IMP: Integrative Multi-species Prediction

Drosophila melanogaster

124 known processes

Frq1 (Dmel_CG5744)

Frequenin 1

(Aliases: HL-II,frq1,CG5744,frq,Dmel\CG5744,Frq)

Entrez: 32797
FLYBASE: FBgn0030897
UniProtKB: M9PHW6
UniProtKB: P37236

Process Predictions
Disease Predictions

Frq1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
synaptic transmission	GO:0007268	288	0.993
neuromuscular junction development	GO:0007528	149	0.928
neurotransmitter transport	GO:0006836	37	0.918
regulation of neurotransmitter secretion	GO:0046928	14	0.810	Fly
regulation of synapse structure and activity	GO:0050803	128	0.746
regulation of neurotransmitter levels	GO:0001505	38	0.683
signal release	GO:0023061	49	0.664
regulation of synaptic transmission	GO:0050804	69	0.622	Fly
establishment of localization in cell	GO:0051649	402	0.615
cation transport	GO:0006812	110	0.606	Rat
synapse organization	GO:0050808	196	0.603
secretion by cell	GO:0032940	101	0.500
regulation of secretion by cell	GO:1903530	39	0.484	Rat Fly
neurotransmitter secretion	GO:0007269	35	0.466
establishment of vesicle localization	GO:0051650	51	0.450
secretion	GO:0046903	109	0.446
synaptic growth at neuromuscular junction	GO:0051124	119	0.439
regulation of synapse organization	GO:0050807	110	0.386
regulation of neurotransmitter transport	GO:0051588	14	0.366	Fly
metal ion transport	GO:0030001	74	0.315	Rat
ion transmembrane transport	GO:0034220	122	0.287	Rat
regulation of transport	GO:0051049	181	0.274	Rat Fly
regulation of secretion	GO:0051046	44	0.273	Rat Fly
regulation of synaptic growth at neuromuscular junction	GO:0008582	89	0.271
cgmp biosynthetic process	GO:0006182	8	0.264
regulation of multicellular organismal development	GO:2000026	414	0.250	Rat
synaptic vesicle transport	GO:0048489	50	0.228
synapse assembly	GO:0007416	143	0.224
neuromuscular synaptic transmission	GO:0007274	67	0.218
regulation of membrane potential	GO:0042391	35	0.215
response to abiotic stimulus	GO:0009628	341	0.195
neuron neuron synaptic transmission	GO:0007270	14	0.192
synaptic vesicle recycling	GO:0036465	28	0.187
regulation of synapse assembly	GO:0051963	94	0.181
regulation of nervous system development	GO:0051960	248	0.167	Rat
single organism behavior	GO:0044708	391	0.166
single organism membrane fusion	GO:0044801	42	0.163
regulation of excitatory postsynaptic membrane potential	GO:0060079	3	0.161
axonogenesis	GO:0007409	290	0.159
regulation of cell differentiation	GO:0045595	302	0.159	Rat
synaptic vesicle localization	GO:0097479	53	0.156
ion transport	GO:0006811	145	0.151	Rat
locomotory behavior	GO:0007626	176	0.139
vesicle mediated transport	GO:0016192	381	0.133	Rat
vitamin transport	GO:0051180	2	0.121
growth	GO:0040007	359	0.117
regulation of cellular component biogenesis	GO:0044087	201	0.114
regulation of localization	GO:0032879	275	0.113	Rat Fly
establishment of synaptic vesicle localization	GO:0097480	50	0.112
axon development	GO:0061564	297	0.104
positive regulation of cgmp metabolic process	GO:0030825	1	0.102
synaptic transmission glutamatergic	GO:0035249	7	0.101
membrane organization	GO:0061024	112	0.098
adult locomotory behavior	GO:0008344	76	0.092
cellular homeostasis	GO:0019725	80	0.091
transmembrane transport	GO:0055085	139	0.091	Rat
negative regulation of cell communication	GO:0010648	223	0.091
single organism membrane organization	GO:0044802	93	0.087
developmental growth	GO:0048589	280	0.084
inorganic cation transmembrane transport	GO:0098662	61	0.082	Rat
regulation of cellular localization	GO:0060341	136	0.081	Rat Fly
regulation of transmembrane transport	GO:0034762	27	0.080	Rat
multi organism behavior	GO:0051705	175	0.078
cellular protein modification process	GO:0006464	438	0.077
