IMP: Integrative Multi-species Prediction

Drosophila melanogaster

99 known processes

h (Dmel_CG6494)

hairy

(Aliases: Hairy,l(3)rM384,HRY,Dmel\CG6494,dDr1,brr,bHLHc14,l(3)08247,CG6494,bHLHb39,8247)

Entrez: 38995
FLYBASE: FBgn0001168
UniProtKB: P14003

Process Predictions
Disease Predictions

h biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
negative regulation of transcription dna templated	GO:0045892	237	0.972
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.797
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.795	Mouse
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.782
negative regulation of rna metabolic process	GO:0051253	251	0.703
negative regulation of cellular biosynthetic process	GO:0031327	277	0.700
negative regulation of gene expression	GO:0010629	387	0.668
positive regulation of transcription dna templated	GO:0045893	266	0.661	Mouse
positive regulation of biosynthetic process	GO:0009891	316	0.605	Mouse
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.556
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.551
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.549
positive regulation of cellular biosynthetic process	GO:0031328	316	0.533	Mouse
negative regulation of rna biosynthetic process	GO:1902679	240	0.530
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.501
transcription from rna polymerase ii promoter	GO:0006366	368	0.484
organic acid metabolic process	GO:0006082	103	0.480
negative regulation of biosynthetic process	GO:0009890	277	0.396
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.389	Mouse
spermatid development	GO:0007286	98	0.381
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.336	Mouse
cell proliferation	GO:0008283	299	0.313	Mouse Fly
regulation of protein metabolic process	GO:0051246	256	0.311	Mouse
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.306	Mouse
immune system process	GO:0002376	347	0.256	Human Mouse
organonitrogen compound metabolic process	GO:1901564	318	0.251
negative regulation of cellular metabolic process	GO:0031324	382	0.241
negative regulation of cell communication	GO:0010648	223	0.211
protein localization	GO:0008104	284	0.208	Mouse
spermatid differentiation	GO:0048515	114	0.189
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.185	Mouse
regulation of localization	GO:0032879	275	0.183
epithelial cell differentiation	GO:0030855	322	0.156	Mouse Worm
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.154
positive regulation of response to stimulus	GO:0048584	323	0.154	Mouse
establishment of localization in cell	GO:0051649	402	0.149	Mouse
protein complex assembly	GO:0006461	200	0.136	Mouse
positive regulation of macromolecule metabolic process	GO:0010604	405	0.136	Mouse
protein modification process	GO:0036211	438	0.123	Mouse
regulation of protein transport	GO:0051223	57	0.121
response to abiotic stimulus	GO:0009628	341	0.120
phosphorylation	GO:0016310	294	0.117	Mouse
positive regulation of rna biosynthetic process	GO:1902680	266	0.113	Mouse
regulation of response to stress	GO:0080134	200	0.110	Fly
carboxylic acid metabolic process	GO:0019752	92	0.107
positive regulation of signaling	GO:0023056	243	0.107	Mouse
intracellular signal transduction	GO:0035556	300	0.107	Mouse
positive regulation of rna metabolic process	GO:0051254	271	0.104	Mouse
male gamete generation	GO:0048232	201	0.102
dendrite development	GO:0016358	204	0.102	Fly
dorsal ventral pattern formation	GO:0009953	133	0.100	Fly
dna metabolic process	GO:0006259	227	0.099
histone modification	GO:0016570	106	0.099
oxoacid metabolic process	GO:0043436	103	0.095
chromosome organization	GO:0051276	360	0.094
positive regulation of gene expression	GO:0010628	290	0.093	Mouse
body morphogenesis	GO:0010171	2	0.090
regulation of protein localization	GO:0032880	76	0.089
regulation of phosphorus metabolic process	GO:0051174	210	0.085	Mouse
regulation of transport	GO:0051049	181	0.085
macromolecular complex assembly	GO:0065003	256	0.085	Mouse
