120	385	0.556
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.513	Worm Fly
segmentation	GO:0035282	207	0.435
negative regulation of rna biosynthetic process	GO:1902679	240	0.400	Worm Fly
imaginal disc derived wing morphogenesis	GO:0007476	337	0.387
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.319	Worm Fly
periodic partitioning	GO:0007365	29	0.300
cell recognition	GO:0008037	102	0.290
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.280	Mouse Worm Fly
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.258	Worm Fly
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.254	Worm Fly
long term memory	GO:0007616	62	0.241
regionalization	GO:0003002	416	0.232
regulation of multicellular organismal development	GO:2000026	414	0.221
negative regulation of gene expression	GO:0010629	387	0.218	Worm Fly
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.216	Worm Fly
negative regulation of response to stimulus	GO:0048585	258	0.202
negative regulation of cell differentiation	GO:0045596	143	0.198
cellular protein modification process	GO:0006464	438	0.197
bmp signaling pathway	GO:0030509	27	0.196
morphogenesis of an epithelium	GO:0002009	276	0.183
neuron recognition	GO:0008038	101	0.182
neuron fate determination	GO:0048664	1	0.178
protein modification process	GO:0036211	438	0.170
nephron epithelium development	GO:0072009	3	0.170
single organism behavior	GO:0044708	391	0.168
neuron fate commitment	GO:0048663	50	0.159	Zebrafish
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.158	Mouse Worm Fly
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.157	Mouse Worm Fly
stem cell proliferation	GO:0072089	88	0.155
central nervous system development	GO:0007417	201	0.155	Zebrafish Mouse Fly
carboxylic acid metabolic process	GO:0019752	92	0.148
epithelial cell differentiation	GO:0030855	322	0.146	Worm
transcription from rna polymerase ii promoter	GO:0006366	368	0.144	Mouse Worm Fly
neuroblast proliferation	GO:0007405	74	0.143
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.140	Worm Fly
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.138
nephron epithelium morphogenesis	GO:0072088	3	0.131
epithelial cell development	GO:0002064	274	0.130
nephron tubule morphogenesis	GO:0072078	3	0.129
memory	GO:0007613	94	0.129
columnar cuboidal epithelial cell development	GO:0002066	249	0.129
regulation of bmp signaling pathway	GO:0030510	23	0.128
connective tissue development	GO:0061448	3	0.120
negative regulation of developmental process	GO:0051093	201	0.118
intracellular signal transduction	GO:0035556	300	0.116
growth	GO:0040007	359	0.112	Mouse
developmental growth	GO:0048589	280	0.107
imaginal disc derived wing vein morphogenesis	GO:0008586	44	0.106
myotube differentiation	GO:0014902	46	0.106
embryonic pattern specification	GO:0009880	174	0.105
positive regulation of rna metabolic process	GO:0051254	271	0.105	Mouse Worm Fly
imaginal disc pattern formation	GO:0007447	91	0.102	Fly
organonitrogen compound metabolic process	GO:1901564	318	0.101
respiratory system development	GO:0060541	213	0.101	Fly
regulation of embryonic development	GO:0045995	68	0.100
kidney epithelium development	GO:0072073	3	0.100
cellular amine metabolic process	GO:0044106	12	0.096
negative regulation of signal transduction	GO:0009968	206	0.089
axonogenesis	GO:0007409	290	0.088	Fly
eye antennal disc development	GO:0035214	60	0.088
multi organism reproductive behavior	GO:0044705	121	0.087
skeletal muscle organ development	GO:0060538	48	0.087
limb morphogenesis	GO:0035108	1	0.086	Mouse
telencephalon development	GO:0021537	2	0.086	Fly
anterior posterior axis specification	GO:0009948	109	0.085
epidermis development	GO:0008544	65	0.083	Worm
response to external biotic stimulus	GO:0043207	293	0.082
neurological system process	GO:0050877	358	0.081
