Drosophila melanogaster

226 known processes

Nc (Dmel_CG8091)

Nedd2-like caspase

(Aliases: Nc\Dronc,dronc,caspase-9,anon-EST:GressD6,anon-EST:GreesD6,Dronc/Casp9,anon-WO0118547.313,Dronc,CG8091,CG8090,Dmel\CG8091,DRONC)

Nc biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
positive regulation of endopeptidase activityGO:0010950260.856
humoral immune responseGO:00069591170.785
Fly
positive regulation of cysteine type endopeptidase activityGO:2001056240.736
tissue deathGO:00162711020.629
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043281250.626
regulation of retinal cell programmed cell deathGO:0046668180.620
developmental programmed cell deathGO:00106231380.610
histolysisGO:00075591020.537
sperm individualizationGO:0007291480.514
male gamete generationGO:00482322010.507
positive regulation of peptidase activityGO:0010952290.490
spermatogenesisGO:00072832000.480
positive regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043280230.479
salivary gland developmentGO:00074311620.476
defense responseGO:00069523000.458
gland morphogenesisGO:00226121450.443
positive regulation of retinal cell programmed cell deathGO:004667090.439
salivary gland morphogenesisGO:00074351450.381
retinal cell programmed cell deathGO:0046666250.381
regulation of organ morphogenesisGO:2000027780.368
regulation of anatomical structure morphogenesisGO:00226032420.367
execution phase of apoptosisGO:009719470.353
Worm Fly
regulation of compound eye retinal cell programmed cell deathGO:0046669180.350
dendrite developmentGO:00163582040.342
spermatid differentiationGO:00485151140.334
activation of cysteine type endopeptidase activity involved in apoptotic processGO:0006919160.329
positive regulation of proteolysisGO:0045862520.320
compound eye developmentGO:00487493070.310
autophagic cell deathGO:0048102830.282
negative regulation of response to stimulusGO:00485852580.270
regulation of humoral immune responseGO:0002920510.263
Fly
regulation of endopeptidase activityGO:0052548360.263
protein complex assemblyGO:00064612000.256
salivary gland cell autophagic cell deathGO:0035071830.239
gland developmentGO:00487321910.238
peptidoglycan recognition protein signaling pathwayGO:0061057160.231
Fly
regulation of protein metabolic processGO:00512462560.231
positive regulation of compound eye retinal cell programmed cell deathGO:004667290.225
immune responseGO:00069552460.223
compound eye morphogenesisGO:00017452490.222
salivary gland histolysisGO:0035070880.219
negative regulation of signalingGO:00230572190.218
Fly
positive regulation of protein metabolic processGO:00512471280.218
exocrine system developmentGO:00352721620.212
proteolysisGO:00065081920.212
positive regulation of apoptotic signaling pathwayGO:200123540.207
secondary metabolic processGO:0019748750.205
protein complex biogenesisGO:00702712010.204
macromolecular complex assemblyGO:00650032560.204
response to ionizing radiationGO:0010212320.203
Fly
sensory organ morphogenesisGO:00905962600.201
response to extracellular stimulusGO:00099911160.200
Fly
organonitrogen compound metabolic processGO:19015643180.196
Fly
protein k48 linked ubiquitinationGO:007093630.194
cell deathGO:00082192790.189
phenol containing compound metabolic processGO:0018958570.189
compound eye retinal cell programmed cell deathGO:0046667230.185
cellular catabolic processGO:00442483720.184
programmed cell deathGO:00125012570.182
apoptotic processGO:00069151590.181
eye morphogenesisGO:00485922600.178
eye developmentGO:00016543230.176
protein maturationGO:0051604710.172
catabolic processGO:00090564090.141
response to radiationGO:00093141550.139
Fly
zymogen activationGO:0031638200.137
regulation of cysteine type endopeptidase activityGO:2000116270.136
positive regulation of response to stimulusGO:00485843230.131
immune system processGO:00023763470.129
peptide metabolic processGO:0006518800.126
Fly
cellular amino acid metabolic processGO:0006520610.126
imaginal disc derived appendage developmentGO:00487373990.125
positive regulation of cellular protein metabolic processGO:00322701180.124
positive regulation of response to biotic stimulusGO:0002833310.123
Fly
nurse cell apoptotic processGO:0045476170.122
organic substance catabolic processGO:19015753080.121
Worm
regulation of catabolic processGO:00098941700.119
regulation of peptidase activityGO:0052547390.118
regulation of proteolysisGO:0030162870.118
spermatid developmentGO:0007286980.117
melanin metabolic processGO:0006582470.112
regulation of cell developmentGO:00602842150.110
