IMP: Integrative Multi-species Prediction

Drosophila melanogaster

81 known processes

Atg13 (Dmel_CG7331)

Autophagy-specific gene 13

(Aliases: BcDNA:HL01508,CG7331,Dmel\CG7331)

Entrez: 40998
FLYBASE: FBgn0261108
UniProtKB: Q9VHR6

Process Predictions
Disease Predictions

Atg13 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
macroautophagy	GO:0016236	42	0.863
regulation of autophagy	GO:0010506	62	0.852
positive regulation of autophagy	GO:0010508	21	0.796
regulation of response to external stimulus	GO:0032101	115	0.746
regulation of response to stress	GO:0080134	200	0.744
muscle structure development	GO:0061061	224	0.727
response to starvation	GO:0042594	97	0.700
autophagy	GO:0006914	108	0.677
response to nutrient levels	GO:0031667	114	0.648
negative regulation of response to stimulus	GO:0048585	258	0.613
catabolic process	GO:0009056	409	0.444
larval midgut histolysis	GO:0035069	22	0.426
apoptotic process involved in development	GO:1902742	20	0.419
response to extracellular stimulus	GO:0009991	116	0.416
response to oxidative stress	GO:0006979	86	0.410
eggshell formation	GO:0030703	105	0.401
cell proliferation	GO:0008283	299	0.385
regulation of response to nutrient levels	GO:0032107	18	0.380
response to endogenous stimulus	GO:0009719	119	0.370
larval midgut cell programmed cell death	GO:0035096	19	0.357
positive regulation of rna metabolic process	GO:0051254	271	0.350
negative regulation of signaling	GO:0023057	219	0.346
cellular catabolic process	GO:0044248	372	0.343
negative regulation of cell communication	GO:0010648	223	0.342
phosphorylation	GO:0016310	294	0.341
lipid localization	GO:0010876	54	0.327
cellular response to extracellular stimulus	GO:0031668	64	0.322
regulation of cellular catabolic process	GO:0031329	157	0.313
positive regulation of macroautophagy	GO:0016239	8	0.310
regulation of intracellular signal transduction	GO:1902531	236	0.308
regulation of cell death	GO:0010941	173	0.296
regulation of defense response to virus	GO:0050688	14	0.285
glycerolipid metabolic process	GO:0046486	34	0.271
positive regulation of response to external stimulus	GO:0032103	44	0.260
positive regulation of cellular catabolic process	GO:0031331	95	0.257
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.252
defense response to other organism	GO:0098542	225	0.252
regulation of multi organism process	GO:0043900	131	0.226
regulation of cell differentiation	GO:0045595	302	0.224
negative regulation of signal transduction	GO:0009968	206	0.218
regulation of apoptotic process	GO:0042981	130	0.215
regulation of cellular response to stress	GO:0080135	89	0.212
signal transduction by phosphorylation	GO:0023014	107	0.206
cellular response to starvation	GO:0009267	61	0.205
regulation of catabolic process	GO:0009894	170	0.204
regulation of response to extracellular stimulus	GO:0032104	18	0.203
negative regulation of intracellular signal transduction	GO:1902532	57	0.203
nurse cell apoptotic process	GO:0045476	17	0.200
positive regulation of catabolic process	GO:0009896	105	0.198
regulation of response to biotic stimulus	GO:0002831	63	0.178
intracellular signal transduction	GO:0035556	300	0.177
growth	GO:0040007	359	0.174
protein targeting to nucleus	GO:0044744	51	0.172
positive regulation of macromolecule metabolic process	GO:0010604	405	0.170
defense response	GO:0006952	300	0.167
regulation of protein transport	GO:0051223	57	0.162
chorion containing eggshell formation	GO:0007304	105	0.157
inositol lipid mediated signaling	GO:0048017	4	0.156
establishment of localization in cell	GO:0051649	402	0.156
transcription from rna polymerase ii promoter	GO:0006366	368	0.155
positive regulation of rna biosynthetic process	GO:1902680	266	0.154
cellular macromolecule localization	GO:0070727	220	0.152
response to biotic stimulus	GO:0009607	294	0.149
regulation of localization	GO:0032879	275	0.148
positive regulation of cell communication	GO:0010647	250	0.145
positive regulation of programmed cell death	GO:0043068	62	0.144
immune effector process	GO:0002252	98	0.144
regulation of immune system process	GO:0002682	176	0.137
positive regulation of response to stimulus	GO:0048584	323	0.131
cellular response to chemical stimulus	GO:0070887	199	0.128
regulation of protein modification process	GO:0031399	112	0.127
digestive system development	GO:0055123	149	0.119