neurotransmitter metabolic process	GO:0042133	2	0.076
tube morphogenesis	GO:0035239	191	0.075	Zebrafish
nitrogen compound transport	GO:0071705	85	0.075
terminal button organization	GO:0072553	19	0.072
camera type eye development	GO:0043010	4	0.071
positive regulation of synapse assembly	GO:0051965	29	0.070
positive regulation of synaptic transmission	GO:0050806	15	0.069
regulation of neurogenesis	GO:0050767	158	0.064	Rat
catabolic process	GO:0009056	409	0.064
regulation of neuromuscular synaptic transmission	GO:1900073	15	0.064
muscle structure development	GO:0061061	224	0.062
potassium ion transport	GO:0006813	20	0.061
positive regulation of cell communication	GO:0010647	250	0.058
calcium ion transmembrane transport	GO:0070588	17	0.057	Rat
muscle system process	GO:0003012	21	0.057
positive regulation of signaling	GO:0023056	243	0.057
organic substance transport	GO:0071702	257	0.056
developmental maturation	GO:0021700	172	0.056
regulation of developmental growth	GO:0048638	174	0.056
eye development	GO:0001654	323	0.055
rhythmic excitation	GO:0043179	1	0.055
small molecule metabolic process	GO:0044281	305	0.055
tube development	GO:0035295	244	0.054	Zebrafish
exocytosis	GO:0006887	28	0.054	Rat
chemotaxis	GO:0006935	249	0.054
homeostatic process	GO:0042592	199	0.053
regulation of terminal button organization	GO:2000331	11	0.053
positive regulation of exocytosis	GO:0045921	4	0.053	Rat
cellular macromolecule localization	GO:0070727	220	0.052
cellular protein localization	GO:0034613	160	0.050
acetate ester metabolic process	GO:1900619	2	0.049
cellular component assembly involved in morphogenesis	GO:0010927	151	0.049
regulation of synaptic transmission glutamatergic	GO:0051966	5	0.048
neuron maturation	GO:0042551	31	0.047
negative regulation of signaling	GO:0023057	219	0.047
endocytosis	GO:0006897	310	0.047
synaptic vesicle endocytosis	GO:0048488	28	0.047
rhythmic synaptic transmission	GO:0060024	2	0.046
cell maturation	GO:0048469	144	0.046
regulation of glutamate receptor signaling pathway	GO:1900449	1	0.045
vesicle localization	GO:0051648	55	0.045
male courtship behavior veined wing extension	GO:0048065	22	0.045
positive regulation of synaptic vesicle endocytosis	GO:1900244	4	0.044
regulation of growth	GO:0040008	233	0.043
membrane depolarization	GO:0051899	4	0.043
single organism cellular localization	GO:1902580	180	0.042
associative learning	GO:0008306	65	0.042
regulation of ion transmembrane transport	GO:0034765	27	0.042	Rat
negative regulation of response to stimulus	GO:0048585	258	0.041
positive regulation of cellular component organization	GO:0051130	156	0.041
cell recognition	GO:0008037	102	0.041
regulation of cell development	GO:0060284	215	0.040	Rat
positive regulation of transport	GO:0051050	92	0.040	Rat
divalent inorganic cation transport	GO:0072511	30	0.040	Rat
neuron projection guidance	GO:0097485	241	0.039
endoplasmic reticulum organization	GO:0007029	13	0.038
single organism catabolic process	GO:0044712	228	0.036
cell projection assembly	GO:0030031	94	0.035
negative regulation of synaptic growth at neuromuscular junction	GO:0045886	39	0.035
positive regulation of synaptic vesicle recycling	GO:1903423	4	0.034
acetylcholine metabolic process	GO:0008291	2	0.034
muscle cell differentiation	GO:0042692	103	0.034
response to biotic stimulus	GO:0009607	294	0.033
response to radiation	GO:0009314	155	0.033
regulation of vesicle mediated transport	GO:0060627	59	0.033	Rat
regulation of cell projection organization	GO:0031344	92	0.032	Rat
carbohydrate derivative metabolic process	GO:1901135	217	0.032
membrane fusion	GO:0061025	42	0.032
organelle assembly	GO:0070925	198	0.032
organonitrogen compound metabolic process	GO:1901564	318	0.031
