IMP: Integrative Multi-species Prediction

Drosophila melanogaster

85 known processes

Cul-5 (Dmel_CG1401)

Cullin-5

(Aliases: Dmel\CG1401,CG1401,Cul5,CUL5,cul5,cul-5)

Entrez: 43434
FLYBASE: FBgn0039632
UniProtKB: Q9VAQ0

Process Predictions
Disease Predictions

Cul-5 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
tissue morphogenesis	GO:0048729	297	0.810
intracellular signal transduction	GO:0035556	300	0.803
growth	GO:0040007	359	0.757
cell division	GO:0051301	248	0.659
negative regulation of gene expression	GO:0010629	387	0.633
epithelial cell development	GO:0002064	274	0.575
regulation of intracellular signal transduction	GO:1902531	236	0.561
stem cell division	GO:0017145	69	0.522
stem cell proliferation	GO:0072089	88	0.483
regulation of multicellular organismal development	GO:2000026	414	0.468
embryonic morphogenesis	GO:0048598	206	0.465
morphogenesis of an epithelium	GO:0002009	276	0.463
establishment of localization in cell	GO:0051649	402	0.462
regionalization	GO:0003002	416	0.453
negative regulation of cellular metabolic process	GO:0031324	382	0.430
dendrite morphogenesis	GO:0048813	199	0.423
regulation of cellular catabolic process	GO:0031329	157	0.422
segmentation	GO:0035282	207	0.393
positive regulation of protein metabolic process	GO:0051247	128	0.386
macromolecular complex assembly	GO:0065003	256	0.378
germarium derived egg chamber formation	GO:0007293	101	0.369
catabolic process	GO:0009056	409	0.369
tube morphogenesis	GO:0035239	191	0.367
cellularization	GO:0007349	90	0.347
regulation of synapse assembly	GO:0051963	94	0.341
organelle assembly	GO:0070925	198	0.337
eggshell formation	GO:0030703	105	0.337
developmental growth	GO:0048589	280	0.329
purine ribonucleoside metabolic process	GO:0046128	127	0.327
ubiquitin dependent protein catabolic process	GO:0006511	78	0.315
dorsal appendage formation	GO:0046843	47	0.306
cellular protein catabolic process	GO:0044257	83	0.297
regulation of growth	GO:0040008	233	0.296
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.296
neuromuscular junction development	GO:0007528	149	0.293
epithelial cell differentiation	GO:0030855	322	0.289
modification dependent macromolecule catabolic process	GO:0043632	79	0.286
gastrulation	GO:0007369	70	0.284
regulation of proteolysis	GO:0030162	87	0.277
gene silencing	GO:0016458	138	0.273
regulation of protein metabolic process	GO:0051246	256	0.273
cellular macromolecule localization	GO:0070727	220	0.263
positive regulation of signaling	GO:0023056	243	0.257
positive regulation of biosynthetic process	GO:0009891	316	0.257
tube development	GO:0035295	244	0.256
embryonic pattern specification	GO:0009880	174	0.250
regulation of cellular component biogenesis	GO:0044087	201	0.250
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.249
regulation of catabolic process	GO:0009894	170	0.246
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.245
phosphorylation	GO:0016310	294	0.243	Worm
regulation of anatomical structure morphogenesis	GO:0022603	242	0.242
programmed cell death	GO:0012501	257	0.238
protein complex biogenesis	GO:0070271	201	0.238
protein modification process	GO:0036211	438	0.237	Mouse Worm
ovarian follicle cell development	GO:0030707	248	0.232
positive regulation of cellular protein metabolic process	GO:0032270	118	0.229
axon development	GO:0061564	297	0.223
positive regulation of cellular component organization	GO:0051130	156	0.223
negative regulation of rna biosynthetic process	GO:1902679	240	0.221
positive regulation of developmental process	GO:0051094	143	0.219
cell proliferation	GO:0008283	299	0.216
blastoderm segmentation	GO:0007350	159	0.215
positive regulation of gene expression	GO:0010628	290	0.214
carbohydrate derivative metabolic process	GO:1901135	217	0.212
columnar cuboidal epithelial cell development	GO:0002066	249	0.211
hindgut morphogenesis	GO:0007442	58	0.208
anterior posterior pattern specification	GO:0009952	136	0.204