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.116
protein transport	GO:0015031	155	0.115
organic substance transport	GO:0071702	257	0.113
cellular response to external stimulus	GO:0071496	66	0.111
macromolecular complex assembly	GO:0065003	256	0.107
positive regulation of signal transduction	GO:0009967	223	0.104
defense response to virus	GO:0051607	23	0.100
positive regulation of response to nutrient levels	GO:0032109	8	0.099
mapk cascade	GO:0000165	107	0.099
positive regulation of protein metabolic process	GO:0051247	128	0.098
response to other organism	GO:0051707	293	0.098
negative regulation of growth	GO:0045926	84	0.098
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.096
oxoacid metabolic process	GO:0043436	103	0.096
response to external biotic stimulus	GO:0043207	293	0.096
lipid modification	GO:0030258	24	0.095
regulation of immune response	GO:0050776	118	0.094
regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043281	25	0.094
regulation of macroautophagy	GO:0016241	15	0.094
cellular protein modification process	GO:0006464	438	0.093
positive regulation of cellular biosynthetic process	GO:0031328	316	0.091
production of molecular mediator of immune response	GO:0002440	46	0.090
response to organic substance	GO:0010033	284	0.088
protein localization	GO:0008104	284	0.088
regulation of cell development	GO:0060284	215	0.088
embryonic development via the syncytial blastoderm	GO:0001700	148	0.087
positive regulation of proteolysis	GO:0045862	52	0.087
phosphatidylinositol phosphorylation	GO:0046854	10	0.085
digestive tract development	GO:0048565	149	0.085
positive regulation of signaling	GO:0023056	243	0.083
positive regulation of production of molecular mediator of immune response	GO:0002702	28	0.081
single organism catabolic process	GO:0044712	228	0.080
regionalization	GO:0003002	416	0.080
regulation of defense response	GO:0031347	102	0.080
organelle assembly	GO:0070925	198	0.079
regulation of programmed cell death	GO:0043067	152	0.077
negative regulation of biosynthetic process	GO:0009890	277	0.077
positive regulation of multicellular organismal process	GO:0051240	143	0.076
protein import into nucleus	GO:0006606	51	0.075
renal system development	GO:0072001	72	0.074
positive regulation of biosynthetic process	GO:0009891	316	0.074
protein phosphorylation	GO:0006468	169	0.073
positive regulation of cellular protein metabolic process	GO:0032270	118	0.072
embryonic morphogenesis	GO:0048598	206	0.072
regulation of phosphorylation	GO:0042325	147	0.071
regulation of immune effector process	GO:0002697	52	0.070
positive regulation of developmental process	GO:0051094	143	0.070
autophagic vacuole assembly	GO:0000045	2	0.069
organelle localization	GO:0051640	148	0.068
lipid storage	GO:0019915	38	0.068
regulation of mapk cascade	GO:0043408	92	0.066
negative regulation of rna biosynthetic process	GO:1902679	240	0.066
positive regulation of response to extracellular stimulus	GO:0032106	8	0.065
positive regulation of apoptotic process	GO:0043065	47	0.064
positive regulation of immune effector process	GO:0002699	28	0.064
fatty acid metabolic process	GO:0006631	20	0.063
response to virus	GO:0009615	28	0.063
negative regulation of cellular biosynthetic process	GO:0031327	277	0.063
defense response to bacterium	GO:0042742	178	0.062
death	GO:0016265	284	0.062
phosphatidylinositol mediated signaling	GO:0048015	4	0.061
somatic muscle development	GO:0007525	66	0.060
digestive tract morphogenesis	GO:0048546	127	0.060
multicellular organismal aging	GO:0010259	140	0.059
regulation of protein kinase activity	GO:0045859	51	0.058
cellular response to endogenous stimulus	GO:0071495	80	0.058
lipid metabolic process	GO:0006629	121	0.058
regulation of nurse cell apoptotic process	GO:0045477	9	0.055
positive regulation of phosphorylation	GO:0042327	87	0.054
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.053
organelle fission	GO:0048285	340	0.053
muscle cell differentiation	GO:0042692	103	0.053
protein localization to organelle	GO:0033365	82	0.053
positive regulation of gene expression	GO:0010628	290	0.053
regulation of cell proliferation	GO:0042127	163	0.053
dorsal ventral pattern formation	GO:0009953	133	0.052
regulation of humoral immune response	GO:0002920	51	0.052
regulation of protein phosphorylation	GO:0001932	64	0.052
regulation of protein secretion	GO:0050708	13	0.051
