IMP: Integrative Multi-species Prediction

Drosophila melanogaster

60 known processes

BicC (Dmel_CG4824)

Bicaudal C

(Aliases: Bic-C,Dmel\CG4824,CG4824,BG:DS00913.2,Dromel_CG4824_FBtr0080804_bicc_mORF,l(2)br34,br34)

FLYBASE: FBgn0000182
Entrez: 34946
UniProtKB: E2QCR4
UniProtKB: Q24009

Process Predictions
Disease Predictions

BicC biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
ovarian follicle cell development	GO:0030707	248	0.727
chorion containing eggshell formation	GO:0007304	105	0.686
segmentation	GO:0035282	207	0.439
anterior posterior pattern specification	GO:0009952	136	0.422
embryonic pattern specification	GO:0009880	174	0.406
negative regulation of gene expression	GO:0010629	387	0.322
cellular component assembly involved in morphogenesis	GO:0010927	151	0.316
blastoderm segmentation	GO:0007350	159	0.312
fertilization	GO:0009566	26	0.290
zygotic determination of anterior posterior axis embryo	GO:0007354	27	0.274
eggshell chorion assembly	GO:0007306	66	0.272
regulation of oocyte development	GO:0060281	27	0.241
oocyte anterior posterior axis specification	GO:0007314	72	0.235
oocyte development	GO:0048599	124	0.227
oocyte construction	GO:0007308	112	0.212
eggshell formation	GO:0030703	105	0.208
regulation of pole plasm oskar mrna localization	GO:0007317	27	0.200
dorsal appendage formation	GO:0046843	47	0.196
cellular macromolecule localization	GO:0070727	220	0.187
germarium derived egg chamber formation	GO:0007293	101	0.184
tripartite regional subdivision	GO:0007351	103	0.180
embryonic axis specification	GO:0000578	107	0.173
rna processing	GO:0006396	147	0.168
regionalization	GO:0003002	416	0.161
dna conformation change	GO:0071103	105	0.154	Fly
axis specification	GO:0009798	167	0.154
morphogenesis of follicular epithelium	GO:0016333	36	0.153
purine ribonucleoside metabolic process	GO:0046128	127	0.149
epithelial cell differentiation	GO:0030855	322	0.142
germarium derived oocyte fate determination	GO:0007294	26	0.140
establishment or maintenance of cytoskeleton polarity	GO:0030952	44	0.137
single organism cellular localization	GO:1902580	180	0.136
negative regulation of cellular metabolic process	GO:0031324	382	0.136
egg coat formation	GO:0035803	11	0.135
maternal determination of anterior posterior axis embryo	GO:0008358	74	0.130
oocyte localization involved in germarium derived egg chamber formation	GO:0030720	12	0.123
vitelline membrane formation	GO:0030704	11	0.123
anterior posterior axis specification	GO:0009948	109	0.121
columnar cuboidal epithelial cell development	GO:0002066	249	0.120
nucleobase containing compound catabolic process	GO:0034655	165	0.115
regulation of organelle organization	GO:0033043	196	0.115
oocyte microtubule cytoskeleton organization	GO:0016325	35	0.112
oocyte differentiation	GO:0009994	145	0.111
pole plasm mrna localization	GO:0019094	49	0.110
cell division	GO:0051301	248	0.104
pole plasm oskar mrna localization	GO:0045451	46	0.096
extracellular structure organization	GO:0043062	46	0.096
gene silencing	GO:0016458	138	0.091
chromatin organization	GO:0006325	207	0.091	Fly
embryo development ending in birth or egg hatching	GO:0009792	152	0.090
single fertilization	GO:0007338	24	0.090
aromatic compound catabolic process	GO:0019439	166	0.083
posttranscriptional gene silencing by rna	GO:0035194	45	0.082
actin filament based process	GO:0030029	220	0.082
cellular catabolic process	GO:0044248	372	0.081
negative regulation of cell communication	GO:0010648	223	0.081	Human
regulation of multicellular organismal development	GO:2000026	414	0.078
single organism intracellular transport	GO:1902582	207	0.078
oocyte axis specification	GO:0007309	108	0.078
organelle fusion	GO:0048284	46	0.077
regulation of cellular protein metabolic process	GO:0032268	243	0.076	Fly
terminal region determination	GO:0007362	25	0.076
anterior posterior axis specification embryo	GO:0008595	103	0.075
vitelline membrane formation involved in chorion containing eggshell formation	GO:0007305	11	0.075