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.203
regulation of phosphorylation	GO:0042325	147	0.203
male gamete generation	GO:0048232	201	0.200
regulation of proteasomal protein catabolic process	GO:0061136	39	0.197
anterior posterior axis specification	GO:0009948	109	0.197
endosomal transport	GO:0016197	44	0.196
actin cytoskeleton organization	GO:0030036	206	0.189
positive regulation of response to stimulus	GO:0048584	323	0.188
negative regulation of cell cycle	GO:0045786	116	0.188	Worm
regulation of phosphorus metabolic process	GO:0051174	210	0.181
single organism intracellular transport	GO:1902582	207	0.180
synapse assembly	GO:0007416	143	0.177
regulation of cellular protein catabolic process	GO:1903362	44	0.177
positive regulation of rna biosynthetic process	GO:1902680	266	0.176
cellular catabolic process	GO:0044248	372	0.170
positive regulation of cellular biosynthetic process	GO:0031328	316	0.169
regulation of developmental growth	GO:0048638	174	0.169
negative regulation of biosynthetic process	GO:0009890	277	0.168
cell motility	GO:0048870	251	0.168	Mouse
protein complex assembly	GO:0006461	200	0.168
purine ribonucleotide metabolic process	GO:0009150	145	0.167
protein catabolic process	GO:0030163	101	0.166
regulation of cell cycle process	GO:0010564	181	0.164
regulation of organelle organization	GO:0033043	196	0.163
cell cycle phase transition	GO:0044770	140	0.163
mitotic cell cycle phase transition	GO:0044772	138	0.163
hindgut development	GO:0061525	58	0.161
localization of cell	GO:0051674	257	0.156	Mouse
nucleoside triphosphate metabolic process	GO:0009141	120	0.151
regulation of mitotic cell cycle	GO:0007346	190	0.149	Worm
neuronal stem cell division	GO:0036445	35	0.148
dendrite development	GO:0016358	204	0.146
organelle fission	GO:0048285	340	0.146
asymmetric neuroblast division	GO:0055059	33	0.145
regulation of cell cycle phase transition	GO:1901987	130	0.144
neuroblast division	GO:0055057	35	0.137
cellular protein localization	GO:0034613	160	0.137
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.133
digestive tract development	GO:0048565	149	0.133
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.132
negative regulation of cellular biosynthetic process	GO:0031327	277	0.132
single organism cellular localization	GO:1902580	180	0.132
axis specification	GO:0009798	167	0.131
camera type eye development	GO:0043010	4	0.131
nucleoside triphosphate catabolic process	GO:0009143	108	0.130
proteolysis	GO:0006508	192	0.129
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.127
negative regulation of response to stimulus	GO:0048585	258	0.125
regulation of cell division	GO:0051302	72	0.125
positive regulation of transcription dna templated	GO:0045893	266	0.125
anterior posterior axis specification embryo	GO:0008595	103	0.124
purine nucleoside metabolic process	GO:0042278	127	0.124
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.123
establishment or maintenance of cell polarity	GO:0007163	167	0.123
regulation of protein catabolic process	GO:0042176	55	0.122
negative regulation of rna metabolic process	GO:0051253	251	0.122
regulation of nuclear division	GO:0051783	58	0.120
regulation of cell differentiation	GO:0045595	302	0.120
positive regulation of cell communication	GO:0010647	250	0.120
eggshell chorion assembly	GO:0007306	66	0.119
proteasomal protein catabolic process	GO:0010498	59	0.119
regulation of cellular protein metabolic process	GO:0032268	243	0.119
regulation of phosphate metabolic process	GO:0019220	210	0.118
positive regulation of proteolysis involved in cellular protein catabolic process	GO:1903052	24	0.117
regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032434	37	0.117
positive regulation of proteasomal protein catabolic process	GO:1901800	20	0.115
oocyte anterior posterior axis specification	GO:0007314	72	0.115
oocyte differentiation	GO:0009994	145	0.115