response to oxygen containing compound	GO:1901700	200	0.050
positive regulation of cell death	GO:0010942	69	0.049
cellular ketone metabolic process	GO:0042180	24	0.048
histolysis	GO:0007559	102	0.048
cellular protein localization	GO:0034613	160	0.046
apoptotic signaling pathway	GO:0097190	27	0.045
urogenital system development	GO:0001655	72	0.045
cell death	GO:0008219	279	0.045
antimicrobial peptide production	GO:0002775	46	0.044
cellular response to nutrient levels	GO:0031669	62	0.044
developmental programmed cell death	GO:0010623	138	0.044
positive regulation of intracellular signal transduction	GO:1902533	116	0.043
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.042
endomembrane system organization	GO:0010256	119	0.042
regulation of phosphorus metabolic process	GO:0051174	210	0.042
maintenance of location	GO:0051235	73	0.042
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.042
regulation of cellular protein metabolic process	GO:0032268	243	0.042
regulation of antimicrobial peptide production	GO:0002784	44	0.042
lipid biosynthetic process	GO:0008610	46	0.041
cell maturation	GO:0048469	144	0.040
cell type specific apoptotic process	GO:0097285	38	0.040
regulation of cell cycle	GO:0051726	291	0.040
regulation of production of molecular mediator of immune response	GO:0002700	44	0.039
cell fate specification	GO:0001708	71	0.039
smoothened signaling pathway	GO:0007224	49	0.039
anion homeostasis	GO:0055081	3	0.039
single organism cellular localization	GO:1902580	180	0.039
protein modification process	GO:0036211	438	0.038
single organism intracellular transport	GO:1902582	207	0.038
negative regulation of rna metabolic process	GO:0051253	251	0.037
determination of adult lifespan	GO:0008340	137	0.037
stem cell division	GO:0017145	69	0.037
negative regulation of cell proliferation	GO:0008285	69	0.037
negative regulation of programmed cell death	GO:0043069	72	0.035
regulation of cellular amino acid metabolic process	GO:0006521	0	0.035
tissue death	GO:0016271	102	0.035
renal tubule morphogenesis	GO:0061333	44	0.033
cell division	GO:0051301	248	0.033
positive regulation of transcription dna templated	GO:0045893	266	0.033
cell growth	GO:0016049	108	0.033
intracellular transport	GO:0046907	228	0.033
cardiovascular system development	GO:0072358	82	0.033
cardiocyte differentiation	GO:0035051	29	0.033
programmed cell death	GO:0012501	257	0.032
positive regulation of cell differentiation	GO:0045597	64	0.032
positive regulation of cysteine type endopeptidase activity	GO:2001056	24	0.031
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.031
regulation of cellular amine metabolic process	GO:0033238	3	0.031
stem cell differentiation	GO:0048863	117	0.030
positive regulation of nurse cell apoptotic process	GO:0045850	5	0.030
aging	GO:0007568	143	0.030
positive regulation of cell migration	GO:0030335	2	0.030
ion transport	GO:0006811	145	0.029
columnar cuboidal epithelial cell development	GO:0002066	249	0.029
negative regulation of cell death	GO:0060548	81	0.029
positive regulation of phosphorus metabolic process	GO:0010562	139	0.029
gland development	GO:0048732	191	0.029
regulation of catalytic activity	GO:0050790	185	0.028
regulation of multicellular organismal development	GO:2000026	414	0.028
protein complex assembly	GO:0006461	200	0.028
defense response to gram negative bacterium	GO:0050829	94	0.028
regulation of phosphate metabolic process	GO:0019220	210	0.027
regulation of protein serine threonine kinase activity	GO:0071900	25	0.027
regulation of cellular ketone metabolic process	GO:0010565	3	0.027
neuronal stem cell division	GO:0036445	35	0.027
positive regulation of immune system process	GO:0002684	68	0.027
lipid phosphorylation	GO:0046834	11	0.027
autophagic cell death	GO:0048102	83	0.026
stress activated mapk cascade	GO:0051403	52	0.026
apoptotic process	GO:0006915	159	0.026
negative regulation of multicellular organismal process	GO:0051241	142	0.026
regulation of stress activated mapk cascade	GO:0032872	41	0.026
cellular response to ethanol	GO:0071361	4	0.026
cellular macromolecular complex assembly	GO:0034622	153	0.026
regulation of antimicrobial humoral response	GO:0002759	50	0.026
positive regulation of phosphate metabolic process	GO:0045937	139	0.026
activation of cysteine type endopeptidase activity involved in apoptotic process	GO:0006919	16	0.026