adult behavior	GO:0030534	137	0.081
regulation of intracellular signal transduction	GO:1902531	236	0.081
blastoderm segmentation	GO:0007350	159	0.080
compound eye photoreceptor cell differentiation	GO:0001751	140	0.079
cellular ketone metabolic process	GO:0042180	24	0.079
axon development	GO:0061564	297	0.078	Fly
kidney development	GO:0001822	3	0.077
cellular amide metabolic process	GO:0043603	80	0.075
tissue morphogenesis	GO:0048729	297	0.075
positive regulation of macromolecule metabolic process	GO:0010604	405	0.072	Mouse Worm Fly
regulation of neural precursor cell proliferation	GO:2000177	35	0.071
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.071
neural precursor cell proliferation	GO:0061351	75	0.071
response to organic substance	GO:0010033	284	0.069
nephron tubule development	GO:0072080	3	0.069
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.068	Mouse Worm Fly
oxoacid metabolic process	GO:0043436	103	0.067
nephron morphogenesis	GO:0072028	3	0.067
lateral inhibition	GO:0046331	206	0.065
cellular amino acid metabolic process	GO:0006520	61	0.064
circulatory system development	GO:0072359	82	0.064
anterior posterior pattern specification	GO:0009952	136	0.064
protein modification by small protein conjugation or removal	GO:0070647	106	0.064
negative regulation of cell communication	GO:0010648	223	0.063
negative regulation of cellular biosynthetic process	GO:0031327	277	0.063	Worm Fly
positive regulation of biosynthetic process	GO:0009891	316	0.061	Mouse Worm Fly
vesicle mediated transport	GO:0016192	381	0.061
dendrite morphogenesis	GO:0048813	199	0.060
kidney morphogenesis	GO:0060993	3	0.060
cognition	GO:0050890	141	0.060
cardiovascular system development	GO:0072358	82	0.060
pigmentation	GO:0043473	75	0.059	Mouse
forebrain development	GO:0030900	2	0.059	Fly
smoothened signaling pathway	GO:0007224	49	0.059
gland development	GO:0048732	191	0.059
myoblast proliferation	GO:0051450	3	0.057
detection of chemical stimulus involved in sensory perception of smell	GO:0050911	50	0.054
negative regulation of signaling	GO:0023057	219	0.054
negative regulation of immune system process	GO:0002683	50	0.054
compound eye morphogenesis	GO:0001745	249	0.054
myotube cell development	GO:0014904	3	0.053
positive regulation of cellular biosynthetic process	GO:0031328	316	0.053	Mouse Worm Fly
immune response regulating signaling pathway	GO:0002764	2	0.053
renal tubule development	GO:0061326	64	0.053
body morphogenesis	GO:0010171	2	0.051	Worm
brain development	GO:0007420	120	0.051	Zebrafish Mouse Fly
dorsal ventral pattern formation	GO:0009953	133	0.051	Mouse
head development	GO:0060322	135	0.051	Zebrafish Mouse Fly
regulation of phosphorus metabolic process	GO:0051174	210	0.050
cellular response to organic substance	GO:0071310	132	0.050
dendrite development	GO:0016358	204	0.050
ovarian follicle cell development	GO:0030707	248	0.050
peripheral nervous system development	GO:0007422	52	0.050
epithelial tube morphogenesis	GO:0060562	88	0.049
phosphorylation	GO:0016310	294	0.049
wing disc pattern formation	GO:0035222	66	0.049
stem cell maintenance	GO:0019827	67	0.049
notch signaling pathway	GO:0007219	120	0.048
neuroblast division	GO:0055057	35	0.048
reproductive behavior	GO:0019098	122	0.047
rhythmic process	GO:0048511	106	0.047
multi multicellular organism process	GO:0044706	123	0.047
posttranscriptional regulation of gene expression	GO:0010608	145	0.047
imaginal disc derived leg morphogenesis	GO:0007480	80	0.047
regulation of glial cell differentiation	GO:0045685	1	0.047
regulation of nervous system development	GO:0051960	248	0.046
positive regulation of multicellular organismal process	GO:0051240	143	0.046
regulation of neuroblast proliferation	GO:1902692	34	0.046
regulation of cell differentiation	GO:0045595	302	0.046