positive regulation of macromolecule metabolic processGO:00106044050.110
apoptotic process involved in developmentGO:1902742200.105
positive regulation of programmed cell deathGO:0043068620.104
regulation of programmed cell deathGO:00430671520.104
imaginal disc derived wing morphogenesisGO:00074763370.103
cellular response to extracellular stimulusGO:0031668640.102
Fly
positive regulation of macroautophagyGO:001623980.102
Fly
deathGO:00162652840.101
response to biotic stimulusGO:00096072940.100
Mouse Fly
imaginal disc derived appendage morphogenesisGO:00351143950.100
embryonic morphogenesisGO:00485982060.095
positive regulation of developmental processGO:00510941430.095
carboxylic acid metabolic processGO:0019752920.094
protein processingGO:0016485680.093
positive regulation of signal transductionGO:00099672230.092
dendrite morphogenesisGO:00488131990.091
defense response to bacteriumGO:00427421780.091
Fly
melanization defense responseGO:0035006450.091
antibacterial peptide biosynthetic processGO:0002780220.088
Fly
appendage morphogenesisGO:00351073970.087
positive regulation of antibacterial peptide biosynthetic processGO:0006963200.086
Fly
macromolecule catabolic processGO:00090571610.086
Worm
cellularizationGO:0007349900.084
positive regulation of cell communicationGO:00106472500.084
cellular macromolecule catabolic processGO:00442651360.082
regulation of apoptotic processGO:00429811300.081
forebrain developmentGO:003090020.081
epithelial cell migrationGO:00106311480.080
nuclear divisionGO:00002803320.080
positive regulation of cell deathGO:0010942690.079
asymmetric cell divisionGO:0008356370.077
regulation of apoptotic signaling pathwayGO:2001233100.076
response to external biotic stimulusGO:00432072930.075
Mouse Fly
epithelial cell developmentGO:00020642740.075
autophagyGO:00069141080.075
antimicrobial peptide productionGO:0002775460.075
Fly
regulation of dna metabolic processGO:0051052340.075
positive regulation of multicellular organismal processGO:00512401430.074
positive regulation of signalingGO:00230562430.073
developmental maturationGO:00217001720.073
antimicrobial humoral responseGO:0019730990.073
Fly
cell type specific apoptotic processGO:0097285380.073
organelle fissionGO:00482853400.071
pigment metabolic processGO:0042440840.068
appendage developmentGO:00487364010.067
neuromuscular synaptic transmissionGO:0007274670.067
Fly
s adenosylmethionine cycleGO:003335330.067
embryonic development via the syncytial blastodermGO:00017001480.065
brain developmentGO:00074201200.064
protein heterooligomerizationGO:005129140.063
anatomical structure homeostasisGO:0060249970.062
protein modification by small protein conjugation or removalGO:00706471060.061
regulation of multicellular organismal developmentGO:20000264140.061
regulation of molecular functionGO:00650092170.060
establishment of localization in cellGO:00516494020.060
Mouse
biosynthetic process of antibacterial peptides active against gram negative bacteriaGO:0002812140.059
Fly
synaptic transmissionGO:00072682880.057
Fly
positive regulation of molecular functionGO:00440931360.056
positive regulation of humoral immune responseGO:0002922280.056
Fly
regulation of cellular catabolic processGO:00313291570.056
regulation of execution phase of apoptosisGO:190011750.055
response to starvationGO:0042594970.055
Fly
sulfur compound metabolic processGO:0006790590.053
localization of cellGO:00516742570.052
positive regulation of cellular biosynthetic processGO:00313283160.052
Fly
single organism catabolic processGO:00447122280.052
Fly
defense response to virusGO:0051607230.050
Fly
wnt signaling pathwayGO:0016055980.050
antibacterial humoral responseGO:0019731440.049
Fly
cellular component disassemblyGO:0022411460.049
regulation of cellular protein metabolic processGO:00322682430.048
central nervous system developmentGO:00074172010.048
apoptotic signaling pathwayGO:0097190270.048
organonitrogen compound biosynthetic processGO:19015661170.047
Fly
glycosyl compound metabolic processGO:19016571270.046
regulation of defense response to bacteriumGO:1900424300.044
Fly
positive regulation of nitrogen compound metabolic processGO:00511733540.043
Fly
positive regulation of macromolecule biosynthetic processGO:00105572830.043
Fly
cellular modified amino acid metabolic processGO:0006575450.042
positive regulation of antimicrobial peptide biosynthetic processGO:0002807260.041
Fly
homeostatic processGO:00425921990.040
head involutionGO:0008258350.040
regulation of response to external stimulusGO:00321011150.040
