IMP: Integrative Multi-species Prediction

Drosophila melanogaster

19 known processes

Npc2h (Dmel_CG11315)

Niemann-Pick type C-2h

(Aliases: BcDNA:RH04252,BcDNA:RH68460,CG11315,DmML1A,npc2h,BcDNA:GH26608,Dmel\CG11315)

FLYBASE: FBgn0039801
Entrez: 43649
UniProtKB: Q8IMH5
UniProtKB: Q9VA41

Process Predictions
Disease Predictions

Npc2h biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
sterol homeostasis	GO:0055092	4	0.055	Fly
salivary gland development	GO:0007431	162	0.053
gland development	GO:0048732	191	0.051
endocytosis	GO:0006897	310	0.049
innate immune response	GO:0045087	144	0.045
immune system process	GO:0002376	347	0.043
salivary gland cell autophagic cell death	GO:0035071	83	0.043
cell death	GO:0008219	279	0.041
sensory organ morphogenesis	GO:0090596	260	0.041
programmed cell death	GO:0012501	257	0.041
developmental programmed cell death	GO:0010623	138	0.040
tissue death	GO:0016271	102	0.039
death	GO:0016265	284	0.036
compound eye development	GO:0048749	307	0.036
salivary gland morphogenesis	GO:0007435	145	0.034
organic substance catabolic process	GO:1901575	308	0.033
eye pigment biosynthetic process	GO:0006726	32	0.031
lateral inhibition	GO:0046331	206	0.031
histolysis	GO:0007559	102	0.031
response to bacterium	GO:0009617	198	0.031	Fly
phagocytosis	GO:0006909	215	0.031
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.030
gland morphogenesis	GO:0022612	145	0.028
salivary gland histolysis	GO:0035070	88	0.027
defense response to bacterium	GO:0042742	178	0.027	Fly
compound eye morphogenesis	GO:0001745	249	0.025
organic cyclic compound catabolic process	GO:1901361	168	0.024
autophagic cell death	GO:0048102	83	0.024
pigmentation	GO:0043473	75	0.024
detection of stimulus	GO:0051606	156	0.023
eye development	GO:0001654	323	0.023
exocrine system development	GO:0035272	162	0.022
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.021
cellular protein modification process	GO:0006464	438	0.021
chaeta development	GO:0022416	97	0.020
protein modification process	GO:0036211	438	0.020
vesicle mediated transport	GO:0016192	381	0.020
positive regulation of cell communication	GO:0010647	250	0.020
cellular amino acid metabolic process	GO:0006520	61	0.020
aromatic compound catabolic process	GO:0019439	166	0.020
homeostatic process	GO:0042592	199	0.019	Fly
imaginal disc derived appendage development	GO:0048737	399	0.019
humoral immune response	GO:0006959	117	0.019
defense response	GO:0006952	300	0.019
organic substance transport	GO:0071702	257	0.018	Fly
kidney development	GO:0001822	3	0.018
sulfur compound metabolic process	GO:0006790	59	0.018
response to wounding	GO:0009611	94	0.018
appendage development	GO:0048736	401	0.018
catabolic process	GO:0009056	409	0.018
regulation of localization	GO:0032879	275	0.017
response to abiotic stimulus	GO:0009628	341	0.017
post embryonic appendage morphogenesis	GO:0035120	385	0.017
regionalization	GO:0003002	416	0.016
negative regulation of cell communication	GO:0010648	223	0.016
cell proliferation	GO:0008283	299	0.016
organonitrogen compound metabolic process	GO:1901564	318	0.016
regulation of cell cycle	GO:0051726	291	0.016
positive regulation of signaling	GO:0023056	243	0.015
regulation of transport	GO:0051049	181	0.015
response to other organism	GO:0051707	293	0.015	Fly
carbohydrate derivative metabolic process	GO:1901135	217	0.015
androgen metabolic process	GO:0008209	1	0.015
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.014
response to oxygen containing compound	GO:1901700	200	0.014
response to lipopolysaccharide	GO:0032496	4	0.014
