Drosophila melanogaster

120 known processes

shark (Dmel_CG18247)

Src homology 2, ankyrin repeat, tyrosine kinase

(Aliases: l(2)W4,Shark,l(2R)W4,Syk,SHARK,Dmel\CG18247,Tk7,dtk7,Dtk7,SYK/SHARK,CG18247)

shark biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
homeostatic processGO:00425921990.645
Mouse
embryonic morphogenesisGO:00485982060.568
regulation of molecular functionGO:00650092170.266
Human Mouse
ovarian follicle cell developmentGO:00307072480.258
regulation of synapse assemblyGO:0051963940.226
positive regulation of phosphate metabolic processGO:00459371390.219
Mouse
intracellular signal transductionGO:00355563000.199
cellular nitrogen compound catabolic processGO:00442701650.180
single organism biosynthetic processGO:00447112060.177
Mouse
embryonic development via the syncytial blastodermGO:00017001480.149
vesicle mediated transportGO:00161923810.148
carboxylic acid metabolic processGO:0019752920.147
Mouse
response to radiationGO:00093141550.142
cell migrationGO:00164772380.139
Human Zebrafish
cardiovascular system developmentGO:0072358820.134
Zebrafish Mouse
organophosphate metabolic processGO:00196371950.129
cell proliferationGO:00082832990.129
Mouse
positive regulation of catalytic activityGO:00430851180.129
Mouse
immune response regulating signaling pathwayGO:000276420.128
Mouse
phagocytosisGO:00069092150.127
exocrine system developmentGO:00352721620.122
intercellular bridge organizationGO:0043063140.120
regulation of cell cycleGO:00517262910.119
positive regulation of catabolic processGO:00098961050.116
asymmetric stem cell divisionGO:0098722490.110
leg disc developmentGO:0035218920.110
localization of cellGO:00516742570.109
Human Zebrafish
regulation of catalytic activityGO:00507901850.108
Mouse
appendage morphogenesisGO:00351073970.108
regulation of phosphorus metabolic processGO:00511742100.102
Mouse
small gtpase mediated signal transductionGO:0007264880.101
positive regulation of cellular catabolic processGO:0031331950.098
ras protein signal transductionGO:0007265880.096
digestive tract morphogenesisGO:00485461270.093
nucleobase containing small molecule metabolic processGO:00550861740.093
purine ribonucleotide catabolic processGO:00091541090.092
nuclear dna replicationGO:003326010.090
cellular lipid metabolic processGO:0044255830.089
Mouse
regulation of anatomical structure sizeGO:00900661630.087
ribonucleotide metabolic processGO:00092591450.087
response to uvGO:0009411240.086
purine ribonucleoside triphosphate metabolic processGO:00092051190.084
digestive system developmentGO:00551231490.084
dorsal closureGO:0007391790.083
positive regulation of phosphorus metabolic processGO:00105621390.083
Mouse
imaginal disc pattern formationGO:0007447910.082
purine ribonucleotide metabolic processGO:00091501450.080
endocytosisGO:00068973100.078
regulation of cellular catabolic processGO:00313291570.077
morphogenesis of an epitheliumGO:00020092760.073
wound healingGO:0042060750.072
Mouse
nucleoside triphosphate metabolic processGO:00091411200.071
regulation of autophagyGO:0010506620.070
carbohydrate derivative metabolic processGO:19011352170.069
single organism cell adhesionGO:0098602470.069
Human Mouse
establishment or maintenance of cytoskeleton polarityGO:0030952440.068
tube morphogenesisGO:00352391910.065
tube developmentGO:00352952440.065
immune system processGO:00023763470.064
Human Mouse Rat
negative regulation of transcription from rna polymerase ii promoterGO:00001221190.064
regulation of cell differentiationGO:00455953020.062
Human Mouse
regulation of catabolic processGO:00098941700.062
ectodermal digestive tract morphogenesisGO:004856770.061
positive regulation of nucleoside metabolic processGO:0045979470.060
regulation of growthGO:00400082330.058
phosphorylationGO:00163102940.058
