IMP: Integrative Multi-species Prediction

Drosophila melanogaster

119 known processes

cort (Dmel_CG11330)

cortex

(Aliases: Cort,CG11330,cor,Dmel\CG11330)

Entrez: 33937
FLYBASE: FBgn0000351
UniProtKB: M9PCR0
UniProtKB: Q960N3

Process Predictions
Disease Predictions

cort biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
meiotic nuclear division	GO:0007126	151	0.999
female meiotic division	GO:0007143	70	0.994
meiotic cell cycle	GO:0051321	171	0.993
organelle fission	GO:0048285	340	0.960
nuclear division	GO:0000280	332	0.926
pole cell development	GO:0007277	26	0.901
pole cell formation	GO:0007279	19	0.894
cellularization	GO:0007349	90	0.870
reciprocal meiotic recombination	GO:0007131	19	0.809
meiotic cell cycle process	GO:1903046	132	0.628
meiotic spindle organization	GO:0000212	36	0.496
cytoskeleton dependent cytokinesis	GO:0061640	81	0.457
dna recombination	GO:0006310	32	0.436
meiotic chromosome segregation	GO:0045132	59	0.375
spindle assembly involved in meiosis	GO:0090306	20	0.347
reciprocal dna recombination	GO:0035825	19	0.318
cell division	GO:0051301	248	0.308
single fertilization	GO:0007338	24	0.259
spindle assembly	GO:0051225	80	0.236
chromosome segregation	GO:0007059	157	0.213
positive regulation of gene expression	GO:0010628	290	0.199
spindle assembly involved in female meiosis	GO:0007056	14	0.190
distributive segregation	GO:0032837	6	0.174
spindle organization	GO:0007051	253	0.169
mitotic nuclear division	GO:0007067	213	0.164
cellular catabolic process	GO:0044248	372	0.162
spindle assembly involved in female meiosis i	GO:0007057	5	0.161
regulation of mitotic cell cycle	GO:0007346	190	0.157
positive regulation of rna metabolic process	GO:0051254	271	0.151
cellular macromolecule catabolic process	GO:0044265	136	0.148
positive regulation of transcription dna templated	GO:0045893	266	0.145
female meiosis i	GO:0007144	8	0.145
regionalization	GO:0003002	416	0.135
mitotic spindle organization	GO:0007052	220	0.132
blastoderm segmentation	GO:0007350	159	0.131
ubiquitin dependent protein catabolic process	GO:0006511	78	0.127
regulation of microtubule polymerization or depolymerization	GO:0031110	27	0.120
cell maturation	GO:0048469	144	0.120
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.120
regulation of cell cycle phase transition	GO:1901987	130	0.116
female meiosis chromosome segregation	GO:0016321	33	0.111
negative regulation of cellular metabolic process	GO:0031324	382	0.110
positive regulation of biosynthetic process	GO:0009891	316	0.093
organelle assembly	GO:0070925	198	0.092
organonitrogen compound metabolic process	GO:1901564	318	0.091
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.088
oxoacid metabolic process	GO:0043436	103	0.086
protein modification process	GO:0036211	438	0.085
single organism cellular localization	GO:1902580	180	0.079
developmental growth	GO:0048589	280	0.078
chromatin organization	GO:0006325	207	0.075
regulation of cell cycle	GO:0051726	291	0.069
male pronucleus assembly	GO:0035039	6	0.069
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.068
establishment of localization in cell	GO:0051649	402	0.068
segmentation	GO:0035282	207	0.068
positive regulation of macromolecule metabolic process	GO:0010604	405	0.066
cellular response to dna damage stimulus	GO:0006974	223	0.066
anterior posterior pattern specification	GO:0009952	136	0.066
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.066
embryo development ending in birth or egg hatching	GO:0009792	152	0.065
cytokinesis	GO:0000910	90	0.064
embryonic pattern specification	GO:0009880	174	0.063
organic substance transport	GO:0071702	257	0.062
cellular protein modification process	GO:0006464	438	0.061
developmental maturation	GO:0021700	172	0.061
multicellular organismal aging	GO:0010259	140	0.060
