IMP: Integrative Multi-species Prediction

Drosophila melanogaster

218 known processes

XNP (Dmel_CG4548)

CG4548 gene product from transcript CG4548-RA

(Aliases: xnp,EP(3)0635,EP635,dATRX,Dmel\CG4548,dXNP,CG4548,xnp/atr-x,DATR-X,DATRX,ATR-X/XNP)

FLYBASE: FBgn0039338
Entrez: 43080
UniProtKB: Q9GQN5

Process Predictions
Disease Predictions

XNP biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
negative regulation of gene expression epigenetic	GO:0045814	77	0.992
chromosome organization	GO:0051276	360	0.933
gene silencing	GO:0016458	138	0.932
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.858
chromatin silencing	GO:0006342	76	0.816
protein maturation	GO:0051604	71	0.774
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.634
negative regulation of gene expression	GO:0010629	387	0.629
intracellular signal transduction	GO:0035556	300	0.625
regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043281	25	0.617
negative regulation of cellular metabolic process	GO:0031324	382	0.551
dendrite development	GO:0016358	204	0.534
germarium derived egg chamber formation	GO:0007293	101	0.513
regulation of intracellular signal transduction	GO:1902531	236	0.474
purine ribonucleoside metabolic process	GO:0046128	127	0.456
small gtpase mediated signal transduction	GO:0007264	88	0.438
negative regulation of rna metabolic process	GO:0051253	251	0.426
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.423	Human Mouse
positive regulation of hydrolase activity	GO:0051345	78	0.412
positive regulation of cysteine type endopeptidase activity	GO:2001056	24	0.400
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.396	Human Mouse
regulation of gene expression epigenetic	GO:0040029	128	0.377
negative regulation of cellular biosynthetic process	GO:0031327	277	0.371
regulation of cell cycle	GO:0051726	291	0.323	Mouse
regulation of protein metabolic process	GO:0051246	256	0.313
regulation of molecular function	GO:0065009	217	0.312
purine nucleoside catabolic process	GO:0006152	112	0.308
axon development	GO:0061564	297	0.302
regulation of organelle organization	GO:0033043	196	0.278	Mouse
regulation of cysteine type endopeptidase activity	GO:2000116	27	0.269
aromatic compound catabolic process	GO:0019439	166	0.265
positive regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043280	23	0.265
axon guidance	GO:0007411	233	0.259
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.246
mushroom body development	GO:0016319	70	0.243
protein processing	GO:0016485	68	0.221
glycosyl compound catabolic process	GO:1901658	112	0.218
catabolic process	GO:0009056	409	0.215
positive regulation of endopeptidase activity	GO:0010950	26	0.215
axonogenesis	GO:0007409	290	0.203
ribonucleoside metabolic process	GO:0009119	127	0.194
regulation of cellular catabolic process	GO:0031329	157	0.191
regulation of proteolysis	GO:0030162	87	0.190
regulation of hydrolase activity	GO:0051336	97	0.188
programmed cell death	GO:0012501	257	0.183
heterochromatin organization involved in chromatin silencing	GO:0070868	9	0.172
nucleoside catabolic process	GO:0009164	112	0.171
chromatin modification	GO:0016568	147	0.171	Human
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.169
regulation of cellular protein metabolic process	GO:0032268	243	0.167
regulation of endopeptidase activity	GO:0052548	36	0.160
negative regulation of cell communication	GO:0010648	223	0.147
positive regulation of molecular function	GO:0044093	136	0.138
activation of cysteine type endopeptidase activity	GO:0097202	17	0.137
dendrite morphogenesis	GO:0048813	199	0.135
cellular nitrogen compound catabolic process	GO:0044270	165	0.127
regulation of ras protein signal transduction	GO:0046578	93	0.126
organic cyclic compound catabolic process	GO:1901361	168	0.122
positive regulation of peptidase activity	GO:0010952	29	0.120
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.118	Human Mouse
neuron projection guidance	GO:0097485	241	0.114
regulation of phosphate metabolic process	GO:0019220	210	0.112
regulation of peptidase activity	GO:0052547	39	0.112
nucleoside metabolic process	GO:0009116	127	0.110
oocyte differentiation	GO:0009994	145	0.109
central nervous system development	GO:0007417	201	0.108	Mouse
negative regulation of response to stimulus	GO:0048585	258	0.106
positive regulation of transcription dna templated	GO:0045893	266	0.105	Human Mouse
negative regulation of transcription dna templated	GO:0045892	237	0.104
