IMP: Integrative Multi-species Prediction

Drosophila melanogaster

64 known processes

fs(1)N (Dmel_CG11411)

female sterile (1) Nasrat

(Aliases: EG:8D8.1,fs(1)K1540,Fs(1)N,Dmel\CG11411,fs(1)[nas],Nas,fs(1)A371,fs(1)Nasrat,CG11411,fs(1)M6,371,8D8.1,fs(1)Nas)

Entrez: 45973
FLYBASE: FBgn0004650
UniProtKB: O76904

Process Predictions
Disease Predictions

fs(1)N biological process predictions

Show only novel predictionsHighlight processes of functional analogs

Filter by process size:

Biological process	GO term ID	Process size	Probability
egg coat formation	GO:0035803	11	0.994
vitelline membrane formation	GO:0030704	11	0.993
vitelline membrane formation involved in chorion containing eggshell formation	GO:0007305	11	0.957
extracellular matrix assembly	GO:0085029	13	0.822
fertilization	GO:0009566	26	0.797
chorion containing eggshell formation	GO:0007304	105	0.701
zygotic determination of anterior posterior axis embryo	GO:0007354	27	0.686
epithelial cell differentiation	GO:0030855	322	0.667
single fertilization	GO:0007338	24	0.640
immune system process	GO:0002376	347	0.623
eggshell formation	GO:0030703	105	0.544
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.521
eggshell chorion assembly	GO:0007306	66	0.466
long term memory	GO:0007616	62	0.458
neurological system process	GO:0050877	358	0.450
terminal region determination	GO:0007362	25	0.438
response to external biotic stimulus	GO:0043207	293	0.411
immune response	GO:0006955	246	0.386
extracellular structure organization	GO:0043062	46	0.370
regionalization	GO:0003002	416	0.337
oocyte microtubule cytoskeleton organization	GO:0016325	35	0.325
negative regulation of cellular biosynthetic process	GO:0031327	277	0.324
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.276
regulation of immune system process	GO:0002682	176	0.273
response to abiotic stimulus	GO:0009628	341	0.253
hemopoiesis	GO:0030097	46	0.245
negative regulation of biosynthetic process	GO:0009890	277	0.221
cellular component assembly involved in morphogenesis	GO:0010927	151	0.221
cell division	GO:0051301	248	0.217
appendage morphogenesis	GO:0035107	397	0.216
taxis	GO:0042330	304	0.211
nuclear division	GO:0000280	332	0.206
tube morphogenesis	GO:0035239	191	0.205
sensory organ morphogenesis	GO:0090596	260	0.197
anterior posterior axis specification embryo	GO:0008595	103	0.177
negative regulation of rna metabolic process	GO:0051253	251	0.171
blastoderm segmentation	GO:0007350	159	0.170
single organism behavior	GO:0044708	391	0.159
negative regulation of gene expression	GO:0010629	387	0.158
endocytosis	GO:0006897	310	0.155
epithelial cell development	GO:0002064	274	0.143
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.141
ovarian follicle cell development	GO:0030707	248	0.139
vesicle mediated transport	GO:0016192	381	0.136
axis specification	GO:0009798	167	0.135
establishment or maintenance of cytoskeleton polarity	GO:0030952	44	0.134
response to other organism	GO:0051707	293	0.128
positive regulation of immune response	GO:0050778	63	0.125
positive regulation of macromolecule metabolic process	GO:0010604	405	0.123
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.119
anterior posterior axis specification	GO:0009948	109	0.118
negative regulation of cellular metabolic process	GO:0031324	382	0.117
pole plasm mrna localization	GO:0019094	49	0.114
eye morphogenesis	GO:0048592	260	0.108
actin filament based process	GO:0030029	220	0.107
regulation of cell differentiation	GO:0045595	302	0.106
chromosome organization	GO:0051276	360	0.104
negative regulation of response to stimulus	GO:0048585	258	0.103
regulation of cell cycle process	GO:0010564	181	0.103
regulation of canonical wnt signaling pathway	GO:0060828	15	0.102