oxoacid metabolic process	GO:0043436	103	0.014
body morphogenesis	GO:0010171	2	0.014
positive regulation of signal transduction	GO:0009967	223	0.014
negative regulation of biosynthetic process	GO:0009890	277	0.014
regulation of molecular function	GO:0065009	217	0.014
phototransduction	GO:0007602	52	0.013
dna metabolic process	GO:0006259	227	0.013
organelle fission	GO:0048285	340	0.013
cell recognition	GO:0008037	102	0.013	Fly
actin filament organization	GO:0007015	126	0.013
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.013
glycerolipid catabolic process	GO:0046503	3	0.013
pigment metabolic process involved in pigmentation	GO:0043474	33	0.012
pigment biosynthetic process	GO:0046148	36	0.012
regulation of cell death	GO:0010941	173	0.012
wing disc morphogenesis	GO:0007472	344	0.012
negative regulation of signal transduction	GO:0009968	206	0.012
organic acid metabolic process	GO:0006082	103	0.012
detection of abiotic stimulus	GO:0009582	66	0.012
cellular response to chemical stimulus	GO:0070887	199	0.012
negative regulation of response to stimulus	GO:0048585	258	0.012
negative regulation of signaling	GO:0023057	219	0.012
developmental pigmentation	GO:0048066	68	0.012
negative regulation of cellular metabolic process	GO:0031324	382	0.012
glutathione metabolic process	GO:0006749	37	0.011
single organism biosynthetic process	GO:0044711	206	0.011	Fly
positive regulation of lipid storage	GO:0010884	4	0.011
regulation of vesicle mediated transport	GO:0060627	59	0.011
nucleobase containing compound catabolic process	GO:0034655	165	0.011
lipid metabolic process	GO:0006629	121	0.011	Fly
cellular nitrogen compound catabolic process	GO:0044270	165	0.011
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.011
positive regulation of cellular biosynthetic process	GO:0031328	316	0.011
positive regulation of response to stimulus	GO:0048584	323	0.011
carboxylic acid metabolic process	GO:0019752	92	0.011
regulation of catabolic process	GO:0009894	170	0.011
establishment of localization in cell	GO:0051649	402	0.011
positive regulation of macromolecule metabolic process	GO:0010604	405	0.011
organophosphate metabolic process	GO:0019637	195	0.011
defense response to other organism	GO:0098542	225	0.011	Fly
response to nitrogen compound	GO:1901698	90	0.011
response to temperature stimulus	GO:0009266	106	0.011
regulation of cell proliferation	GO:0042127	163	0.011
organophosphate catabolic process	GO:0046434	112	0.011
intracellular signal transduction	GO:0035556	300	0.011
nuclear division	GO:0000280	332	0.011
cellular response to dna damage stimulus	GO:0006974	223	0.011
transcription from rna polymerase ii promoter	GO:0006366	368	0.011
apoptotic process	GO:0006915	159	0.011
regulation of intracellular signal transduction	GO:1902531	236	0.011
imaginal disc derived wing morphogenesis	GO:0007476	337	0.011
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.010
eye morphogenesis	GO:0048592	260	0.010
steroid metabolic process	GO:0008202	20	0.010	Fly
dorsal ventral axis specification	GO:0009950	66	0.010
response to hexose	GO:0009746	3	0.010
single organism catabolic process	GO:0044712	228	0.010
positive regulation of catalytic activity	GO:0043085	118	0.010
cellular macromolecule catabolic process	GO:0044265	136	0.010
cellular modified amino acid metabolic process	GO:0006575	45	0.010

Npc2h disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.034
nervous system disease	DOID:863	0.015
disease of metabolism	DOID:0014667	0.013
inherited metabolic disorder	DOID:655	0.012

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