negative regulation of catabolic process	GO:0009895	36	0.045
regulation of protein metabolic process	GO:0051246	256	0.045
mesoderm development	GO:0007498	78	0.045
nucleobase containing compound catabolic process	GO:0034655	165	0.044
amine metabolic process	GO:0009308	12	0.044
salivary gland development	GO:0007431	162	0.043
immune response activating signal transduction	GO:0002757	2	0.043
stem cell development	GO:0048864	79	0.043
regulation of phosphate metabolic process	GO:0019220	210	0.042
axis specification	GO:0009798	167	0.042
nephron development	GO:0072006	3	0.042
epithelial tube formation	GO:0072175	7	0.041
regulation of gene expression epigenetic	GO:0040029	128	0.041
regulation of gene silencing	GO:0060968	63	0.040
histone modification	GO:0016570	106	0.040
muscle cell differentiation	GO:0042692	103	0.040
eye photoreceptor cell differentiation	GO:0001754	145	0.040
stem cell differentiation	GO:0048863	117	0.040
skeletal muscle fiber development	GO:0048741	3	0.040
formation of anatomical boundary	GO:0048859	37	0.039	Worm
open tracheal system development	GO:0007424	204	0.038	Fly
establishment of planar polarity	GO:0001736	87	0.038
malpighian tubule morphogenesis	GO:0007443	44	0.037
response to organic cyclic compound	GO:0014070	89	0.037
response to endogenous stimulus	GO:0009719	119	0.037
regulation of immune response	GO:0050776	118	0.037
leg disc development	GO:0035218	92	0.037
organic substance catabolic process	GO:1901575	308	0.037
cell adhesion	GO:0007155	136	0.037
regulation of notch signaling pathway	GO:0008593	100	0.037
stem cell division	GO:0017145	69	0.037
anterior posterior pattern specification imaginal disc	GO:0007448	16	0.036	Fly
positive regulation of signaling	GO:0023056	243	0.036
motor neuron axon guidance	GO:0008045	58	0.036
single organism intracellular transport	GO:1902582	207	0.035
small molecule metabolic process	GO:0044281	305	0.035
embryonic morphogenesis	GO:0048598	206	0.035	Zebrafish Mouse Worm
negative regulation of nervous system development	GO:0051961	92	0.034
cell proliferation	GO:0008283	299	0.034
regulation of cell morphogenesis	GO:0022604	163	0.033
regulation of cellular amino acid metabolic process	GO:0006521	0	0.033
biological adhesion	GO:0022610	138	0.032
cell fate specification	GO:0001708	71	0.032	Zebrafish Worm
leg disc morphogenesis	GO:0007478	80	0.032
digestive system development	GO:0055123	149	0.032
single organism biosynthetic process	GO:0044711	206	0.032
hindgut development	GO:0061525	58	0.032
response to fibroblast growth factor	GO:0071774	10	0.031
mesenchymal cell differentiation	GO:0048762	1	0.031
compound eye development	GO:0048749	307	0.031
phagocytosis	GO:0006909	215	0.031
retina morphogenesis in camera type eye	GO:0060042	2	0.031
regulation of organ morphogenesis	GO:2000027	78	0.030
neuronal stem cell maintenance	GO:0097150	4	0.030
striated muscle tissue development	GO:0014706	27	0.030
regulation of cellular amine metabolic process	GO:0033238	3	0.030
sensory organ morphogenesis	GO:0090596	260	0.030
positive regulation of cell communication	GO:0010647	250	0.030
jak stat cascade	GO:0007259	49	0.030
regulation of mitotic cell cycle	GO:0007346	190	0.029
regulation of phosphorylation	GO:0042325	147	0.029
single organism cellular localization	GO:1902580	180	0.029
macromolecule catabolic process	GO:0009057	161	0.028
learning or memory	GO:0007611	141	0.028
multicellular organismal reproductive behavior	GO:0033057	110	0.028
imaginal disc derived leg segmentation	GO:0036011	26	0.028
regulation of cellular ketone metabolic process	GO:0010565	3	0.027
morphogenesis of a polarized epithelium	GO:0001738	93	0.027
multicellular organism growth	GO:0035264	46	0.027	Mouse
locomotory behavior	GO:0007626	176	0.027
muscle tissue development	GO:0060537	30	0.026
