IMP: Integrative Multi-species Prediction

Drosophila melanogaster

45 known processes

Spn77Ba (Dmel_CG6680)

Serpin 77Ba

(Aliases: l(3)77ABi,Dmel\CG6680,CG6680,spn77Ba)

FLYBASE: FBgn0262057
Entrez: 40234
UniProtKB: Q0E8C8

Process Predictions
Disease Predictions

Spn77Ba biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
respiratory system development	GO:0060541	213	0.757
open tracheal system development	GO:0007424	204	0.756
mating	GO:0007618	120	0.421
sensory perception	GO:0007600	196	0.411
response to abiotic stimulus	GO:0009628	341	0.280
response to mechanical stimulus	GO:0009612	28	0.276
detection of stimulus	GO:0051606	156	0.245
cellular response to abiotic stimulus	GO:0071214	58	0.243
male courtship behavior	GO:0008049	63	0.236
chemical homeostasis	GO:0048878	92	0.212
multi multicellular organism process	GO:0044706	123	0.209
negative regulation of gene expression	GO:0010629	387	0.200
ion transmembrane transport	GO:0034220	122	0.198
neurological system process	GO:0050877	358	0.197
response to organic substance	GO:0010033	284	0.195
transmembrane transport	GO:0055085	139	0.193
sensory perception of chemical stimulus	GO:0007606	116	0.190
cellular response to chemical stimulus	GO:0070887	199	0.179
sensory perception of mechanical stimulus	GO:0050954	72	0.174
regulation of behavior	GO:0050795	75	0.173
positive regulation of response to external stimulus	GO:0032103	44	0.173
multicellular organismal reproductive behavior	GO:0033057	110	0.165
positive regulation of response to biotic stimulus	GO:0002833	31	0.158
response to temperature stimulus	GO:0009266	106	0.157
immune response	GO:0006955	246	0.151
mating behavior	GO:0007617	106	0.148
metal ion transport	GO:0030001	74	0.146
homeostatic process	GO:0042592	199	0.145
male mating behavior	GO:0060179	70	0.145
regulation of immune response	GO:0050776	118	0.145
locomotory behavior	GO:0007626	176	0.143
reproductive behavior	GO:0019098	122	0.141
cation transmembrane transport	GO:0098655	88	0.139
detection of mechanical stimulus involved in sensory perception of pain	GO:0050966	2	0.138
regulation of immune system process	GO:0002682	176	0.138
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.135
courtship behavior	GO:0007619	68	0.132
ion homeostasis	GO:0050801	55	0.129
response to biotic stimulus	GO:0009607	294	0.121
taxis	GO:0042330	304	0.120
melanin metabolic process	GO:0006582	47	0.118
multi organism reproductive behavior	GO:0044705	121	0.118
salt aversion	GO:0035199	3	0.118
defense response	GO:0006952	300	0.118
growth	GO:0040007	359	0.117
multi organism behavior	GO:0051705	175	0.115
inorganic cation transmembrane transport	GO:0098662	61	0.114
regulation of response to stress	GO:0080134	200	0.113
cation transport	GO:0006812	110	0.112
regulation of innate immune response	GO:0045088	71	0.111
peptide metabolic process	GO:0006518	80	0.108
cuticle development	GO:0042335	86	0.107
defense response to bacterium	GO:0042742	178	0.106
larval locomotory behavior	GO:0008345	27	0.105
humoral immune response	GO:0006959	117	0.103
single organism behavior	GO:0044708	391	0.102
cation homeostasis	GO:0055080	51	0.098
synaptic transmission	GO:0007268	288	0.098
proteolysis	GO:0006508	192	0.096
melanization defense response	GO:0035006	45	0.096
fluid transport	GO:0042044	19	0.093
positive regulation of cellular biosynthetic process	GO:0031328	316	0.093
regulation of anatomical structure size	GO:0090066	163	0.092
regionalization	GO:0003002	416	0.091
innate immune response	GO:0045087	144	0.089
positive regulation of antimicrobial peptide production	GO:0002225	28	0.089
negative regulation of response to stimulus	GO:0048585	258	0.088
metal ion homeostasis	GO:0055065	44	0.086
regulation of cellular amide metabolic process	GO:0034248	39	0.086