cellular protein catabolic process	GO:0044257	83	0.060
response to abiotic stimulus	GO:0009628	341	0.059
regulation of cell cycle process	GO:0010564	181	0.059
catabolic process	GO:0009056	409	0.059
modification dependent macromolecule catabolic process	GO:0043632	79	0.057
axis specification	GO:0009798	167	0.054
organic acid metabolic process	GO:0006082	103	0.053
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.052
chromosome separation	GO:0051304	42	0.051
embryonic axis specification	GO:0000578	107	0.051
regulation of multicellular organismal development	GO:2000026	414	0.051
anterior posterior axis specification	GO:0009948	109	0.051
negative regulation of cellular biosynthetic process	GO:0031327	277	0.050
regulation of organelle organization	GO:0033043	196	0.049
localization of cell	GO:0051674	257	0.049
negative regulation of gene expression	GO:0010629	387	0.049
regulation of cellular ketone metabolic process	GO:0010565	3	0.048
metaphase anaphase transition of cell cycle	GO:0044784	28	0.048
microtubule polymerization or depolymerization	GO:0031109	39	0.046
establishment of spindle localization	GO:0051293	22	0.046
cell cycle phase transition	GO:0044770	140	0.046
negative regulation of signaling	GO:0023057	219	0.045
protein catabolic process	GO:0030163	101	0.045
small molecule metabolic process	GO:0044281	305	0.044
neurological system process	GO:0050877	358	0.044
regulation of cellular amino acid metabolic process	GO:0006521	0	0.044
aging	GO:0007568	143	0.044
cell proliferation	GO:0008283	299	0.043
mitotic cell cycle phase transition	GO:0044772	138	0.042
anterior posterior axis specification embryo	GO:0008595	103	0.042
single organism catabolic process	GO:0044712	228	0.042
proteolysis	GO:0006508	192	0.041
intracellular signal transduction	GO:0035556	300	0.040
regulation of developmental growth	GO:0048638	174	0.039
cellular response to organic substance	GO:0071310	132	0.039
establishment of cell polarity	GO:0030010	40	0.039
cellular response to chemical stimulus	GO:0070887	199	0.039
organic substance catabolic process	GO:1901575	308	0.038
negative regulation of cell cycle process	GO:0010948	109	0.038
single organism intracellular transport	GO:1902582	207	0.038
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.037
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.037
regulation of microtubule based process	GO:0032886	49	0.037
rna localization	GO:0006403	115	0.036
learning or memory	GO:0007611	141	0.036
microtubule anchoring	GO:0034453	11	0.035
male meiosis	GO:0007140	52	0.035
protein targeting to peroxisome	GO:0006625	2	0.035
cellular macromolecule localization	GO:0070727	220	0.035
positive regulation of rna biosynthetic process	GO:1902680	266	0.034
positive regulation of multicellular organismal process	GO:0051240	143	0.034
protein modification by small protein conjugation	GO:0032446	79	0.033
camera type eye development	GO:0043010	4	0.033
chromosome organization	GO:0051276	360	0.033
regulation of microtubule cytoskeleton organization	GO:0070507	41	0.033
oocyte construction	GO:0007308	112	0.033
tripartite regional subdivision	GO:0007351	103	0.032
macromolecule catabolic process	GO:0009057	161	0.031
mitotic cytokinesis	GO:0000281	50	0.031
establishment of spindle orientation	GO:0051294	18	0.030
modification dependent protein catabolic process	GO:0019941	78	0.030
oocyte development	GO:0048599	124	0.030
response to drug	GO:0042493	17	0.030
cellular amino acid metabolic process	GO:0006520	61	0.029
nucleoside triphosphate metabolic process	GO:0009141	120	0.029
carboxylic acid metabolic process	GO:0019752	92	0.029
protein modification by small protein conjugation or removal	GO:0070647	106	0.029
recombinational repair	GO:0000725	13	0.029
gene silencing	GO:0016458	138	0.029
protein phosphorylation	GO:0006468	169	0.029
