Drosophila melanogaster

60 known processes

Sirt2 (Dmel_CG5085)

CG5085 gene product from transcript CG5085-RA

(Aliases: dSIRT2,D.mel2,Dmel\CG5085,CG5085)

Sirt2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
positive regulation of nitrogen compound metabolic processGO:00511733540.107
organic substance catabolic processGO:19015753080.092
cellular protein modification processGO:00064644380.085
protein modification processGO:00362114380.071
small molecule metabolic processGO:00442813050.070
anterior posterior pattern specificationGO:00099521360.069
epithelial cell developmentGO:00020642740.066
columnar cuboidal epithelial cell developmentGO:00020662490.063
mitotic cell cycle phase transitionGO:00447721380.063
establishment of localization in cellGO:00516494020.057
Rat
positive regulation of cellular biosynthetic processGO:00313283160.057
organelle fissionGO:00482853400.054
protein modification by small protein conjugation or removalGO:00706471060.050
regulation of cell cycle phase transitionGO:19019871300.049
positive regulation of lipid catabolic processGO:005099610.048
catabolic processGO:00090564090.047
response to oxygen containing compoundGO:19017002000.046
regionalizationGO:00030024160.044
positive regulation of catabolic processGO:00098961050.043
locomotory behaviorGO:00076261760.042
developmental growthGO:00485892800.041
response to abiotic stimulusGO:00096283410.041
negative regulation of mitotic cell cycleGO:00459301090.041
cellular macromolecule catabolic processGO:00442651360.039
regulation of protein metabolic processGO:00512462560.038
cell migrationGO:00164772380.038
ion transportGO:00068111450.038
positive regulation of biosynthetic processGO:00098913160.037
blastoderm segmentationGO:00073501590.037
cellular catabolic processGO:00442483720.036
mitotic g2 m transition checkpointGO:0044818700.036
compound eye morphogenesisGO:00017452490.036
regulation of catalytic activityGO:00507901850.036
localization of cellGO:00516742570.036
regulation of cell cycle processGO:00105641810.035
negative regulation of cell cycle phase transitionGO:19019881030.035
programmed cell deathGO:00125012570.034
Rat
regulation of localizationGO:00328792750.034
Rat
tripartite regional subdivisionGO:00073511030.033
nuclear divisionGO:00002803320.033
regulation of phosphorylationGO:00423251470.033
Rat
positive regulation of rna biosynthetic processGO:19026802660.032
single organism intracellular transportGO:19025822070.032
positive regulation of rna metabolic processGO:00512542710.031
covalent chromatin modificationGO:00165691060.031
regulation of mitotic cell cycleGO:00073461900.031
negative regulation of cell cycle processGO:00109481090.031
regulation of mitotic cell cycle phase transitionGO:19019901300.030
cell motilityGO:00488702510.030
positive regulation of transcription from rna polymerase ii promoterGO:00459442040.029
jak stat cascadeGO:0007259490.029
developmental maturationGO:00217001720.029
negative regulation of transcription dna templatedGO:00458922370.027
organelle assemblyGO:00709251980.027
columnar cuboidal epithelial cell differentiationGO:00020652560.027
positive regulation of macromolecule biosynthetic processGO:00105572830.027
regulation of cellular amino acid metabolic processGO:000652100.026
positive regulation of gene expressionGO:00106282900.025
negative regulation of macromolecule biosynthetic processGO:00105582700.025
cilium organizationGO:0044782410.025
protein modification by small protein conjugationGO:0032446790.025
regulation of anatomical structure sizeGO:00900661630.025
growthGO:00400073590.025
chromatin remodelingGO:0006338720.025
axis specificationGO:00097981670.025
wing disc morphogenesisGO:00074723440.025
cell cycle phase transitionGO:00447701400.025
dna damage checkpointGO:0000077780.025
segmentationGO:00352822070.025
cellular response to chemical stimulusGO:00708871990.024
modification dependent macromolecule catabolic processGO:0043632790.024
vesicle mediated transportGO:00161923810.024
response to organic substanceGO:00100332840.024
positive regulation of nucleic acid templated transcriptionGO:19035082660.024
phagocytosisGO:00069092150.024
regulation of cellular protein metabolic processGO:00322682430.024
taxisGO:00423303040.024
regulation of cell cycleGO:00517262910.023
respiratory system developmentGO:00605412130.023
anterior posterior axis specificationGO:00099481090.023
regulation of neuron differentiationGO:00456641030.023
positive regulation of macromolecule metabolic processGO:00106044050.023
regulation of nurse cell apoptotic processGO:004547790.023
telencephalon developmentGO:002153720.023
chromatin modificationGO:00165681470.023
ovarian follicle cell developmentGO:00307072480.023
learning or memoryGO:00076111410.022
macromolecule catabolic processGO:00090571610.022
proteolysisGO:00065081920.022