positive regulation of rna biosynthetic process	GO:1902680	266	0.026	Mouse Worm Fly
syncytium formation by plasma membrane fusion	GO:0000768	43	0.026
synaptic target recognition	GO:0008039	45	0.026
cell death	GO:0008219	279	0.026	Zebrafish
regulation of response to stress	GO:0080134	200	0.026
skeletal muscle tissue development	GO:0007519	13	0.026
epithelial structure maintenance	GO:0010669	17	0.026
imaginal disc derived wing vein specification	GO:0007474	48	0.025
cytoplasmic transport	GO:0016482	130	0.025
positive regulation of cell proliferation	GO:0008284	47	0.025
androgen metabolic process	GO:0008209	1	0.025
positive regulation of cell differentiation	GO:0045597	64	0.025
regulation of heart morphogenesis	GO:2000826	3	0.025
negative regulation of multicellular organismal process	GO:0051241	142	0.025
positive regulation of signal transduction	GO:0009967	223	0.025
eye morphogenesis	GO:0048592	260	0.025
eye photoreceptor cell fate commitment	GO:0042706	37	0.025
detection of stimulus involved in sensory perception	GO:0050906	92	0.024
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.024
regulation of epithelial cell differentiation	GO:0030856	4	0.024
cellular response to endogenous stimulus	GO:0071495	80	0.024
central nervous system neuron differentiation	GO:0021953	8	0.024	Fly
positive regulation of transcription dna templated	GO:0045893	266	0.023	Mouse Worm Fly
cuticle development	GO:0042335	86	0.023
pattern recognition receptor signaling pathway	GO:0002221	2	0.023
segment polarity determination	GO:0007367	25	0.023
myoblast fusion	GO:0007520	43	0.023
positive regulation of gene expression	GO:0010628	290	0.023	Mouse Worm Fly
response to abiotic stimulus	GO:0009628	341	0.022
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.022
positive regulation of response to stimulus	GO:0048584	323	0.022
establishment of protein localization	GO:0045184	163	0.022
regulation of stem cell proliferation	GO:0072091	40	0.022
regulation of cell proliferation	GO:0042127	163	0.022
regulation of muscle organ development	GO:0048634	13	0.022
protein modification by small protein conjugation	GO:0032446	79	0.022
defense response	GO:0006952	300	0.021
single organism cell adhesion	GO:0098602	47	0.021
purine nucleotide metabolic process	GO:0006163	146	0.021
negative regulation of protein metabolic process	GO:0051248	85	0.021
hindgut morphogenesis	GO:0007442	58	0.021
cellular response to chemical stimulus	GO:0070887	199	0.021
hematopoietic or lymphoid organ development	GO:0048534	57	0.021
vacuolar transport	GO:0007034	13	0.021
striated muscle cell differentiation	GO:0051146	90	0.021
negative regulation of cellular protein metabolic process	GO:0032269	85	0.021
retina development in camera type eye	GO:0060041	4	0.021
central nervous system projection neuron axonogenesis	GO:0021952	6	0.021	Fly
spinal cord development	GO:0021510	1	0.021
defense response to other organism	GO:0098542	225	0.021
organelle assembly	GO:0070925	198	0.021
cellular macromolecule localization	GO:0070727	220	0.021
limb development	GO:0060173	1	0.021	Mouse
negative regulation of cell fate commitment	GO:0010454	17	0.021
regulation of molecular function	GO:0065009	217	0.021
catabolic process	GO:0009056	409	0.021
embryonic organ development	GO:0048568	50	0.020
photoreceptor cell fate commitment	GO:0046552	41	0.020
skin development	GO:0043588	65	0.020	Worm
establishment of tissue polarity	GO:0007164	87	0.020
dorsal ventral axis specification	GO:0009950	66	0.020
salivary gland morphogenesis	GO:0007435	145	0.020
organic acid metabolic process	GO:0006082	103	0.020
organ formation	GO:0048645	39	0.020
embryonic axis specification	GO:0000578	107	0.020
adult locomotory behavior	GO:0008344	76	0.019
neuron fate specification	GO:0048665	12	0.019