enzyme linked receptor protein signaling pathwayGO:00071671790.057
Mouse
cell motilityGO:00488702510.057
Human Zebrafish
positive regulation of intracellular signal transductionGO:19025331160.055
Mouse
humoral immune responseGO:00069591170.055
neuronal stem cell divisionGO:0036445350.055
immune responseGO:00069552460.054
Human Mouse Rat
regulation of cell proliferationGO:00421271630.054
Mouse
positive regulation of nucleotide catabolic processGO:0030813460.053
response to woundingGO:0009611940.053
Mouse
gonad developmentGO:0008406500.053
cell divisionGO:00513012480.053
small molecule metabolic processGO:00442813050.053
Mouse
regulation of ras protein signal transductionGO:0046578930.051
protein phosphorylationGO:00064681690.050
Human Mouse Rat
negative regulation of growthGO:0045926840.049
lipid homeostasisGO:0055088330.049
nucleoside phosphate metabolic processGO:00067531620.048
positive regulation of ras gtpase activityGO:0032320360.047
regionalizationGO:00030024160.047
regulation of intracellular signal transductionGO:19025312360.046
Mouse
positive regulation of cell communicationGO:00106472500.046
Mouse
regulation of multicellular organismal developmentGO:20000264140.045
regulation of immune system processGO:00026821760.045
Human Mouse Rat
purine nucleotide metabolic processGO:00061631460.045
nucleotide catabolic processGO:00091661090.045
transcription from rna polymerase ii promoterGO:00063663680.044
nucleotide metabolic processGO:00091171610.044
positive regulation of signalingGO:00230562430.043
Mouse
central nervous system developmentGO:00074172010.042
mitotic spindle organizationGO:00070522200.042
developmental programmed cell deathGO:00106231380.040
positive regulation of nucleic acid templated transcriptionGO:19035082660.040
morphogenesis of embryonic epitheliumGO:0016331940.040
cellular protein modification processGO:00064644380.040
Human Mouse Rat
positive regulation of transcription from rna polymerase ii promoterGO:00459442040.040
oxoacid metabolic processGO:00434361030.039
Mouse
apoptotic signaling pathwayGO:0097190270.039
developmental cell growthGO:0048588520.039
cellular catabolic processGO:00442483720.039
ribonucleoside triphosphate metabolic processGO:00091991190.038
regulation of nurse cell apoptotic processGO:004547790.037
regulation of small gtpase mediated signal transductionGO:0051056930.037
negative regulation of response to stimulusGO:00485852580.037
purine ribonucleoside metabolic processGO:00461281270.037
chemical homeostasisGO:0048878920.036
positive regulation of multicellular organismal processGO:00512401430.036
Human Zebrafish Mouse
purine ribonucleoside catabolic processGO:00461301120.036
developmental growth involved in morphogenesisGO:0060560650.035
positive regulation of proteolysisGO:0045862520.035
positive regulation of macromolecule metabolic processGO:00106044050.035
Mouse
regulation of immune responseGO:00507761180.034
Mouse Rat
wnt signaling pathwayGO:0016055980.034
dendrite morphogenesisGO:00488131990.034
cellular homeostasisGO:0019725800.034
positive regulation of cellular biosynthetic processGO:00313283160.033
Mouse
purine nucleotide catabolic processGO:00061951090.033
neuromuscular junction developmentGO:00075281490.032
gland developmentGO:00487321910.032
anterior posterior pattern specificationGO:00099521360.031
digestive tract developmentGO:00485651490.031
negative regulation of nitrogen compound metabolic processGO:00511722650.031
positive regulation of transferase activityGO:0051347260.031
Mouse
zymogen activationGO:0031638200.031
actin filament depolymerizationGO:003004250.031
ribonucleoside catabolic processGO:00424541120.031
regulation of cellular component biogenesisGO:00440872010.031
lipid metabolic processGO:00066291210.031
Mouse