endocytosisGO:00068973100.022
embryonic axis specificationGO:00005781070.022
regulation of molecular functionGO:00650092170.022
regulation of cellular amine metabolic processGO:003323830.022
cellular response to organic substanceGO:00713101320.022
phosphorylationGO:00163102940.022
Rat
modification dependent protein catabolic processGO:0019941780.022
regulation of cell deathGO:00109411730.022
Rat
negative regulation of developmental processGO:00510932010.021
Rat
regulation of catabolic processGO:00098941700.021
negative regulation of g2 m transition of mitotic cell cycleGO:001097280.021
single organism behaviorGO:00447083910.021
regulation of nervous system developmentGO:00519602480.021
Rat
negative regulation of gene expressionGO:00106293870.021
female meiotic divisionGO:0007143700.021
organonitrogen compound metabolic processGO:19015643180.021
embryonic pattern specificationGO:00098801740.020
mitotic cell cycle embryonicGO:0045448380.020
positive regulation of transcription dna templatedGO:00458932660.020
negative regulation of nitrogen compound metabolic processGO:00511722650.020
transcription from rna polymerase ii promoterGO:00063663680.020
epithelial cell migrationGO:00106311480.020
regulation of transcription from rna polymerase ii promoterGO:00063573780.020
axon developmentGO:00615642970.020
transmembrane transportGO:00550851390.020
protein ubiquitinationGO:0016567700.020
regulation of neurogenesisGO:00507671580.019
Rat
regulation of immune system processGO:00026821760.019
protein catabolic processGO:00301631010.019
adult locomotory behaviorGO:0008344760.019
positive regulation of nucleobase containing compound metabolic processGO:00459353320.019
regulation of cellular catabolic processGO:00313291570.019
immune response regulating signaling pathwayGO:000276420.019
regulation of phosphate metabolic processGO:00192202100.019
Rat
positive regulation of signal transductionGO:00099672230.019
gtp catabolic processGO:0006184720.018
mitotic g2 dna damage checkpointGO:0007095690.018
negative regulation of cellular macromolecule biosynthetic processGO:20001132670.018
proteolysis involved in cellular protein catabolic processGO:0051603830.018
mitotic dna damage checkpointGO:0044773740.018
meiotic cell cycle processGO:19030461320.018
single organism membrane organizationGO:0044802930.018
forebrain developmentGO:003090020.018
spermatogenesisGO:00072832000.018
positive regulation of response to stimulusGO:00485843230.018
amine metabolic processGO:0009308120.017
regulation of multi organism processGO:00439001310.017
epithelial cell differentiationGO:00308553220.017
regulation of cell sizeGO:0008361630.017
microtubule based movementGO:0007018510.017
negative regulation of nucleobase containing compound metabolic processGO:00459342610.017
g2 dna damage checkpointGO:0031572690.017
ubiquitin dependent protein catabolic processGO:0006511780.016
peptide metabolic processGO:0006518800.016
positive regulation of cell motilityGO:200014730.016
negative regulation of mitotic cell cycle phase transitionGO:19019911030.016
response to woundingGO:0009611940.016
central nervous system developmentGO:00074172010.016
Rat
antimicrobial humoral responseGO:0019730990.016
organonitrogen compound catabolic processGO:19015651280.016
adult behaviorGO:00305341370.016
cation transportGO:00068121100.016
gene silencingGO:00164581380.016
synaptic transmissionGO:00072682880.016
positive regulation of phosphorus metabolic processGO:00105621390.016
intracellular protein transmembrane transportGO:006500240.015
imaginal disc derived wing morphogenesisGO:00074763370.015
chromatin organizationGO:00063252070.015
sex differentiationGO:0007548810.015
negative regulation of cellular metabolic processGO:00313243820.015
Rat
small gtpase mediated signal transductionGO:0007264880.015
positive regulation of signalingGO:00230562430.015
Rat
regulation of protein modification processGO:00313991120.015
negative regulation of rna metabolic processGO:00512532510.015
camera type eye morphogenesisGO:004859320.015
aromatic compound catabolic processGO:00194391660.015
eye developmentGO:00016543230.014
regulation of protein modification by small protein conjugation or removalGO:1903320250.014
cellular nitrogen compound catabolic processGO:00442701650.014
acylglycerol catabolic processGO:004646430.014
establishment of protein localizationGO:00451841630.014
developmental programmed cell deathGO:00106231380.014
protein localizationGO:00081042840.014
protein phosphorylationGO:00064681690.014
cellular protein catabolic processGO:0044257830.014
gliogenesisGO:0042063800.013
Rat
single organism biosynthetic processGO:00447112060.013
protein modification by small protein removalGO:0070646280.013
organic cyclic compound catabolic processGO:19013611680.013
signal transduction by phosphorylationGO:00230141070.013