Mouse Fly
antennal morphogenesisGO:0048800140.039
defense response to gram negative bacteriumGO:0050829940.039
Fly
cellular response to sterol depletionGO:007150130.039
Fly
ovarian follicle cell developmentGO:00307072480.039
regulation of transcription from rna polymerase ii promoterGO:00063573780.039
Fly
antibacterial peptide productionGO:0002778220.038
Fly
carbohydrate derivative metabolic processGO:19011352170.037
wing disc morphogenesisGO:00074723440.037
positive regulation of hydrolase activityGO:0051345780.037
positive regulation of production of molecular mediator of immune responseGO:0002702280.036
Fly
positive regulation of antibacterial peptide productionGO:0002803200.036
Fly
response to abiotic stimulusGO:00096283410.036
Human Mouse Fly
organonitrogen compound catabolic processGO:19015651280.036
nucleobase containing small molecule metabolic processGO:00550861740.035
defense response to other organismGO:00985422250.035
Fly
positive regulation of response to external stimulusGO:0032103440.035
Fly
cellular protein modification processGO:00064644380.035
protein modification processGO:00362114380.035
protein ubiquitinationGO:0016567700.034
cellular response to external stimulusGO:0071496660.033
Human Fly
regulation of cell differentiationGO:00455953020.033
positive regulation of antimicrobial humoral responseGO:0002760280.033
Fly
amide biosynthetic processGO:0043604420.032
Fly
ribonucleoside metabolic processGO:00091191270.032
purine ribonucleoside metabolic processGO:00461281270.032
intracellular transportGO:00469072280.031
regulation of catalytic activityGO:00507901850.031
peptide biosynthetic processGO:0043043420.031
Fly
positive regulation of immune effector processGO:0002699280.031
Fly
transcription from rna polymerase ii promoterGO:00063663680.031
small molecule metabolic processGO:00442813050.031
purine containing compound metabolic processGO:00725211550.030
chemical homeostasisGO:0048878920.030
cell divisionGO:00513012480.030
response to bacteriumGO:00096171980.030
Mouse Fly
tissue migrationGO:00901301550.030
organic acid catabolic processGO:0016054160.030
positive regulation of response to nutrient levelsGO:003210980.030
Fly
regulation of cell shapeGO:00083601130.030
chromosome segregationGO:00070591570.029
organic hydroxy compound metabolic processGO:1901615830.029
post embryonic appendage morphogenesisGO:00351203850.029
aromatic compound catabolic processGO:00194391660.029
activation of cysteine type endopeptidase activityGO:0097202170.028
response to organic substanceGO:00100332840.028
Human Mouse
regulation of production of molecular mediator of immune responseGO:0002700440.028
Fly
purine nucleoside metabolic processGO:00422781270.028
positive regulation of rna biosynthetic processGO:19026802660.028
Fly
response to virusGO:0009615280.028
Fly
cell motilityGO:00488702510.027
epithelial cell differentiationGO:00308553220.027
negative regulation of multicellular organismal processGO:00512411420.027
spindle organizationGO:00070512530.027
regulation of multi organism processGO:00439001310.026
Fly
cellular protein catabolic processGO:0044257830.026
meiotic cell cycleGO:00513211710.026
organic cyclic compound catabolic processGO:19013611680.026
regulation of response to stressGO:00801342000.026
Mouse Fly
nucleobase containing compound catabolic processGO:00346551650.025
positive regulation of antimicrobial peptide productionGO:0002225280.025
Fly
positive regulation of nucleobase containing compound metabolic processGO:00459353320.025
Fly
embryo development ending in birth or egg hatchingGO:00097921520.025
protein oligomerizationGO:0051259160.025
synaptic growth at neuromuscular junctionGO:00511241190.025
regulation of wnt signaling pathwayGO:0030111680.025
cell migrationGO:00164772380.025
regulation of nervous system developmentGO:00519602480.025
negative regulation of signal transductionGO:00099682060.025
cellular nitrogen compound catabolic processGO:00442701650.025
regulation of hydrolase activityGO:0051336970.025
meiotic nuclear divisionGO:00071261510.024
cell cell signaling involved in cell fate commitmentGO:00451682100.024
protein modification by small protein conjugationGO:0032446790.024
positive regulation of gene expressionGO:00106282900.024
Fly
single organism biosynthetic processGO:00447112060.024
er nucleus signaling pathwayGO:000698490.024
Mouse Fly
positive regulation of defense responseGO:0031349590.023
Fly
positive regulation of transcription from rna polymerase ii promoterGO:00459442040.023
Fly
