Drosophila melanogaster

87 known processes

CTCF (Dmel_CG8591)

CG8591 gene product from transcript CG8591-RA

(Aliases: dCTCF,Dmel\CG8591,CG8591)

CTCF biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
negative regulation of gene expression epigeneticGO:0045814771.000
chromatin silencingGO:0006342761.000
gene silencingGO:00164581381.000
negative regulation of biosynthetic processGO:00098902770.999
negative regulation of transcription dna templatedGO:00458922370.999
regulation of gene expression epigeneticGO:00400291280.999
negative regulation of cellular macromolecule biosynthetic processGO:20001132670.999
negative regulation of rna metabolic processGO:00512532510.999
negative regulation of cellular biosynthetic processGO:00313272770.999
negative regulation of nucleobase containing compound metabolic processGO:00459342610.998
negative regulation of macromolecule biosynthetic processGO:00105582700.997
negative regulation of rna biosynthetic processGO:19026792400.996
negative regulation of gene expressionGO:00106293870.993
heterochromatin organizationGO:0070828250.989
negative regulation of nucleic acid templated transcriptionGO:19035072400.988
chromosome organizationGO:00512763600.975
negative regulation of cellular metabolic processGO:00313243820.968
positive regulation of rna metabolic processGO:00512542710.959
Human Mouse
transcription from rna polymerase ii promoterGO:00063663680.912
Human Mouse
positive regulation of transcription dna templatedGO:00458932660.899
Human Mouse
chromatin remodelingGO:0006338720.883
positive regulation of macromolecule metabolic processGO:00106044050.866
Human Mouse
positive regulation of nitrogen compound metabolic processGO:00511733540.856
Human Mouse
negative regulation of nitrogen compound metabolic processGO:00511722650.845
chromatin organizationGO:00063252070.826
Human Mouse
regulation of chromatin silencingGO:0031935360.785
response to external biotic stimulusGO:00432072930.781
positive regulation of rna biosynthetic processGO:19026802660.780
Human Mouse
positive regulation of gene expressionGO:00106282900.773
Human Mouse
protein acetylationGO:0006473390.763
Mouse
regulation of gene silencingGO:0060968630.744
meiotic nuclear divisionGO:00071261510.721
regulation of transcription from rna polymerase ii promoterGO:00063573780.713
Human Mouse
single organism behaviorGO:00447083910.709
embryonic morphogenesisGO:00485982060.703
chromatin modificationGO:00165681470.636
Human Mouse
positive regulation of biosynthetic processGO:00098913160.630
Human Mouse
organelle fissionGO:00482853400.612
taxisGO:00423303040.580
positive regulation of macromolecule biosynthetic processGO:00105572830.579
Human Mouse
positive regulation of cellular biosynthetic processGO:00313283160.562
Human Mouse
heterochromatin organization involved in chromatin silencingGO:007086890.476
gene silencing by rnaGO:0031047570.448
histone modificationGO:00165701060.428
Human Mouse
response to biotic stimulusGO:00096072940.426
positive regulation of nucleobase containing compound metabolic processGO:00459353320.404
Human Mouse
tube developmentGO:00352952440.401
positive regulation of nucleic acid templated transcriptionGO:19035082660.397
Human Mouse
compound eye photoreceptor cell differentiationGO:00017511400.368
negative regulation of transcription from rna polymerase ii promoterGO:00001221190.351
Human Mouse
digestive tract morphogenesisGO:00485461270.345
regulation of heterochromatin assemblyGO:003144580.333
dna metabolic processGO:00062592270.331
nuclear divisionGO:00002803320.329
anatomical structure homeostasisGO:0060249970.311
chromatin mediated maintenance of transcriptionGO:004809670.311
localization of cellGO:00516742570.310
chromatin assemblyGO:0031497480.303
Human
digestive tract developmentGO:00485651490.290
retina development in camera type eyeGO:006004140.288
epidermis developmentGO:0008544650.284
defense response to other organismGO:00985422250.253
posttranscriptional gene silencing by rnaGO:0035194450.247
protein acylationGO:0043543420.246
Mouse
appendage morphogenesisGO:00351073970.244
positive regulation of transcription from rna polymerase ii promoterGO:00459442040.238
Human Mouse
negative regulation of response to stimulusGO:00485852580.236
response to bacteriumGO:00096171980.233
internal protein amino acid acetylationGO:0006475380.229
Mouse
neuron projection guidanceGO:00974852410.213
