Drosophila melanogaster

47 known processes

I-2 (Dmel_CG10574)

Inhibitor-2

(Aliases: SET,I-2PP1,CG10574,Dmel\CG10574,Dm I-2,I-2Dm)

I-2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
mitotic nuclear divisionGO:00070672130.218
regulation of protein dephosphorylationGO:003530450.188
epithelial cell developmentGO:00020642740.174
organelle fissionGO:00482853400.171
dephosphorylationGO:0016311510.155
chromosome segregationGO:00070591570.151
imaginal disc derived appendage morphogenesisGO:00351143950.146
nuclear divisionGO:00002803320.141
defense response to other organismGO:00985422250.124
defense responseGO:00069523000.118
cell divisionGO:00513012480.113
protein modification processGO:00362114380.111
response to other organismGO:00517072930.111
regulation of protein metabolic processGO:00512462560.110
positive regulation of macromolecule metabolic processGO:00106044050.107
regulation of phosphorus metabolic processGO:00511742100.104
post embryonic appendage morphogenesisGO:00351203850.103
regulation of cell cycleGO:00517262910.097
chemotaxisGO:00069352490.096
taxisGO:00423303040.092
response to light stimulusGO:00094161240.092
regulation of phosphate metabolic processGO:00192202100.091
adult behaviorGO:00305341370.091
vesicle mediated transportGO:00161923810.089
single organism catabolic processGO:00447122280.089
neuron projection guidanceGO:00974852410.087
establishment of localization in cellGO:00516494020.087
defense response to bacteriumGO:00427421780.086
multi multicellular organism processGO:00447061230.083
axon developmentGO:00615642970.083
catabolic processGO:00090564090.082
axonogenesisGO:00074092900.080
ovarian follicle cell developmentGO:00307072480.080
endocytosisGO:00068973100.079
adult locomotory behaviorGO:0008344760.077
response to biotic stimulusGO:00096072940.077
establishment of organelle localizationGO:00516561220.075
cellular protein modification processGO:00064644380.074
immune system processGO:00023763470.073
organonitrogen compound metabolic processGO:19015643180.072
single organism behaviorGO:00447083910.071
regulation of cellular protein metabolic processGO:00322682430.070
regulation of localizationGO:00328792750.070
regulation of protein modification processGO:00313991120.070
epithelial cell differentiationGO:00308553220.069
neurological system processGO:00508773580.067
chromosome organizationGO:00512763600.066
protein dephosphorylationGO:0006470270.061
protein complex biogenesisGO:00702712010.061
immune responseGO:00069552460.061
microtubule cytoskeleton organization involved in mitosisGO:1902850520.060
innate immune responseGO:00450871440.058
imaginal disc derived appendage developmentGO:00487373990.058
organic substance catabolic processGO:19015753080.057
cellular catabolic processGO:00442483720.056
columnar cuboidal epithelial cell differentiationGO:00020652560.056
amino sugar catabolic processGO:004634830.055
appendage developmentGO:00487364010.054
leg disc developmentGO:0035218920.054
organelle localizationGO:00516401480.052
response to radiationGO:00093141550.052
regulation of catalytic activityGO:00507901850.051
epithelial cell migrationGO:00106311480.051
axon guidanceGO:00074112330.051
deathGO:00162652840.051
columnar cuboidal epithelial cell developmentGO:00020662490.051
matingGO:00076181200.051
appendage morphogenesisGO:00351073970.049
growthGO:00400073590.049
locomotory behaviorGO:00076261760.048
modification dependent protein catabolic processGO:0019941780.048
sister chromatid segregationGO:0000819920.048
proteasome mediated ubiquitin dependent protein catabolic processGO:0043161540.048
cytoplasmic transportGO:00164821300.048
modification dependent macromolecule catabolic processGO:0043632790.048
chromatin organizationGO:00063252070.047
response to bacteriumGO:00096171980.047
regulation of mitotic cell cycleGO:00073461900.047
cell motilityGO:00488702510.047
regulation of mitotic cell cycle phase transitionGO:19019901300.047
wing disc morphogenesisGO:00074723440.047
imaginal disc derived wing morphogenesisGO:00074763370.047
cell deathGO:00082192790.046
protein localizationGO:00081042840.046
spindle assemblyGO:0051225800.045
regulation of transportGO:00510491810.045
response to external biotic stimulusGO:00432072930.045
negative regulation of cell cycleGO:00457861160.045
proteolysis involved in cellular protein catabolic processGO:0051603830.045