positive regulation of immune effector process	GO:0002699	28	0.083
catabolic process	GO:0009056	409	0.083
epiboly	GO:0090504	2	0.081
response to pain	GO:0048265	3	0.079
ion transport	GO:0006811	145	0.076
regulation of cell proliferation	GO:0042127	163	0.075
response to endogenous stimulus	GO:0009719	119	0.074
wound healing spreading of epidermal cells	GO:0035313	1	0.073
immune effector process	GO:0002252	98	0.071
cell migration	GO:0016477	238	0.070
positive regulation of immune response	GO:0050778	63	0.070
developmental growth	GO:0048589	280	0.070
positive regulation of antimicrobial peptide biosynthetic process	GO:0002807	26	0.070
morphogenesis of an epithelium	GO:0002009	276	0.070
feeding behavior	GO:0007631	50	0.069
sensory perception of pain	GO:0019233	4	0.068
phenol containing compound metabolic process	GO:0018958	57	0.067
water homeostasis	GO:0030104	3	0.066
regulation of response to external stimulus	GO:0032101	115	0.065
immune system process	GO:0002376	347	0.065
forebrain development	GO:0030900	2	0.065
body morphogenesis	GO:0010171	2	0.065
detection of stimulus involved in sensory perception	GO:0050906	92	0.064
response to bacterium	GO:0009617	198	0.064
amide biosynthetic process	GO:0043604	42	0.063
kidney development	GO:0001822	3	0.062
positive regulation of response to stimulus	GO:0048584	323	0.062
muscle structure development	GO:0061061	224	0.061
positive regulation of multi organism process	GO:0043902	40	0.060
positive regulation of antimicrobial humoral response	GO:0002760	28	0.060
epiboly involved in wound healing	GO:0090505	2	0.060
regulation of tube size	GO:0035150	46	0.059
regulation of multicellular organismal development	GO:2000026	414	0.058
lateral inhibition	GO:0046331	206	0.058
response to oxygen containing compound	GO:1901700	200	0.057
cranial nerve development	GO:0021545	1	0.057
regulation of synaptic transmission	GO:0050804	69	0.057
regulation of response to biotic stimulus	GO:0002831	63	0.057
molting cycle chitin based cuticle	GO:0007591	56	0.056
localization of cell	GO:0051674	257	0.055
compound eye photoreceptor cell differentiation	GO:0001751	140	0.055
cellular response to water stimulus	GO:0071462	2	0.053
cellular amide metabolic process	GO:0043603	80	0.053
rhythmic behavior	GO:0007622	76	0.052
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.052
drinking behavior	GO:0042756	2	0.051
response to other organism	GO:0051707	293	0.051
macromolecule catabolic process	GO:0009057	161	0.051
terminal branching open tracheal system	GO:0007430	17	0.051
regulation of multi organism process	GO:0043900	131	0.050
activation of innate immune response	GO:0002218	4	0.050
response to nitrogen compound	GO:1901698	90	0.049
cell motility	GO:0048870	251	0.049
positive regulation of immune system process	GO:0002684	68	0.049
tissue morphogenesis	GO:0048729	297	0.049
negative regulation of cellular metabolic process	GO:0031324	382	0.049
positive regulation of biosynthetic process	GO:0009891	316	0.049
sensory perception of salty taste	GO:0050914	3	0.048
establishment of localization in cell	GO:0051649	402	0.048
inter male aggressive behavior	GO:0002121	60	0.048
tracheal outgrowth open tracheal system	GO:0007426	18	0.047
negative regulation of rna metabolic process	GO:0051253	251	0.046
regulation of reproductive process	GO:2000241	54	0.046
organonitrogen compound metabolic process	GO:1901564	318	0.046
segmentation	GO:0035282	207	0.046
monovalent inorganic cation transport	GO:0015672	40	0.046
extracellular matrix disassembly	GO:0022617	4	0.045
regulation of epithelial cell migration open tracheal system	GO:2000274	11	0.045
vesicle mediated transport	GO:0016192	381	0.045
regulation of immune effector process	GO:0002697	52	0.045
regulation of cellular protein metabolic process	GO:0032268	243	0.044
defense response to gram positive bacterium	GO:0050830	41	0.044