fibroblast growth factor receptor signaling pathway	GO:0008543	10	0.019
endocytosis	GO:0006897	310	0.019
response to sterol	GO:0036314	34	0.019
intracellular transport	GO:0046907	228	0.019
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.019	Mouse Worm Fly
heart morphogenesis	GO:0003007	32	0.019
protein phosphorylation	GO:0006468	169	0.019
male gamete generation	GO:0048232	201	0.019
positive regulation of bmp signaling pathway	GO:0030513	5	0.019
response to nitrogen compound	GO:1901698	90	0.018
organic substance transport	GO:0071702	257	0.018
negative regulation of cell development	GO:0010721	62	0.018
negative regulation of developmental growth	GO:0048640	64	0.018
determination of bilateral symmetry	GO:0009855	13	0.018
enteroendocrine cell differentiation	GO:0035883	1	0.018
negative regulation of gene expression epigenetic	GO:0045814	77	0.018
anterior commissure morphogenesis	GO:0021960	2	0.018	Fly
developmental pigmentation	GO:0048066	68	0.018
establishment of protein localization to organelle	GO:0072594	62	0.018
apical constriction	GO:0003383	18	0.018
camera type eye development	GO:0043010	4	0.018
determination of left right symmetry	GO:0007368	9	0.018
embryonic foregut morphogenesis	GO:0048617	3	0.018
reproductive structure development	GO:0048608	74	0.017	Fly
positive regulation of protein metabolic process	GO:0051247	128	0.017
negative regulation of epidermal growth factor receptor signaling pathway	GO:0042059	29	0.017
response to wounding	GO:0009611	94	0.017
cellular response to oxygen containing compound	GO:1901701	79	0.017
regulation of smoothened signaling pathway	GO:0008589	28	0.017
response to biotic stimulus	GO:0009607	294	0.017
hematopoietic progenitor cell differentiation	GO:0002244	1	0.017
protein maturation	GO:0051604	71	0.017
positive regulation of cellular amine metabolic process	GO:0033240	0	0.017
equator specification	GO:0045317	4	0.017
tube development	GO:0035295	244	0.017	Zebrafish Mouse
positive regulation of developmental process	GO:0051094	143	0.017
nitrogen compound transport	GO:0071705	85	0.017
establishment or maintenance of cytoskeleton polarity	GO:0030952	44	0.017
cellular nitrogen compound catabolic process	GO:0044270	165	0.017
anterior posterior axis specification embryo	GO:0008595	103	0.016
epithelial cell morphogenesis	GO:0003382	25	0.016
multi organism behavior	GO:0051705	175	0.016
regulation of transport	GO:0051049	181	0.016
negative regulation of transforming growth factor beta receptor signaling pathway	GO:0030512	4	0.016
cellular catabolic process	GO:0044248	372	0.016
muscle tissue morphogenesis	GO:0060415	2	0.016
nephron tubule formation	GO:0072079	3	0.016
retinal ganglion cell axon guidance	GO:0031290	12	0.016
embryonic development via the syncytial blastoderm	GO:0001700	148	0.016
mapk cascade	GO:0000165	107	0.016
exocrine system development	GO:0035272	162	0.016
regulation of immune system process	GO:0002682	176	0.016
regulation of reproductive process	GO:2000241	54	0.016
regulation of cell cycle phase transition	GO:1901987	130	0.016
negative regulation of erbb signaling pathway	GO:1901185	29	0.016
axon choice point recognition	GO:0016198	26	0.016
neuronal stem cell division	GO:0036445	35	0.016
taxis	GO:0042330	304	0.016	Fly
regulation of cell cycle process	GO:0010564	181	0.016
defense response to bacterium	GO:0042742	178	0.016
epithelial cell migration	GO:0010631	148	0.015
regulation of myotube differentiation	GO:0010830	6	0.015
defense response to fungus	GO:0050832	48	0.015
renal tubule morphogenesis	GO:0061333	44	0.015
pigment metabolic process	GO:0042440	84	0.015
cellular response to lipopolysaccharide	GO:0071222	3	0.015
positive regulation of mitotic cell cycle	GO:0045931	34	0.015
regulation of chromatin silencing	GO:0031935	36	0.015