proteolysisGO:00065081920.044
dna damage checkpointGO:0000077780.044
mitotic sister chromatid segregationGO:0000070870.044
macromolecule catabolic processGO:00090571610.044
steroid catabolic processGO:000670610.043
regulation of cellular catabolic processGO:00313291570.043
negative regulation of cellular metabolic processGO:00313243820.043
mitotic cell cycle phase transitionGO:00447721380.043
regulation of immune responseGO:00507761180.043
cellular ion homeostasisGO:0006873390.042
organelle assemblyGO:00709251980.042
cognitionGO:00508901410.040
defense response to gram negative bacteriumGO:0050829940.040
histone modificationGO:00165701060.040
programmed cell deathGO:00125012570.040
regulation of cell cycle phase transitionGO:19019871300.040
proteasomal protein catabolic processGO:0010498590.039
positive regulation of response to stimulusGO:00485843230.039
ion homeostasisGO:0050801550.039
intracellular signal transductionGO:00355563000.039
regulation of organelle organizationGO:00330431960.039
organic substance transportGO:00717022570.038
positive regulation of cell communicationGO:00106472500.038
spermatogenesisGO:00072832000.038
cellular protein catabolic processGO:0044257830.037
glucosamine containing compound catabolic processGO:190107230.037
negative regulation of protein metabolic processGO:0051248850.037
ubiquitin dependent protein catabolic processGO:0006511780.037
regulation of cell cycle processGO:00105641810.037
phagocytosisGO:00069092150.037
multi organism behaviorGO:00517051750.037
regulation of immune system processGO:00026821760.036
regulation of proteasomal protein catabolic processGO:0061136390.036
regulation of proteolysis involved in cellular protein catabolic processGO:1903050440.036
positive regulation of immune responseGO:0050778630.036
spindle organizationGO:00070512530.036
leg disc morphogenesisGO:0007478800.036
male gamete generationGO:00482322010.035
positive regulation of signalingGO:00230562430.035
positive regulation of defense responseGO:0031349590.035
phosphorylationGO:00163102940.035
protein complex assemblyGO:00064612000.034
regulation of response to stressGO:00801342000.034
cellular amine metabolic processGO:0044106120.034
cellular homeostasisGO:0019725800.033
regulation of intracellular signal transductionGO:19025312360.033
learningGO:0007612750.033
chromosome condensationGO:0030261410.032
border follicle cell migrationGO:00072981130.032
protein catabolic processGO:00301631010.032
ethanolamine containing compound metabolic processGO:004243940.032
regulation of metaphase anaphase transition of cell cycleGO:1902099260.032
inseminationGO:0007320220.031
covalent chromatin modificationGO:00165691060.031
meiotic chromosome segregationGO:0045132590.030
amine metabolic processGO:0009308120.030
embryonic development via the syncytial blastodermGO:00017001480.030
dna integrity checkpointGO:0031570810.030
lipid metabolic processGO:00066291210.030
response to abiotic stimulusGO:00096283410.030
regulation of mapk cascadeGO:0043408920.030
regulation of catabolic processGO:00098941700.030
small gtpase mediated signal transductionGO:0007264880.030
homeostatic processGO:00425921990.030
regionalizationGO:00030024160.030
protein ubiquitinationGO:0016567700.029
non sensory hair organizationGO:0035316470.029
chemosensory behaviorGO:00076351060.029
chromosome separationGO:0051304420.029
olfactory learningGO:0008355560.029
small molecule metabolic processGO:00442813050.028
camera type eye developmentGO:004301040.028
germ line cyst formationGO:0048134440.028
positive regulation of immune system processGO:0002684680.028
cellular ketone metabolic processGO:0042180240.028
rna processingGO:00063961470.028
regulation of mitosisGO:0007088560.028
negative regulation of mitotic cell cycle phase transitionGO:19019911030.028
macromolecular complex assemblyGO:00650032560.028
cell cycle phase transitionGO:00447701400.028
microtubule organizing center organizationGO:00310231680.028
exocrine system developmentGO:00352721620.028
positive regulation of protein metabolic processGO:00512471280.028
cellular chemical homeostasisGO:0055082400.027
g protein coupled receptor signaling pathwayGO:00071861360.027
mitotic spindle organizationGO:00070522200.027
organonitrogen compound catabolic processGO:19015651280.027
epithelium migrationGO:00901321480.027
regulation of molecular functionGO:00650092170.027