negative regulation of cellular metabolic process	GO:0031324	382	0.025
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.025
organonitrogen compound metabolic process	GO:1901564	318	0.025
negative regulation of response to external stimulus	GO:0032102	22	0.024
regulation of stress activated protein kinase signaling cascade	GO:0070302	42	0.024
internal protein amino acid acetylation	GO:0006475	38	0.024
vesicle mediated transport	GO:0016192	381	0.024
regulation of lipid metabolic process	GO:0019216	15	0.024
glycerophospholipid metabolic process	GO:0006650	23	0.023
single organism membrane organization	GO:0044802	93	0.023
monocarboxylic acid metabolic process	GO:0032787	29	0.023
skeletal muscle fiber development	GO:0048741	3	0.023
cell motility	GO:0048870	251	0.023
establishment of protein localization	GO:0045184	163	0.022
antimicrobial peptide biosynthetic process	GO:0002777	38	0.022
malpighian tubule development	GO:0072002	64	0.022
small molecule metabolic process	GO:0044281	305	0.022
regulation of antimicrobial peptide biosynthetic process	GO:0002805	38	0.022
cellular amine metabolic process	GO:0044106	12	0.022
secretion	GO:0046903	109	0.022
somatic stem cell division	GO:0048103	37	0.021
autophagic vacuole fusion	GO:0000046	15	0.021
regulation of kinase activity	GO:0043549	53	0.021
endocytosis	GO:0006897	310	0.021
chemical homeostasis	GO:0048878	92	0.021
regulation of transport	GO:0051049	181	0.021
protein localization to nucleus	GO:0034504	55	0.021
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.020
positive regulation of protein modification process	GO:0031401	58	0.020
larval development	GO:0002164	104	0.020
chorion containing eggshell pattern formation	GO:0030381	11	0.020
carboxylic acid metabolic process	GO:0019752	92	0.020
activation of mapk activity	GO:0000187	9	0.020
negative regulation of developmental process	GO:0051093	201	0.020
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.019
negative regulation of cell differentiation	GO:0045596	143	0.019
cellular response to growth factor stimulus	GO:0071363	30	0.019
epithelial cell differentiation	GO:0030855	322	0.018
salivary gland development	GO:0007431	162	0.018
wnt signaling pathway	GO:0016055	98	0.018
negative regulation of cellular component organization	GO:0051129	108	0.018
striated muscle cell development	GO:0055002	50	0.018
single organism biosynthetic process	GO:0044711	206	0.018
neurological system process	GO:0050877	358	0.018
phospholipid metabolic process	GO:0006644	23	0.018
epithelial tube morphogenesis	GO:0060562	88	0.018
regulation of establishment of protein localization	GO:0070201	61	0.017
positive regulation of transport	GO:0051050	92	0.017
positive regulation of catalytic activity	GO:0043085	118	0.017
cellular component assembly involved in morphogenesis	GO:0010927	151	0.017
response to ethanol	GO:0045471	59	0.017
peptidyl lysine modification	GO:0018205	57	0.017
immune response activating signal transduction	GO:0002757	2	0.017
regulation of steroid metabolic process	GO:0019218	2	0.016
positive regulation of cell development	GO:0010720	61	0.016
response to bacterium	GO:0009617	198	0.016
regulation of cellular component biogenesis	GO:0044087	201	0.016
regulation of multicellular organism growth	GO:0040014	40	0.016
developmental growth	GO:0048589	280	0.016
apoptotic cell clearance	GO:0043277	14	0.016
mitotic spindle organization	GO:0007052	220	0.016
response to oxygen levels	GO:0070482	59	0.016
imaginal disc pattern formation	GO:0007447	91	0.016
negative regulation of defense response	GO:0031348	35	0.016
regulation of apoptotic signaling pathway	GO:2001233	10	0.016
negative regulation of phosphorylation	GO:0042326	35	0.016
cell migration	GO:0016477	238	0.016
regulation of protein metabolic process	GO:0051246	256	0.016
regulation of transferase activity	GO:0051338	58	0.016
salivary gland morphogenesis	GO:0007435	145	0.016
extrinsic apoptotic signaling pathway	GO:0097191	1	0.015
cellular response to hormone stimulus	GO:0032870	44	0.015
negative regulation of protein metabolic process	GO:0051248	85	0.015
organic substance catabolic process	GO:1901575	308	0.015
vesicle targeting to from or within golgi	GO:0048199	1	0.015
positive regulation of protein catabolic process	GO:0045732	34	0.015
cytoplasmic transport	GO:0016482	130	0.015
imaginal disc derived appendage development	GO:0048737	399	0.015