posttranscriptional gene silencingGO:0016441460.212
endocytosisGO:00068973100.208
chromosome segregationGO:00070591570.208
imaginal disc derived appendage morphogenesisGO:00351143950.193
cell fate specificationGO:0001708710.190
imaginal disc derived appendage developmentGO:00487373990.187
regulation of transcription by chromatin organizationGO:003440130.175
response to other organismGO:00517072930.174
immune system processGO:00023763470.173
covalent chromatin modificationGO:00165691060.167
Human Mouse
positive regulation of response to stimulusGO:00485843230.166
dna replicationGO:0006260480.164
ribonucleoside monophosphate catabolic processGO:0009158390.164
chemotaxisGO:00069352490.158
protein modification processGO:00362114380.156
Human Mouse
negative regulation of chromatin silencingGO:003193690.155
positive regulation of chromatin silencingGO:0031937160.153
dna packagingGO:0006323910.151
Human
regulation of chromatin modificationGO:1903308280.147
Human Mouse
positive regulation of cellular component organizationGO:00511301560.141
embryonic development via the syncytial blastodermGO:00017001480.141
nucleosome mobilizationGO:004276690.133
appendage developmentGO:00487364010.131
dna methylation or demethylationGO:004472840.131
Mouse
digestive system developmentGO:00551231490.124
histone h4 acetylationGO:0043967130.123
genital disc developmentGO:0035215440.121
positive regulation of developmental processGO:00510941430.119
regionalizationGO:00030024160.118
wing disc morphogenesisGO:00074723440.117
regulation of dna metabolic processGO:0051052340.114
internal peptidyl lysine acetylationGO:0018393380.114
Mouse
atp dependent chromatin remodelingGO:0043044220.114
positive regulation of gene expression epigeneticGO:0045815160.111
embryo development ending in birth or egg hatchingGO:00097921520.109
peptidyl lysine acetylationGO:0018394390.105
Mouse
gland developmentGO:00487321910.100
histone methylationGO:0016571400.099
Human Mouse
sex differentiationGO:0007548810.098
histone acetylationGO:0016573380.097
Mouse
purine ribonucleoside monophosphate metabolic processGO:0009167500.097
cellular response to oxygen containing compoundGO:1901701790.097
defense response to bacteriumGO:00427421780.095
meiotic cell cycleGO:00513211710.094
cell proliferationGO:00082832990.091
protein localizationGO:00081042840.091
purine nucleoside monophosphate catabolic processGO:0009128380.087
dna alkylationGO:000630540.085
Mouse
imaginal disc derived wing morphogenesisGO:00074763370.080
skin developmentGO:0043588650.080
chromatin assembly or disassemblyGO:0006333520.077
Human
heterochromatin assemblyGO:0031507130.077
peptidyl lysine modificationGO:0018205570.077
Mouse
organelle assemblyGO:00709251980.077
regulation of symbiosis encompassing mutualism through parasitismGO:0043903150.074
response to endogenous stimulusGO:00097191190.073
neurological system processGO:00508773580.073
atp metabolic processGO:0046034490.072
regulation of multi organism processGO:00439001310.071
cell migrationGO:00164772380.070
cell motilityGO:00488702510.069
regulation of i kappab kinase nf kappab signalingGO:004312220.068
regulation of cellular component biogenesisGO:00440872010.068
dna methylationGO:000630640.067
Mouse
histone h3 k27 methylationGO:007073460.067
regulation of cell fate specificationGO:0042659270.067
negative regulation of cellular component organizationGO:00511291080.067
ribonucleoside monophosphate metabolic processGO:0009161510.066
meiosis iGO:0007127590.066
cellular macromolecular complex assemblyGO:00346221530.066
post embryonic appendage morphogenesisGO:00351203850.065
camera type eye developmentGO:004301040.065
dna templated transcription elongationGO:0006354180.064
rna interferenceGO:0016246270.064
axon developmentGO:00615642970.064
salivary gland developmentGO:00074311620.063
respiratory system developmentGO:00605412130.062
embryonic hindgut morphogenesisGO:0048619480.062
gastrulationGO:0007369700.061
epithelial cell differentiationGO:00308553220.061
defense responseGO:00069523000.060
salivary gland histolysisGO:0035070880.060
histone h3 k9 acetylationGO:004397030.059
regulation of cell cycle processGO:00105641810.059
production of small rna involved in gene silencing by rnaGO:0070918150.059
regulation of intracellular signal transductionGO:19025312360.059
cellular amine metabolic processGO:0044106120.058
regulation of cell cycleGO:00517262910.058
regulation of cellular amino acid metabolic processGO:000652100.057