small molecule metabolic process	GO:0044281	305	0.084
cytoplasmic transport	GO:0016482	130	0.083	Mouse
spermatogenesis	GO:0007283	200	0.082
brain development	GO:0007420	120	0.081	Zebrafish Mouse Fly
catabolic process	GO:0009056	409	0.080
chromatin organization	GO:0006325	207	0.080
macromolecule catabolic process	GO:0009057	161	0.078
head development	GO:0060322	135	0.076	Zebrafish Mouse Fly
gene silencing	GO:0016458	138	0.076
response to endogenous stimulus	GO:0009719	119	0.075
gland development	GO:0048732	191	0.073
sensory perception of mechanical stimulus	GO:0050954	72	0.073
intracellular transport	GO:0046907	228	0.072	Mouse
mitotic nuclear division	GO:0007067	213	0.072	Fly
cellular response to organic substance	GO:0071310	132	0.072
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	38	0.071	Mouse
muscle structure development	GO:0061061	224	0.070	Mouse
positive regulation of cell communication	GO:0010647	250	0.069	Mouse
negative regulation of response to stimulus	GO:0048585	258	0.066
regulation of anatomical structure morphogenesis	GO:0022603	242	0.065	Mouse
protein acetylation	GO:0006473	39	0.064
regulation of phosphate metabolic process	GO:0019220	210	0.064	Mouse
cellular protein localization	GO:0034613	160	0.062	Mouse
post embryonic appendage morphogenesis	GO:0035120	385	0.062
response to organic substance	GO:0010033	284	0.060
regulation of cellular localization	GO:0060341	136	0.059
positive regulation of signal transduction	GO:0009967	223	0.058	Mouse
protein transport	GO:0015031	155	0.058	Mouse
regulation of multi organism process	GO:0043900	131	0.057
single organism biosynthetic process	GO:0044711	206	0.057
organic substance transport	GO:0071702	257	0.057	Mouse
cellular response to chemical stimulus	GO:0070887	199	0.056
regulation of cellular response to stress	GO:0080135	89	0.055	Fly
notch signaling pathway	GO:0007219	120	0.054	Human Zebrafish Mouse Fly
positive regulation of cellular component organization	GO:0051130	156	0.053	Fly
photoreceptor cell differentiation	GO:0046530	170	0.053	Fly
cellular macromolecule localization	GO:0070727	220	0.052	Mouse
organic substance catabolic process	GO:1901575	308	0.052
g2 dna damage checkpoint	GO:0031572	69	0.049
regulation of epithelial cell differentiation	GO:0030856	4	0.049	Mouse
transforming growth factor beta receptor signaling pathway	GO:0007179	16	0.049
regulation of cellular protein metabolic process	GO:0032268	243	0.049	Mouse
regulation of organelle organization	GO:0033043	196	0.048	Fly
regulation of cell proliferation	GO:0042127	163	0.047	Mouse Fly
negative regulation of signal transduction	GO:0009968	206	0.047
negative regulation of cell cycle process	GO:0010948	109	0.044
positive regulation of protein metabolic process	GO:0051247	128	0.044	Mouse
positive regulation of multicellular organismal process	GO:0051240	143	0.044	Mouse Fly
regulation of catabolic process	GO:0009894	170	0.043
proteolysis	GO:0006508	192	0.042
regulation of gene expression epigenetic	GO:0040029	128	0.042	Fly
chromatin silencing	GO:0006342	76	0.042
establishment of protein localization	GO:0045184	163	0.042	Mouse
cellular response to dna damage stimulus	GO:0006974	223	0.042	Fly
regulation of immune response	GO:0050776	118	0.041
posttranscriptional gene silencing	GO:0016441	46	0.040
centrosome organization	GO:0051297	163	0.040
nuclear transport	GO:0051169	72	0.040	Mouse
cellular catabolic process	GO:0044248	372	0.040
peptidyl threonine phosphorylation	GO:0018107	2	0.040
organelle fission	GO:0048285	340	0.039	Fly
protein modification by small protein conjugation or removal	GO:0070647	106	0.039
cellular response to transforming growth factor beta stimulus	GO:0071560	18	0.039
positive regulation of cell differentiation	GO:0045597	64	0.037	Mouse Fly
protein complex biogenesis	GO:0070271	201	0.037	Mouse
regulation of cellular response to growth factor stimulus	GO:0090287	13	0.037
hindbrain development	GO:0030902	2	0.036	Mouse