localization of cell	GO:0051674	257	0.015
negative regulation of nervous system development	GO:0051961	92	0.015
response to growth factor	GO:0070848	31	0.014
appendage development	GO:0048736	401	0.014
cellular amino acid metabolic process	GO:0006520	61	0.014
phagocytosis	GO:0006909	215	0.014
stress activated protein kinase signaling cascade	GO:0031098	55	0.014
protein complex biogenesis	GO:0070271	201	0.014
jnk cascade	GO:0007254	50	0.014
regulation of peptidyl lysine acetylation	GO:2000756	7	0.014
carbohydrate metabolic process	GO:0005975	82	0.014
cholesterol transport	GO:0030301	2	0.014
neuron remodeling	GO:0016322	29	0.014
regulation of meiosis	GO:0040020	3	0.014
positive regulation of protein phosphorylation	GO:0001934	34	0.014
regulation of molecular function	GO:0065009	217	0.014
response to acid chemical	GO:0001101	25	0.013
cellular amide metabolic process	GO:0043603	80	0.013
post embryonic appendage morphogenesis	GO:0035120	385	0.013
nuclear transport	GO:0051169	72	0.013
nitrogen compound transport	GO:0071705	85	0.013
midgut development	GO:0007494	23	0.013
organic acid transport	GO:0015849	18	0.013
exocrine system development	GO:0035272	162	0.013
nucleobase containing compound catabolic process	GO:0034655	165	0.013
tube development	GO:0035295	244	0.013
regulation of jnk cascade	GO:0046328	40	0.013
cellular lipid metabolic process	GO:0044255	83	0.013
regulation of lipid transport	GO:0032368	3	0.013
protein ubiquitination	GO:0016567	70	0.013
response to abiotic stimulus	GO:0009628	341	0.013
response to lipopolysaccharide	GO:0032496	4	0.013
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	65	0.013
meiotic cell cycle	GO:0051321	171	0.012
negative regulation of developmental growth	GO:0048640	64	0.012
negative regulation of transcription dna templated	GO:0045892	237	0.012
innate immune response	GO:0045087	144	0.012
protein heterooligomerization	GO:0051291	4	0.012
regulation of hemocyte proliferation	GO:0035206	37	0.012
salivary gland histolysis	GO:0035070	88	0.012
actin filament based process	GO:0030029	220	0.012
negative regulation of sequence specific dna binding transcription factor activity	GO:0043433	4	0.012
cellular response to oxygen containing compound	GO:1901701	79	0.012
leg disc development	GO:0035218	92	0.012
hindgut morphogenesis	GO:0007442	58	0.012
gland morphogenesis	GO:0022612	145	0.012
appendage morphogenesis	GO:0035107	397	0.012
homeostatic process	GO:0042592	199	0.012
response to monosaccharide	GO:0034284	4	0.012
positive regulation of jun kinase activity	GO:0043507	4	0.012
protein import	GO:0017038	55	0.012
regulation of ion transport	GO:0043269	39	0.012
regulation of phosphatase activity	GO:0010921	3	0.011
triglyceride biosynthetic process	GO:0019432	2	0.011
peptidyl amino acid modification	GO:0018193	105	0.011
positive regulation of mapk cascade	GO:0043410	63	0.011
spindle organization	GO:0007051	253	0.011
regulation of cell projection organization	GO:0031344	92	0.011
internal peptidyl lysine acetylation	GO:0018393	38	0.011
positive regulation of defense response to virus by host	GO:0002230	10	0.011
positive regulation of defense response to bacterium	GO:1900426	23	0.011
nucleobase containing small molecule metabolic process	GO:0055086	174	0.011
regulation of antibacterial peptide biosynthetic process	GO:0002808	22	0.011
membrane invagination	GO:0010324	11	0.011
protein secretion	GO:0009306	45	0.011
response to organophosphorus	GO:0046683	2	0.011
nucleocytoplasmic transport	GO:0006913	72	0.011
negative regulation of notch signaling pathway	GO:0045746	41	0.011
positive regulation of cellular component organization	GO:0051130	156	0.010
organophosphate biosynthetic process	GO:0090407	46	0.010
multicellular organism growth	GO:0035264	46	0.010
regulation of proteolysis	GO:0030162	87	0.010
gene silencing by rna	GO:0031047	57	0.010
organophosphate metabolic process	GO:0019637	195	0.010
telencephalon development	GO:0021537	2	0.010
positive regulation of neuron apoptotic process	GO:0043525	1	0.010
embryonic heart tube development	GO:0035050	22	0.010
positive regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043280	23	0.010

Atg13 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of metabolism	DOID:0014667	0.043
disease of anatomical entity	DOID:7	0.040
nervous system disease	DOID:863	0.011

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