IMP: Integrative Multi-species Prediction

Drosophila melanogaster

0 known processes

Mdh (Dmel_CG5889)

CG5889 gene product from transcript CG5889-RC

(Aliases: Dmel\CG5889,CG5889,MDH,anon-EST:Posey79)

Entrez: 43936
FLYBASE: FBgn0029155
UniProtKB: Q9VB69
UniProtKB: E1JIZ5
UniProtKB: E1JIZ4

Process Predictions
Disease Predictions

Mdh biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
organonitrogen compound metabolic process	GO:1901564	318	0.118
ion transport	GO:0006811	145	0.103
single organism biosynthetic process	GO:0044711	206	0.070
carboxylic acid metabolic process	GO:0019752	92	0.068
transmembrane transport	GO:0055085	139	0.062
sulfur compound metabolic process	GO:0006790	59	0.060
chaeta development	GO:0022416	97	0.059
small molecule metabolic process	GO:0044281	305	0.058
response to organic substance	GO:0010033	284	0.049
cation transmembrane transport	GO:0098655	88	0.047
nicotinamide nucleotide metabolic process	GO:0046496	2	0.046
ion transmembrane transport	GO:0034220	122	0.044
pyridine containing compound metabolic process	GO:0072524	3	0.044
detection of stimulus	GO:0051606	156	0.041
response to alcohol	GO:0097305	95	0.041
inorganic cation transmembrane transport	GO:0098662	61	0.040
homeostatic process	GO:0042592	199	0.040
cation transport	GO:0006812	110	0.039
organic substance transport	GO:0071702	257	0.038
cellular amino acid metabolic process	GO:0006520	61	0.036
organophosphate metabolic process	GO:0019637	195	0.036
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.036
organic acid metabolic process	GO:0006082	103	0.033
oxidoreduction coenzyme metabolic process	GO:0006733	2	0.033
nad metabolic process	GO:0019674	1	0.033
response to abiotic stimulus	GO:0009628	341	0.031
oxoacid metabolic process	GO:0043436	103	0.030
response to oxygen containing compound	GO:1901700	200	0.030
monovalent inorganic cation transport	GO:0015672	40	0.030
intracellular transport	GO:0046907	228	0.029
establishment of localization in cell	GO:0051649	402	0.027
acyl coa metabolic process	GO:0006637	3	0.027
regulation of cellular ketone metabolic process	GO:0010565	3	0.026
organonitrogen compound biosynthetic process	GO:1901566	117	0.025
imaginal disc derived wing morphogenesis	GO:0007476	337	0.025
sulfur compound biosynthetic process	GO:0044272	16	0.023
chemical homeostasis	GO:0048878	92	0.022
regionalization	GO:0003002	416	0.022
neurological system process	GO:0050877	358	0.022
programmed cell death	GO:0012501	257	0.021
cellular homeostasis	GO:0019725	80	0.021
mitochondrion organization	GO:0007005	65	0.021
regulation of transport	GO:0051049	181	0.020
ion homeostasis	GO:0050801	55	0.020
regulation of multicellular organismal development	GO:2000026	414	0.019
regulation of localization	GO:0032879	275	0.019
transcription from rna polymerase ii promoter	GO:0006366	368	0.019
negative regulation of biosynthetic process	GO:0009890	277	0.019
regulation of programmed cell death	GO:0043067	152	0.019
response to hexose	GO:0009746	3	0.019
death	GO:0016265	284	0.018
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.018
negative regulation of multicellular organismal process	GO:0051241	142	0.018
phagocytosis	GO:0006909	215	0.018
alpha amino acid metabolic process	GO:1901605	20	0.018
cell death	GO:0008219	279	0.018
oxidation reduction process	GO:0055114	123	0.018
metal ion transport	GO:0030001	74	0.017
nucleotide metabolic process	GO:0009117	161	0.017
protein complex biogenesis	GO:0070271	201	0.017
positive regulation of cellular biosynthetic process	GO:0031328	316	0.017
post embryonic appendage morphogenesis	GO:0035120	385	0.017