regulation of dna replicationGO:0006275130.057
ribonucleoprotein complex assemblyGO:0022618230.057
blastoderm segmentationGO:00073501590.057
regulation of chromatin organizationGO:1902275320.056
Human Mouse
regulation of meiosisGO:004002030.056
ribonucleoprotein complex subunit organizationGO:0071826280.055
negative regulation of cell cycleGO:00457861160.055
regulation of defense responseGO:00313471020.054
regulation of immune system processGO:00026821760.053
axon guidanceGO:00074112330.052
sister chromatid segregationGO:0000819920.051
negative regulation of small gtpase mediated signal transductionGO:0051058130.051
rna processingGO:00063961470.050
regulation of chromosome organizationGO:0033044640.050
Human Mouse
chromosome condensationGO:0030261410.049
protein complex biogenesisGO:00702712010.048
regulation of mrna processingGO:0050684710.047
vesicle mediated transportGO:00161923810.047
positive regulation of mrna processingGO:005068540.047
response to dsrnaGO:0043331150.046
nucleoside monophosphate catabolic processGO:0009125390.046
response to oxygen containing compoundGO:19017002000.046
gene silencing by mirnaGO:0035195220.045
regulation of chromatin assemblyGO:001084790.045
sensory organ morphogenesisGO:00905962600.044
regulation of protein metabolic processGO:00512462560.043
Human Mouse
anterior posterior pattern specificationGO:00099521360.043
homeostatic processGO:00425921990.042
positive regulation of cellular amino acid metabolic processGO:004576400.042
cellular response to endogenous stimulusGO:0071495800.042
regulation of mitotic cell cycleGO:00073461900.041
protein complex assemblyGO:00064612000.041
programmed cell deathGO:00125012570.041
response to organic substanceGO:00100332840.041
organonitrogen compound catabolic processGO:19015651280.040
exocrine system developmentGO:00352721620.039
ubiquitin dependent protein catabolic processGO:0006511780.039
dsrna fragmentationGO:0031050150.038
purine ribonucleoside monophosphate catabolic processGO:0009169380.038
cellular response to organic substanceGO:00713101320.038
segmentationGO:00352822070.037
atp catabolic processGO:0006200380.037
regulation of cell deathGO:00109411730.036
dna dependent dna replicationGO:0006261170.035
purine nucleoside monophosphate metabolic processGO:0009126500.035
cellular response to chemical stimulusGO:00708871990.035
organophosphate metabolic processGO:00196371950.034
negative regulation of signal transductionGO:00099682060.033
cellular protein modification processGO:00064644380.032
Human Mouse
dna conformation changeGO:00711031050.032
Human
meiotic chromosome segregationGO:0045132590.031
regulation of cell proliferationGO:00421271630.031
regulation of multicellular organismal developmentGO:20000264140.031
protein alkylationGO:0008213430.031
Human Mouse
spindle organizationGO:00070512530.031
defense response to gram negative bacteriumGO:0050829940.030
proteolysisGO:00065081920.029
purine ribonucleoside triphosphate metabolic processGO:00092051190.029
tube morphogenesisGO:00352391910.029
transcription elongation from rna polymerase ii promoterGO:0006368180.029
regulation of cell developmentGO:00602842150.029
purine ribonucleoside metabolic processGO:00461281270.029
regulation of mrna metabolic processGO:1903311720.029
apoptotic signaling pathwayGO:0097190270.028
maternal specification of dorsal ventral axis oocyte germ line encodedGO:000731140.028
morphogenesis of an epitheliumGO:00020092760.028
axis specificationGO:00097981670.027
body morphogenesisGO:001017120.027
cellular response to dna damage stimulusGO:00069742230.027
regulation of dna templated transcription elongationGO:0032784170.027
mitotic cell cycle embryonicGO:0045448380.027
histone h4 k20 methylationGO:003477040.026
nucleoside triphosphate metabolic processGO:00091411200.026
positive regulation of multicellular organismal processGO:00512401430.025
cellular response to dsrnaGO:0071359150.025
purine containing compound metabolic processGO:00725211550.025
regulation of nuclear divisionGO:0051783580.025
hindbrain developmentGO:003090220.025
embryonic organ developmentGO:0048568500.025
positive regulation of signal transductionGO:00099672230.024
embryonic axis specificationGO:00005781070.024
histone h3 acetylationGO:0043966110.024
eye photoreceptor cell differentiationGO:00017541450.024
mitotic sister chromatid segregationGO:0000070870.024