positive regulation of response to stimulusGO:00485843230.030
Mouse Rat
nucleoside phosphate catabolic processGO:19012921100.030
regulation of cell morphogenesis involved in differentiationGO:0010769610.030
kidney developmentGO:000182230.030
development of primary sexual characteristicsGO:0045137500.030
axon developmentGO:00615642970.030
heterocycle catabolic processGO:00467001660.029
regulation of gtpase activityGO:0043087440.029
regulation of phosphate metabolic processGO:00192202100.029
Mouse
glycosyl compound metabolic processGO:19016571270.029
substrate adhesion dependent cell spreadingGO:003444620.028
reproductive system developmentGO:0061458740.028
chorion containing eggshell formationGO:00073041050.028
regulation of localizationGO:00328792750.027
Zebrafish Mouse Rat
anterior posterior axis specification embryoGO:00085951030.027
regulation of hydrolase activityGO:0051336970.027
actin cytoskeleton organizationGO:00300362060.027
renal tubule developmentGO:0061326640.026
organophosphate catabolic processGO:00464341120.026
dna replicationGO:0006260480.026
response to endogenous stimulusGO:00097191190.026
salivary gland cell autophagic cell deathGO:0035071830.026
cell adhesionGO:00071551360.026
Human Mouse
regulation of synapse organizationGO:00508071100.026
gastrulation involving germ band extensionGO:0010004360.026
camera type eye morphogenesisGO:004859320.026
embryo development ending in birth or egg hatchingGO:00097921520.025
regulation of developmental growthGO:00486381740.025
positive regulation of cell differentiationGO:0045597640.025
Human Mouse
epithelium migrationGO:00901321480.025
Zebrafish
developmental growthGO:00485892800.025
synapse assemblyGO:00074161430.025
nucleoside triphosphate catabolic processGO:00091431080.025
synaptic growth at neuromuscular junctionGO:00511241190.025
positive regulation of phosphorylationGO:0042327870.025
Mouse
aromatic compound catabolic processGO:00194391660.025
meiotic cell cycleGO:00513211710.025
negative regulation of cell communicationGO:00106482230.025
centrosome organizationGO:00512971630.024
connective tissue developmentGO:006144830.024
positive regulation of immune responseGO:0050778630.024
Mouse Rat
regulation of anatomical structure morphogenesisGO:00226032420.024
purine containing compound metabolic processGO:00725211550.024
regulation of nervous system developmentGO:00519602480.024
ameboidal type cell migrationGO:00016671510.024
Zebrafish
cell growthGO:00160491080.024
positive regulation of autophagyGO:0010508210.024
cytokinetic cell separationGO:000092010.024
histolysisGO:00075591020.024
positive regulation of molecular functionGO:00440931360.023
Mouse
protein complex assemblyGO:00064612000.023
neural precursor cell proliferationGO:0061351750.023
positive regulation of nitrogen compound metabolic processGO:00511733540.023
gland morphogenesisGO:00226121450.022
guanosine containing compound metabolic processGO:1901068740.022
dna metabolic processGO:00062592270.022
positive regulation of rna biosynthetic processGO:19026802660.022
antimicrobial humoral responseGO:0019730990.022
positive regulation of purine nucleotide metabolic processGO:1900544550.022
chitin based cuticle sclerotizationGO:0007593190.021
regulation of cell morphogenesisGO:00226041630.021
taxisGO:00423303040.021
Human
adherens junction organizationGO:0034332270.021
organic acid metabolic processGO:00060821030.021
Mouse
purine nucleoside catabolic processGO:00061521120.020
response to other organismGO:00517072930.020
Mouse
glycosyl compound catabolic processGO:19016581120.020
regulation of protein metabolic processGO:00512462560.020
Mouse
single organism catabolic processGO:00447122280.020
regulation of endopeptidase activityGO:0052548360.020
cellular macromolecular complex assemblyGO:00346221530.020