mitotic nuclear division	GO:0007067	213	0.072
regulation of mrna metabolic process	GO:1903311	72	0.071
rna catabolic process	GO:0006401	37	0.071
long term memory	GO:0007616	62	0.070
intracellular mrna localization	GO:0008298	66	0.070
epithelial cell development	GO:0002064	274	0.068
establishment or maintenance of cell polarity	GO:0007163	167	0.066
negative regulation of biosynthetic process	GO:0009890	277	0.066
cell motility	GO:0048870	251	0.064
carbohydrate derivative metabolic process	GO:1901135	217	0.062
regulation of cellular localization	GO:0060341	136	0.059
response to other organism	GO:0051707	293	0.057
macromolecule catabolic process	GO:0009057	161	0.057
establishment of localization in cell	GO:0051649	402	0.057
death	GO:0016265	284	0.055
positive regulation of rna metabolic process	GO:0051254	271	0.055
gene silencing by rna	GO:0031047	57	0.054
cellular macromolecule catabolic process	GO:0044265	136	0.053
protein localization to organelle	GO:0033365	82	0.053
programmed cell death	GO:0012501	257	0.051
glycosyl compound metabolic process	GO:1901657	127	0.050
oocyte dorsal ventral axis specification	GO:0007310	34	0.050
phosphorylation	GO:0016310	294	0.050
pole plasm rna localization	GO:0007316	52	0.050
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.050
mrna processing	GO:0006397	104	0.049
cellular nitrogen compound catabolic process	GO:0044270	165	0.049
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.049
pole plasm assembly	GO:0007315	61	0.048
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.048
vesicle mediated transport	GO:0016192	381	0.047
periodic partitioning	GO:0007365	29	0.047
chromosome organization	GO:0051276	360	0.046	Fly
pole plasm protein localization	GO:0007318	10	0.046
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.046
atp metabolic process	GO:0046034	49	0.046
establishment or maintenance of microtubule cytoskeleton polarity	GO:0030951	41	0.046
nucleus localization	GO:0051647	34	0.045
phagocytosis	GO:0006909	215	0.045
ameboidal type cell migration	GO:0001667	151	0.045
intracellular mrna localization involved in anterior posterior axis specification	GO:0060811	53	0.044
imaginal disc derived wing morphogenesis	GO:0007476	337	0.044
heterocycle catabolic process	GO:0046700	166	0.043
body morphogenesis	GO:0010171	2	0.043
microtubule organizing center organization	GO:0031023	168	0.043
negative regulation of rna metabolic process	GO:0051253	251	0.042
neurological system process	GO:0050877	358	0.042
rna localization	GO:0006403	115	0.042
localization of cell	GO:0051674	257	0.042
oocyte nucleus localization involved in oocyte dorsal ventral axis specification	GO:0051663	12	0.041
endocytosis	GO:0006897	310	0.041
protein modification process	GO:0036211	438	0.040
defense response to gram negative bacterium	GO:0050829	94	0.040
mrna catabolic process	GO:0006402	33	0.039
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.039
negative regulation of response to stimulus	GO:0048585	258	0.039	Human
response to external biotic stimulus	GO:0043207	293	0.039
regulation of translation	GO:0006417	56	0.039	Fly
protein localization	GO:0008104	284	0.038
regulation of meiosis	GO:0040020	3	0.037
organic cyclic compound catabolic process	GO:1901361	168	0.037
carbohydrate derivative biosynthetic process	GO:1901137	85	0.036
posttranscriptional gene silencing	GO:0016441	46	0.036
mitotic spindle organization	GO:0007052	220	0.036
rna 3 end processing	GO:0031123	45	0.036
cellular protein localization	GO:0034613	160	0.036
establishment or maintenance of polarity of follicular epithelium	GO:0016334	26	0.035
centrosome organization	GO:0051297	163	0.035
extracellular matrix assembly	GO:0085029	13	0.035
chromosome condensation	GO:0030261	41	0.034	Fly
regulation of gene expression epigenetic	GO:0040029	128	0.034
cellular macromolecular complex assembly	GO:0034622	153	0.034
developmental growth	GO:0048589	280	0.033
regulation of cell division	GO:0051302	72	0.033