cellular macromolecule catabolic processGO:00442651360.024
positive regulation of cellular component biogenesisGO:0044089800.023
deathGO:00162652840.023
regulation of cell differentiationGO:00455953020.023
ribose phosphate metabolic processGO:00196931450.023
regulation of mitotic sister chromatid segregationGO:0033047280.023
regulation of phosphatase activityGO:001092130.023
regulation of compound eye cone cell fate specificationGO:004268240.023
regulation of cellular protein metabolic processGO:00322682430.022
Human Mouse
response to alcoholGO:0097305950.022
axonogenesisGO:00074092900.022
regulation of transferase activityGO:0051338580.022
posttranscriptional regulation of gene expressionGO:00106081450.022
response to temperature stimulusGO:00092661060.022
negative regulation of developmental processGO:00510932010.022
response to nitrogen compoundGO:1901698900.021
production of mirnas involved in gene silencing by mirnaGO:0035196100.021
positive regulation of cellular amine metabolic processGO:003324000.021
cell divisionGO:00513012480.021
positive regulation of cell differentiationGO:0045597640.021
muscle organ developmentGO:00075171270.020
sex determinationGO:0007530180.020
phagocytosisGO:00069092150.020
regulation of response to dna damage stimulusGO:2001020230.020
phosphorylationGO:00163102940.020
regulation of cell fate commitmentGO:0010453290.020
regulation of protein localization to nucleusGO:1900180290.020
histone exchangeGO:0043486210.020
peptidyl amino acid modificationGO:00181931050.020
Mouse
proteasomal protein catabolic processGO:0010498590.020
memoryGO:0007613940.020
positive regulation of cell developmentGO:0010720610.019
double strand break repairGO:0006302260.019
regulation of cell divisionGO:0051302720.019
regulation of organelle organizationGO:00330431960.019
Human Mouse
response to ionizing radiationGO:0010212320.019
wnt signaling pathwayGO:0016055980.019
organonitrogen compound metabolic processGO:19015643180.019
multi organism behaviorGO:00517051750.019
positive regulation of cell cycle processGO:0090068280.019
regulation of transcription elongation from rna polymerase ii promoterGO:0034243150.019
cellular response to nitrogen compoundGO:1901699510.019
sister chromatid cohesionGO:0007062180.019
dna recombinationGO:0006310320.019
protein phosphorylationGO:00064681690.018
macromolecular complex assemblyGO:00650032560.018
Human
salivary gland morphogenesisGO:00074351450.018
compound eye cone cell fate commitmentGO:004267650.018
jak stat cascadeGO:0007259490.018
dna repairGO:0006281540.018
cell cycle checkpointGO:0000075950.018
positive regulation of molecular functionGO:00440931360.018
muscle structure developmentGO:00610612240.018
negative regulation of signalingGO:00230572190.018
nucleoside phosphate metabolic processGO:00067531620.018
regulation of cellular ketone metabolic processGO:001056530.017
positive regulation of cell communicationGO:00106472500.017
histone h4 k12 acetylationGO:004398320.017
developmental pigmentationGO:0048066680.017
purine ribonucleoside triphosphate catabolic processGO:00092071080.017
regulation of sister chromatid cohesionGO:000706320.017
learning or memoryGO:00076111410.017
apoptotic processGO:00069151590.017
nucleoside monophosphate metabolic processGO:0009123520.017
positive regulation of cell cycleGO:0045787430.017
protein maturationGO:0051604710.017
histone h4 k16 acetylationGO:004398440.016
modification dependent protein catabolic processGO:0019941780.016
regulation of protein import into nucleusGO:0042306280.016
syncytial blastoderm mitotic cell cycleGO:0035186210.016
hematopoietic or lymphoid organ developmentGO:0048534570.016
regenerationGO:0031099160.016
eye developmentGO:00016543230.016
regulation of histone h3 k27 methylationGO:006108530.016
cellular catabolic processGO:00442483720.016
nucleobase containing compound catabolic processGO:00346551650.016
multicellular organismal reproductive behaviorGO:00330571100.016
immune system developmentGO:0002520570.016
hindgut morphogenesisGO:0007442580.015
rna splicing via transesterification reactions with bulged adenosine as nucleophileGO:0000377730.015
positive regulation of cellular protein metabolic processGO:00322701180.015
regulation of rna splicingGO:0043484690.015
cellular amino acid metabolic processGO:0006520610.015
response to organic cyclic compoundGO:0014070890.015
negative regulation of ras protein signal transductionGO:0046580130.015