positive regulation of developmental process	GO:0051094	143	0.031
protein localization	GO:0008104	284	0.031
axon guidance	GO:0007411	233	0.031
striated muscle cell development	GO:0055002	50	0.031
programmed cell death	GO:0012501	257	0.031
organelle localization	GO:0051640	148	0.031
positive regulation of synaptic transmission glutamatergic	GO:0051968	3	0.030
neuron recognition	GO:0008038	101	0.030
organic substance catabolic process	GO:1901575	308	0.030
negative regulation of signal transduction	GO:0009968	206	0.029
nucleoside catabolic process	GO:0009164	112	0.029
phagocytosis	GO:0006909	215	0.029
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.028
purine containing compound metabolic process	GO:0072521	155	0.028
macromolecular complex assembly	GO:0065003	256	0.028
positive regulation of cellular component biogenesis	GO:0044089	80	0.028
purine ribonucleotide catabolic process	GO:0009154	109	0.028
endomembrane system organization	GO:0010256	119	0.028
carboxylic acid metabolic process	GO:0019752	92	0.028
hindbrain development	GO:0030902	2	0.027
positive regulation of synaptic growth at neuromuscular junction	GO:0045887	26	0.027
nucleobase containing small molecule metabolic process	GO:0055086	174	0.027
regulation of cell proliferation	GO:0042127	163	0.027
regulation of synaptic vesicle endocytosis	GO:1900242	7	0.027
synaptic vesicle exocytosis	GO:0016079	16	0.027
regionalization	GO:0003002	416	0.026
response to external biotic stimulus	GO:0043207	293	0.026
positive regulation of purine nucleotide metabolic process	GO:1900544	55	0.026
regulation of synaptic vesicle exocytosis	GO:2000300	3	0.026
regulation of embryonic pattern specification	GO:1902875	27	0.026
establishment of protein localization	GO:0045184	163	0.025
nucleoside phosphate catabolic process	GO:1901292	110	0.025
monovalent inorganic cation transport	GO:0015672	40	0.024
single organism biosynthetic process	GO:0044711	206	0.024
anatomical structure homeostasis	GO:0060249	97	0.024
cellular amine metabolic process	GO:0044106	12	0.024
purine ribonucleotide metabolic process	GO:0009150	145	0.024
retina development in camera type eye	GO:0060041	4	0.024
cellular response to organic substance	GO:0071310	132	0.023
positive regulation of response to stimulus	GO:0048584	323	0.023
protein heterooligomerization	GO:0051291	4	0.023
regulation of ion transport	GO:0043269	39	0.023	Rat
chromatin modification	GO:0016568	147	0.023
regulation of synaptic activity	GO:0060025	9	0.023
membrane biogenesis	GO:0044091	8	0.023
sensory organ morphogenesis	GO:0090596	260	0.023	Zebrafish
dendrite development	GO:0016358	204	0.023
purine nucleotide metabolic process	GO:0006163	146	0.022
cell proliferation	GO:0008283	299	0.022
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.022
response to mechanical stimulus	GO:0009612	28	0.022
axis specification	GO:0009798	167	0.022
positive regulation of cell death	GO:0010942	69	0.022
mushroom body development	GO:0016319	70	0.022
organophosphate metabolic process	GO:0019637	195	0.022
immune system process	GO:0002376	347	0.022
embryonic pattern specification	GO:0009880	174	0.022
myotube cell development	GO:0014904	3	0.021
chromatin organization	GO:0006325	207	0.021
cellular response to lipopolysaccharide	GO:0071222	3	0.021
positive regulation of molecular function	GO:0044093	136	0.021
carbohydrate derivative catabolic process	GO:1901136	118	0.021
intracellular signal transduction	GO:0035556	300	0.021	Rat
regulation of dendrite development	GO:0050773	37	0.021
positive regulation of cell migration	GO:0030335	2	0.021
protein depolymerization	GO:0051261	31	0.020
positive regulation of protein metabolic process	GO:0051247	128	0.020
organonitrogen compound catabolic process	GO:1901565	128	0.020