negative regulation of intracellular signal transduction	GO:1902532	57	0.015
cranial nerve development	GO:0021545	1	0.015
chromatin modification	GO:0016568	147	0.015
lipid metabolic process	GO:0006629	121	0.015
developmental induction	GO:0031128	3	0.015
instar larval development	GO:0002168	55	0.015
regulation of protein phosphorylation	GO:0001932	64	0.015
response to ecdysone	GO:0035075	34	0.015
proteolysis	GO:0006508	192	0.015
embryo development ending in birth or egg hatching	GO:0009792	152	0.015	Zebrafish Mouse Worm
chorion containing eggshell formation	GO:0007304	105	0.015
positive regulation of intracellular signal transduction	GO:1902533	116	0.015
protein localization	GO:0008104	284	0.015
protein catabolic process	GO:0030163	101	0.014
behavioral response to ethanol	GO:0048149	49	0.014
cellular protein localization	GO:0034613	160	0.014
spermatogenesis	GO:0007283	200	0.014
negative regulation of smoothened signaling pathway	GO:0045879	16	0.014
regulation of mapk cascade	GO:0043408	92	0.014
heart development	GO:0007507	82	0.014
negative regulation of growth	GO:0045926	84	0.014
response to starvation	GO:0042594	97	0.014
response to organonitrogen compound	GO:0010243	75	0.014
gene silencing	GO:0016458	138	0.014
regulation of epithelial cell proliferation	GO:0050678	4	0.014
cellular lipid metabolic process	GO:0044255	83	0.014
cell aging	GO:0007569	2	0.014
sex determination	GO:0007530	18	0.014
carbohydrate derivative metabolic process	GO:1901135	217	0.014
sensory perception of chemical stimulus	GO:0007606	116	0.014
regulation of protein localization	GO:0032880	76	0.013
regulation of cellular protein metabolic process	GO:0032268	243	0.013
innate immune response activating signal transduction	GO:0002758	2	0.013
protein localization to organelle	GO:0033365	82	0.013
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	65	0.013
regulation of catalytic activity	GO:0050790	185	0.013
glutathione metabolic process	GO:0006749	37	0.013
regulation of cellular component size	GO:0032535	98	0.013
catechol containing compound biosynthetic process	GO:0009713	3	0.013
negative regulation of sequence specific dna binding transcription factor activity	GO:0043433	4	0.013
single organismal cell cell adhesion	GO:0016337	45	0.013
response to alcohol	GO:0097305	95	0.013
cellular response to starvation	GO:0009267	61	0.013
imaginal disc derived leg joint morphogenesis	GO:0016348	15	0.013
negative regulation of bmp signaling pathway	GO:0030514	12	0.013
male mating behavior	GO:0060179	70	0.013
circadian rhythm	GO:0007623	105	0.013
positive regulation of fibroblast growth factor receptor signaling pathway	GO:0045743	5	0.013
chromatin organization	GO:0006325	207	0.013
signal transduction by phosphorylation	GO:0023014	107	0.013
chromatin remodeling	GO:0006338	72	0.013
somatic muscle development	GO:0007525	66	0.013
response to other organism	GO:0051707	293	0.013
negative regulation of cell cycle phase transition	GO:1901988	103	0.013
chromosome organization	GO:0051276	360	0.013
locomotor rhythm	GO:0045475	56	0.013
regulation of localization	GO:0032879	275	0.013
neuroblast differentiation	GO:0014016	29	0.013
outflow tract morphogenesis	GO:0003151	4	0.013
regulation of developmental growth	GO:0048638	174	0.013
positive regulation of immune response	GO:0050778	63	0.012
wound healing	GO:0042060	75	0.012
tube morphogenesis	GO:0035239	191	0.012
cell junction assembly	GO:0034329	42	0.012
protein targeting	GO:0006605	64	0.012
modification dependent macromolecule catabolic process	GO:0043632	79	0.012
peptide biosynthetic process	GO:0043043	42	0.012
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.012
embryonic epithelial tube formation	GO:0001838	6	0.012
establishment or maintenance of cell polarity	GO:0007163	167	0.012