developmental programmed cell deathGO:00106231380.015
regulation of glial cell differentiationGO:004568510.015
regulation of cellular amine metabolic processGO:003323830.014
connective tissue developmentGO:006144830.014
production of sirna involved in rna interferenceGO:0030422110.014
regulation of mapk cascadeGO:0043408920.014
dna endoreduplicationGO:0042023220.014
chromosome organization involved in meiosisGO:0070192100.014
regulation of protein modification processGO:00313991120.014
Human Mouse
ncrna processingGO:0034470300.014
receptor mediated endocytosisGO:0006898210.014
mitotic chromosome condensationGO:0007076220.014
regulation of apoptotic processGO:00429811300.014
proteolysis involved in cellular protein catabolic processGO:0051603830.014
developmental growthGO:00485892800.014
regulation of response to stressGO:00801342000.014
reproductive structure developmentGO:0048608740.014
response to hormoneGO:0009725450.013
terminal region determinationGO:0007362250.013
antennal developmentGO:0007469250.013
morphogenesis of a branching epitheliumGO:0061138450.013
response to lipopolysaccharideGO:003249640.013
photoreceptor cell differentiationGO:00465301700.013
leg disc developmentGO:0035218920.013
eye pigmentationGO:0048069430.013
positive regulation of multi organism processGO:0043902400.013
regulation of cell shapeGO:00083601130.013
protein localization to organelleGO:0033365820.013
establishment or maintenance of bipolar cell polarityGO:0061245340.013
salivary gland cell autophagic cell deathGO:0035071830.013
embryonic pattern specificationGO:00098801740.012
regulation of phosphorylationGO:00423251470.012
mitotic dna damage checkpointGO:0044773740.012
positive regulation of transferase activityGO:0051347260.012
negative regulation of chromosome organizationGO:2001251190.012
branching morphogenesis of an epithelial tubeGO:0048754450.012
negative regulation of g1 s transition of mitotic cell cycleGO:2000134130.012
nucleotide metabolic processGO:00091171610.012
gland morphogenesisGO:00226121450.012
positive regulation of immune system processGO:0002684680.012
regulation of mrna splicing via spliceosomeGO:0048024640.012
negative regulation of immune system processGO:0002683500.012
meiotic cell cycle processGO:19030461320.012
nucleosome organizationGO:0034728590.012
Human
negative regulation of sister chromatid segregationGO:0033046130.012
negative regulation of cardiac cell fate specificationGO:200004470.011
regulation of phosphate metabolic processGO:00192202100.011
purine nucleoside triphosphate metabolic processGO:00091441190.011
mitotic spindle organizationGO:00070522200.011
establishment or maintenance of apical basal cell polarityGO:0035088340.011
regulation of programmed cell deathGO:00430671520.011
reproductive system developmentGO:0061458740.011
oocyte dorsal ventral axis specificationGO:0007310340.011
ribonucleoside triphosphate metabolic processGO:00091991190.011
small molecule metabolic processGO:00442813050.011
regulation of cellular response to stressGO:0080135890.011
regulation of meiotic cell cycleGO:005144590.011
negative regulation of cell communicationGO:00106482230.011
regulation of embryonic developmentGO:0045995680.011
regulation of molecular functionGO:00650092170.011
Human
embryonic organ morphogenesisGO:004856250.011
cell type specific apoptotic processGO:0097285380.011
regulation of localizationGO:00328792750.010
eye morphogenesisGO:00485922600.010
mrna processingGO:00063971040.010
negative regulation of apoptotic processGO:0043066630.010
aromatic compound catabolic processGO:00194391660.010
nucleoside triphosphate catabolic processGO:00091431080.010
compound eye photoreceptor fate commitmentGO:0001752360.010
hindgut developmentGO:0061525580.010
enzyme linked receptor protein signaling pathwayGO:00071671790.010
oxoacid metabolic processGO:00434361030.010
regulation of gene silencing by mirnaGO:006096480.010
positive regulation of nervous system developmentGO:0051962690.010
purine containing compound catabolic processGO:00725231120.010
chemosensory behaviorGO:00076351060.010
cell cycle comprising mitosis without cytokinesisGO:0033301250.010
negative regulation of cellular protein metabolic processGO:0032269850.010

CTCF disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
cancerDOID:16200.073
organ system cancerDOID:005068600.073
disease of cellular proliferationDOID:1456600.073
disease of anatomical entityDOID:700.013