IMP: Integrative Multi-species Prediction

Drosophila melanogaster

162 known processes

Mcm10 (Dmel_CG9241)

Sensitized chromosome inheritance modifier 19

(Aliases: CG9241,mcm10,Dmel\CG9241,Scim19,DmMCM10)

Entrez: 35390
FLYBASE: FBgn0032929
UniProtKB: Q9VIE6

Process Predictions
Disease Predictions

Mcm10 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

Filter by process size:

Biological process	GO term ID	Process size	Probability
chromosome organization	GO:0051276	360	0.999
mitotic sister chromatid segregation	GO:0000070	87	0.990
chromosome segregation	GO:0007059	157	0.892
mitotic sister chromatid separation	GO:0051306	30	0.835
regulation of mitotic sister chromatid segregation	GO:0033047	28	0.819
sister chromatid segregation	GO:0000819	92	0.819
dna metabolic process	GO:0006259	227	0.815
nuclear dna replication	GO:0033260	1	0.810
nuclear division	GO:0000280	332	0.770
regulation of metaphase anaphase transition of cell cycle	GO:1902099	26	0.757
dna conformation change	GO:0071103	105	0.734
cell cycle phase transition	GO:0044770	140	0.732
regulation of mitotic cell cycle	GO:0007346	190	0.697
dna endoreduplication	GO:0042023	22	0.680
negative regulation of cellular metabolic process	GO:0031324	382	0.664
mitotic nuclear division	GO:0007067	213	0.646
chromatin organization	GO:0006325	207	0.561
metaphase anaphase transition of cell cycle	GO:0044784	28	0.555
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.549
mitotic cell cycle phase transition	GO:0044772	138	0.543
organelle fission	GO:0048285	340	0.533
positive regulation of metaphase anaphase transition of cell cycle	GO:1902101	10	0.530
regulation of mitotic sister chromatid separation	GO:0010965	28	0.509
covalent chromatin modification	GO:0016569	106	0.476
regulation of cellular catabolic process	GO:0031329	157	0.475
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.466
cell cycle dna replication	GO:0044786	23	0.457
eye morphogenesis	GO:0048592	260	0.454
dna packaging	GO:0006323	91	0.446
regulation of sister chromatid segregation	GO:0033045	28	0.437
eggshell chorion gene amplification	GO:0007307	9	0.425
dna amplification	GO:0006277	11	0.394
chromosome separation	GO:0051304	42	0.370
regulation of mitotic metaphase anaphase transition	GO:0030071	26	0.367
gene silencing	GO:0016458	138	0.358
dna replication	GO:0006260	48	0.315
cell cycle checkpoint	GO:0000075	95	0.314
cellular response to dna damage stimulus	GO:0006974	223	0.292
meiotic chromosome segregation	GO:0045132	59	0.285
regulation of chromosome segregation	GO:0051983	32	0.280
positive regulation of mitotic sister chromatid separation	GO:1901970	10	0.272
negative regulation of biosynthetic process	GO:0009890	277	0.261
mitotic cell cycle checkpoint	GO:0007093	88	0.255
chromosome condensation	GO:0030261	41	0.229
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.224
meiotic nuclear division	GO:0007126	151	0.222
regulation of catabolic process	GO:0009894	170	0.219
chromatin modification	GO:0016568	147	0.212
regulation of cell cycle process	GO:0010564	181	0.211
metaphase anaphase transition of mitotic cell cycle	GO:0007091	28	0.200
recombinational repair	GO:0000725	13	0.179
negative regulation of cell cycle process	GO:0010948	109	0.175
negative regulation of mitotic cell cycle	GO:0045930	109	0.174
regulation of proteasomal protein catabolic process	GO:0061136	39	0.170
protein dna complex assembly	GO:0065004	63	0.164
centrosome cycle	GO:0007098	137	0.161
regulation of chromosome organization	GO:0033044	64	0.157
regulation of gene expression epigenetic	GO:0040029	128	0.154
negative regulation of gene expression	GO:0010629	387	0.152
regulation of proteolysis	GO:0030162	87	0.151
mitotic chromosome condensation	GO:0007076	22	0.151
spindle organization	GO:0007051	253	0.147
positive regulation of dna endoreduplication	GO:0032877	4	0.132
positive regulation of proteolysis	GO:0045862	52	0.127
compound eye morphogenesis	GO:0001745	249	0.126
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.125
proteasomal protein catabolic process	GO:0010498	59	0.120
small molecule metabolic process	GO:0044281	305	0.119
positive regulation of cell cycle	GO:0045787	43	0.116
single organism biosynthetic process	GO:0044711	206	0.113
regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032434	37	0.112
cellular catabolic process	GO:0044248	372	0.112
positive regulation of mitotic metaphase anaphase transition	GO:0045842	10	0.111
regulation of proteolysis involved in cellular protein catabolic process	GO:1903050	44	0.111
negative regulation of mitotic sister chromatid separation	GO:2000816	13	0.108
negative regulation of mitotic sister chromatid segregation	GO:0033048	13	0.105
regulation of nuclear division	GO:0051783	58	0.097
chromatin remodeling	GO:0006338	72	0.096
nucleosome organization	GO:0034728	59	0.092
negative regulation of cellular biosynthetic process	GO:0031327	277	0.087
dna replication initiation	GO:0006270	6	0.087
notch signaling pathway	GO:0007219	120	0.084
posttranscriptional gene silencing by rna	GO:0035194	45	0.083
negative regulation of cellular protein metabolic process	GO:0032269	85	0.080
regulation of cell cycle phase transition	GO:1901987	130	0.076
cellular protein catabolic process	GO:0044257	83	0.076
mitotic metaphase plate congression	GO:0007080	13	0.074
posttranscriptional regulation of gene expression	GO:0010608	145	0.074
mitotic spindle organization	GO:0007052	220	0.074
regulation of phosphate metabolic process	GO:0019220	210	0.073
developmental growth	GO:0048589	280	0.073
centrosome duplication	GO:0051298	121	0.072
regulation of neuron differentiation	GO:0045664	103	0.070
regulation of cellular protein catabolic process	GO:1903362	44	0.069
nucleosome assembly	GO:0006334	35	0.068
double strand break repair	GO:0006302	26	0.067
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.067
ras protein signal transduction	GO:0007265	88	0.066
regulation of g1 s transition of mitotic cell cycle	GO:2000045	23	0.066
phosphorylation	GO:0016310	294	0.065
regulation of cell cycle	GO:0051726	291	0.064
positive regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032436	19	0.063
spindle checkpoint	GO:0031577	11	0.061
glial cell differentiation	GO:0010001	35	0.060
positive regulation of cellular catabolic process	GO:0031331	95	0.059
mitotic cell cycle embryonic	GO:0045448	38	0.058
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.058
organonitrogen compound metabolic process	GO:1901564	318	0.058
body morphogenesis	GO:0010171	2	0.058
cellular protein modification process	GO:0006464	438	0.058
regulation of mitosis	GO:0007088	56	0.057
dna geometric change	GO:0032392	16	0.056
positive regulation of macromolecule metabolic process	GO:0010604	405	0.056
response to temperature stimulus	GO:0009266	106	0.054
heterochromatin organization	GO:0070828	25	0.054
establishment of organelle localization	GO:0051656	122	0.053
regulation of meiosis	GO:0040020	3	0.053
mitotic spindle assembly checkpoint	GO:0007094	11	0.053
spindle assembly checkpoint	GO:0071173	11	0.053
peptidyl amino acid modification	GO:0018193	105	0.052
dna dependent dna replication	GO:0006261	17	0.051
regulation of protein catabolic process	GO:0042176	55	0.051
maintenance of location	GO:0051235	73	0.051
regulation of microtubule cytoskeleton organization	GO:0070507	41	0.051
epithelial cell differentiation	GO:0030855	322	0.051
negative regulation of cell cycle phase transition	GO:1901988	103	0.051
compound eye development	GO:0048749	307	0.050
negative regulation of neurogenesis	GO:0050768	53	0.049
positive regulation of multicellular organismal process	GO:0051240	143	0.048
protein phosphorylation	GO:0006468	169	0.048
regulation of photoreceptor cell differentiation	GO:0046532	34	0.047
organic substance catabolic process	GO:1901575	308	0.045
histone modification	GO:0016570	106	0.044
protein modification process	GO:0036211	438	0.043
regulation of developmental growth	GO:0048638	174	0.043
eye development	GO:0001654	323	0.043
dna duplex unwinding	GO:0032508	16	0.043
sensory organ morphogenesis	GO:0090596	260	0.042
negative regulation of chromosome segregation	GO:0051985	14	0.042
lymph gland development	GO:0048542	28	0.042
nucleoside phosphate metabolic process	GO:0006753	162	0.042
regulation of dna replication	GO:0006275	13	0.041
ribonucleoside metabolic process	GO:0009119	127	0.041
posttranscriptional gene silencing	GO:0016441	46	0.041
somatic stem cell division	GO:0048103	37	0.041