positive regulation of rna metabolic processGO:00512542710.023
Fly
response to nutrient levelsGO:00316671140.023
Fly
response to other organismGO:00517072930.023
Mouse Fly
epithelium migrationGO:00901321480.023
response to gamma radiationGO:0010332170.022
peripheral nervous system developmentGO:0007422520.022
Fly
regulation of response to biotic stimulusGO:0002831630.022
Fly
eye antennal disc morphogenesisGO:0007455340.022
cellular amide metabolic processGO:0043603800.022
Fly
neuron deathGO:0070997270.022
regulation of protein modification processGO:00313991120.022
regulation of antimicrobial peptide biosynthetic processGO:0002805380.021
Fly
neuron remodelingGO:0016322290.021
endocytosisGO:00068973100.021
Worm
immune effector processGO:0002252980.021
Fly
negative regulation of organelle organizationGO:0010639560.021
multi organism behaviorGO:00517051750.021
negative regulation of programmed cell deathGO:0043069720.021
Fly
regulation of defense responseGO:00313471020.021
Mouse Fly
border follicle cell migrationGO:00072981130.021
ovarian follicle cell migrationGO:00072971210.021
response to x rayGO:001016580.020
Fly
regulation of macroautophagyGO:0016241150.020
Fly
regulation of response to extracellular stimulusGO:0032104180.020
Fly
ameboidal type cell migrationGO:00016671510.020
chromatin organizationGO:00063252070.020
cytoskeleton dependent cytokinesisGO:0061640810.020
lateral inhibitionGO:00463312060.020
posttranscriptional regulation of gene expressionGO:00106081450.020
regulation of cellular ketone metabolic processGO:001056530.020
hemocyte differentiationGO:0042386380.019
head developmentGO:00603221350.019
small molecule catabolic processGO:0044282210.019
chromosome organizationGO:00512763600.019
positive regulation of autophagyGO:0010508210.019
Fly
vesicle mediated transportGO:00161923810.019
Worm
cellular response to starvationGO:0009267610.019
Fly
axis specificationGO:00097981670.019
photoreceptor cell differentiationGO:00465301700.019
chaeta morphogenesisGO:0008407420.019
positive regulation of nucleic acid templated transcriptionGO:19035082660.018
Fly
cellular ketone metabolic processGO:0042180240.018
positive regulation of transcription dna templatedGO:00458932660.018
Fly
cellular response to organic substanceGO:00713101320.018
Human Mouse
phagocytosisGO:00069092150.018
Worm
regulation of transportGO:00510491810.018
Mouse
modification dependent macromolecule catabolic processGO:0043632790.018
mitotic spindle organizationGO:00070522200.018
endomembrane system organizationGO:00102561190.018
regulation of chromosome organizationGO:0033044640.018
morphogenesis of an epitheliumGO:00020092760.018
regulation of response to nutrient levelsGO:0032107180.017
Fly
skeletal muscle fiber developmentGO:004874130.017
positive regulation of cellular catabolic processGO:0031331950.017
Fly
antennal developmentGO:0007469250.017
eye photoreceptor cell differentiationGO:00017541450.017
positive regulation of multi organism processGO:0043902400.017
Fly
gonad developmentGO:0008406500.016
positive regulation of cell developmentGO:0010720610.016
multicellular organismal agingGO:00102591400.016
negative regulation of immune responseGO:0050777390.016
negative regulation of cell differentiationGO:00455961430.016
male meiosisGO:0007140520.016
enzyme linked receptor protein signaling pathwayGO:00071671790.016
cellular homeostasisGO:0019725800.015
negative regulation of cellular component organizationGO:00511291080.015
respiratory system developmentGO:00605412130.015
chemosensory behaviorGO:00076351060.015
meiotic cell cycle processGO:19030461320.015
regulation of cell proliferationGO:00421271630.015
proteolysis involved in cellular protein catabolic processGO:0051603830.015
heterocycle catabolic processGO:00467001660.015
photoreceptor cell developmentGO:0042461960.015
regulation of cell deathGO:00109411730.015
protein localizationGO:00081042840.015
Mouse
ubiquitin dependent protein catabolic processGO:0006511780.015
negative regulation of biosynthetic processGO:00098902770.015
eye photoreceptor cell developmentGO:0042462810.015
ras protein signal transductionGO:0007265880.015
antimicrobial peptide biosynthetic processGO:0002777380.015
Fly
organic acid metabolic processGO:00060821030.014
regulation of cell morphogenesisGO:00226041630.014
negative regulation of compound eye retinal cell programmed cell deathGO:004667370.014
body morphogenesisGO:001017120.014
regulation of antimicrobial peptide productionGO:0002784440.014
Fly
maintenance of locationGO:0051235730.014