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.020
transcription from rna polymerase ii promoter	GO:0006366	368	0.020
cognition	GO:0050890	141	0.020
sarcomere organization	GO:0045214	26	0.020
purine ribonucleoside metabolic process	GO:0046128	127	0.020
sensory perception of sound	GO:0007605	56	0.020
segmentation	GO:0035282	207	0.020
positive regulation of catalytic activity	GO:0043085	118	0.019
positive regulation of biosynthetic process	GO:0009891	316	0.019
cyclic nucleotide metabolic process	GO:0009187	28	0.019
appendage development	GO:0048736	401	0.019
regulation of cell projection assembly	GO:0060491	30	0.019
organic acid metabolic process	GO:0006082	103	0.019
cellular protein complex disassembly	GO:0043624	35	0.019
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.019
regulation of phosphorus metabolic process	GO:0051174	210	0.019
adult behavior	GO:0030534	137	0.019
cellular catabolic process	GO:0044248	372	0.019
cation transmembrane transport	GO:0098655	88	0.018	Rat
carbohydrate derivative biosynthetic process	GO:1901137	85	0.018
positive regulation of cgmp biosynthetic process	GO:0030828	1	0.018
camera type eye morphogenesis	GO:0048593	2	0.018
regulation of cytoskeleton organization	GO:0051493	89	0.018
regulation of behavior	GO:0050795	75	0.018
learning	GO:0007612	75	0.018
single organism carbohydrate metabolic process	GO:0044723	72	0.018
aging	GO:0007568	143	0.018
regulation of wnt signaling pathway	GO:0030111	68	0.018
positive regulation of multicellular organismal process	GO:0051240	143	0.018
positive regulation of neurotransmitter secretion	GO:0001956	2	0.018
positive regulation of nervous system development	GO:0051962	69	0.018
wnt signaling pathway	GO:0016055	98	0.017
regulation of cell death	GO:0010941	173	0.017
cell growth	GO:0016049	108	0.017
peripheral nervous system development	GO:0007422	52	0.017
regulation of system process	GO:0044057	36	0.017
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.017
learning or memory	GO:0007611	141	0.017
neuroblast proliferation	GO:0007405	74	0.017
establishment of organelle localization	GO:0051656	122	0.017
action potential	GO:0001508	13	0.017
regulation of synaptic plasticity	GO:0048167	14	0.017
protein complex assembly	GO:0006461	200	0.017
negative regulation of multicellular organismal process	GO:0051241	142	0.017
branching involved in open tracheal system development	GO:0060446	45	0.017
striated muscle cell differentiation	GO:0051146	90	0.017
response to nutrient levels	GO:0031667	114	0.017
dendrite morphogenesis	GO:0048813	199	0.017
cell death	GO:0008219	279	0.017
chemical homeostasis	GO:0048878	92	0.017
negative regulation of developmental process	GO:0051093	201	0.017
regulation of anatomical structure size	GO:0090066	163	0.016
purine ribonucleoside catabolic process	GO:0046130	112	0.016
skeletal muscle fiber development	GO:0048741	3	0.016
positive regulation of growth	GO:0045927	75	0.016
proteolysis	GO:0006508	192	0.016
positive regulation of phosphate metabolic process	GO:0045937	139	0.016
positive regulation of apoptotic signaling pathway	GO:2001235	4	0.016
cell adhesion	GO:0007155	136	0.016
blastoderm segmentation	GO:0007350	159	0.016
positive regulation of programmed cell death	GO:0043068	62	0.016
chromatin remodeling	GO:0006338	72	0.016
neuron projection extension	GO:1990138	32	0.015
nuclear division	GO:0000280	332	0.015
nucleoside triphosphate catabolic process	GO:0009143	108	0.015
protein complex biogenesis	GO:0070271	201	0.015
muscle cell development	GO:0055001	50	0.015
photoreceptor cell development	GO:0042461	96	0.015
forebrain development	GO:0030900	2	0.015
regulation of multi organism process	GO:0043900	131	0.015
positive regulation of signal transduction	GO:0009967	223	0.015