heterocycle catabolic process	GO:0046700	166	0.101
negative regulation of signal transduction	GO:0009968	206	0.099
nucleotide metabolic process	GO:0009117	161	0.099
nucleoside triphosphate metabolic process	GO:0009141	120	0.098
positive regulation of catalytic activity	GO:0043085	118	0.095
proteolysis	GO:0006508	192	0.094
ras protein signal transduction	GO:0007265	88	0.092
response to abiotic stimulus	GO:0009628	341	0.092
heterochromatin organization	GO:0070828	25	0.092
protein complex assembly	GO:0006461	200	0.091
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.088
chemotaxis	GO:0006935	249	0.088
cellular protein modification process	GO:0006464	438	0.086
stem cell division	GO:0017145	69	0.084
purine ribonucleoside catabolic process	GO:0046130	112	0.084
nucleobase containing compound catabolic process	GO:0034655	165	0.084
single organism catabolic process	GO:0044712	228	0.083
apoptotic signaling pathway	GO:0097190	27	0.083
positive regulation of cellular catabolic process	GO:0031331	95	0.082
camera type eye morphogenesis	GO:0048593	2	0.080
dna metabolic process	GO:0006259	227	0.080
nucleobase containing small molecule metabolic process	GO:0055086	174	0.079
chromatin organization	GO:0006325	207	0.079
organonitrogen compound catabolic process	GO:1901565	128	0.078
regulation of nucleotide catabolic process	GO:0030811	48	0.076
negative regulation of cell differentiation	GO:0045596	143	0.075
purine containing compound metabolic process	GO:0072521	155	0.075
negative regulation of biosynthetic process	GO:0009890	277	0.075
regulation of actin filament based process	GO:0032970	42	0.074
carbohydrate derivative metabolic process	GO:1901135	217	0.072
purine nucleoside metabolic process	GO:0042278	127	0.071
negative regulation of signaling	GO:0023057	219	0.070
appendage morphogenesis	GO:0035107	397	0.068
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.068
regulation of catalytic activity	GO:0050790	185	0.066
organonitrogen compound metabolic process	GO:1901564	318	0.066
zymogen activation	GO:0031638	20	0.066
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.065
axon midline choice point recognition	GO:0016199	26	0.064
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.064
regulation of cell cycle process	GO:0010564	181	0.064	Mouse
actin filament based process	GO:0030029	220	0.064
positive regulation of cellular component organization	GO:0051130	156	0.063	Mouse
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.063
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.062	Human Mouse
organic substance catabolic process	GO:1901575	308	0.062
negative regulation of protein metabolic process	GO:0051248	85	0.061
dna conformation change	GO:0071103	105	0.058
chromosome segregation	GO:0007059	157	0.057
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.056
regulation of cellular amine metabolic process	GO:0033238	3	0.056
chromosome condensation	GO:0030261	41	0.055
retina morphogenesis in camera type eye	GO:0060042	2	0.054
purine containing compound catabolic process	GO:0072523	112	0.054
regulation of protein deacetylation	GO:0090311	2	0.054
negative regulation of rna biosynthetic process	GO:1902679	240	0.054
positive regulation of nucleotide metabolic process	GO:0045981	55	0.053
regulation of cell death	GO:0010941	173	0.053
gland development	GO:0048732	191	0.053
protein modification process	GO:0036211	438	0.051
regulation of phosphorylation	GO:0042325	147	0.051
cellular amine metabolic process	GO:0044106	12	0.050
sister chromatid segregation	GO:0000819	92	0.050
purine nucleotide catabolic process	GO:0006195	109	0.048
positive regulation of proteolysis	GO:0045862	52	0.048
activation of cysteine type endopeptidase activity involved in apoptotic process	GO:0006919	16	0.047
endocytosis	GO:0006897	310	0.047
regulation of gene silencing	GO:0060968	63	0.046
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.045
positive regulation of nucleoside metabolic process	GO:0045979	47	0.045
positive regulation of phosphate metabolic process	GO:0045937	139	0.045
regulation of cellular component biogenesis	GO:0044087	201	0.045
regulation of chromatin silencing	GO:0031935	36	0.045
cellular response to hydrogen peroxide	GO:0070301	7	0.044
positive regulation of response to stimulus	GO:0048584	323	0.044
phagocytosis	GO:0006909	215	0.043
ribonucleotide metabolic process	GO:0009259	145	0.042
organelle inheritance	GO:0048308	2	0.042
actin cytoskeleton organization	GO:0030036	206	0.041