single organism biosynthetic process	GO:0044711	206	0.029
positive regulation of protein metabolic process	GO:0051247	128	0.028
purine ribonucleotide metabolic process	GO:0009150	145	0.028
protein localization	GO:0008104	284	0.028
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.028
meiotic cytokinesis	GO:0033206	33	0.027
ion transmembrane transport	GO:0034220	122	0.027
protein complex assembly	GO:0006461	200	0.027
regulation of protein metabolic process	GO:0051246	256	0.027
regulation of protein catabolic process	GO:0042176	55	0.027
single organism behavior	GO:0044708	391	0.027
phosphorylation	GO:0016310	294	0.027
dna packaging	GO:0006323	91	0.027
intracellular transport	GO:0046907	228	0.027
dorsal ventral pattern formation	GO:0009953	133	0.027
oocyte axis specification	GO:0007309	108	0.026
male meiosis cytokinesis	GO:0007112	26	0.026
intracellular protein transport	GO:0006886	104	0.026
nucleoside phosphate metabolic process	GO:0006753	162	0.026
positive regulation of cell communication	GO:0010647	250	0.026
purine ribonucleotide catabolic process	GO:0009154	109	0.026
cellular protein localization	GO:0034613	160	0.026
endocytosis	GO:0006897	310	0.026
positive regulation of protein complex assembly	GO:0031334	22	0.025
establishment or maintenance of cell polarity	GO:0007163	167	0.025
protein complex biogenesis	GO:0070271	201	0.025
mitotic spindle elongation	GO:0000022	81	0.025
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.025
cognition	GO:0050890	141	0.025
histone modification	GO:0016570	106	0.024
central nervous system development	GO:0007417	201	0.024
response to light stimulus	GO:0009416	124	0.024
purine ribonucleoside metabolic process	GO:0046128	127	0.024
positive regulation of response to stimulus	GO:0048584	323	0.024
chromosome condensation	GO:0030261	41	0.023
cell cycle g1 s phase transition	GO:0044843	31	0.023
larval development	GO:0002164	104	0.023
carbohydrate derivative metabolic process	GO:1901135	217	0.022
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.022
double strand break repair via homologous recombination	GO:0000724	13	0.022
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.022
cellular ketone metabolic process	GO:0042180	24	0.022
dephosphorylation	GO:0016311	51	0.022
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	54	0.022
sensory organ morphogenesis	GO:0090596	260	0.022
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.022
lateral inhibition	GO:0046331	206	0.022
programmed cell death	GO:0012501	257	0.022
meiosis i	GO:0007127	59	0.022
camera type eye morphogenesis	GO:0048593	2	0.021
positive regulation of cellular protein metabolic process	GO:0032270	118	0.021
protein transport	GO:0015031	155	0.021
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.021
regulation of cellular component biogenesis	GO:0044087	201	0.021
mitotic cell cycle embryonic	GO:0045448	38	0.021
regulation of cellular amine metabolic process	GO:0033238	3	0.021
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.021
negative regulation of mitotic cell cycle	GO:0045930	109	0.021
cellular homeostasis	GO:0019725	80	0.020
ion transport	GO:0006811	145	0.020
regulation of multi organism process	GO:0043900	131	0.020
centrosome organization	GO:0051297	163	0.020
protein import into peroxisome matrix	GO:0016558	2	0.020
spindle localization	GO:0051653	22	0.020
double strand break repair	GO:0006302	26	0.020
cell migration	GO:0016477	238	0.020
cellular component assembly involved in morphogenesis	GO:0010927	151	0.020
cell motility	GO:0048870	251	0.019
vesicle mediated transport	GO:0016192	381	0.019
dna metabolic process	GO:0006259	227	0.019
response to other organism	GO:0051707	293	0.019
mitotic sister chromatid segregation	GO:0000070	87	0.019
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.019
cellular response to abiotic stimulus	GO:0071214	58	0.018