regulation of cellular component biogenesis	GO:0044087	201	0.033
post embryonic appendage morphogenesis	GO:0035120	385	0.033
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.033
positive regulation of transport	GO:0051050	92	0.033
positive regulation of response to stimulus	GO:0048584	323	0.032
organelle assembly	GO:0070925	198	0.032
nucleotide metabolic process	GO:0009117	161	0.032
negative regulation of rna biosynthetic process	GO:1902679	240	0.031
torso signaling pathway	GO:0008293	21	0.031
oocyte microtubule cytoskeleton polarization	GO:0008103	22	0.031
protein modification by small protein conjugation or removal	GO:0070647	106	0.031
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.031	Fly
dna packaging	GO:0006323	91	0.031	Fly
positive regulation of biosynthetic process	GO:0009891	316	0.030	Fly
morphogenesis of an epithelium	GO:0002009	276	0.030
appendage morphogenesis	GO:0035107	397	0.030
synaptic transmission	GO:0007268	288	0.029
nucleoside phosphate metabolic process	GO:0006753	162	0.029
regulation of cell cycle	GO:0051726	291	0.029
purine ribonucleotide metabolic process	GO:0009150	145	0.029
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.029
tissue morphogenesis	GO:0048729	297	0.029
cellular protein complex assembly	GO:0043623	71	0.028
tube morphogenesis	GO:0035239	191	0.028
response to bacterium	GO:0009617	198	0.028
cytoplasmic translation	GO:0002181	0	0.028
establishment of organelle localization	GO:0051656	122	0.028
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.027
response to organonitrogen compound	GO:0010243	75	0.027
purine ribonucleoside monophosphate metabolic process	GO:0009167	50	0.027
cellular ketone metabolic process	GO:0042180	24	0.027
pronuclear fusion	GO:0007344	4	0.027
germarium derived oocyte differentiation	GO:0030706	29	0.027
mrna 3 end processing	GO:0031124	28	0.027
purine nucleotide metabolic process	GO:0006163	146	0.026
response to oxygen containing compound	GO:1901700	200	0.026
organic substance catabolic process	GO:1901575	308	0.026
positive regulation of signaling	GO:0023056	243	0.026
catabolic process	GO:0009056	409	0.025
regulation of notch signaling pathway	GO:0008593	100	0.025
response to nitrogen compound	GO:1901698	90	0.024
dna replication	GO:0006260	48	0.024
organic substance transport	GO:0071702	257	0.024
actin filament organization	GO:0007015	126	0.024
cognition	GO:0050890	141	0.024
cell migration	GO:0016477	238	0.024
nucleotide catabolic process	GO:0009166	109	0.024
sex differentiation	GO:0007548	81	0.024
regulation of mrna processing	GO:0050684	71	0.023
maintenance of location in cell	GO:0051651	28	0.023
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.023
wing disc morphogenesis	GO:0007472	344	0.023
nucleoside triphosphate metabolic process	GO:0009141	120	0.023
positive regulation of cell communication	GO:0010647	250	0.022
regulation of cellular catabolic process	GO:0031329	157	0.022
negative regulation of cellular biosynthetic process	GO:0031327	277	0.022
cellular protein modification process	GO:0006464	438	0.022
regulation of protein complex disassembly	GO:0043244	29	0.022
nucleoside phosphate catabolic process	GO:1901292	110	0.021
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.021
adult behavior	GO:0030534	137	0.021
spindle organization	GO:0007051	253	0.021
negative regulation of signal transduction	GO:0009968	206	0.021	Human
positive regulation of organelle organization	GO:0010638	65	0.021
negative regulation of oskar mrna translation	GO:0007319	5	0.021
regulation of cellular amine metabolic process	GO:0033238	3	0.021
regulation of catabolic process	GO:0009894	170	0.020
organophosphate metabolic process	GO:0019637	195	0.020
protein localization to nucleus	GO:0034504	55	0.020
digestive tract morphogenesis	GO:0048546	127	0.020
male gamete generation	GO:0048232	201	0.020
notch signaling pathway	GO:0007219	120	0.020
regulation of rna splicing	GO:0043484	69	0.020
ribonucleotide metabolic process	GO:0009259	145	0.020