production of molecular mediator of immune response	GO:0002440	46	0.044
epithelial cell migration open tracheal system	GO:0007427	32	0.043
cellular response to organic substance	GO:0071310	132	0.042
cholesterol homeostasis	GO:0042632	3	0.042
pigment metabolic process	GO:0042440	84	0.042
response to inorganic substance	GO:0010035	44	0.042
response to fibroblast growth factor	GO:0071774	10	0.041
negative regulation of immune system process	GO:0002683	50	0.041
defense response to other organism	GO:0098542	225	0.040
regulation of antimicrobial peptide production	GO:0002784	44	0.039
behavioral response to pain	GO:0048266	3	0.039
protein complex biogenesis	GO:0070271	201	0.039
response to external biotic stimulus	GO:0043207	293	0.039
divalent metal ion transport	GO:0070838	26	0.038
developmental growth involved in morphogenesis	GO:0060560	65	0.038
negative regulation of cellular biosynthetic process	GO:0031327	277	0.038
regulation of antimicrobial peptide biosynthetic process	GO:0002805	38	0.038
larval behavior	GO:0030537	42	0.037
response to radiation	GO:0009314	155	0.037
organic substance catabolic process	GO:1901575	308	0.037
regulation of synapse structure and activity	GO:0050803	128	0.037
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.037
l amino acid import	GO:0043092	2	0.037
negative regulation of cell communication	GO:0010648	223	0.036
peptide biosynthetic process	GO:0043043	42	0.036
sensory organ morphogenesis	GO:0090596	260	0.036
positive regulation of macromolecule metabolic process	GO:0010604	405	0.035
regulation of localization	GO:0032879	275	0.035
adult behavior	GO:0030534	137	0.035
transcription from rna polymerase ii promoter	GO:0006366	368	0.034
antimicrobial peptide biosynthetic process	GO:0002777	38	0.034
positive regulation of cellular amide metabolic process	GO:0034250	26	0.034
protein complex assembly	GO:0006461	200	0.034
negative regulation of multicellular organismal process	GO:0051241	142	0.034
cellular response to fibroblast growth factor stimulus	GO:0044344	10	0.034
eye morphogenesis	GO:0048592	260	0.033
response to light stimulus	GO:0009416	124	0.032
establishment or maintenance of apical basal cell polarity	GO:0035088	34	0.032
embryonic morphogenesis	GO:0048598	206	0.032
molting cycle	GO:0042303	56	0.032
calcium ion transport	GO:0006816	24	0.031
response to alcohol	GO:0097305	95	0.031
aggressive behavior	GO:0002118	63	0.031
response to decreased oxygen levels	GO:0036293	58	0.030
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.030
response to organonitrogen compound	GO:0010243	75	0.029
negative regulation of rna biosynthetic process	GO:1902679	240	0.029
response to pheromone	GO:0019236	19	0.029
wound healing	GO:0042060	75	0.029
regulation of growth	GO:0040008	233	0.029
negative regulation of defense response	GO:0031348	35	0.029
neuron death	GO:0070997	27	0.029
axis specification	GO:0009798	167	0.029
regulation of humoral immune response	GO:0002920	51	0.028
response to hypoxia	GO:0001666	53	0.028
cellular component assembly involved in morphogenesis	GO:0010927	151	0.028
photoreceptor cell differentiation	GO:0046530	170	0.028
regulation of developmental growth	GO:0048638	174	0.028
negative regulation of signal transduction	GO:0009968	206	0.028
regulation of membrane potential	GO:0042391	35	0.028
nuclear division	GO:0000280	332	0.028
regulation of cellular component size	GO:0032535	98	0.028
response to wounding	GO:0009611	94	0.028
heart process	GO:0003015	37	0.027
response to alkaloid	GO:0043279	26	0.027
cellular catabolic process	GO:0044248	372	0.027
positive regulation of molecular function	GO:0044093	136	0.027
circadian behavior	GO:0048512	76	0.026
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.026
chitin based cuticle development	GO:0040003	49	0.026