covalent chromatin modification	GO:0016569	106	0.018
cellular amine metabolic process	GO:0044106	12	0.018
response to temperature stimulus	GO:0009266	106	0.018
body morphogenesis	GO:0010171	2	0.018
regulation of nervous system development	GO:0051960	248	0.018
positive regulation of catabolic process	GO:0009896	105	0.018
fertilization	GO:0009566	26	0.018
actin cytoskeleton organization	GO:0030036	206	0.018
regulation of response to stress	GO:0080134	200	0.018
protein import	GO:0017038	55	0.018
microtubule cytoskeleton organization involved in mitosis	GO:1902850	52	0.018
g1 s transition of mitotic cell cycle	GO:0000082	31	0.018
growth	GO:0040007	359	0.018
negative regulation of growth	GO:0045926	84	0.017
negative regulation of response to stimulus	GO:0048585	258	0.017
regulation of catabolic process	GO:0009894	170	0.017
telencephalon development	GO:0021537	2	0.017
mitotic dna damage checkpoint	GO:0044773	74	0.017
regulation of synapse structure and activity	GO:0050803	128	0.017
mitotic cell cycle checkpoint	GO:0007093	88	0.017
response to organic substance	GO:0010033	284	0.017
negative regulation of rna metabolic process	GO:0051253	251	0.017
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.017
purine nucleoside metabolic process	GO:0042278	127	0.017
spindle midzone assembly	GO:0051255	4	0.017
response to biotic stimulus	GO:0009607	294	0.017
regulation of nuclear division	GO:0051783	58	0.016
cellular response to oxygen containing compound	GO:1901701	79	0.016
synapse assembly	GO:0007416	143	0.016
mitotic g2 dna damage checkpoint	GO:0007095	69	0.016
response to radiation	GO:0009314	155	0.016
regulation of catalytic activity	GO:0050790	185	0.016
eye morphogenesis	GO:0048592	260	0.016
regulation of mitotic metaphase anaphase transition	GO:0030071	26	0.016
regulation of cell differentiation	GO:0045595	302	0.016
positive regulation of signal transduction	GO:0009967	223	0.016
regulation of protein transport	GO:0051223	57	0.016
positive regulation of cellular amine metabolic process	GO:0033240	0	0.016
purine nucleotide metabolic process	GO:0006163	146	0.015
syncytial blastoderm mitotic cell cycle	GO:0035186	21	0.015
ribonucleoside monophosphate catabolic process	GO:0009158	39	0.015
purine ribonucleoside catabolic process	GO:0046130	112	0.015
purine nucleoside catabolic process	GO:0006152	112	0.015
carbohydrate derivative catabolic process	GO:1901136	118	0.015
macromolecular complex assembly	GO:0065003	256	0.015
positive regulation of cellular component organization	GO:0051130	156	0.014
protein targeting	GO:0006605	64	0.014
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.014
meiosis ii	GO:0007135	23	0.014
regulation of cyclin dependent protein serine threonine kinase activity	GO:0000079	3	0.014
negative regulation of rna biosynthetic process	GO:1902679	240	0.014
ribonucleoside monophosphate metabolic process	GO:0009161	51	0.014
organonitrogen compound catabolic process	GO:1901565	128	0.014
regulation of mitosis	GO:0007088	56	0.014
negative regulation of biosynthetic process	GO:0009890	277	0.014
regulation of synapse organization	GO:0050807	110	0.014
cellular protein complex assembly	GO:0043623	71	0.014
chromatin modification	GO:0016568	147	0.014
positive regulation of cell cycle process	GO:0090068	28	0.014
cellular nitrogen compound catabolic process	GO:0044270	165	0.014
positive regulation of cell cycle	GO:0045787	43	0.014
organic cyclic compound catabolic process	GO:1901361	168	0.014
nitrogen compound transport	GO:0071705	85	0.014
ribonucleotide metabolic process	GO:0009259	145	0.013
ovarian follicle cell development	GO:0030707	248	0.013
maintenance of protein location in cell	GO:0032507	26	0.013
intracellular protein transmembrane import	GO:0044743	4	0.013
organophosphate catabolic process	GO:0046434	112	0.013