purine ribonucleotide metabolic process	GO:0009150	145	0.040
purine nucleotide metabolic process	GO:0006163	146	0.039
regulation of anatomical structure morphogenesis	GO:0022603	242	0.038
gonad development	GO:0008406	50	0.038	Mouse Worm
small molecule metabolic process	GO:0044281	305	0.037
transcription from rna polymerase ii promoter	GO:0006366	368	0.037	Human Mouse
positive regulation of phosphorus metabolic process	GO:0010562	139	0.036
glycosyl compound metabolic process	GO:1901657	127	0.036
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.035
mitotic cell cycle phase transition	GO:0044772	138	0.034
cellular catabolic process	GO:0044248	372	0.033
mitotic sister chromatid segregation	GO:0000070	87	0.033
protein complex biogenesis	GO:0070271	201	0.033
organelle fission	GO:0048285	340	0.033
positive regulation of protein metabolic process	GO:0051247	128	0.032
regulation of transcription by chromatin organization	GO:0034401	3	0.032
nuclear division	GO:0000280	332	0.032
hindbrain development	GO:0030902	2	0.031
germarium derived female germ line cyst formation	GO:0030727	42	0.031
cellular response to oxygen containing compound	GO:1901701	79	0.030
regionalization	GO:0003002	416	0.029
regulation of programmed cell death	GO:0043067	152	0.029
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.029
positive regulation of cellular biosynthetic process	GO:0031328	316	0.029	Human Mouse
phosphorylation	GO:0016310	294	0.028
ribose phosphate metabolic process	GO:0019693	145	0.028
positive regulation of cell communication	GO:0010647	250	0.028
nucleotide catabolic process	GO:0009166	109	0.028
localization of cell	GO:0051674	257	0.028
peptidyl amino acid modification	GO:0018193	105	0.028
camera type eye development	GO:0043010	4	0.028
positive regulation of developmental process	GO:0051094	143	0.028
organophosphate metabolic process	GO:0019637	195	0.027
regulation of protein complex assembly	GO:0043254	42	0.027
positive regulation of signaling	GO:0023056	243	0.027
nucleoside phosphate catabolic process	GO:1901292	110	0.027
cell cycle checkpoint	GO:0000075	95	0.027
purine ribonucleotide catabolic process	GO:0009154	109	0.027
regulation of ras gtpase activity	GO:0032318	38	0.026
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.026
regulation of cell shape	GO:0008360	113	0.026
eggshell chorion assembly	GO:0007306	66	0.026
negative regulation of cellular protein metabolic process	GO:0032269	85	0.026
anterior posterior pattern specification	GO:0009952	136	0.026
carbohydrate derivative catabolic process	GO:1901136	118	0.025
larval development	GO:0002164	104	0.025	Worm
cell motility	GO:0048870	251	0.025
protein phosphorylation	GO:0006468	169	0.025
cellular response to chemical stimulus	GO:0070887	199	0.025	Mouse
peptidyl lysine trimethylation	GO:0018023	6	0.025
gliogenesis	GO:0042063	80	0.024
guanosine containing compound catabolic process	GO:1901069	74	0.024
cellular response to reactive oxygen species	GO:0034614	14	0.024
axon choice point recognition	GO:0016198	26	0.024
regulation of catabolic process	GO:0009894	170	0.024
regulation of meiosis	GO:0040020	3	0.024
cell death	GO:0008219	279	0.023
vesicle mediated transport	GO:0016192	381	0.023
epithelial cell development	GO:0002064	274	0.023	Mouse
regulation of apoptotic signaling pathway	GO:2001233	10	0.022
positive regulation of signal transduction	GO:0009967	223	0.022
organic substance transport	GO:0071702	257	0.022
head development	GO:0060322	135	0.022	Mouse
cellular response to organic substance	GO:0071310	132	0.021
cell migration	GO:0016477	238	0.021
regulation of mapk cascade	GO:0043408	92	0.021
response to organic cyclic compound	GO:0014070	89	0.021
regulation of phosphorus metabolic process	GO:0051174	210	0.021
positive regulation of intracellular signal transduction	GO:1902533	116	0.020
regulation of protein modification process	GO:0031399	112	0.020
cellular amino acid metabolic process	GO:0006520	61	0.020
female germ line cyst formation	GO:0048135	42	0.020
dna methylation or demethylation	GO:0044728	4	0.020
positive regulation of developmental growth	GO:0048639	62	0.020
death	GO:0016265	284	0.019
positive regulation of rac gtpase activity	GO:0032855	8	0.019
regulation of cell cycle phase transition	GO:1901987	130	0.019
negative regulation of intracellular signal transduction	GO:1902532	57	0.019
ribonucleoside catabolic process	GO:0042454	112	0.019
genitalia development	GO:0048806	26	0.019	Worm