cellular amino acid metabolic process	GO:0006520	61	0.020
spermatogenesis	GO:0007283	200	0.020
intracellular signal transduction	GO:0035556	300	0.020
response to abiotic stimulus	GO:0009628	341	0.020
nucleobase containing small molecule metabolic process	GO:0055086	174	0.020
negative regulation of signaling	GO:0023057	219	0.019	Human
germ cell migration	GO:0008354	43	0.019
positive regulation of mrna catabolic process	GO:0061014	5	0.019
regulation of cellular ketone metabolic process	GO:0010565	3	0.019
developmental maturation	GO:0021700	172	0.019
ribonucleoprotein complex subunit organization	GO:0071826	28	0.019
intracellular transport	GO:0046907	228	0.019
positive regulation of developmental process	GO:0051094	143	0.019
regulation of growth	GO:0040008	233	0.019
defense response to bacterium	GO:0042742	178	0.019
response to temperature stimulus	GO:0009266	106	0.019
regulation of mitosis	GO:0007088	56	0.018
cell proliferation	GO:0008283	299	0.018
oxoacid metabolic process	GO:0043436	103	0.018
ribonucleoside catabolic process	GO:0042454	112	0.018
nucleoside monophosphate metabolic process	GO:0009123	52	0.018
dorsal ventral axis specification ovarian follicular epithelium	GO:0008069	13	0.018
mrna metabolic process	GO:0016071	124	0.018
muscle structure development	GO:0061061	224	0.017
positive regulation of cellular amine metabolic process	GO:0033240	0	0.017
centrosome duplication	GO:0051298	121	0.017
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.017
macromolecular complex disassembly	GO:0032984	37	0.017
negative regulation of phosphate metabolic process	GO:0045936	45	0.017
regulation of cell proliferation	GO:0042127	163	0.017
regulation of protein metabolic process	GO:0051246	256	0.017	Fly
purine nucleoside metabolic process	GO:0042278	127	0.016
peptidyl threonine phosphorylation	GO:0018107	2	0.016
regulation of transport	GO:0051049	181	0.016
myofibril assembly	GO:0030239	36	0.016
ribose phosphate metabolic process	GO:0019693	145	0.016
regulation of cell maturation	GO:1903429	27	0.016
transcription from rna polymerase ii promoter	GO:0006366	368	0.016
positive regulation of cellular catabolic process	GO:0031331	95	0.016
learning or memory	GO:0007611	141	0.016
sodium dependent phosphate transport	GO:0044341	2	0.015
response to drug	GO:0042493	17	0.015
rna interference	GO:0016246	27	0.015
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.015
single organism catabolic process	GO:0044712	228	0.015
nucleoside metabolic process	GO:0009116	127	0.015
histone modification	GO:0016570	106	0.015
regulation of catalytic activity	GO:0050790	185	0.015
digestive tract development	GO:0048565	149	0.015
organelle fission	GO:0048285	340	0.015
regulation of intracellular signal transduction	GO:1902531	236	0.015
extracellular matrix organization	GO:0030198	32	0.015
polarity specification of dorsal ventral axis	GO:0009951	6	0.015
gland development	GO:0048732	191	0.015
positive regulation of multicellular organismal process	GO:0051240	143	0.015
positive regulation of protein transport	GO:0051222	37	0.015
establishment of protein localization	GO:0045184	163	0.015
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.015
positive regulation of mrna metabolic process	GO:1903313	5	0.014
purine containing compound metabolic process	GO:0072521	155	0.014
modification dependent macromolecule catabolic process	GO:0043632	79	0.014
organelle localization	GO:0051640	148	0.014
regulation of nuclear division	GO:0051783	58	0.014
chaeta morphogenesis	GO:0008407	42	0.014
intracellular mrna localization involved in pattern specification process	GO:0060810	56	0.014
purine ribonucleoside monophosphate catabolic process	GO:0009169	38	0.014
maintenance of protein location in cell	GO:0032507	26	0.013
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.013
ribonucleoside metabolic process	GO:0009119	127	0.013
defense response to other organism	GO:0098542	225	0.013
positive regulation of intracellular protein transport	GO:0090316	30	0.013