carbohydrate derivative metabolic process	GO:1901135	217	0.101
embryonic morphogenesis	GO:0048598	206	0.100
torso signaling pathway	GO:0008293	21	0.098
tube development	GO:0035295	244	0.098
response to fungus	GO:0009620	50	0.095
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.094
defense response	GO:0006952	300	0.091
morphogenesis of a branching epithelium	GO:0061138	45	0.091
digestive tract morphogenesis	GO:0048546	127	0.091
gene silencing	GO:0016458	138	0.090
positive regulation of multicellular organismal process	GO:0051240	143	0.088
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.088
post embryonic appendage morphogenesis	GO:0035120	385	0.085
positive regulation of response to stimulus	GO:0048584	323	0.083
kidney development	GO:0001822	3	0.083
regulation of anatomical structure morphogenesis	GO:0022603	242	0.082
positive regulation of rna metabolic process	GO:0051254	271	0.082
appendage development	GO:0048736	401	0.081
compound eye photoreceptor cell differentiation	GO:0001751	140	0.079
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.078
anterior posterior pattern specification	GO:0009952	136	0.076
regulation of response to stress	GO:0080134	200	0.075
response to biotic stimulus	GO:0009607	294	0.075
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.075
defense response to other organism	GO:0098542	225	0.075
male pronucleus assembly	GO:0035039	6	0.074
cell maturation	GO:0048469	144	0.073
regulation of immune response	GO:0050776	118	0.071
extracellular matrix organization	GO:0030198	32	0.070
chromatin remodeling	GO:0006338	72	0.069
female meiotic division	GO:0007143	70	0.068
regulation of organelle organization	GO:0033043	196	0.068
positive regulation of cell communication	GO:0010647	250	0.063
negative regulation of transcription dna templated	GO:0045892	237	0.060
morphogenesis of follicular epithelium	GO:0016333	36	0.060
compound eye morphogenesis	GO:0001745	249	0.059
embryonic axis specification	GO:0000578	107	0.059
growth	GO:0040007	359	0.059
organelle fission	GO:0048285	340	0.057
imaginal disc derived appendage development	GO:0048737	399	0.057
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.057
tripartite regional subdivision	GO:0007351	103	0.056
regulation of gene expression epigenetic	GO:0040029	128	0.056
intracellular mrna localization	GO:0008298	66	0.056
purine nucleoside metabolic process	GO:0042278	127	0.056
eye photoreceptor cell differentiation	GO:0001754	145	0.056
positive regulation of signaling	GO:0023056	243	0.055
aging	GO:0007568	143	0.054
wnt signaling pathway	GO:0016055	98	0.053
regulation of organ morphogenesis	GO:2000027	78	0.053
body morphogenesis	GO:0010171	2	0.052
regulation of growth	GO:0040008	233	0.052
establishment of localization in cell	GO:0051649	402	0.051
negative regulation of cell differentiation	GO:0045596	143	0.050
muscle structure development	GO:0061061	224	0.050
cognition	GO:0050890	141	0.049
localization of cell	GO:0051674	257	0.049
regulation of cellular protein metabolic process	GO:0032268	243	0.049
regulation of multicellular organismal development	GO:2000026	414	0.048
actin cytoskeleton organization	GO:0030036	206	0.048
protein modification process	GO:0036211	438	0.046
maternal determination of anterior posterior axis embryo	GO:0008358	74	0.046
positive regulation of cellular biosynthetic process	GO:0031328	316	0.046
immune system development	GO:0002520	57	0.046
phagocytosis	GO:0006909	215	0.046
response to radiation	GO:0009314	155	0.045
macromolecular complex assembly	GO:0065003	256	0.045
meiotic nuclear division	GO:0007126	151	0.045
nucleus organization	GO:0006997	45	0.044
innate immune response	GO:0045087	144	0.044
regulation of cell cycle	GO:0051726	291	0.044
dorsal ventral axis specification ovarian follicular epithelium	GO:0008069	13	0.043