neuroblast proliferation	GO:0007405	74	0.108
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.106
modification dependent protein catabolic process	GO:0019941	78	0.106
neurological system process	GO:0050877	358	0.102
cuticle development	GO:0042335	86	0.102
chorion containing eggshell formation	GO:0007304	105	0.102
establishment of protein localization	GO:0045184	163	0.100
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.100
mapk cascade	GO:0000165	107	0.098
regulation of synapse organization	GO:0050807	110	0.098
positive regulation of multicellular organismal process	GO:0051240	143	0.097
ameboidal type cell migration	GO:0001667	151	0.097
single organism biosynthetic process	GO:0044711	206	0.096
germarium derived female germ line cyst formation	GO:0030727	42	0.095
endocytosis	GO:0006897	310	0.093
macromolecule catabolic process	GO:0009057	161	0.093
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.093
vesicle mediated transport	GO:0016192	381	0.093
regulation of protein modification process	GO:0031399	112	0.092
positive regulation of macromolecule metabolic process	GO:0010604	405	0.092
regulation of proteolysis involved in cellular protein catabolic process	GO:1903050	44	0.092
positive regulation of catabolic process	GO:0009896	105	0.091
purine ribonucleotide catabolic process	GO:0009154	109	0.088
transcription from rna polymerase ii promoter	GO:0006366	368	0.088
meiotic cell cycle	GO:0051321	171	0.087	Worm
cardiovascular system development	GO:0072358	82	0.087
actin filament organization	GO:0007015	126	0.086
somatic stem cell division	GO:0048103	37	0.085
positive regulation of protein catabolic process	GO:0045732	34	0.085
spermatogenesis	GO:0007283	200	0.084
defense response to virus	GO:0051607	23	0.084
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	54	0.082
purine containing compound metabolic process	GO:0072521	155	0.082
regulation of cell cycle	GO:0051726	291	0.082
cellular component assembly involved in morphogenesis	GO:0010927	151	0.081
asymmetric stem cell division	GO:0098722	49	0.080
regulation of synaptic growth at neuromuscular junction	GO:0008582	89	0.079
oocyte nucleus localization involved in oocyte dorsal ventral axis specification	GO:0051663	12	0.078
nucleoside catabolic process	GO:0009164	112	0.077
purine nucleotide metabolic process	GO:0006163	146	0.077
nucleoside phosphate catabolic process	GO:1901292	110	0.076
organonitrogen compound metabolic process	GO:1901564	318	0.076
protein localization	GO:0008104	284	0.076
negative regulation of multicellular organismal process	GO:0051241	142	0.076
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.075
single organism catabolic process	GO:0044712	228	0.075
ribonucleoside metabolic process	GO:0009119	127	0.075
positive regulation of rna metabolic process	GO:0051254	271	0.074
cell cycle checkpoint	GO:0000075	95	0.074
negative regulation of mitotic cell cycle	GO:0045930	109	0.074	Worm
regulation of embryonic development	GO:0045995	68	0.073
immune system process	GO:0002376	347	0.073
appendage development	GO:0048736	401	0.073
positive regulation of phosphorus metabolic process	GO:0010562	139	0.071
regulation of chromosome organization	GO:0033044	64	0.071
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.068
reproductive system development	GO:0061458	74	0.068
protein targeting	GO:0006605	64	0.068
rhythmic process	GO:0048511	106	0.067
intracellular protein transport	GO:0006886	104	0.067
organophosphate metabolic process	GO:0019637	195	0.066
organonitrogen compound biosynthetic process	GO:1901566	117	0.066
negative regulation of signaling	GO:0023057	219	0.065
positive regulation of signal transduction	GO:0009967	223	0.065
cystoblast division	GO:0007282	10	0.065
small gtpase mediated signal transduction	GO:0007264	88	0.065
regulation of molecular function	GO:0065009	217	0.065
cell death	GO:0008219	279	0.064
digestive system development	GO:0055123	149	0.064