appendage development	GO:0048736	401	0.013
regulation of developmental growth	GO:0048638	174	0.013
carbohydrate derivative catabolic process	GO:1901136	118	0.013
cell maturation	GO:0048469	144	0.013
regulation of anatomical structure size	GO:0090066	163	0.013
lysosomal transport	GO:0007041	13	0.013
small gtpase mediated signal transduction	GO:0007264	88	0.013
positive regulation of cellular biosynthetic process	GO:0031328	316	0.013	Fly
single organism biosynthetic process	GO:0044711	206	0.013
positive regulation of intracellular transport	GO:0032388	42	0.013
cell fate determination	GO:0001709	91	0.012
regulation of protein catabolic process	GO:0042176	55	0.012
regulation of intracellular transport	GO:0032386	64	0.012
positive regulation of multicellular organism growth	GO:0040018	21	0.012
translation	GO:0006412	69	0.012	Fly
positive regulation of nuclear transcribed mrna catabolic process deadenylation dependent decay	GO:1900153	4	0.012
negative regulation of developmental process	GO:0051093	201	0.012
purine containing compound catabolic process	GO:0072523	112	0.012
pigmentation	GO:0043473	75	0.012
cell death	GO:0008219	279	0.012
defense response to gram positive bacterium	GO:0050830	41	0.012
organic acid metabolic process	GO:0006082	103	0.012
eye morphogenesis	GO:0048592	260	0.012
oocyte fate determination	GO:0030716	27	0.012
organonitrogen compound biosynthetic process	GO:1901566	117	0.011
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.011
cytoplasm organization	GO:0007028	64	0.011
camera type eye development	GO:0043010	4	0.011
regulation of protein import into nucleus	GO:0042306	28	0.011
cytoplasmic transport nurse cell to oocyte	GO:0007303	12	0.011
protein import	GO:0017038	55	0.011
protein import into nucleus	GO:0006606	51	0.011
regulation of sterol transport	GO:0032371	1	0.011
learning	GO:0007612	75	0.011
membrane organization	GO:0061024	112	0.011
regulation of oskar mrna translation	GO:0046011	8	0.011
multicellular organismal aging	GO:0010259	140	0.011
posttranscriptional regulation of gene expression	GO:0010608	145	0.011	Fly
purine ribonucleoside catabolic process	GO:0046130	112	0.011
peptidyl amino acid modification	GO:0018193	105	0.011
regulation of cardioblast differentiation	GO:0051890	9	0.011
nephron tubule development	GO:0072080	3	0.011
stress activated mapk cascade	GO:0051403	52	0.011
embryonic morphogenesis	GO:0048598	206	0.011
response to hypoxia	GO:0001666	53	0.011
purine nucleoside catabolic process	GO:0006152	112	0.011
chromatin remodeling	GO:0006338	72	0.011	Fly
regulation of apoptotic process	GO:0042981	130	0.011
single organism behavior	GO:0044708	391	0.011
organonitrogen compound metabolic process	GO:1901564	318	0.011
nucleoside catabolic process	GO:0009164	112	0.011
regulation of nervous system development	GO:0051960	248	0.011
developmental pigmentation	GO:0048066	68	0.011
transmembrane transport	GO:0055085	139	0.011
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.011
small molecule metabolic process	GO:0044281	305	0.011
regulation of locomotion	GO:0040012	42	0.011
amine metabolic process	GO:0009308	12	0.011
oocyte maturation	GO:0001556	3	0.010
positive regulation of peptidyl tyrosine phosphorylation	GO:0050731	4	0.010
cytoplasmic transport	GO:0016482	130	0.010
nucleus organization	GO:0006997	45	0.010
camera type eye morphogenesis	GO:0048593	2	0.010
regulation of proteolysis	GO:0030162	87	0.010
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.010
positive regulation of protein import into nucleus	GO:0042307	21	0.010
purine nucleoside monophosphate catabolic process	GO:0009128	38	0.010
stem cell differentiation	GO:0048863	117	0.010
meiosis i	GO:0007127	59	0.010

BicC disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
cancer	DOID:162	0.031
disease of cellular proliferation	DOID:14566	0.031
cardiovascular system disease	DOID:1287	0.024
disease of anatomical entity	DOID:7	0.024
organ system cancer	DOID:0050686	0.019

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