brain development	GO:0007420	120	0.026
protein localization	GO:0008104	284	0.025
defense response to fungus	GO:0050832	48	0.025
phagocytosis	GO:0006909	215	0.025
regulation of defense response	GO:0031347	102	0.025
small molecule metabolic process	GO:0044281	305	0.025
regulation of neuron differentiation	GO:0045664	103	0.025
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.025
melanotic encapsulation of foreign target	GO:0035011	30	0.024
protein processing	GO:0016485	68	0.024
glial cell development	GO:0021782	27	0.024
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.024
regulation of secondary metabolic process	GO:0043455	7	0.024
neuromuscular junction development	GO:0007528	149	0.024
aromatic amino acid family metabolic process	GO:0009072	3	0.024
divalent inorganic cation transport	GO:0072511	30	0.023
macromolecular complex assembly	GO:0065003	256	0.023
regulation of feeding behavior	GO:0060259	16	0.023
blastoderm segmentation	GO:0007350	159	0.023
positive regulation of cell communication	GO:0010647	250	0.022
carbohydrate derivative metabolic process	GO:1901135	217	0.022
autophagic cell death	GO:0048102	83	0.022
positive regulation of cell death	GO:0010942	69	0.022
negative regulation of signaling	GO:0023057	219	0.022
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	65	0.022
cell proliferation	GO:0008283	299	0.022
extrinsic apoptotic signaling pathway	GO:0097191	1	0.021
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.021
regulation of phosphorus metabolic process	GO:0051174	210	0.021
compound eye morphogenesis	GO:0001745	249	0.021
positive regulation of defense response	GO:0031349	59	0.021
response to oxygen levels	GO:0070482	59	0.021
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.021
sensory perception of sound	GO:0007605	56	0.021
regulation of hydrolase activity	GO:0051336	97	0.021
response to organophosphorus	GO:0046683	2	0.021
mitotic nuclear division	GO:0007067	213	0.021
cellular response to dna damage stimulus	GO:0006974	223	0.021
anion homeostasis	GO:0055081	3	0.020
regulation of catalytic activity	GO:0050790	185	0.020
compound eye development	GO:0048749	307	0.020
rhythmic process	GO:0048511	106	0.020
behavioral response to ethanol	GO:0048149	49	0.020
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.020
morphogenesis of follicular epithelium	GO:0016333	36	0.020
telencephalon development	GO:0021537	2	0.020
establishment or maintenance of bipolar cell polarity	GO:0061245	34	0.020
regulation of nervous system development	GO:0051960	248	0.020
inorganic ion transmembrane transport	GO:0098660	73	0.020
innate immune response activating signal transduction	GO:0002758	2	0.020
detection of external stimulus	GO:0009581	66	0.020
organonitrogen compound biosynthetic process	GO:1901566	117	0.020
amine metabolic process	GO:0009308	12	0.020
antimicrobial peptide production	GO:0002775	46	0.020
anatomical structure homeostasis	GO:0060249	97	0.019
positive regulation of humoral immune response	GO:0002922	28	0.019
intracellular protein transport	GO:0006886	104	0.019
negative regulation of biosynthetic process	GO:0009890	277	0.019
regulation of molecular function	GO:0065009	217	0.019
cellular response to acid chemical	GO:0071229	8	0.019
intracellular signal transduction	GO:0035556	300	0.019
branching involved in open tracheal system development	GO:0060446	45	0.019
sensory perception of smell	GO:0007608	80	0.019
cytoplasmic transport	GO:0016482	130	0.019
regulation of tube length open tracheal system	GO:0035159	24	0.019
catecholamine biosynthetic process	GO:0042423	3	0.019
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	38	0.019
regulation of proteolysis	GO:0030162	87	0.019
single organism intracellular transport	GO:1902582	207	0.019
response to glucose	GO:0009749	2	0.019
