IMP: Integrative Multi-species Prediction

Drosophila melanogaster

60 known processes

Atg5 (Dmel_CG1643)

Autophagy-specific gene 5

(Aliases: DmAtg5,Dmel\CG1643,CG1643,ATG5)

Entrez: 31666
FLYBASE: FBgn0029943
UniProtKB: Q9W3R7

Process Predictions
Disease Predictions

Atg5 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
actin filament based process	GO:0030029	220	0.432
membrane fusion	GO:0061025	42	0.283
cellular catabolic process	GO:0044248	372	0.277
organonitrogen compound metabolic process	GO:1901564	318	0.182
defense response to virus	GO:0051607	23	0.165
small molecule metabolic process	GO:0044281	305	0.165
macroautophagy	GO:0016236	42	0.148
organic acid metabolic process	GO:0006082	103	0.128
establishment of localization in cell	GO:0051649	402	0.124	Mouse
catabolic process	GO:0009056	409	0.108
membrane organization	GO:0061024	112	0.103
single organism catabolic process	GO:0044712	228	0.102
single organism intracellular transport	GO:1902582	207	0.093	Mouse
single organism membrane fusion	GO:0044801	42	0.092
response to other organism	GO:0051707	293	0.088	Mouse
protein transport	GO:0015031	155	0.076	Mouse
histolysis	GO:0007559	102	0.073
response to external biotic stimulus	GO:0043207	293	0.070	Mouse
developmental programmed cell death	GO:0010623	138	0.069
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.064
purine nucleoside metabolic process	GO:0042278	127	0.063
organelle fusion	GO:0048284	46	0.062
protein modification process	GO:0036211	438	0.061	Mouse
heterocycle catabolic process	GO:0046700	166	0.059
peptide metabolic process	GO:0006518	80	0.058
autophagy	GO:0006914	108	0.057
organic substance catabolic process	GO:1901575	308	0.057
intracellular transport	GO:0046907	228	0.056	Mouse
synapse organization	GO:0050808	196	0.056
defense response to bacterium	GO:0042742	178	0.055
regulation of localization	GO:0032879	275	0.051	Mouse
negative regulation of signaling	GO:0023057	219	0.051
cellular amide metabolic process	GO:0043603	80	0.048
defense response to other organism	GO:0098542	225	0.047
organelle membrane fusion	GO:0090174	16	0.045
carboxylic acid metabolic process	GO:0019752	92	0.045
vesicle mediated transport	GO:0016192	381	0.044
response to bacterium	GO:0009617	198	0.041
larval midgut histolysis	GO:0035069	22	0.041
response to organic substance	GO:0010033	284	0.040
regulation of cellular localization	GO:0060341	136	0.039	Mouse
single organism biosynthetic process	GO:0044711	206	0.039
cellular macromolecule localization	GO:0070727	220	0.039
phagocytosis	GO:0006909	215	0.038
positive regulation of signaling	GO:0023056	243	0.038
cellular response to external stimulus	GO:0071496	66	0.038
positive regulation of developmental growth	GO:0048639	62	0.037
nucleotide catabolic process	GO:0009166	109	0.037
fatty acid catabolic process	GO:0009062	9	0.036
protein localization	GO:0008104	284	0.035	Mouse
negative regulation of cell communication	GO:0010648	223	0.035
nucleobase containing small molecule metabolic process	GO:0055086	174	0.034
secretion by cell	GO:0032940	101	0.033	Mouse
ribonucleoside metabolic process	GO:0009119	127	0.033
establishment of protein localization	GO:0045184	163	0.031	Mouse
organic substance transport	GO:0071702	257	0.031	Mouse
synapse assembly	GO:0007416	143	0.031
dendrite development	GO:0016358	204	0.031
nucleotide metabolic process	GO:0009117	161	0.030
regulation of synapse assembly	GO:0051963	94	0.030
organic acid catabolic process	GO:0016054	16	0.029
purine nucleoside catabolic process	GO:0006152	112	0.029
ribonucleotide metabolic process	GO:0009259	145	0.029