single organism intracellular transport	GO:1902582	207	0.036	Mouse
stem cell differentiation	GO:0048863	117	0.036	Human Mouse
forebrain development	GO:0030900	2	0.036	Zebrafish Mouse
protein localization to organelle	GO:0033365	82	0.035	Mouse
immune system development	GO:0002520	57	0.035	Human Mouse
regulation of cell death	GO:0010941	173	0.035
response to bacterium	GO:0009617	198	0.034
regulation of cell differentiation	GO:0045595	302	0.034	Human Zebrafish Mouse Fly
jak stat cascade	GO:0007259	49	0.033	Mouse
muscle organ development	GO:0007517	127	0.033
response to lipopolysaccharide	GO:0032496	4	0.032
posttranscriptional regulation of gene expression	GO:0010608	145	0.031
carbohydrate derivative metabolic process	GO:1901135	217	0.031
cellular macromolecule catabolic process	GO:0044265	136	0.030
innate immune response	GO:0045087	144	0.030
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.029	Mouse
secretion	GO:0046903	109	0.029
regulation of establishment of protein localization	GO:0070201	61	0.029
regulation of intracellular transport	GO:0032386	64	0.028
positive regulation of immune system process	GO:0002684	68	0.028	Mouse
organic cyclic compound catabolic process	GO:1901361	168	0.028
response to other organism	GO:0051707	293	0.028
cellular response to endogenous stimulus	GO:0071495	80	0.028
protein catabolic process	GO:0030163	101	0.027
regulation of response to external stimulus	GO:0032101	115	0.027
regulation of notch signaling pathway	GO:0008593	100	0.027	Mouse
cellular response to oxygen containing compound	GO:1901701	79	0.027
stem cell maintenance	GO:0019827	67	0.027	Human Mouse
regulation of protein catabolic process	GO:0042176	55	0.027
cellular protein modification process	GO:0006464	438	0.026	Mouse
hemopoiesis	GO:0030097	46	0.026	Human
protein ubiquitination	GO:0016567	70	0.026
stem cell development	GO:0048864	79	0.026	Human Mouse
mitochondrion organization	GO:0007005	65	0.025
regulation of gene silencing	GO:0060968	63	0.025
skin development	GO:0043588	65	0.025	Mouse Worm
imaginal disc pattern formation	GO:0007447	91	0.025	Fly
nucleocytoplasmic transport	GO:0006913	72	0.025	Mouse
developmental growth	GO:0048589	280	0.024
positive regulation of cell death	GO:0010942	69	0.024
regulation of bmp signaling pathway	GO:0030510	23	0.023	Mouse
negative regulation of cell proliferation	GO:0008285	69	0.023	Mouse
positive regulation of cell development	GO:0010720	61	0.023	Mouse Fly
monocarboxylic acid metabolic process	GO:0032787	29	0.023
response to growth factor	GO:0070848	31	0.023
regulation of proteolysis	GO:0030162	87	0.023
regulation of response to dna damage stimulus	GO:2001020	23	0.023	Fly
hematopoietic or lymphoid organ development	GO:0048534	57	0.023	Human Mouse
positive regulation of intracellular signal transduction	GO:1902533	116	0.022	Mouse
protein k48 linked ubiquitination	GO:0070936	3	0.022
response to biotic stimulus	GO:0009607	294	0.022
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.022	Mouse
positive regulation of cell proliferation	GO:0008284	47	0.022	Mouse Fly
single organism cellular localization	GO:1902580	180	0.022	Mouse
embryonic development via the syncytial blastoderm	GO:0001700	148	0.022
dna damage checkpoint	GO:0000077	78	0.022
negative regulation of immune system process	GO:0002683	50	0.021	Human
protein localization to nucleus	GO:0034504	55	0.021	Mouse
tissue morphogenesis	GO:0048729	297	0.021	Mouse
cellular protein complex assembly	GO:0043623	71	0.021
cellular response to growth factor stimulus	GO:0071363	30	0.021
negative regulation of cell cycle	GO:0045786	116	0.021
response to transforming growth factor beta	GO:0071559	18	0.021
single organism catabolic process	GO:0044712	228	0.020
positive regulation of notch signaling pathway	GO:0045747	34	0.020	Mouse
cell division	GO:0051301	248	0.020	Fly
regulation of molecular function	GO:0065009	217	0.020	Mouse
nucleobase containing small molecule metabolic process	GO:0055086	174	0.019
gland morphogenesis	GO:0022612	145	0.019