regulation of synaptic activity	GO:0060025	9	0.019
cellular response to growth factor stimulus	GO:0071363	30	0.019
positive regulation of production of molecular mediator of immune response	GO:0002702	28	0.019
cellular protein modification process	GO:0006464	438	0.019
regulation of cellular amino acid metabolic process	GO:0006521	0	0.018
detection of abiotic stimulus	GO:0009582	66	0.018
cellular ion homeostasis	GO:0006873	39	0.018
regulation of microtubule based process	GO:0032886	49	0.018
organelle fission	GO:0048285	340	0.018
negative regulation of transcription dna templated	GO:0045892	237	0.018
organic substance transport	GO:0071702	257	0.018
extracellular matrix organization	GO:0030198	32	0.018
regulation of antimicrobial humoral response	GO:0002759	50	0.018
embryonic axis specification	GO:0000578	107	0.018
regulation of transport	GO:0051049	181	0.018
sterol homeostasis	GO:0055092	4	0.018
anterior posterior axis specification embryo	GO:0008595	103	0.018
epithelial fluid transport	GO:0042045	17	0.018
cellular response to oxygen containing compound	GO:1901701	79	0.018
cellular response to endogenous stimulus	GO:0071495	80	0.017
cell death	GO:0008219	279	0.017
positive regulation of phosphorus metabolic process	GO:0010562	139	0.017
negative regulation of cell differentiation	GO:0045596	143	0.017
multicellular organismal aging	GO:0010259	140	0.017
intrinsic apoptotic signaling pathway in response to dna damage	GO:0008630	11	0.017
regulation of intracellular signal transduction	GO:1902531	236	0.017
regulation of cell differentiation	GO:0045595	302	0.017
regulation of cell size	GO:0008361	63	0.017
regulation of multicellular organism growth	GO:0040014	40	0.017
posttranscriptional regulation of gene expression	GO:0010608	145	0.017
endocytosis	GO:0006897	310	0.017
developmental programmed cell death	GO:0010623	138	0.017
circadian sleep wake cycle sleep	GO:0050802	23	0.017
muscle contraction	GO:0006936	13	0.017
regulation of peptidase activity	GO:0052547	39	0.017
mapk cascade	GO:0000165	107	0.017
biological adhesion	GO:0022610	138	0.016
regulation of intracellular transport	GO:0032386	64	0.016
pupal development	GO:0035209	11	0.016
mitochondrion organization	GO:0007005	65	0.016
fat soluble vitamin biosynthetic process	GO:0042362	1	0.016
indole containing compound biosynthetic process	GO:0042435	4	0.016
histolysis	GO:0007559	102	0.016
organophosphate metabolic process	GO:0019637	195	0.016
basement membrane organization	GO:0071711	10	0.016
positive regulation of growth	GO:0045927	75	0.016
mesodermal cell fate specification	GO:0007501	2	0.016
smoothened signaling pathway	GO:0007224	49	0.016
cellular response to external stimulus	GO:0071496	66	0.016
vitamin biosynthetic process	GO:0009110	1	0.016
serotonin metabolic process	GO:0042428	2	0.016
primary amino compound biosynthetic process	GO:1901162	2	0.016
establishment or maintenance of cell polarity	GO:0007163	167	0.015
positive regulation of transcription dna templated	GO:0045893	266	0.015
response to lipopolysaccharide	GO:0032496	4	0.015
carboxylic acid metabolic process	GO:0019752	92	0.015
regulation of protein metabolic process	GO:0051246	256	0.015
dna metabolic process	GO:0006259	227	0.015
nucleoside phosphate metabolic process	GO:0006753	162	0.015
cellular response to monosaccharide stimulus	GO:0071326	2	0.015
fibroblast growth factor receptor signaling pathway	GO:0008543	10	0.015
wound healing spreading of cells	GO:0044319	2	0.015
protein catabolic process	GO:0030163	101	0.015
chemotaxis	GO:0006935	249	0.015
appendage development	GO:0048736	401	0.015
liquid clearance open tracheal system	GO:0035002	13	0.015
positive regulation of signal transduction	GO:0009967	223	0.015
tissue death	GO:0016271	102	0.015
organic acid metabolic process	GO:0006082	103	0.015