stem cell division	GO:0017145	69	0.028
response to biotic stimulus	GO:0009607	294	0.026	Mouse
notch signaling pathway	GO:0007219	120	0.026
purine nucleotide catabolic process	GO:0006195	109	0.026
organic cyclic compound catabolic process	GO:1901361	168	0.026
defense response	GO:0006952	300	0.025
purine containing compound metabolic process	GO:0072521	155	0.025
actin cytoskeleton organization	GO:0030036	206	0.025
regulation of transport	GO:0051049	181	0.025	Mouse
organophosphate metabolic process	GO:0019637	195	0.024
positive regulation of response to stimulus	GO:0048584	323	0.024
ribonucleoside catabolic process	GO:0042454	112	0.024
cellular ion homeostasis	GO:0006873	39	0.024	Mouse
carbohydrate derivative metabolic process	GO:1901135	217	0.023
growth	GO:0040007	359	0.023
purine ribonucleoside catabolic process	GO:0046130	112	0.023
positive regulation of macromolecule metabolic process	GO:0010604	405	0.023
nucleobase containing compound catabolic process	GO:0034655	165	0.023
neuromuscular junction development	GO:0007528	149	0.023
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.022
nucleoside triphosphate catabolic process	GO:0009143	108	0.022
carbohydrate derivative catabolic process	GO:1901136	118	0.022
purine ribonucleotide metabolic process	GO:0009150	145	0.022
regulation of catabolic process	GO:0009894	170	0.022
regulation of catalytic activity	GO:0050790	185	0.021
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.021
negative regulation of cellular component organization	GO:0051129	108	0.021	Mouse
cellular nitrogen compound catabolic process	GO:0044270	165	0.021
regulation of immune effector process	GO:0002697	52	0.021	Mouse
regulation of molecular function	GO:0065009	217	0.021
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.021
golgi organization	GO:0007030	66	0.021
axis specification	GO:0009798	167	0.021
nucleoside metabolic process	GO:0009116	127	0.021
autophagic vacuole fusion	GO:0000046	15	0.021
nucleoside phosphate metabolic process	GO:0006753	162	0.021
larval midgut cell programmed cell death	GO:0035096	19	0.021
regulation of cellular protein metabolic process	GO:0032268	243	0.020	Mouse
cytoplasmic transport	GO:0016482	130	0.020	Mouse
actin filament organization	GO:0007015	126	0.020
positive regulation of signal transduction	GO:0009967	223	0.020
death	GO:0016265	284	0.020
protein prenylation	GO:0018342	3	0.020
skeletal muscle fiber development	GO:0048741	3	0.020
metal ion homeostasis	GO:0055065	44	0.020	Mouse
regulation of notch signaling pathway	GO:0008593	100	0.019
cellular protein localization	GO:0034613	160	0.019
tissue death	GO:0016271	102	0.019
gtp catabolic process	GO:0006184	72	0.018
positive regulation of cell communication	GO:0010647	250	0.018
regulation of hydrolase activity	GO:0051336	97	0.018
cellular homeostasis	GO:0019725	80	0.017	Mouse
negative regulation of signal transduction	GO:0009968	206	0.017
regulation of response to biotic stimulus	GO:0002831	63	0.017
endocytosis	GO:0006897	310	0.017
very long chain fatty acid catabolic process	GO:0042760	2	0.017
regulation of autophagy	GO:0010506	62	0.017
positive regulation of catabolic process	GO:0009896	105	0.017
ribose phosphate metabolic process	GO:0019693	145	0.017
regulation of synapse structure and activity	GO:0050803	128	0.016
forebrain development	GO:0030900	2	0.016
purine ribonucleoside metabolic process	GO:0046128	127	0.016
autophagic cell death	GO:0048102	83	0.016
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.015
protein k48 linked ubiquitination	GO:0070936	3	0.015
developmental maturation	GO:0021700	172	0.015