glandular epithelial cell differentiation	GO:0002067	1	0.012
embryonic hindgut morphogenesis	GO:0048619	48	0.012
eye antennal disc morphogenesis	GO:0007455	34	0.012
courtship behavior	GO:0007619	68	0.012
covalent chromatin modification	GO:0016569	106	0.012
activation of innate immune response	GO:0002218	4	0.012
oocyte dorsal ventral axis specification	GO:0007310	34	0.012
gland morphogenesis	GO:0022612	145	0.012
paracrine signaling	GO:0038001	7	0.012
methylation	GO:0032259	47	0.012
larval development	GO:0002164	104	0.012
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.012	Mouse Worm Fly
establishment of localization in cell	GO:0051649	402	0.012
mesenchymal cell development	GO:0014031	1	0.012
regulation of programmed cell death	GO:0043067	152	0.012
determination of ventral identity	GO:0048264	1	0.012
immune system process	GO:0002376	347	0.012
chromatin silencing	GO:0006342	76	0.011
eye development	GO:0001654	323	0.011
regulation of i kappab kinase nf kappab signaling	GO:0043122	2	0.011
hindbrain development	GO:0030902	2	0.011	Mouse
regulation of defense response	GO:0031347	102	0.011
response to oxygen containing compound	GO:1901700	200	0.011
immune system development	GO:0002520	57	0.011
lipopolysaccharide mediated signaling pathway	GO:0031663	1	0.011
negative regulation of phosphorylation	GO:0042326	35	0.011
maintenance of location	GO:0051235	73	0.011
germ line stem cell maintenance	GO:0030718	50	0.011
neuroepithelial cell differentiation	GO:0060563	6	0.011
negative regulation of mapk cascade	GO:0043409	23	0.011
cell motility	GO:0048870	251	0.011
nuclear import	GO:0051170	51	0.011
defense response to gram negative bacterium	GO:0050829	94	0.011
appendage segmentation	GO:0035285	26	0.011
rhythmic behavior	GO:0007622	76	0.011
positive regulation of response to biotic stimulus	GO:0002833	31	0.011
negative regulation of cellular catabolic process	GO:0031330	34	0.011
regulation of response to external stimulus	GO:0032101	115	0.011
regulation of neurogenesis	GO:0050767	158	0.011
photoreceptor cell differentiation	GO:0046530	170	0.011
immune effector process	GO:0002252	98	0.011
response to temperature stimulus	GO:0009266	106	0.011
positive regulation of phosphate metabolic process	GO:0045937	139	0.011
positive regulation of multi organism process	GO:0043902	40	0.011
positive regulation of immune system process	GO:0002684	68	0.011
dna endoreduplication	GO:0042023	22	0.011
nuclear transport	GO:0051169	72	0.011
genital disc development	GO:0035215	44	0.011	Fly
positive regulation of cellular protein metabolic process	GO:0032270	118	0.011
cholesterol transport	GO:0030301	2	0.011
response to hypoxia	GO:0001666	53	0.010
pigment cell differentiation	GO:0050931	3	0.010
foregut morphogenesis	GO:0007440	10	0.010
positive regulation of peptidyl tyrosine phosphorylation	GO:0050731	4	0.010
organonitrogen compound biosynthetic process	GO:1901566	117	0.010
regulation of protein modification process	GO:0031399	112	0.010
response to alkaloid	GO:0043279	26	0.010
nucleoside phosphate catabolic process	GO:1901292	110	0.010
axon midline choice point recognition	GO:0016199	26	0.010

inv disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
organ system cancer	DOID:0050686	0.135
disease of cellular proliferation	DOID:14566	0.135
cancer	DOID:162	0.135
musculoskeletal system disease	DOID:17	0.089
connective tissue disease	DOID:65	0.089
disease of anatomical entity	DOID:7	0.089
bone disease	DOID:0080001	0.089
bone development disease	DOID:0080006	0.089
cardiovascular system disease	DOID:1287	0.043
musculoskeletal system cancer	DOID:0060100	0.013
disease of metabolism	DOID:0014667	0.012
inherited metabolic disorder	DOID:655	0.012
heart disease	DOID:114	0.011
congenital heart disease	DOID:1682	0.011

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