negative regulation of cellular metabolic processGO:00313243820.014
negative regulation of protein metabolic processGO:0051248850.014
chorion containing eggshell formationGO:00073041050.014
cell maturationGO:00484691440.014
response to oxygen containing compoundGO:19017002000.014
Mouse
chaeta developmentGO:0022416970.014
regulation of small gtpase mediated signal transductionGO:0051056930.014
proteasomal protein catabolic processGO:0010498590.014
regulation of epithelial cell proliferationGO:005067840.014
regulation of synaptic growth at neuromuscular junctionGO:0008582890.013
digestive tract morphogenesisGO:00485461270.013
establishment of vesicle localizationGO:0051650510.013
regulation of immune effector processGO:0002697520.013
Fly
single organism cellular localizationGO:19025801800.013
modification dependent protein catabolic processGO:0019941780.013
dna catabolic processGO:0006308160.013
single organism behaviorGO:00447083910.013
small gtpase mediated signal transductionGO:0007264880.013
tissue morphogenesisGO:00487292970.013
olfactory behaviorGO:0042048970.013
alpha amino acid metabolic processGO:1901605200.013
oxoacid metabolic processGO:00434361030.013
striated muscle cell differentiationGO:0051146900.013
eye antennal disc developmentGO:0035214600.012
eggshell formationGO:00307031050.012
organelle assemblyGO:00709251980.012
regulation of cellular amine metabolic processGO:003323830.012
compound eye photoreceptor cell differentiationGO:00017511400.012
neuron maturationGO:0042551310.012
lipid homeostasisGO:0055088330.012
regulation of synapse assemblyGO:0051963940.012
digestive tract developmentGO:00485651490.012
response to light stimulusGO:00094161240.012
negative regulation of developmental processGO:00510932010.012
regulation of cellular amino acid metabolic processGO:000652100.012
cellular response to nutrient levelsGO:0031669620.012
Fly
positive regulation of intracellular signal transductionGO:19025331160.012
Human Mouse
triglyceride homeostasisGO:0070328180.012
nucleoside metabolic processGO:00091161270.012
translationGO:0006412690.012
cellular component assembly involved in morphogenesisGO:00109271510.012
camera type eye developmentGO:004301040.012
positive regulation of biosynthetic processGO:00098913160.012
Fly
cellular protein localizationGO:00346131600.012
regulation of chromatin organizationGO:1902275320.012
positive regulation of catalytic activityGO:00430851180.012
nucleoside phosphate metabolic processGO:00067531620.012
regulation of cellular amide metabolic processGO:0034248390.012
Fly
mapk cascadeGO:00001651070.012
eye pigmentationGO:0048069430.011
muscle cell differentiationGO:00426921030.011
positive regulation of catabolic processGO:00098961050.011
Fly
vesicle localizationGO:0051648550.011
acylglycerol homeostasisGO:0055090190.011
regulation of immune responseGO:00507761180.011
Fly
intracellular protein transportGO:00068861040.011
regulation of growthGO:00400082330.011
innate immune responseGO:00450871440.011
developmental pigmentationGO:0048066680.011
columnar cuboidal epithelial cell developmentGO:00020662490.011
protein catabolic processGO:00301631010.011
Worm
mitotic dna integrity checkpointGO:0044774750.011
Human
cellular response to chemical stimulusGO:00708871990.011
Human Mouse
reproductive system developmentGO:0061458740.011
neuron apoptotic processGO:0051402170.011
negative regulation of cellular biosynthetic processGO:00313272770.011
negative regulation of cell developmentGO:0010721620.011
establishment of protein localizationGO:00451841630.011
Mouse
cilium morphogenesisGO:0060271390.010
negative regulation of cell deathGO:0060548810.010
Fly
cellular protein complex assemblyGO:0043623710.010
interspecies interaction between organismsGO:0044419160.010
secretion by cellGO:00329401010.010
Mouse
microtubule based transportGO:0010970420.010
compound eye photoreceptor developmentGO:0042051780.010
tube morphogenesisGO:00352391910.010
notch signaling pathwayGO:00072191200.010
acetylcholine metabolic processGO:000829120.010
taxisGO:00423303040.010
columnar cuboidal epithelial cell differentiationGO:00020652560.010
proteasome mediated ubiquitin dependent protein catabolic processGO:0043161540.010
positive regulation of cellular amino acid metabolic processGO:004576400.010
male sex differentiationGO:0046661250.010
positive regulation of innate immune responseGO:0045089380.010
Fly

Nc disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.031
musculoskeletal system diseaseDOID:1700.010
cardiovascular system diseaseDOID:128700.010