regulation of cellular component sizeGO:0032535980.020
regulation of phosphatase activityGO:001092130.019
regulation of transportGO:00510491810.019
Mouse Rat
dendrite developmentGO:00163582040.019
camera type eye developmentGO:004301040.019
cell deathGO:00082192790.019
organonitrogen compound catabolic processGO:19015651280.019
immune response activating signal transductionGO:000275720.019
Mouse
positive regulation of gtpase activityGO:0043547430.019
response to oxygen containing compoundGO:19017002000.019
tissue deathGO:00162711020.019
cell cycle dna replicationGO:0044786230.019
dna conformation changeGO:00711031050.019
eye developmentGO:00016543230.019
positive regulation of purine nucleotide catabolic processGO:0033123460.019
compound eye developmentGO:00487493070.018
regulation of organelle organizationGO:00330431960.018
nucleoside catabolic processGO:00091641120.018
wing disc morphogenesisGO:00074723440.018
hemopoiesisGO:0030097460.018
Human Mouse
blastoderm segmentationGO:00073501590.018
regulation of multi organism processGO:00439001310.018
muscle structure developmentGO:00610612240.018
response to abiotic stimulusGO:00096283410.017
regulation of gtp catabolic processGO:0033124440.017
positive regulation of signal transductionGO:00099672230.017
Mouse
negative regulation of signalingGO:00230572190.017
cytoplasm organizationGO:0007028640.017
protein importGO:0017038550.017
Human
response to lipopolysaccharideGO:003249640.016
lipid biosynthetic processGO:0008610460.016
Mouse
negative regulation of rna biosynthetic processGO:19026792400.016
salivary gland morphogenesisGO:00074351450.016
spindle organizationGO:00070512530.016
protein palmitoylationGO:001834520.016
regulation of axonogenesisGO:0050770320.016
reproductive behaviorGO:00190981220.016
hindgut developmentGO:0061525580.016
rho protein signal transductionGO:0007266140.016
proteolysisGO:00065081920.016
regulation of mapk cascadeGO:0043408920.015
Mouse
secondary metabolic processGO:0019748750.015
neuromuscular synaptic transmissionGO:0007274670.015
cellular response to molecule of bacterial originGO:007121930.015
positive regulation of reproductive processGO:200024370.015
nucleobase containing compound catabolic processGO:00346551650.015
pigment metabolic processGO:0042440840.015
regulation of cell sizeGO:0008361630.015
carbohydrate derivative biosynthetic processGO:1901137850.015
growthGO:00400073590.015
positive regulation of nurse cell apoptotic processGO:004585050.015
regulation of nucleotide metabolic processGO:0006140620.015
sex differentiationGO:0007548810.015
carbohydrate derivative catabolic processGO:19011361180.015
purine ribonucleoside triphosphate catabolic processGO:00092071080.015
organonitrogen compound biosynthetic processGO:19015661170.015
one carbon metabolic processGO:000673030.015
axon guidanceGO:00074112330.015
innate immune responseGO:00450871440.014
Mouse
regulation of synapse structure and activityGO:00508031280.014
anatomical structure homeostasisGO:0060249970.014
Mouse
ribose phosphate metabolic processGO:00196931450.014
neuroblast proliferationGO:0007405740.014
tissue morphogenesisGO:00487292970.014
establishment or maintenance of microtubule cytoskeleton polarityGO:0030951410.014
malpighian tubule developmentGO:0072002640.014
positive regulation of macromolecule biosynthetic processGO:00105572830.014
Mouse
programmed cell deathGO:00125012570.014
heart processGO:0003015370.014
regulation of nucleotide catabolic processGO:0030811480.014
germarium derived egg chamber formationGO:00072931010.014
positive regulation of cell motilityGO:200014730.014
Zebrafish
gliogenesisGO:0042063800.014
mushroom body developmentGO:0016319700.014
cell fate specificationGO:0001708710.014
circulatory system processGO:0003013370.013