morphogenesis of an epithelium	GO:0002009	276	0.042
eye development	GO:0001654	323	0.042
cellular macromolecule localization	GO:0070727	220	0.041
regulation of programmed cell death	GO:0043067	152	0.041
photoreceptor cell differentiation	GO:0046530	170	0.041
embryo development ending in birth or egg hatching	GO:0009792	152	0.041
negative regulation of cell communication	GO:0010648	223	0.041
gastrulation	GO:0007369	70	0.040
regulation of protein metabolic process	GO:0051246	256	0.040
central nervous system development	GO:0007417	201	0.040
hematopoietic or lymphoid organ development	GO:0048534	57	0.040
positive regulation of immune system process	GO:0002684	68	0.040
regulation of molecular function	GO:0065009	217	0.039
chromatin organization	GO:0006325	207	0.037
regulation of catalytic activity	GO:0050790	185	0.037
programmed cell death	GO:0012501	257	0.037
developmental programmed cell death	GO:0010623	138	0.036
wing disc morphogenesis	GO:0007472	344	0.036
positive regulation of cell motility	GO:2000147	3	0.035
digestive tract development	GO:0048565	149	0.035
positive regulation of signal transduction	GO:0009967	223	0.034
mitotic nuclear division	GO:0007067	213	0.034
erbb signaling pathway	GO:0038127	58	0.034
mitotic spindle organization	GO:0007052	220	0.033
positive regulation of transcription dna templated	GO:0045893	266	0.033
intracellular signal transduction	GO:0035556	300	0.032
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.032
mrna polyadenylation	GO:0006378	11	0.032
organophosphate metabolic process	GO:0019637	195	0.032
positive regulation of biosynthetic process	GO:0009891	316	0.031
dorsal ventral pattern formation	GO:0009953	133	0.031
cellular protein modification process	GO:0006464	438	0.031
regulation of anatomical structure size	GO:0090066	163	0.030
tissue morphogenesis	GO:0048729	297	0.030
epidermal growth factor receptor signaling pathway	GO:0007173	58	0.030
regulation of cell proliferation	GO:0042127	163	0.030
regulation of embryonic development	GO:0045995	68	0.030
regulation of cellular component size	GO:0032535	98	0.030
response to organic substance	GO:0010033	284	0.030
positive regulation of developmental process	GO:0051094	143	0.029
renal system development	GO:0072001	72	0.029
sensory perception	GO:0007600	196	0.029
rna localization	GO:0006403	115	0.029
rna interference	GO:0016246	27	0.028
sex differentiation	GO:0007548	81	0.028
segmentation	GO:0035282	207	0.028
memory	GO:0007613	94	0.028
pronuclear fusion	GO:0007344	4	0.027
stem cell differentiation	GO:0048863	117	0.027
rhythmic process	GO:0048511	106	0.027
regulation of cell fate commitment	GO:0010453	29	0.027
regulation of apoptotic process	GO:0042981	130	0.027
eye antennal disc development	GO:0035214	60	0.027
cellular macromolecule catabolic process	GO:0044265	136	0.027
columnar cuboidal epithelial cell development	GO:0002066	249	0.027
canonical wnt signaling pathway	GO:0060070	21	0.027
response to endogenous stimulus	GO:0009719	119	0.027
developmental maturation	GO:0021700	172	0.026
negative regulation of immune system process	GO:0002683	50	0.026
kidney epithelium development	GO:0072073	3	0.026
ion transport	GO:0006811	145	0.026
positive regulation of cellular amine metabolic process	GO:0033240	0	0.026
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.026
positive regulation of cellular component organization	GO:0051130	156	0.026
cell migration	GO:0016477	238	0.026
sex determination	GO:0007530	18	0.025
cell fate determination	GO:0001709	91	0.025
regulation of cellular component biogenesis	GO:0044087	201	0.025
regulation of cell maturation	GO:1903429	27	0.024
negative regulation of cell cycle process	GO:0010948	109	0.024
positive regulation of cell migration	GO:0030335	2	0.024