lateral inhibition	GO:0046331	206	0.015
aromatic compound catabolic process	GO:0019439	166	0.015
exocrine system development	GO:0035272	162	0.015
body morphogenesis	GO:0010171	2	0.015
lipid metabolic process	GO:0006629	121	0.015
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.015
amine metabolic process	GO:0009308	12	0.014
biosynthetic process of antibacterial peptides active against gram negative bacteria	GO:0002812	14	0.014
protein complex biogenesis	GO:0070271	201	0.014
nitrogen compound transport	GO:0071705	85	0.014
regulation of hemocyte proliferation	GO:0035206	37	0.014
protein complex assembly	GO:0006461	200	0.014
single organism membrane organization	GO:0044802	93	0.014
asymmetric stem cell division	GO:0098722	49	0.014
programmed cell death	GO:0012501	257	0.014
secretion	GO:0046903	109	0.014	Mouse
vacuolar transport	GO:0007034	13	0.014
regulation of cellular ketone metabolic process	GO:0010565	3	0.014
organonitrogen compound catabolic process	GO:1901565	128	0.014
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.014
organonitrogen compound biosynthetic process	GO:1901566	117	0.014
purine nucleotide metabolic process	GO:0006163	146	0.014
gland morphogenesis	GO:0022612	145	0.013
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.013
membrane invagination	GO:0010324	11	0.013
response to virus	GO:0009615	28	0.013
proteolysis	GO:0006508	192	0.012
ribonucleoside monophosphate metabolic process	GO:0009161	51	0.012
purine containing compound catabolic process	GO:0072523	112	0.012
regulation of programmed cell death	GO:0043067	152	0.012	Mouse
positive regulation of transport	GO:0051050	92	0.012	Mouse
regulation of nucleotide catabolic process	GO:0030811	48	0.012
striated muscle cell differentiation	GO:0051146	90	0.012	Mouse
regulation of cell morphogenesis	GO:0022604	163	0.012	Mouse
regulation of multi organism process	GO:0043900	131	0.012
cellular lipid metabolic process	GO:0044255	83	0.012
dendrite morphogenesis	GO:0048813	199	0.012
regulation of establishment of protein localization	GO:0070201	61	0.012	Mouse
autophagic vacuole assembly	GO:0000045	2	0.012	Mouse
macromolecular complex assembly	GO:0065003	256	0.012
neurological system process	GO:0050877	358	0.012
ribonucleotide catabolic process	GO:0009261	109	0.011
regulation of i kappab kinase nf kappab signaling	GO:0043122	2	0.011
regulation of multicellular organismal development	GO:2000026	414	0.011
glycosyl compound metabolic process	GO:1901657	127	0.011
single organism cell adhesion	GO:0098602	47	0.011
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.011
regulation of defense response to virus	GO:0050688	14	0.011
intracellular protein transport	GO:0006886	104	0.011
synaptic growth at neuromuscular junction	GO:0051124	119	0.011
regulation of cellular catabolic process	GO:0031329	157	0.011
ion homeostasis	GO:0050801	55	0.011	Mouse
cell proliferation	GO:0008283	299	0.011
endomembrane system organization	GO:0010256	119	0.011
imaginal disc derived appendage development	GO:0048737	399	0.010
cellular amino acid metabolic process	GO:0006520	61	0.010
atp catabolic process	GO:0006200	38	0.010
cellular protein modification process	GO:0006464	438	0.010	Mouse
cellular response to starvation	GO:0009267	61	0.010
larval development	GO:0002164	104	0.010
immune effector process	GO:0002252	98	0.010	Mouse
wnt signaling pathway	GO:0016055	98	0.010

Atg5 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	musculoskeletal system disease	DOID:17	0	0.020
	disease of anatomical entity	DOID:7	0	0.020

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