oocyte microtubule cytoskeleton polarizationGO:0008103220.013
positive regulation of endopeptidase activityGO:0010950260.013
positive regulation of biosynthetic processGO:00098913160.013
Mouse
axonogenesisGO:00074092900.013
regulation of synaptic growth at neuromuscular junctionGO:0008582890.013
columnar cuboidal epithelial cell developmentGO:00020662490.013
regulation of mitotic cell cycleGO:00073461900.013
catabolic processGO:00090564090.013
regulation of substrate adhesion dependent cell spreadingGO:190002410.013
negative regulation of nucleic acid templated transcriptionGO:19035072400.013
regulation of cell cycle processGO:00105641810.013
somatic muscle developmentGO:0007525660.013
guanosine containing compound catabolic processGO:1901069740.013
eggshell formationGO:00307031050.013
pole plasm assemblyGO:0007315610.013
organophosphate biosynthetic processGO:0090407460.013
ribonucleotide catabolic processGO:00092611090.013
posttranscriptional regulation of gene expressionGO:00106081450.013
signal transduction by phosphorylationGO:00230141070.013
regulation of transcription from rna polymerase ii promoterGO:00063573780.013
embryonic pattern specificationGO:00098801740.013
gastrulation with mouth forming firstGO:0001703360.013
chromosome organizationGO:00512763600.012
gtp catabolic processGO:0006184720.012
regulation of humoral immune responseGO:0002920510.012
positive regulation of gtp catabolic processGO:0033126430.012
actin filament polymerizationGO:0030041270.012
brain developmentGO:00074201200.012
negative regulation of signal transductionGO:00099682060.012
autophagyGO:00069141080.012
open tracheal system developmentGO:00074242040.012
epithelial tube morphogenesisGO:0060562880.012
developmental maturationGO:00217001720.012
ribonucleoside metabolic processGO:00091191270.012
organic cyclic compound catabolic processGO:19013611680.011
autophagic cell deathGO:0048102830.011
stem cell proliferationGO:0072089880.011
adult somatic muscle developmentGO:0007527140.011
release of sequestered calcium ion into cytosolGO:005120910.011
multi multicellular organism processGO:00447061230.011
regulation of cell divisionGO:0051302720.011
mapk cascadeGO:00001651070.011
epithelial cell differentiationGO:00308553220.011
sensory organ morphogenesisGO:00905962600.011
renal system developmentGO:0072001720.011
imaginal disc derived leg morphogenesisGO:0007480800.011
intrinsic apoptotic signaling pathwayGO:0097193160.011
intrinsic apoptotic signaling pathway in response to dna damageGO:0008630110.011
salivary gland histolysisGO:0035070880.011
positive regulation of cellular component organizationGO:00511301560.011
germline ring canal formationGO:0030725130.011
forebrain developmentGO:003090020.011
maintenance of protein location in cellGO:0032507260.011
urogenital system developmentGO:0001655720.011
neuron projection guidanceGO:00974852410.010
positive regulation of nucleobase containing compound metabolic processGO:00459353320.010
regulation of actin filament based processGO:0032970420.010
regulation of cellular component movementGO:0051270420.010
Zebrafish
organonitrogen compound metabolic processGO:19015643180.010
response to growth factorGO:0070848310.010
protein localization to nucleusGO:0034504550.010
Human
glycerophospholipid metabolic processGO:0006650230.010
intracellular mrna localization involved in anterior posterior axis specificationGO:0060811530.010
regulation of viral genome replicationGO:004506940.010
organic substance catabolic processGO:19015753080.010
chemotaxisGO:00069352490.010
Human
purine containing compound catabolic processGO:00725231120.010

shark disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.026
nervous system diseaseDOID:86300.015
disease of metabolismDOID:001466700.011