regulation of dna templated transcription in response to stress	GO:0043620	4	0.019
macromolecular complex assembly	GO:0065003	256	0.019
response to external biotic stimulus	GO:0043207	293	0.019
regulation of cytoskeleton organization	GO:0051493	89	0.018
meiotic cell cycle	GO:0051321	171	0.018
response to dsrna	GO:0043331	15	0.018
organophosphate catabolic process	GO:0046434	112	0.018
positive regulation of cellular protein metabolic process	GO:0032270	118	0.018
positive regulation of rna metabolic process	GO:0051254	271	0.018	Human Mouse
cell cycle dna replication	GO:0044786	23	0.018	Mouse
regulation of cellular amino acid metabolic process	GO:0006521	0	0.018
nucleoside phosphate metabolic process	GO:0006753	162	0.018
regulation of nucleoside metabolic process	GO:0009118	50	0.017
actin filament organization	GO:0007015	126	0.017
body morphogenesis	GO:0010171	2	0.017
regulation of phosphatase activity	GO:0010921	3	0.017
regulation of neuron differentiation	GO:0045664	103	0.017
small rna loading onto risc	GO:0070922	6	0.017
nucleosome mobilization	GO:0042766	9	0.017
positive regulation of macromolecule metabolic process	GO:0010604	405	0.017	Human Mouse
nucleoside triphosphate catabolic process	GO:0009143	108	0.016
intracellular transport	GO:0046907	228	0.016
rho protein signal transduction	GO:0007266	14	0.016
regulation of chromatin organization	GO:1902275	32	0.016
forebrain development	GO:0030900	2	0.016	Mouse
nucleocytoplasmic transport	GO:0006913	72	0.016
regulation of localization	GO:0032879	275	0.015
dna integrity checkpoint	GO:0031570	81	0.015
cellular protein complex assembly	GO:0043623	71	0.015
positive regulation of purine nucleotide catabolic process	GO:0033123	46	0.015
regulation of hemocyte proliferation	GO:0035206	37	0.015
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.014	Human Mouse
embryo development ending in birth or egg hatching	GO:0009792	152	0.014	Worm
cell proliferation	GO:0008283	299	0.014
regulation of gtp catabolic process	GO:0033124	44	0.014
response to organic substance	GO:0010033	284	0.014	Mouse
negative regulation of transcription factor import into nucleus	GO:0042992	4	0.014
homeostatic process	GO:0042592	199	0.014	Mouse
positive regulation of multicellular organismal process	GO:0051240	143	0.014
mitotic dna damage checkpoint	GO:0044773	74	0.014
positive regulation of programmed cell death	GO:0043068	62	0.014
positive regulation of cell differentiation	GO:0045597	64	0.013
gene silencing by rna	GO:0031047	57	0.013
cellular macromolecular complex assembly	GO:0034622	153	0.013
amine metabolic process	GO:0009308	12	0.013
positive regulation of organelle organization	GO:0010638	65	0.013	Mouse
intracellular mrna localization	GO:0008298	66	0.013
negative regulation of cell cycle process	GO:0010948	109	0.013
regulation of chromosome organization	GO:0033044	64	0.013	Mouse
ovarian follicle cell development	GO:0030707	248	0.013
regulation of cellular ketone metabolic process	GO:0010565	3	0.012
negative regulation of organelle organization	GO:0010639	56	0.012
regulation of nuclear division	GO:0051783	58	0.012
neural precursor cell proliferation	GO:0061351	75	0.012
positive regulation of catabolic process	GO:0009896	105	0.012
rna interference	GO:0016246	27	0.012
positive regulation of neurogenesis	GO:0050769	41	0.012
ribonucleoside monophosphate catabolic process	GO:0009158	39	0.012
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.012
regulation of immune system process	GO:0002682	176	0.012
negative regulation of cell cycle	GO:0045786	116	0.012
regulation of neurogenesis	GO:0050767	158	0.011
response to ecdysone	GO:0035075	34	0.011
sex differentiation	GO:0007548	81	0.011	Mouse Worm
columnar cuboidal epithelial cell development	GO:0002066	249	0.011
organic acid metabolic process	GO:0006082	103	0.011
morphogenesis of an epithelium	GO:0002009	276	0.011	Worm
spindle organization	GO:0007051	253	0.011
leg disc morphogenesis	GO:0007478	80	0.011
asymmetric stem cell division	GO:0098722	49	0.011
gtp catabolic process	GO:0006184	72	0.011
retina development in camera type eye	GO:0060041	4	0.011
response to temperature stimulus	GO:0009266	106	0.010
negative regulation of protein processing	GO:0010955	31	0.010
positive regulation of gene expression	GO:0010628	290	0.010	Human Mouse
mitotic dna integrity checkpoint	GO:0044774	75	0.010

XNP disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org

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