positive regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032436	19	0.064
regulation of synapse structure and activity	GO:0050803	128	0.063
oocyte development	GO:0048599	124	0.063
purine nucleotide catabolic process	GO:0006195	109	0.062
negative regulation of signal transduction	GO:0009968	206	0.061
organelle localization	GO:0051640	148	0.061
endomembrane system organization	GO:0010256	119	0.061
positive regulation of phosphate metabolic process	GO:0045937	139	0.061
epithelial tube morphogenesis	GO:0060562	88	0.061
positive regulation of cellular catabolic process	GO:0031331	95	0.061
regulation of response to stress	GO:0080134	200	0.060
circadian rhythm	GO:0007623	105	0.060
carbohydrate derivative biosynthetic process	GO:1901137	85	0.059
maintenance of location	GO:0051235	73	0.059
cellular response to dna damage stimulus	GO:0006974	223	0.059
response to oxygen containing compound	GO:1901700	200	0.059
cellular macromolecule catabolic process	GO:0044265	136	0.059
oocyte maturation	GO:0001556	3	0.058
digestive tract morphogenesis	GO:0048546	127	0.058
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.058
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.058
nucleobase containing small molecule metabolic process	GO:0055086	174	0.057
signal transduction by phosphorylation	GO:0023014	107	0.057
carbohydrate derivative catabolic process	GO:1901136	118	0.057
pole cell formation	GO:0007279	19	0.056
regulation of organ morphogenesis	GO:2000027	78	0.056
body morphogenesis	GO:0010171	2	0.054
cellular response to oxygen containing compound	GO:1901701	79	0.054
ribonucleotide metabolic process	GO:0009259	145	0.052
purine nucleoside catabolic process	GO:0006152	112	0.052
nucleocytoplasmic transport	GO:0006913	72	0.051
fusome organization	GO:0045478	13	0.050
intracellular transport	GO:0046907	228	0.050
organic substance catabolic process	GO:1901575	308	0.050
regulation of mapk cascade	GO:0043408	92	0.049
protein modification by small protein conjugation	GO:0032446	79	0.049	Mouse
protein localization to organelle	GO:0033365	82	0.048
synaptic growth at neuromuscular junction	GO:0051124	119	0.048
small molecule metabolic process	GO:0044281	305	0.048
neural precursor cell proliferation	GO:0061351	75	0.048
actin filament based process	GO:0030029	220	0.048
nucleoside metabolic process	GO:0009116	127	0.048
glycosyl compound catabolic process	GO:1901658	112	0.047
positive regulation of proteolysis	GO:0045862	52	0.047
regulation of neuron differentiation	GO:0045664	103	0.046
gene silencing by rna	GO:0031047	57	0.046
renal system development	GO:0072001	72	0.046
female germ line cyst formation	GO:0048135	42	0.045
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.045
imaginal disc derived leg segmentation	GO:0036011	26	0.045
positive regulation of developmental growth	GO:0048639	62	0.045
positive regulation of mitotic cell cycle	GO:0045931	34	0.045
negative regulation of developmental process	GO:0051093	201	0.045
asymmetric cell division	GO:0008356	37	0.045
camera type eye morphogenesis	GO:0048593	2	0.045
appendage morphogenesis	GO:0035107	397	0.044
ribonucleoside catabolic process	GO:0042454	112	0.044
nucleoside phosphate metabolic process	GO:0006753	162	0.044
apoptotic process	GO:0006915	159	0.044
negative regulation of cell cycle phase transition	GO:1901988	103	0.043
establishment of protein localization to organelle	GO:0072594	62	0.043
reproductive structure development	GO:0048608	74	0.043
circulatory system development	GO:0072359	82	0.043
regulation of wnt signaling pathway	GO:0030111	68	0.043
head development	GO:0060322	135	0.043	Mouse
molting cycle	GO:0042303	56	0.043
hematopoietic or lymphoid organ development	GO:0048534	57	0.042
protein transport	GO:0015031	155	0.042
urogenital system development	GO:0001655	72	0.042
cell adhesion	GO:0007155	136	0.042
kidney development	GO:0001822	3	0.042
central nervous system development	GO:0007417	201	0.042	Mouse