positive regulation of catalytic activity	GO:0043085	118	0.015
protein transport	GO:0015031	155	0.015
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.015
cellular response to lipopolysaccharide	GO:0071222	3	0.015
cellular macromolecule catabolic process	GO:0044265	136	0.015
positive regulation of phosphorylation	GO:0042327	87	0.015
instar larval development	GO:0002168	55	0.015
signal transduction by phosphorylation	GO:0023014	107	0.015
action potential	GO:0001508	13	0.015
phosphorylation	GO:0016310	294	0.015
response to ethanol	GO:0045471	59	0.015
regulation of catabolic process	GO:0009894	170	0.014
cellular homeostasis	GO:0019725	80	0.014
immune response activating signal transduction	GO:0002757	2	0.014
neuromuscular synaptic transmission	GO:0007274	67	0.014
actin filament based process	GO:0030029	220	0.014
muscle organ development	GO:0007517	127	0.014
response to salt stress	GO:0009651	11	0.014
detection of chemical stimulus	GO:0009593	93	0.014
cholesterol transport	GO:0030301	2	0.014
synapse assembly	GO:0007416	143	0.014
trachea development	GO:0060438	29	0.014
nucleobase containing small molecule metabolic process	GO:0055086	174	0.014
regulation of tube architecture open tracheal system	GO:0035152	68	0.014
protein modification process	GO:0036211	438	0.014
cell division	GO:0051301	248	0.014
embryonic pattern specification	GO:0009880	174	0.014
asymmetric protein localization	GO:0008105	33	0.014
organelle localization	GO:0051640	148	0.014
endomembrane system organization	GO:0010256	119	0.014
negative regulation of immune response	GO:0050777	39	0.014
cellular amino acid metabolic process	GO:0006520	61	0.014
thermosensory behavior	GO:0040040	19	0.014
positive regulation of apoptotic signaling pathway	GO:2001235	4	0.014
chitin based cuticle sclerotization	GO:0007593	19	0.014
dorsal ventral pattern formation	GO:0009953	133	0.014
negative regulation of fibroblast growth factor receptor signaling pathway	GO:0040037	2	0.014
cellular macromolecular complex assembly	GO:0034622	153	0.014
l glutamate import	GO:0051938	1	0.014
chromosome segregation	GO:0007059	157	0.014
glial cell differentiation	GO:0010001	35	0.014
regulation of cuticle pigmentation	GO:0048079	16	0.014
regulation of cellular catabolic process	GO:0031329	157	0.014
nephron tubule development	GO:0072080	3	0.014
peptidoglycan metabolic process	GO:0000270	3	0.013
regulation of cellular localization	GO:0060341	136	0.013
positive regulation of rna biosynthetic process	GO:1902680	266	0.013
positive regulation of rna metabolic process	GO:0051254	271	0.013
cellular response to organonitrogen compound	GO:0071417	36	0.013
positive regulation of signaling	GO:0023056	243	0.013
negative regulation of epithelial cell proliferation	GO:0050680	4	0.013
catechol containing compound biosynthetic process	GO:0009713	3	0.013
antimicrobial humoral response	GO:0019730	99	0.013
regulation of neurogenesis	GO:0050767	158	0.013
organonitrogen compound catabolic process	GO:1901565	128	0.013
response to organic cyclic compound	GO:0014070	89	0.013
salivary gland cell autophagic cell death	GO:0035071	83	0.013
response to oxidative stress	GO:0006979	86	0.013
detection of mechanical stimulus	GO:0050982	6	0.013
purine ribonucleoside metabolic process	GO:0046128	127	0.013
cellular response to mechanical stimulus	GO:0071260	2	0.013
tube morphogenesis	GO:0035239	191	0.013
sensory perception of touch	GO:0050975	11	0.013
central nervous system development	GO:0007417	201	0.013
cellular response to hexose stimulus	GO:0071331	1	0.013
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.013
cellular response to organic cyclic compound	GO:0071407	32	0.013
eye photoreceptor cell differentiation	GO:0001754	145	0.013
toxin metabolic process	GO:0009404	2	0.013