hair cell differentiation	GO:0035315	47	0.024
ion transmembrane transport	GO:0034220	122	0.024
regulation of mitotic cell cycle	GO:0007346	190	0.024
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.024
protein catabolic process	GO:0030163	101	0.024
oocyte localization involved in germarium derived egg chamber formation	GO:0030720	12	0.024
compound eye development	GO:0048749	307	0.024
regulation of localization	GO:0032879	275	0.023
nephron development	GO:0072006	3	0.023
negative regulation of signaling	GO:0023057	219	0.023
learning or memory	GO:0007611	141	0.023
cell motility	GO:0048870	251	0.022
stem cell development	GO:0048864	79	0.022
single organism biosynthetic process	GO:0044711	206	0.022
regulation of cell morphogenesis	GO:0022604	163	0.022
regulation of oocyte development	GO:0060281	27	0.022
camera type eye development	GO:0043010	4	0.022
dorsal appendage formation	GO:0046843	47	0.022
apoptotic process	GO:0006915	159	0.022
cellular response to dna damage stimulus	GO:0006974	223	0.022
defense response to gram negative bacterium	GO:0050829	94	0.022
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.022
microtubule cytoskeleton organization involved in mitosis	GO:1902850	52	0.021
regulation of mrna processing	GO:0050684	71	0.021
glycosyl compound metabolic process	GO:1901657	127	0.021
positive regulation of cell differentiation	GO:0045597	64	0.021
positive regulation of catalytic activity	GO:0043085	118	0.021
regulation of nervous system development	GO:0051960	248	0.021
organelle assembly	GO:0070925	198	0.021
renal filtration cell differentiation	GO:0061318	12	0.021
cytoplasmic transport	GO:0016482	130	0.021
regulation of intracellular signal transduction	GO:1902531	236	0.020
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.020
organonitrogen compound metabolic process	GO:1901564	318	0.020
regulation of cell shape	GO:0008360	113	0.020
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.020
purine ribonucleoside metabolic process	GO:0046128	127	0.020
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.020
regulation of ion transport	GO:0043269	39	0.020
hematopoietic progenitor cell differentiation	GO:0002244	1	0.019
positive regulation of cellular protein metabolic process	GO:0032270	118	0.019
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.019
hindbrain development	GO:0030902	2	0.019
ribose phosphate metabolic process	GO:0019693	145	0.019
chromatin assembly or disassembly	GO:0006333	52	0.019
pole plasm rna localization	GO:0007316	52	0.019
cellular macromolecular complex assembly	GO:0034622	153	0.019
positive regulation of protein metabolic process	GO:0051247	128	0.019
stem cell maintenance	GO:0019827	67	0.019
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.019
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.019
death	GO:0016265	284	0.019
posttranscriptional gene silencing by rna	GO:0035194	45	0.018
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.018
defense response to bacterium	GO:0042742	178	0.018
actomyosin structure organization	GO:0031032	56	0.018
pole plasm protein localization	GO:0007318	10	0.018
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.018
eye photoreceptor cell fate commitment	GO:0042706	37	0.018
purine ribonucleoside catabolic process	GO:0046130	112	0.018
digestive system development	GO:0055123	149	0.018
ribonucleotide metabolic process	GO:0009259	145	0.018
purine ribonucleotide metabolic process	GO:0009150	145	0.018
regulation of cellular component movement	GO:0051270	42	0.018
small molecule metabolic process	GO:0044281	305	0.018
negative regulation of signal transduction	GO:0009968	206	0.017
negative regulation of immune response	GO:0050777	39	0.017