mitotic dna integrity checkpoint	GO:0044774	75	0.013
transcription from rna polymerase ii promoter	GO:0006366	368	0.013
regulation of cellular protein metabolic process	GO:0032268	243	0.013
regulation of protein modification process	GO:0031399	112	0.013
ribonucleoside catabolic process	GO:0042454	112	0.013
negative regulation of cell communication	GO:0010648	223	0.013
regulation of metaphase anaphase transition of cell cycle	GO:1902099	26	0.013
regulation of anatomical structure morphogenesis	GO:0022603	242	0.013
negative regulation of developmental process	GO:0051093	201	0.013
endomembrane system organization	GO:0010256	119	0.013
purine nucleotide catabolic process	GO:0006195	109	0.013
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.013
nucleus organization	GO:0006997	45	0.013
protein localization to peroxisome	GO:0072662	2	0.013
peptidyl amino acid modification	GO:0018193	105	0.012
positive regulation of protein localization to nucleus	GO:1900182	21	0.012
positive regulation of transport	GO:0051050	92	0.012
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.012
peptidyl threonine phosphorylation	GO:0018107	2	0.012
oocyte differentiation	GO:0009994	145	0.012
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process	GO:0031145	30	0.012
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.012
homeostatic process	GO:0042592	199	0.012
peptidyl threonine modification	GO:0018210	3	0.012
regulation of transport	GO:0051049	181	0.012
amine metabolic process	GO:0009308	12	0.012
negative regulation of nervous system development	GO:0051961	92	0.012
nucleobase containing small molecule metabolic process	GO:0055086	174	0.012
death	GO:0016265	284	0.011
epithelial cell differentiation	GO:0030855	322	0.011
protein polymerization	GO:0051258	42	0.011
establishment of protein localization	GO:0045184	163	0.011
regulation of chromosome segregation	GO:0051983	32	0.011
positive regulation of proteolysis involved in cellular protein catabolic process	GO:1903052	24	0.011
response to glucose	GO:0009749	2	0.011
positive regulation of developmental growth	GO:0048639	62	0.011
regulation of cytoskeleton organization	GO:0051493	89	0.011
regulation of cell division	GO:0051302	72	0.011
mitotic sister chromatid separation	GO:0051306	30	0.011
wing disc morphogenesis	GO:0007472	344	0.011
heterocycle catabolic process	GO:0046700	166	0.011
ribonucleotide catabolic process	GO:0009261	109	0.011
positive regulation of proteolysis	GO:0045862	52	0.011
wound healing	GO:0042060	75	0.011
chromatin remodeling	GO:0006338	72	0.011
positive regulation of phosphate metabolic process	GO:0045937	139	0.011
regulation of cellular response to stress	GO:0080135	89	0.011
ribose phosphate metabolic process	GO:0019693	145	0.011
microtubule polymerization	GO:0046785	15	0.011
metaphase anaphase transition of mitotic cell cycle	GO:0007091	28	0.011
negative regulation of gene expression epigenetic	GO:0045814	77	0.011
regulation of gene expression epigenetic	GO:0040029	128	0.010
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.010
regulation of dna metabolic process	GO:0051052	34	0.010
purine containing compound metabolic process	GO:0072521	155	0.010
regulation of intracellular signal transduction	GO:1902531	236	0.010
oocyte anterior posterior axis specification	GO:0007314	72	0.010
establishment of protein localization to organelle	GO:0072594	62	0.010
single organism membrane organization	GO:0044802	93	0.010
photoreceptor cell development	GO:0042461	96	0.010
hindbrain development	GO:0030902	2	0.010

cort disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
cancer	DOID:162	0.023
disease of cellular proliferation	DOID:14566	0.023
organ system cancer	DOID:0050686	0.023
disease of metabolism	DOID:0014667	0.016

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