gliogenesis	GO:0042063	80	0.040
carbohydrate derivative metabolic process	GO:1901135	217	0.040
digestive system development	GO:0055123	149	0.040
positive regulation of mitotic cell cycle	GO:0045931	34	0.039
negative regulation of protein metabolic process	GO:0051248	85	0.038
cell proliferation	GO:0008283	299	0.038
innate immune response	GO:0045087	144	0.038
cell division	GO:0051301	248	0.037
single organism catabolic process	GO:0044712	228	0.037
proteolysis	GO:0006508	192	0.037
regulation of sister chromatid cohesion	GO:0007063	2	0.037
telomere capping	GO:0016233	11	0.036
purine containing compound metabolic process	GO:0072521	155	0.036
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.036
purine nucleotide metabolic process	GO:0006163	146	0.035
positive regulation of nucleotide metabolic process	GO:0045981	55	0.035
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.035
negative regulation of multicellular organismal process	GO:0051241	142	0.035
positive regulation of catabolic process	GO:0009896	105	0.034
chromatin silencing	GO:0006342	76	0.034
nucleolus organization	GO:0007000	4	0.034
ubiquitin dependent protein catabolic process	GO:0006511	78	0.034
multicellular organism growth	GO:0035264	46	0.034
regulation of lipid metabolic process	GO:0019216	15	0.033
regulation of apoptotic process	GO:0042981	130	0.033
negative regulation of sister chromatid segregation	GO:0033046	13	0.033
endomitotic cell cycle	GO:0007113	7	0.032
positive regulation of nucleotide catabolic process	GO:0030813	46	0.032
intracellular signal transduction	GO:0035556	300	0.032
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	54	0.032
regulation of protein metabolic process	GO:0051246	256	0.032
mitotic dna damage checkpoint	GO:0044773	74	0.031
asymmetric stem cell division	GO:0098722	49	0.031
protein maturation	GO:0051604	71	0.031
ribonucleotide metabolic process	GO:0009259	145	0.031
mitotic spindle checkpoint	GO:0071174	11	0.031
small gtpase mediated signal transduction	GO:0007264	88	0.031
positive regulation of hydrolase activity	GO:0051345	78	0.030
catabolic process	GO:0009056	409	0.030
positive regulation of response to stimulus	GO:0048584	323	0.029
positive regulation of signal transduction	GO:0009967	223	0.028
microtubule organizing center organization	GO:0031023	168	0.027
response to biotic stimulus	GO:0009607	294	0.027
ribose phosphate metabolic process	GO:0019693	145	0.027
purine nucleoside metabolic process	GO:0042278	127	0.027
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.027
organophosphate metabolic process	GO:0019637	195	0.027
purine ribonucleotide metabolic process	GO:0009150	145	0.027
positive regulation of neurogenesis	GO:0050769	41	0.027
purine ribonucleotide catabolic process	GO:0009154	109	0.027
female meiotic division	GO:0007143	70	0.026
female meiosis chromosome segregation	GO:0016321	33	0.026
regulation of gene silencing	GO:0060968	63	0.026
larval development	GO:0002164	104	0.026
karyosome formation	GO:0030717	22	0.026
dna damage checkpoint	GO:0000077	78	0.026
histone methylation	GO:0016571	40	0.025
telomere organization	GO:0032200	21	0.025
lateral inhibition	GO:0046331	206	0.025
double strand break repair via homologous recombination	GO:0000724	13	0.025
epithelial cell development	GO:0002064	274	0.025
nucleobase containing compound catabolic process	GO:0034655	165	0.025
endomembrane system organization	GO:0010256	119	0.024
positive regulation of organelle organization	GO:0010638	65	0.024
homeostatic process	GO:0042592	199	0.024
nucleoside catabolic process	GO:0009164	112	0.024
negative regulation of cellular catabolic process	GO:0031330	34	0.024
purine ribonucleoside metabolic process	GO:0046128	127	0.024
regulation of catalytic activity	GO:0050790	185	0.024
negative regulation of catabolic process	GO:0009895	36	0.024
purine containing compound catabolic process	GO:0072523	112	0.023
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.023
positive regulation of protein metabolic process	GO:0051247	128	0.023
regulation of hydrolase activity	GO:0051336	97	0.023
muscle organ development	GO:0007517	127	0.023
purine nucleoside catabolic process	GO:0006152	112	0.022