nucleobase containing small molecule metabolic process	GO:0055086	174	0.017
positive regulation of molecular function	GO:0044093	136	0.017
organic substance transport	GO:0071702	257	0.017
regulation of wnt signaling pathway	GO:0030111	68	0.017
secretion	GO:0046903	109	0.017
rna catabolic process	GO:0006401	37	0.017
purine ribonucleotide catabolic process	GO:0009154	109	0.017
imaginal disc derived wing morphogenesis	GO:0007476	337	0.016
regulation of cell development	GO:0060284	215	0.016
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.016
regulation of mitosis	GO:0007088	56	0.016
response to oxygen containing compound	GO:1901700	200	0.016
aromatic compound catabolic process	GO:0019439	166	0.016
establishment or maintenance of microtubule cytoskeleton polarity	GO:0030951	41	0.016
determination of adult lifespan	GO:0008340	137	0.016
negative regulation of multicellular organismal process	GO:0051241	142	0.016
oocyte axis specification	GO:0007309	108	0.016
muscle cell differentiation	GO:0042692	103	0.016
purine nucleotide metabolic process	GO:0006163	146	0.016
oocyte anterior posterior axis specification	GO:0007314	72	0.016
hindgut development	GO:0061525	58	0.016
regulation of cellular localization	GO:0060341	136	0.016
regulation of epithelial cell proliferation	GO:0050678	4	0.016
positive regulation of cellular catabolic process	GO:0031331	95	0.015
organic cyclic compound catabolic process	GO:1901361	168	0.015
response to inorganic substance	GO:0010035	44	0.015
organic substance catabolic process	GO:1901575	308	0.015
chromatin modification	GO:0016568	147	0.015
lateral inhibition	GO:0046331	206	0.015
humoral immune response	GO:0006959	117	0.015
mrna metabolic process	GO:0016071	124	0.015
morphogenesis of a branching structure	GO:0001763	45	0.014
regulation of cell size	GO:0008361	63	0.014
wing disc pattern formation	GO:0035222	66	0.014
homeostatic process	GO:0042592	199	0.014
protein phosphorylation	GO:0006468	169	0.014
immune response activating signal transduction	GO:0002757	2	0.014
regulation of actin filament based process	GO:0032970	42	0.014
negative regulation of growth	GO:0045926	84	0.014
cellular amine metabolic process	GO:0044106	12	0.014
secretion by cell	GO:0032940	101	0.014
muscle cell development	GO:0055001	50	0.014
negative regulation of rna biosynthetic process	GO:1902679	240	0.014
female sex differentiation	GO:0046660	20	0.014
gland development	GO:0048732	191	0.014
cellular homeostasis	GO:0019725	80	0.014
atp metabolic process	GO:0046034	49	0.014
negative regulation of developmental process	GO:0051093	201	0.014
urogenital system development	GO:0001655	72	0.014
epithelial cell migration	GO:0010631	148	0.014
mrna processing	GO:0006397	104	0.014
regulation of epithelial cell differentiation	GO:0030856	4	0.013
salivary gland development	GO:0007431	162	0.013
protein localization	GO:0008104	284	0.013
organophosphate catabolic process	GO:0046434	112	0.013
regulation of innate immune response	GO:0045088	71	0.013
regulation of behavior	GO:0050795	75	0.013
spermatogenesis	GO:0007283	200	0.013
positive regulation of intracellular signal transduction	GO:1902533	116	0.013
cellular ketone metabolic process	GO:0042180	24	0.013
nucleotide metabolic process	GO:0009117	161	0.013
positive regulation of peptidyl tyrosine phosphorylation	GO:0050731	4	0.013
chromosome segregation	GO:0007059	157	0.013
somatic muscle development	GO:0007525	66	0.013
establishment of protein localization	GO:0045184	163	0.013
compound eye photoreceptor fate commitment	GO:0001752	36	0.013
reproductive system development	GO:0061458	74	0.013
regulation of compound eye retinal cell programmed cell death	GO:0046669	18	0.013
organonitrogen compound biosynthetic process	GO:1901566	117	0.013
meiotic cell cycle	GO:0051321	171	0.013