nucleobase containing small molecule metabolic process	GO:0055086	174	0.017
cellular response to chemical stimulus	GO:0070887	199	0.017
lateral inhibition	GO:0046331	206	0.017
nucleoside phosphate metabolic process	GO:0006753	162	0.017
vesicle mediated transport	GO:0016192	381	0.016
appendage morphogenesis	GO:0035107	397	0.016
cuticle development	GO:0042335	86	0.016
detection of stimulus involved in sensory perception	GO:0050906	92	0.015
acyl coa biosynthetic process	GO:0071616	2	0.015
phosphorylation	GO:0016310	294	0.015
proteolysis	GO:0006508	192	0.015
macromolecular complex assembly	GO:0065003	256	0.015
negative regulation of gene expression	GO:0010629	387	0.015
endocytosis	GO:0006897	310	0.014
metal ion homeostasis	GO:0055065	44	0.014
catabolic process	GO:0009056	409	0.014
organic substance catabolic process	GO:1901575	308	0.014
inorganic ion transmembrane transport	GO:0098660	73	0.014
positive regulation of macromolecule metabolic process	GO:0010604	405	0.014
carbohydrate derivative biosynthetic process	GO:1901137	85	0.014
negative regulation of cellular metabolic process	GO:0031324	382	0.014
actin cytoskeleton organization	GO:0030036	206	0.014
growth	GO:0040007	359	0.013
detection of abiotic stimulus	GO:0009582	66	0.013
regulation of cellular amine metabolic process	GO:0033238	3	0.013
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.013
thioester metabolic process	GO:0035383	3	0.013
regulation of organelle organization	GO:0033043	196	0.013
single organism carbohydrate metabolic process	GO:0044723	72	0.013
cellular protein modification process	GO:0006464	438	0.013
carbohydrate metabolic process	GO:0005975	82	0.013
spindle organization	GO:0007051	253	0.013
positive regulation of cell communication	GO:0010647	250	0.012
body morphogenesis	GO:0010171	2	0.012
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.012
thioester biosynthetic process	GO:0035384	2	0.012
organophosphate biosynthetic process	GO:0090407	46	0.012
regulation of cell differentiation	GO:0045595	302	0.012
organic hydroxy compound metabolic process	GO:1901615	83	0.012
generation of precursor metabolites and energy	GO:0006091	42	0.012
single organism membrane fusion	GO:0044801	42	0.012
single organism intracellular transport	GO:1902582	207	0.012
protein complex assembly	GO:0006461	200	0.012
regulation of ion transport	GO:0043269	39	0.012
wing disc morphogenesis	GO:0007472	344	0.011
regulation of cell death	GO:0010941	173	0.011
developmental growth	GO:0048589	280	0.011
regulation of cellular localization	GO:0060341	136	0.011
carbohydrate derivative metabolic process	GO:1901135	217	0.011
detection of external stimulus	GO:0009581	66	0.011
positive regulation of developmental process	GO:0051094	143	0.011
cellular amine metabolic process	GO:0044106	12	0.011
organonitrogen compound catabolic process	GO:1901565	128	0.011
response to organophosphorus	GO:0046683	2	0.011
single organism catabolic process	GO:0044712	228	0.011
protein modification process	GO:0036211	438	0.011
cellular nitrogen compound catabolic process	GO:0044270	165	0.010
positive regulation of programmed cell death	GO:0043068	62	0.010
appendage development	GO:0048736	401	0.010
anion transport	GO:0006820	41	0.010

Mdh disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.144
disease of metabolism	DOID:0014667	0.026
nervous system disease	DOID:863	0.023
inherited metabolic disorder	DOID:655	0.022
acquired metabolic disease	DOID:0060158	0.018
carbohydrate metabolism disease	DOID:0050013	0.018
central nervous system disease	DOID:331	0.012

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