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.042
regulation of protein localization	GO:0032880	76	0.042
aromatic compound catabolic process	GO:0019439	166	0.042
eye morphogenesis	GO:0048592	260	0.042
organonitrogen compound catabolic process	GO:1901565	128	0.042
regulation of localization	GO:0032879	275	0.042
nephron epithelium development	GO:0072009	3	0.041
stress activated mapk cascade	GO:0051403	52	0.041
positive regulation of intracellular signal transduction	GO:1902533	116	0.041
regulation of gene silencing	GO:0060968	63	0.040
epithelium migration	GO:0090132	148	0.040
cellular protein modification process	GO:0006464	438	0.039	Mouse Worm
oocyte microtubule cytoskeleton organization	GO:0016325	35	0.039
axon guidance	GO:0007411	233	0.039
neuron projection guidance	GO:0097485	241	0.039
cellular amino acid metabolic process	GO:0006520	61	0.039
posttranscriptional regulation of gene expression	GO:0010608	145	0.039
dna metabolic process	GO:0006259	227	0.038
asymmetric protein localization	GO:0008105	33	0.038
regulation of meiosis	GO:0040020	3	0.038
negative regulation of molecular function	GO:0044092	51	0.038
positive regulation of phosphorylation	GO:0042327	87	0.037
heterochromatin organization	GO:0070828	25	0.037
chaeta development	GO:0022416	97	0.037
mitotic nuclear division	GO:0007067	213	0.037
regulation of protein transport	GO:0051223	57	0.036
germarium derived oocyte fate determination	GO:0007294	26	0.036
glycosyl compound metabolic process	GO:1901657	127	0.036
mitotic spindle organization	GO:0007052	220	0.036
g2 m transition of mitotic cell cycle	GO:0000086	19	0.036
eye antennal disc development	GO:0035214	60	0.035
protein ubiquitination	GO:0016567	70	0.035	Mouse
adult locomotory behavior	GO:0008344	76	0.034
ras protein signal transduction	GO:0007265	88	0.034
wing disc morphogenesis	GO:0007472	344	0.034
organic cyclic compound catabolic process	GO:1901361	168	0.033
nuclear transport	GO:0051169	72	0.033
germline ring canal formation	GO:0030725	13	0.033
heart process	GO:0003015	37	0.033
gland development	GO:0048732	191	0.033
organ growth	GO:0035265	56	0.033
dorsal ventral axis specification	GO:0009950	66	0.033
anterograde axon cargo transport	GO:0008089	6	0.032
regulation of cell death	GO:0010941	173	0.032
oocyte localization involved in germarium derived egg chamber formation	GO:0030720	12	0.032
forebrain development	GO:0030900	2	0.032	Mouse
nucleotide metabolic process	GO:0009117	161	0.032
imaginal disc derived appendage development	GO:0048737	399	0.032
purine ribonucleoside catabolic process	GO:0046130	112	0.032
developmental maturation	GO:0021700	172	0.031
single organism nuclear import	GO:1902593	51	0.031
regulation of bmp signaling pathway	GO:0030510	23	0.031
cell maturation	GO:0048469	144	0.031
tripartite regional subdivision	GO:0007351	103	0.031
multicellular organism growth	GO:0035264	46	0.031
mitochondrion degradation	GO:0000422	8	0.031
atp metabolic process	GO:0046034	49	0.031
regulation of epithelial cell proliferation	GO:0050678	4	0.031
periodic partitioning	GO:0007365	29	0.030
homeostatic process	GO:0042592	199	0.030	Rat
positive regulation of protein kinase activity	GO:0045860	25	0.029
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.029
cellular macromolecular complex assembly	GO:0034622	153	0.029
membrane organization	GO:0061024	112	0.029
positive regulation of cell proliferation	GO:0008284	47	0.029
equator specification	GO:0045317	4	0.029
single organism behavior	GO:0044708	391	0.029
death	GO:0016265	284	0.028
determination of bilateral symmetry	GO:0009855	13	0.028
mitotic cell cycle checkpoint	GO:0007093	88	0.028
ovarian follicle cell migration	GO:0007297	121	0.028
regulation of notch signaling pathway	GO:0008593	100	0.028
imaginal disc derived leg joint morphogenesis	GO:0016348	15	0.028
immune system development	GO:0002520	57	0.028
protein import	GO:0017038	55	0.028