photoreceptor cell differentiation	GO:0046530	170	0.015
regulation of defense response	GO:0031347	102	0.015
negative regulation of synapse assembly	GO:0051964	39	0.015
axon extension	GO:0048675	32	0.015
nucleoside metabolic process	GO:0009116	127	0.015
positive regulation of cell differentiation	GO:0045597	64	0.015
dna metabolic process	GO:0006259	227	0.014
regulation of phosphate metabolic process	GO:0019220	210	0.014
heterocycle catabolic process	GO:0046700	166	0.014
spermatogenesis	GO:0007283	200	0.014
intracellular protein transport	GO:0006886	104	0.014
cellular amino acid metabolic process	GO:0006520	61	0.014
synapse maturation	GO:0060074	7	0.014
protein catabolic process	GO:0030163	101	0.014
response to monosaccharide	GO:0034284	4	0.014
divalent metal ion transport	GO:0070838	26	0.014	Rat
cellular nitrogen compound catabolic process	GO:0044270	165	0.014
kidney development	GO:0001822	3	0.014
appendage morphogenesis	GO:0035107	397	0.014
ribonucleoside metabolic process	GO:0009119	127	0.014
regulation of i kappab kinase nf kappab signaling	GO:0043122	2	0.014
cellular potassium ion transport	GO:0071804	18	0.014
multicellular organismal aging	GO:0010259	140	0.014
ribose phosphate metabolic process	GO:0019693	145	0.014
regulation of mitotic cell cycle	GO:0007346	190	0.014
ribonucleoside catabolic process	GO:0042454	112	0.014
glycosyl compound metabolic process	GO:1901657	127	0.014
apoptotic process	GO:0006915	159	0.014
detection of light stimulus	GO:0009583	58	0.014
body morphogenesis	GO:0010171	2	0.014
oxoacid metabolic process	GO:0043436	103	0.014
epithelial tube morphogenesis	GO:0060562	88	0.014
regulation of cell cycle process	GO:0010564	181	0.014
cytoplasmic transport	GO:0016482	130	0.013
response to organic substance	GO:0010033	284	0.013
taxis	GO:0042330	304	0.013
multicellular organism growth	GO:0035264	46	0.013
positive regulation of phosphorus metabolic process	GO:0010562	139	0.013
motor neuron axon guidance	GO:0008045	58	0.013
nucleotide metabolic process	GO:0009117	161	0.013
organelle fission	GO:0048285	340	0.013
aromatic compound catabolic process	GO:0019439	166	0.013
purine nucleoside catabolic process	GO:0006152	112	0.013
ribonucleotide metabolic process	GO:0009259	145	0.013
calcium ion transport	GO:0006816	24	0.013	Rat
circulatory system process	GO:0003013	37	0.013
muscle organ development	GO:0007517	127	0.013
positive regulation of organelle organization	GO:0010638	65	0.013
stem cell development	GO:0048864	79	0.013
cellular biogenic amine catabolic process	GO:0042402	1	0.013
embryonic organ development	GO:0048568	50	0.013	Zebrafish
regulation of endocytosis	GO:0030100	37	0.013
maternal determination of anterior posterior axis embryo	GO:0008358	74	0.012
response to lipopolysaccharide	GO:0032496	4	0.012
nucleoside phosphate metabolic process	GO:0006753	162	0.012
regulation of immune system process	GO:0002682	176	0.012
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.012
mesenchymal cell development	GO:0014031	1	0.012
embryonic axis specification	GO:0000578	107	0.012
protein modification by small protein conjugation or removal	GO:0070647	106	0.012
post embryonic appendage morphogenesis	GO:0035120	385	0.012
response to toxic substance	GO:0009636	22	0.012
positive regulation of catabolic process	GO:0009896	105	0.012
rna processing	GO:0006396	147	0.012
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	65	0.012
neuron remodeling	GO:0016322	29	0.012
mitotic nuclear division	GO:0007067	213	0.012
stem cell proliferation	GO:0072089	88	0.012
courtship behavior	GO:0007619	68	0.012
bmp signaling pathway	GO:0030509	27	0.012
muscle contraction	GO:0006936	13	0.012
eye morphogenesis	GO:0048592	260	0.012