male gamete generation	GO:0048232	201	0.013
positive regulation of cellular amide metabolic process	GO:0034250	26	0.012
cell recognition	GO:0008037	102	0.012
response to alcohol	GO:0097305	95	0.012
nucleoside phosphate catabolic process	GO:1901292	110	0.012
posttranscriptional regulation of gene expression	GO:0010608	145	0.012
nucleoside metabolic process	GO:0009116	127	0.012
hindgut morphogenesis	GO:0007442	58	0.012
neuron fate commitment	GO:0048663	50	0.012
response to nitrogen compound	GO:1901698	90	0.012
locomotory behavior	GO:0007626	176	0.012
purine nucleoside catabolic process	GO:0006152	112	0.012
chromatin assembly	GO:0031497	48	0.012
gastrulation involving germ band extension	GO:0010004	36	0.012
establishment or maintenance of apical basal cell polarity	GO:0035088	34	0.012
striated muscle cell differentiation	GO:0051146	90	0.012
catabolic process	GO:0009056	409	0.012
gastrulation with mouth forming first	GO:0001703	36	0.012
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.012
protein complex biogenesis	GO:0070271	201	0.012
peptidyl amino acid modification	GO:0018193	105	0.012
regulation of embryonic pattern specification	GO:1902875	27	0.012
embryonic hindgut morphogenesis	GO:0048619	48	0.012
regulation of cellular ketone metabolic process	GO:0010565	3	0.012
transmembrane transport	GO:0055085	139	0.012
positive regulation of mitotic cell cycle	GO:0045931	34	0.012
regulation of response to external stimulus	GO:0032101	115	0.011
embryonic organ development	GO:0048568	50	0.011
spindle organization	GO:0007051	253	0.011
oocyte development	GO:0048599	124	0.011
nucleobase containing compound catabolic process	GO:0034655	165	0.011
retina development in camera type eye	GO:0060041	4	0.011
larval development	GO:0002164	104	0.011
epidermis development	GO:0008544	65	0.011
amine metabolic process	GO:0009308	12	0.011
purine containing compound metabolic process	GO:0072521	155	0.011
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.011
cellular response to chemical stimulus	GO:0070887	199	0.011
regulation of cellular amine metabolic process	GO:0033238	3	0.011
intracellular protein transport	GO:0006886	104	0.011
protein import into nucleus	GO:0006606	51	0.011
neuron recognition	GO:0008038	101	0.011
epithelial tube morphogenesis	GO:0060562	88	0.011
oocyte nucleus localization involved in oocyte dorsal ventral axis specification	GO:0051663	12	0.011
positive regulation of i kappab kinase nf kappab signaling	GO:0043123	1	0.011
nucleoside monophosphate metabolic process	GO:0009123	52	0.011
heterocycle catabolic process	GO:0046700	166	0.011
positive regulation of rna biosynthetic process	GO:1902680	266	0.011
response to bacterium	GO:0009617	198	0.011
regulation of cell division	GO:0051302	72	0.011
protein complex assembly	GO:0006461	200	0.010
axon development	GO:0061564	297	0.010
single organism intracellular transport	GO:1902582	207	0.010
nephron tubule development	GO:0072080	3	0.010
posttranscriptional gene silencing	GO:0016441	46	0.010
salivary gland morphogenesis	GO:0007435	145	0.010
carbohydrate derivative catabolic process	GO:1901136	118	0.010
developmental pigmentation	GO:0048066	68	0.010
response to mechanical stimulus	GO:0009612	28	0.010
purine containing compound catabolic process	GO:0072523	112	0.010
nucleotide catabolic process	GO:0009166	109	0.010
positive regulation of developmental growth	GO:0048639	62	0.010

fs(1)N disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of cellular proliferation	DOID:14566	0.036
organ system cancer	DOID:0050686	0.036
cancer	DOID:162	0.036
disease of anatomical entity	DOID:7	0.016
musculoskeletal system disease	DOID:17	0.012
muscular disease	DOID:0080000	0.012

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