Rat
tissue migrationGO:00901301550.013
negative regulation of cell differentiationGO:00455961430.013
Rat
regulation of phosphorus metabolic processGO:00511742100.013
Rat
anterior posterior axis specification embryoGO:00085951030.013
eye photoreceptor cell differentiationGO:00017541450.013
positive regulation of cell communicationGO:00106472500.013
Rat
regulation of cellular component sizeGO:0032535980.013
male gamete generationGO:00482322010.013
positive regulation of cell deathGO:0010942690.013
negative regulation of protein metabolic processGO:0051248850.013
apoptotic processGO:00069151590.013
Rat
cell cycle comprising mitosis without cytokinesisGO:0033301250.013
positive regulation of developmental processGO:00510941430.013
heterocycle catabolic processGO:00467001660.013
inositol lipid mediated signalingGO:004801740.013
negative regulation of cell cycleGO:00457861160.013
glycerolipid catabolic processGO:004650330.013
response to endogenous stimulusGO:00097191190.013
positive regulation of phosphorylationGO:0042327870.012
dna integrity checkpointGO:0031570810.012
chromosome segregationGO:00070591570.012
cellular amine metabolic processGO:0044106120.012
circulatory system processGO:0003013370.012
head developmentGO:00603221350.012
intracellular signal transductionGO:00355563000.012
Rat
positive regulation of programmed cell deathGO:0043068620.012
cilium assemblyGO:0042384380.012
organophosphate metabolic processGO:00196371950.012
imaginal disc derived appendage morphogenesisGO:00351143950.012
organonitrogen compound biosynthetic processGO:19015661170.012
peroxisome organizationGO:0007031140.012
compound eye photoreceptor cell differentiationGO:00017511400.012
posttranscriptional regulation of gene expressionGO:00106081450.012
brain developmentGO:00074201200.012
response to peptide hormoneGO:0043434290.012
dna replication checkpointGO:000007680.012
translationGO:0006412690.011
positive regulation of lipid metabolic processGO:004583440.011
response to lipopolysaccharideGO:003249640.011
regulation of cell proliferationGO:00421271630.011
Rat
neurological system processGO:00508773580.011
Rat
mitotic dna integrity checkpointGO:0044774750.011
positive regulation of cell migrationGO:003033520.011
negative regulation of multicellular organismal processGO:00512411420.011
Rat
monocarboxylic acid transportGO:001571830.011
organophosphate catabolic processGO:00464341120.011
regulation of nucleotide metabolic processGO:0006140620.011
positive regulation of cellular amine metabolic processGO:003324000.011
memoryGO:0007613940.011
larval developmentGO:00021641040.011
camera type eye developmentGO:004301040.011
morphogenesis of an epitheliumGO:00020092760.011
cell agingGO:000756920.011
response to endoplasmic reticulum stressGO:0034976280.011
appendage developmentGO:00487364010.011
positive regulation of catalytic activityGO:00430851180.011
post embryonic appendage morphogenesisGO:00351203850.011
regulation of lipid transportGO:003236830.011
cellularizationGO:0007349900.011
cognitionGO:00508901410.011
carbohydrate derivative biosynthetic processGO:1901137850.011
positive regulation of molecular functionGO:00440931360.011
negative regulation of cell cycle g2 m phase transitionGO:190275080.011
negative regulation of cellular component organizationGO:00511291080.011
regulation of cell differentiationGO:00455953020.011
Rat
cell growthGO:00160491080.011
ion transmembrane transportGO:00342201220.011
regulation of intracellular signal transductionGO:19025312360.011
Rat
response to nitrogen compoundGO:1901698900.010
regulation of autophagyGO:0010506620.010
heart contractionGO:0060047260.010
negative regulation of cellular biosynthetic processGO:00313272770.010
immune response activating signal transductionGO:000275720.010
eggshell formationGO:00307031050.010
syncytial blastoderm mitotic cell cycleGO:0035186210.010
purine ribonucleoside triphosphate metabolic processGO:00092051190.010
negative regulation of rna biosynthetic processGO:19026792400.010
protein transportGO:00150311550.010
axon guidanceGO:00074112330.010
regulation of protein catabolic processGO:0042176550.010
photoreceptor cell differentiationGO:00465301700.010

Sirt2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.058
nervous system diseaseDOID:86300.038
carbohydrate metabolism diseaseDOID:005001300.025
acquired metabolic diseaseDOID:006015800.025
glucose metabolism diseaseDOID:419400.025
disease of metabolismDOID:001466700.025
diabetes mellitusDOID:935100.025
disease of cellular proliferationDOID:1456600.022
cancerDOID:16200.022
central nervous system diseaseDOID:33100.014
neurodegenerative diseaseDOID:128900.014
organ system cancerDOID:005068600.011
thoracic cancerDOID:509300.011
eye diseaseDOID:561400.011
eye and adnexa diseaseDOID:149200.011
sensory system diseaseDOID:005015500.011