negative regulation of insulin secretion	GO:0046676	1	0.013
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.013
secondary metabolic process	GO:0019748	75	0.012
organ formation	GO:0048645	39	0.012
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.012
kidney epithelium development	GO:0072073	3	0.012
organ growth	GO:0035265	56	0.012
response to fungus	GO:0009620	50	0.012
regulation of anatomical structure morphogenesis	GO:0022603	242	0.012
regulation of system process	GO:0044057	36	0.012
negative regulation of cellular protein metabolic process	GO:0032269	85	0.012
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.012
response to hexose	GO:0009746	3	0.012
camera type eye development	GO:0043010	4	0.012
spermatogenesis	GO:0007283	200	0.012
secretion by cell	GO:0032940	101	0.012
defense response to gram negative bacterium	GO:0050829	94	0.012
regulation of cellular response to oxidative stress	GO:1900407	4	0.012
eye development	GO:0001654	323	0.012
regulation of phosphorylation	GO:0042325	147	0.012
negative regulation of peptide hormone secretion	GO:0090278	1	0.012
positive regulation of cellular amine metabolic process	GO:0033240	0	0.012
negative regulation of cell proliferation	GO:0008285	69	0.012
encapsulation of foreign target	GO:0035010	38	0.012
positive regulation of phosphate metabolic process	GO:0045937	139	0.012
negative regulation of cell development	GO:0010721	62	0.012
negative regulation of phosphorus metabolic process	GO:0010563	45	0.012
fat soluble vitamin metabolic process	GO:0006775	1	0.012
negative regulation of cellular component organization	GO:0051129	108	0.012
nucleotide metabolic process	GO:0009117	161	0.012
nephron epithelium development	GO:0072009	3	0.012
axon development	GO:0061564	297	0.012
positive regulation of neuron apoptotic process	GO:0043525	1	0.011
single organism catabolic process	GO:0044712	228	0.011
mitotic sister chromatid segregation	GO:0000070	87	0.011
positive regulation of nervous system development	GO:0051962	69	0.011
response to copper ion	GO:0046688	4	0.011
positive regulation of gene expression	GO:0010628	290	0.011
ribonucleotide metabolic process	GO:0009259	145	0.011
regulation of chitin based cuticle tanning	GO:0007564	14	0.011
cellular response to transforming growth factor beta stimulus	GO:0071560	18	0.011
phosphate ion transport	GO:0006817	4	0.011
purine nucleoside metabolic process	GO:0042278	127	0.011
mechanosensory behavior	GO:0007638	12	0.011
mitotic spindle organization	GO:0007052	220	0.011
axon guidance	GO:0007411	233	0.011

Spn77Ba disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.265
lower respiratory tract disease	DOID:0050161	0.167
respiratory system disease	DOID:1579	0.167
kidney disease	DOID:557	0.157
urinary system disease	DOID:18	0.157
renal tubular transport disease	DOID:447	0.157
liddle syndrome	DOID:0050477	0.074
nervous system disease	DOID:863	0.068
cardiovascular system disease	DOID:1287	0.043
heart conduction disease	DOID:10273	0.043
disease of metabolism	DOID:0014667	0.035
inherited metabolic disorder	DOID:655	0.035
sensory system disease	DOID:0050155	0.032
acquired metabolic disease	DOID:0060158	0.026
bronchial disease	DOID:1176	0.024
bronchiectasis	DOID:9563	0.024
eye and adnexa disease	DOID:1492	0.021
diabetes mellitus	DOID:9351	0.021
carbohydrate metabolism disease	DOID:0050013	0.021
glucose metabolism disease	DOID:4194	0.021
type 2 diabetes mellitus	DOID:9352	0.019
disease of cellular proliferation	DOID:14566	0.019
cancer	DOID:162	0.019
artery disease	DOID:0050828	0.017
vascular disease	DOID:178	0.017
hypertension	DOID:10763	0.016
organ system cancer	DOID:0050686	0.015
central nervous system disease	DOID:331	0.012
neuropathy	DOID:870	0.012
eye disease	DOID:5614	0.011

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