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.019	Mouse
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.019
regulation of multicellular organismal development	GO:2000026	414	0.019	Human Zebrafish Mouse Fly
intracellular protein transport	GO:0006886	104	0.019	Mouse
positive regulation of ras protein signal transduction	GO:0046579	43	0.019
regulation of mitotic cell cycle	GO:0007346	190	0.019	Mouse Fly
regionalization	GO:0003002	416	0.019	Zebrafish Mouse Worm Fly
regulation of chromatin silencing	GO:0031935	36	0.019
larval behavior	GO:0030537	42	0.019	Fly
ras protein signal transduction	GO:0007265	88	0.019
regulation of immune effector process	GO:0002697	52	0.018
protein deubiquitination	GO:0016579	17	0.018
protein targeting to nucleus	GO:0044744	51	0.018	Mouse
vesicle mediated transport	GO:0016192	381	0.018
regulation of cytoplasmic transport	GO:1903649	47	0.018
microtubule organizing center organization	GO:0031023	168	0.018
cellular component assembly involved in morphogenesis	GO:0010927	151	0.018
protein modification by small protein removal	GO:0070646	28	0.018
regulation of intracellular signal transduction	GO:1902531	236	0.018	Mouse
positive regulation of immune response	GO:0050778	63	0.018
nephron tubule development	GO:0072080	3	0.017	Mouse
regulation of cellular ketone metabolic process	GO:0010565	3	0.017
connective tissue development	GO:0061448	3	0.017
positive regulation of catabolic process	GO:0009896	105	0.017
neurological system process	GO:0050877	358	0.017	Fly
single organism behavior	GO:0044708	391	0.017	Fly
cell death	GO:0008219	279	0.017
mitotic g2 m transition checkpoint	GO:0044818	70	0.017
endomembrane system organization	GO:0010256	119	0.017
smoothened signaling pathway	GO:0007224	49	0.016	Mouse
response to nitrogen compound	GO:1901698	90	0.016
regulation of immune system process	GO:0002682	176	0.016	Human Mouse
negative regulation of gene expression epigenetic	GO:0045814	77	0.016
programmed cell death	GO:0012501	257	0.016
positive regulation of cell motility	GO:2000147	3	0.016
small gtpase mediated signal transduction	GO:0007264	88	0.016
nuclear division	GO:0000280	332	0.016	Fly
regulation of cellular catabolic process	GO:0031329	157	0.015
aromatic compound catabolic process	GO:0019439	166	0.015
immune response regulating signaling pathway	GO:0002764	2	0.015
negative regulation of mitotic cell cycle	GO:0045930	109	0.015
exocrine system development	GO:0035272	162	0.015
apoptotic process	GO:0006915	159	0.015
hematopoietic progenitor cell differentiation	GO:0002244	1	0.015	Human
mitotic cell cycle checkpoint	GO:0007093	88	0.015
gene silencing by rna	GO:0031047	57	0.014
mitotic cell cycle phase transition	GO:0044772	138	0.014
adult behavior	GO:0030534	137	0.014	Fly
positive regulation of cellular protein metabolic process	GO:0032270	118	0.014	Mouse
regulation of transforming growth factor beta receptor signaling pathway	GO:0017015	6	0.014
production of molecular mediator of immune response	GO:0002440	46	0.014
single organism membrane organization	GO:0044802	93	0.014
mesenchymal cell development	GO:0014031	1	0.014	Mouse
immune response	GO:0006955	246	0.014
regulation of apoptotic process	GO:0042981	130	0.014
positive regulation of phosphate metabolic process	GO:0045937	139	0.014	Mouse
appendage development	GO:0048736	401	0.014
cellular response to organic cyclic compound	GO:0071407	32	0.014
regulation of phosphorylation	GO:0042325	147	0.014	Mouse
molting cycle chitin based cuticle	GO:0007591	56	0.013
cellular response to nitrogen compound	GO:1901699	51	0.013
regulation of protein stability	GO:0031647	43	0.013
defense response to gram negative bacterium	GO:0050829	94	0.013
positive regulation of proteolysis	GO:0045862	52	0.013
cell cycle checkpoint	GO:0000075	95	0.013
regulation of cellular amine metabolic process	GO:0033238	3	0.013
cellular nitrogen compound catabolic process	GO:0044270	165	0.013
regulation of vesicle mediated transport	GO:0060627	59	0.013