response to alcohol	GO:0097305	95	0.028
chromosome organization	GO:0051276	360	0.028
positive regulation of cell cycle process	GO:0090068	28	0.028
negative regulation of notch signaling pathway	GO:0045746	41	0.028
non sensory hair organization	GO:0035316	47	0.027
phagocytosis	GO:0006909	215	0.027
ovarian fusome organization	GO:0030723	11	0.027
negative regulation of protein metabolic process	GO:0051248	85	0.026
compound eye development	GO:0048749	307	0.026
positive regulation of defense response	GO:0031349	59	0.026
negative regulation of programmed cell death	GO:0043069	72	0.026
photoreceptor cell differentiation	GO:0046530	170	0.026
hemopoiesis	GO:0030097	46	0.026
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.026
positive regulation of cellular protein catabolic process	GO:1903364	24	0.026
cellular ketone metabolic process	GO:0042180	24	0.026
bmp signaling pathway	GO:0030509	27	0.025
nucleotide catabolic process	GO:0009166	109	0.025
epithelial cell migration	GO:0010631	148	0.025
ovarian follicle cell stalk formation	GO:0030713	17	0.025
negative regulation of developmental growth	GO:0048640	64	0.025
regulation of hydrolase activity	GO:0051336	97	0.025
regulation of transport	GO:0051049	181	0.025
spindle assembly	GO:0051225	80	0.025
germarium derived female germ line cyst encapsulation	GO:0030708	8	0.025
actin mediated cell contraction	GO:0070252	21	0.024
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.024
maintenance of gastrointestinal epithelium	GO:0030277	3	0.024
renal tubule development	GO:0061326	64	0.024
negative regulation of cell communication	GO:0010648	223	0.024
protein phosphorylation	GO:0006468	169	0.024	Worm
regulation of cell proliferation	GO:0042127	163	0.024
protein targeting to nucleus	GO:0044744	51	0.024
nuclear division	GO:0000280	332	0.024
protein import into nucleus	GO:0006606	51	0.024
cellular response to chemical stimulus	GO:0070887	199	0.024
cytoplasmic transport	GO:0016482	130	0.023
neural retina development	GO:0003407	4	0.023
positive regulation of organelle organization	GO:0010638	65	0.023
secretion	GO:0046903	109	0.023
axonogenesis	GO:0007409	290	0.023
oocyte axis specification	GO:0007309	108	0.023
negative regulation of cellular protein metabolic process	GO:0032269	85	0.023
regulation of transposition	GO:0010528	13	0.023
regulation of immune system process	GO:0002682	176	0.022
regulation of embryonic cell shape	GO:0016476	30	0.022
spindle organization	GO:0007051	253	0.022
positive regulation of protein modification process	GO:0031401	58	0.022
organophosphate biosynthetic process	GO:0090407	46	0.022
regulation of endocytosis	GO:0030100	37	0.022
negative regulation of transcription dna templated	GO:0045892	237	0.022
gtp catabolic process	GO:0006184	72	0.022
development of primary sexual characteristics	GO:0045137	50	0.022
regulation of establishment of protein localization	GO:0070201	61	0.022
intercellular bridge organization	GO:0043063	14	0.022
positive regulation of transport	GO:0051050	92	0.022
eye development	GO:0001654	323	0.022
posttranscriptional gene silencing	GO:0016441	46	0.022
regulation of mitosis	GO:0007088	56	0.021
negative regulation of meiotic cell cycle	GO:0051447	2	0.021
cellular lipid metabolic process	GO:0044255	83	0.021
germ line stem cell division	GO:0042078	25	0.021
regulation of ras protein signal transduction	GO:0046578	93	0.021
mitotic cytokinesis	GO:0000281	50	0.021
negative regulation of intracellular signal transduction	GO:1902532	57	0.021
regulation of transferase activity	GO:0051338	58	0.020
regulation of immune effector process	GO:0002697	52	0.020
immune response	GO:0006955	246	0.020
ribose phosphate metabolic process	GO:0019693	145	0.020
negative regulation of cell death	GO:0060548	81	0.020
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.020
embryonic axis specification	GO:0000578	107	0.020
morphogenesis of embryonic epithelium	GO:0016331	94	0.020