cellular macromolecule catabolic process	GO:0044265	136	0.022
regulation of chromatin silencing	GO:0031935	36	0.022
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.022
cell motility	GO:0048870	251	0.022
negative regulation of cell cycle	GO:0045786	116	0.022
nucleoside triphosphate metabolic process	GO:0009141	120	0.022
positive regulation of phosphorus metabolic process	GO:0010562	139	0.022
cell fate determination	GO:0001709	91	0.022
aromatic compound catabolic process	GO:0019439	166	0.022
dna integrity checkpoint	GO:0031570	81	0.021
kinetochore organization	GO:0051383	9	0.021
mesoderm development	GO:0007498	78	0.021
fatty acid homeostasis	GO:0055089	2	0.021
regulation of cellular protein metabolic process	GO:0032268	243	0.021
regulation of multicellular organismal development	GO:2000026	414	0.021
nucleoside metabolic process	GO:0009116	127	0.021
negative regulation of chromosome organization	GO:2001251	19	0.021
spindle assembly	GO:0051225	80	0.021
columnar cuboidal epithelial cell development	GO:0002066	249	0.021
regulation of neurogenesis	GO:0050767	158	0.020
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process	GO:0031145	30	0.020
regulation of cell death	GO:0010941	173	0.020
positive regulation of chromosome segregation	GO:0051984	10	0.020
negative regulation of transcription dna templated	GO:0045892	237	0.020
negative regulation of signal transduction	GO:0009968	206	0.020
female germ line stem cell asymmetric division	GO:0048132	14	0.020
response to external biotic stimulus	GO:0043207	293	0.020
ribonucleotide catabolic process	GO:0009261	109	0.020
nucleosome mobilization	GO:0042766	9	0.020
positive regulation of mitotic cell cycle phase transition	GO:1901992	20	0.019
ribonucleoside catabolic process	GO:0042454	112	0.019
photoreceptor cell differentiation	GO:0046530	170	0.019
positive regulation of nucleoside metabolic process	GO:0045979	47	0.019
heterocycle catabolic process	GO:0046700	166	0.018
regulation of phosphorus metabolic process	GO:0051174	210	0.018
establishment of localization in cell	GO:0051649	402	0.018
regulation of cell development	GO:0060284	215	0.018
sensory organ precursor cell division	GO:0045035	10	0.018
organ growth	GO:0035265	56	0.018
carbohydrate derivative catabolic process	GO:1901136	118	0.018
organic cyclic compound catabolic process	GO:1901361	168	0.017
macromolecular complex assembly	GO:0065003	256	0.017
atp metabolic process	GO:0046034	49	0.017
glial cell development	GO:0021782	27	0.017
positive regulation of phosphate metabolic process	GO:0045937	139	0.017
regulation of localization	GO:0032879	275	0.017
meiotic cell cycle	GO:0051321	171	0.017
heterochromatin assembly	GO:0031507	13	0.017
regulation of growth	GO:0040008	233	0.017
organonitrogen compound catabolic process	GO:1901565	128	0.017
negative regulation of organelle organization	GO:0010639	56	0.017
regulation of nucleotide metabolic process	GO:0006140	62	0.017
protein dna complex subunit organization	GO:0071824	86	0.016
regulation of cell proliferation	GO:0042127	163	0.016
regulation of protein processing	GO:0070613	32	0.016
nuclear migration	GO:0007097	20	0.016
glycosyl compound catabolic process	GO:1901658	112	0.016
regulation of hemocyte proliferation	GO:0035206	37	0.016
nucleobase containing small molecule metabolic process	GO:0055086	174	0.015
positive regulation of growth	GO:0045927	75	0.015
positive regulation of cell proliferation	GO:0008284	47	0.015
nucleoside monophosphate metabolic process	GO:0009123	52	0.015
negative regulation of mitotic metaphase anaphase transition	GO:0045841	13	0.015
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.015
axon development	GO:0061564	297	0.015
positive regulation of proteolysis involved in cellular protein catabolic process	GO:1903052	24	0.015
positive regulation of cell development	GO:0010720	61	0.015
mitotic sister chromatid cohesion	GO:0007064	6	0.015
response to organophosphorus	GO:0046683	2	0.015
protein catabolic process	GO:0030163	101	0.014
nucleotide metabolic process	GO:0009117	161	0.014
response to heat	GO:0009408	63	0.014
regulation of ras protein signal transduction	GO:0046578	93	0.014
eye photoreceptor cell differentiation	GO:0001754	145	0.014