chromatin modification	GO:0016568	147	0.013
negative regulation of signaling	GO:0023057	219	0.013
regulation of programmed cell death	GO:0043067	152	0.013
cellular response to abiotic stimulus	GO:0071214	58	0.013
peptidyl threonine modification	GO:0018210	3	0.013
cellular response to lipid	GO:0071396	20	0.013
secretion by cell	GO:0032940	101	0.013
mitotic g2 dna damage checkpoint	GO:0007095	69	0.013
humoral immune response	GO:0006959	117	0.013
posttranscriptional gene silencing by rna	GO:0035194	45	0.013
peptidyl amino acid modification	GO:0018193	105	0.013	Mouse
nephron development	GO:0072006	3	0.013	Mouse
regulation of hydrolase activity	GO:0051336	97	0.013
positive regulation of intracellular transport	GO:0032388	42	0.013
positive regulation of phosphorylation	GO:0042327	87	0.012	Mouse
spindle organization	GO:0007051	253	0.012
stem cell proliferation	GO:0072089	88	0.012	Fly
positive regulation of transport	GO:0051050	92	0.012
defense response	GO:0006952	300	0.012
cellular macromolecular complex assembly	GO:0034622	153	0.012
dorsal ventral pattern formation imaginal disc	GO:0007450	51	0.012	Fly
growth	GO:0040007	359	0.012
generation of precursor metabolites and energy	GO:0006091	42	0.012
small molecule biosynthetic process	GO:0044283	37	0.012
salivary gland morphogenesis	GO:0007435	145	0.012
positive regulation of cell migration	GO:0030335	2	0.012
regulation of cellular component biogenesis	GO:0044087	201	0.012
positive regulation of apoptotic process	GO:0043065	47	0.012
response to external biotic stimulus	GO:0043207	293	0.012
response to decreased oxygen levels	GO:0036293	58	0.012
positive regulation of molecular function	GO:0044093	136	0.012	Mouse
mapk cascade	GO:0000165	107	0.012
antimicrobial humoral response	GO:0019730	99	0.012
regulation of cell cycle phase transition	GO:1901987	130	0.012
membrane organization	GO:0061024	112	0.012
anterior posterior pattern specification	GO:0009952	136	0.012	Zebrafish Mouse Worm
renal tubule development	GO:0061326	64	0.012	Mouse
mrna 3 end processing	GO:0031124	28	0.012
imaginal disc derived appendage development	GO:0048737	399	0.012
regulation of nuclear division	GO:0051783	58	0.012	Fly
negative regulation of immune response	GO:0050777	39	0.012
imaginal disc derived wing morphogenesis	GO:0007476	337	0.011
rna processing	GO:0006396	147	0.011
regulation of innate immune response	GO:0045088	71	0.011
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.011
negative regulation of multicellular organismal process	GO:0051241	142	0.011	Human Zebrafish Mouse
negative regulation of cell cycle phase transition	GO:1901988	103	0.011
gene silencing by mirna	GO:0035195	22	0.011
regulation of steroid metabolic process	GO:0019218	2	0.011
cell cycle phase transition	GO:0044770	140	0.011
protein import into nucleus	GO:0006606	51	0.011	Mouse
negative regulation of intracellular signal transduction	GO:1902532	57	0.011
imaginal disc derived wing vein morphogenesis	GO:0008586	44	0.011
regulation of defense response	GO:0031347	102	0.011
protein phosphorylation	GO:0006468	169	0.011	Mouse
homeostatic process	GO:0042592	199	0.011
epidermis development	GO:0008544	65	0.011	Mouse Worm
tyrosine phosphorylation of stat protein	GO:0007260	1	0.011	Mouse
regulation of protein complex assembly	GO:0043254	42	0.011
regulation of nucleocytoplasmic transport	GO:0046822	35	0.010
protein targeting	GO:0006605	64	0.010	Mouse
positive regulation of cellular catabolic process	GO:0031331	95	0.010
single organism membrane fusion	GO:0044801	42	0.010
regulation of mrna metabolic process	GO:1903311	72	0.010
circadian rhythm	GO:0007623	105	0.010
positive regulation of developmental process	GO:0051094	143	0.010	Mouse Fly
nucleoside phosphate metabolic process	GO:0006753	162	0.010

h disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.026
disease of metabolism	DOID:0014667	0.014
inherited metabolic disorder	DOID:655	0.014

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