lipid metabolic process	GO:0006629	121	0.020
autophagic vacuole assembly	GO:0000045	2	0.020
mesenchymal cell differentiation	GO:0048762	1	0.020
defense response	GO:0006952	300	0.020
regulation of nucleoside metabolic process	GO:0009118	50	0.020
exocrine system development	GO:0035272	162	0.020
female meiotic division	GO:0007143	70	0.020
wnt signaling pathway	GO:0016055	98	0.019
germ line cyst formation	GO:0048134	44	0.019
eye antennal disc morphogenesis	GO:0007455	34	0.019
jnk cascade	GO:0007254	50	0.019
rna processing	GO:0006396	147	0.019
positive regulation of molecular function	GO:0044093	136	0.019
cytoskeleton dependent cytokinesis	GO:0061640	81	0.019
embryonic organ development	GO:0048568	50	0.019
oocyte microtubule cytoskeleton polarization	GO:0008103	22	0.019
regulation of intracellular protein transport	GO:0033157	46	0.019
chromosome separation	GO:0051304	42	0.019
organic substance transport	GO:0071702	257	0.019
gtp metabolic process	GO:0046039	72	0.018
maternal determination of anterior posterior axis embryo	GO:0008358	74	0.018
compound eye photoreceptor cell differentiation	GO:0001751	140	0.018
retina morphogenesis in camera type eye	GO:0060042	2	0.018
regulation of translation	GO:0006417	56	0.018
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.018
response to abiotic stimulus	GO:0009628	341	0.018	Rat
signal transduction downstream of smoothened	GO:0007227	5	0.018
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.018
intracellular mrna localization	GO:0008298	66	0.018
cellular nitrogen compound catabolic process	GO:0044270	165	0.018
cellular component disassembly	GO:0022411	46	0.018
larval development	GO:0002164	104	0.018
apoptotic signaling pathway	GO:0097190	27	0.018
developmental programmed cell death	GO:0010623	138	0.018
regulation of protein modification by small protein conjugation or removal	GO:1903320	25	0.018
kidney morphogenesis	GO:0060993	3	0.018
germarium derived oocyte differentiation	GO:0030706	29	0.018
endodermal cell fate commitment	GO:0001711	3	0.018
adult behavior	GO:0030534	137	0.018
response to biotic stimulus	GO:0009607	294	0.017
regulation of jnk cascade	GO:0046328	40	0.017
compound eye morphogenesis	GO:0001745	249	0.017
regulation of gene expression epigenetic	GO:0040029	128	0.017
retina development in camera type eye	GO:0060041	4	0.017
regulation of tube size open tracheal system	GO:0035151	43	0.017
regulation of cellular amino acid metabolic process	GO:0006521	0	0.017
stem cell development	GO:0048864	79	0.017
positive regulation of wnt signaling pathway	GO:0030177	25	0.017
carboxylic acid metabolic process	GO:0019752	92	0.017
inositol lipid mediated signaling	GO:0048017	4	0.017
hematopoietic progenitor cell differentiation	GO:0002244	1	0.017
response to ethanol	GO:0045471	59	0.017
regulation of mitotic sister chromatid separation	GO:0010965	28	0.017
specification of symmetry	GO:0009799	13	0.017
protein localization to nucleus	GO:0034504	55	0.017
kidney epithelium development	GO:0072073	3	0.017
biological adhesion	GO:0022610	138	0.016
connective tissue development	GO:0061448	3	0.016
apical constriction	GO:0003383	18	0.016
positive regulation of growth	GO:0045927	75	0.016
response to organic substance	GO:0010033	284	0.016
regulation of programmed cell death	GO:0043067	152	0.016
positive regulation of jun kinase activity	GO:0043507	4	0.016
phosphatidylinositol 3 kinase signaling	GO:0014065	4	0.016
regulation of purine nucleotide metabolic process	GO:1900542	62	0.016
regulation of apoptotic process	GO:0042981	130	0.016
regulation of catalytic activity	GO:0050790	185	0.016
malpighian tubule development	GO:0072002	64	0.016
long term memory	GO:0007616	62	0.016
determination of left right symmetry	GO:0007368	9	0.016

Cul-5 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.043
cancer	DOID:162	0.029
disease of cellular proliferation	DOID:14566	0.029

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