neural precursor cell proliferation	GO:0061351	75	0.014
regulation of cell size	GO:0008361	63	0.014
protein modification by small protein conjugation	GO:0032446	79	0.014
carboxylic acid metabolic process	GO:0019752	92	0.014
protein complex biogenesis	GO:0070271	201	0.014
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.014
protein import into nucleus	GO:0006606	51	0.014
positive regulation of cysteine type endopeptidase activity	GO:2001056	24	0.014
positive regulation of molecular function	GO:0044093	136	0.014
modification dependent macromolecule catabolic process	GO:0043632	79	0.014
regulation of purine nucleotide catabolic process	GO:0033121	48	0.014
localization of cell	GO:0051674	257	0.014
chromatin maintenance	GO:0070827	2	0.013
regulation of cell cycle g1 s phase transition	GO:1902806	23	0.013
nucleoside phosphate catabolic process	GO:1901292	110	0.013
wnt signaling pathway	GO:0016055	98	0.013
mitotic cytokinesis	GO:0000281	50	0.013
negative regulation of mitosis	GO:0045839	16	0.013
regulation of centrosome cycle	GO:0046605	7	0.013
positive regulation of cellular biosynthetic process	GO:0031328	316	0.013
macromolecule catabolic process	GO:0009057	161	0.013
negative regulation of cellular component organization	GO:0051129	108	0.013
nucleotide catabolic process	GO:0009166	109	0.013
actin filament based process	GO:0030029	220	0.013
negative regulation of protein modification process	GO:0031400	29	0.013
dephosphorylation	GO:0016311	51	0.013
regulation of organelle organization	GO:0033043	196	0.013
spermatogenesis	GO:0007283	200	0.013
regulation of purine nucleotide metabolic process	GO:1900542	62	0.012
regulation of dna metabolic process	GO:0051052	34	0.012
modification dependent protein catabolic process	GO:0019941	78	0.012
regulation of nucleotide catabolic process	GO:0030811	48	0.012
single organism nuclear import	GO:1902593	51	0.012
positive regulation of cellular protein metabolic process	GO:0032270	118	0.012
regulation of cytoskeleton organization	GO:0051493	89	0.012
negative regulation of rna metabolic process	GO:0051253	251	0.012
imaginal disc growth	GO:0007446	37	0.012
appendage morphogenesis	GO:0035107	397	0.012
gene silencing by rna	GO:0031047	57	0.012
negative regulation of programmed cell death	GO:0043069	72	0.012
negative regulation of developmental process	GO:0051093	201	0.012
gtp catabolic process	GO:0006184	72	0.011
nucleosome positioning	GO:0016584	3	0.011
signal release	GO:0023061	49	0.011
protein complex assembly	GO:0006461	200	0.011
cystoblast division	GO:0007282	10	0.011
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.011
spindle assembly involved in mitosis	GO:0090307	50	0.011
positive regulation of cell communication	GO:0010647	250	0.011
cell aging	GO:0007569	2	0.011
positive regulation of proteasomal protein catabolic process	GO:1901800	20	0.011
regulation of transcription by chromatin organization	GO:0034401	3	0.011
cell cycle comprising mitosis without cytokinesis	GO:0033301	25	0.011
negative regulation of cell division	GO:0051782	17	0.011
glial cell migration	GO:0008347	31	0.011
chemical homeostasis	GO:0048878	92	0.011
g1 s transition of mitotic cell cycle	GO:0000082	31	0.011
negative regulation of neuron differentiation	GO:0045665	16	0.011
regulation of protein stability	GO:0031647	43	0.011
methylation	GO:0032259	47	0.011
response to other organism	GO:0051707	293	0.011
positive regulation of cellular protein catabolic process	GO:1903364	24	0.010
camera type eye morphogenesis	GO:0048593	2	0.010
stem cell differentiation	GO:0048863	117	0.010
regulation of cysteine type endopeptidase activity	GO:2000116	27	0.010
synaptic vesicle recycling	GO:0036465	28	0.010
g2 m transition of mitotic cell cycle	GO:0000086	19	0.010
organic acid metabolic process	GO:0006082	103	0.010
histone lysine methylation	GO:0034968	32	0.010
ion homeostasis	GO:0050801	55	0.010
dna recombination	GO:0006310	32	0.010

Mcm10 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of cellular proliferation	DOID:14566	0.019
disease of anatomical entity	DOID:7	0.019
cancer	DOID:162	0.011
organ system cancer	DOID:0050686	0.011
musculoskeletal system cancer	DOID:0060100	0.011

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