cytokinesis	GO:0000910	90	0.012
pattern recognition receptor signaling pathway	GO:0002221	2	0.012
isoprenoid transport	GO:0046864	2	0.012
actin filament based process	GO:0030029	220	0.012
response to hexose	GO:0009746	3	0.012
positive regulation of hydrolase activity	GO:0051345	78	0.012
detection of stimulus	GO:0051606	156	0.012
response to other organism	GO:0051707	293	0.012
vesicle organization	GO:0016050	44	0.012
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.012
larval locomotory behavior	GO:0008345	27	0.012
potassium ion transmembrane transport	GO:0071805	18	0.011
skin development	GO:0043588	65	0.011
organic cyclic compound catabolic process	GO:1901361	168	0.011
posttranscriptional regulation of gene expression	GO:0010608	145	0.011
positive regulation of purine nucleotide biosynthetic process	GO:1900373	10	0.011
presynaptic membrane organization	GO:0097090	4	0.011
neuron cell cell adhesion	GO:0007158	1	0.011
regulation of intracellular signal transduction	GO:1902531	236	0.011
neural precursor cell proliferation	GO:0061351	75	0.011
regulation of synaptic vesicle transport	GO:1902803	10	0.011
calcium dependent cell cell adhesion via plasma membrane cell adhesion molecules	GO:0016339	9	0.011
filopodium assembly	GO:0046847	33	0.011
regulation of programmed cell death	GO:0043067	152	0.011
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.011
cellular response to chemical stimulus	GO:0070887	199	0.011
positive regulation of cell motility	GO:2000147	3	0.011
cranial nerve development	GO:0021545	1	0.011
death	GO:0016265	284	0.011
visual learning	GO:0008542	4	0.011
positive regulation of nucleotide biosynthetic process	GO:0030810	10	0.011
dna packaging	GO:0006323	91	0.011
striated muscle contraction	GO:0006941	5	0.011
regulation of gene expression epigenetic	GO:0040029	128	0.011
terpenoid transport	GO:0046865	2	0.011
regulation of catabolic process	GO:0009894	170	0.011
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.011
gtp catabolic process	GO:0006184	72	0.011
regulation of organelle organization	GO:0033043	196	0.011
synaptic vesicle fusion to presynaptic membrane	GO:0031629	7	0.011
chromosome organization	GO:0051276	360	0.010
open tracheal system development	GO:0007424	204	0.010
actin filament based movement	GO:0030048	26	0.010
biological adhesion	GO:0022610	138	0.010
regulation of protein kinase a signaling	GO:0010738	2	0.010
mating	GO:0007618	120	0.010
single organismal cell cell adhesion	GO:0016337	45	0.010
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.010
positive regulation of cell development	GO:0010720	61	0.010
regulation of hydrolase activity	GO:0051336	97	0.010
compound eye development	GO:0048749	307	0.010
organelle fusion	GO:0048284	46	0.010
protein transport	GO:0015031	155	0.010
positive regulation of cellular protein metabolic process	GO:0032270	118	0.010
regulation of cellular ketone metabolic process	GO:0010565	3	0.010
limb development	GO:0060173	1	0.010
imaginal disc derived wing morphogenesis	GO:0007476	337	0.010
necrotic cell death	GO:0070265	1	0.010
regulation of innate immune response	GO:0045088	71	0.010
purine containing compound catabolic process	GO:0072523	112	0.010

Frq1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.055
cardiovascular system disease	DOID:1287	0.024
vascular disease	DOID:178	0.017
artery disease	DOID:0050828	0.017
disease of metabolism	DOID:0014667	0.015
diabetes mellitus	DOID:9351	0.012
carbohydrate metabolism disease	DOID:0050013	0.012
glucose metabolism disease	DOID:4194	0.012
acquired metabolic disease	DOID:0060158	0.012
disease of cellular proliferation	DOID:14566	0.012
cancer	DOID:162	0.012
organ system cancer	DOID:0050686	0.011

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