positive regulation of phosphorus metabolic processGO:00105621390.027
regulation of cellular amino acid metabolic processGO:000652100.026
centrosome organizationGO:00512971630.026
positive regulation of nitrogen compound metabolic processGO:00511733540.026
regulation of mitotic metaphase anaphase transitionGO:0030071260.026
regulation of protein catabolic processGO:0042176550.026
dna packagingGO:0006323910.026
tissue migrationGO:00901301550.026
cell cycle checkpointGO:0000075950.026
entrainment of circadian clock by photoperiodGO:004315390.026
carbohydrate metabolic processGO:0005975820.026
regulation of multicellular organismal developmentGO:20000264140.026
negative regulation of cellular protein metabolic processGO:0032269850.026
cell migrationGO:00164772380.026
epidermal cell differentiationGO:0009913510.026
body morphogenesisGO:001017120.026
behavioral response to ethanolGO:0048149490.025
microtubule bundle formationGO:0001578270.025
carbohydrate derivative metabolic processGO:19011352170.025
organophosphate metabolic processGO:00196371950.025
regulation of cellular localizationGO:00603411360.025
oxidation reduction processGO:00551141230.025
hormone catabolic processGO:004244730.025
hair cell differentiationGO:0035315470.025
chemical homeostasisGO:0048878920.025
regulation of growthGO:00400082330.025
cellular carbohydrate metabolic processGO:0044262220.025
single organism biosynthetic processGO:00447112060.024
cellular macromolecule catabolic processGO:00442651360.024
developmental programmed cell deathGO:00106231380.024
peripheral nervous system developmentGO:0007422520.024
mating behaviorGO:00076171060.024
transmembrane transportGO:00550851390.024
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic processGO:0031145300.024
chromatin modificationGO:00165681470.024
sperm competitionGO:0046692210.024
meiotic cell cycleGO:00513211710.024
neurotransmitter metabolic processGO:004213320.024
rrna processingGO:000636430.023
regulation of cell differentiationGO:00455953020.023
mapk cascadeGO:00001651070.023
spindle assembly involved in mitosisGO:0090307500.023
single organism carbohydrate metabolic processGO:0044723720.023
regulation of defense responseGO:00313471020.023
cellular protein localizationGO:00346131600.023
cell proliferationGO:00082832990.023
positive regulation of signal transductionGO:00099672230.023
regulation of cell deathGO:00109411730.023
signal transduction by phosphorylationGO:00230141070.023
synaptic transmissionGO:00072682880.023
negative regulation of cellular component organizationGO:00511291080.023
regulation of anatomical structure sizeGO:00900661630.023
learning or memoryGO:00076111410.023
regulation of proteolysisGO:0030162870.022
regulation of erk1 and erk2 cascadeGO:0070372390.022
regulation of cellular protein catabolic processGO:1903362440.022
regulation of cell divisionGO:0051302720.022
regulation of nervous system developmentGO:00519602480.022
regulation of proteasomal ubiquitin dependent protein catabolic processGO:0032434370.022
regulation of ras protein signal transductionGO:0046578930.022
cell adhesionGO:00071551360.022
compound eye developmentGO:00487493070.022
regulation of synapse structure and activityGO:00508031280.022
salivary gland morphogenesisGO:00074351450.022
oxoacid metabolic processGO:00434361030.022
cellular macromolecule localizationGO:00707272200.022
erk1 and erk2 cascadeGO:0070371390.022
negative regulation of response to stimulusGO:00485852580.022
mitotic sister chromatid separationGO:0051306300.022
respiratory system developmentGO:00605412130.022
eye developmentGO:00016543230.021
regulation of sister chromatid segregationGO:0033045280.021
endomembrane system organizationGO:00102561190.021
olfactory behaviorGO:0042048970.021
regulation of phosphorylationGO:00423251470.021
regulation of small gtpase mediated signal transductionGO:0051056930.021
agingGO:00075681430.021
gland morphogenesisGO:00226121450.021
positive regulation of erk1 and erk2 cascadeGO:0070374360.021
regulation of circadian rhythmGO:0042752490.021
negative regulation of signal transductionGO:00099682060.021
eye morphogenesisGO:00485922600.020
alcohol metabolic processGO:0006066250.020
salivary gland developmentGO:00074311620.020
negative regulation of gene expressionGO:00106293870.020
regulation of chromosome organizationGO:0033044640.020
metaphase anaphase transition of cell cycleGO:0044784280.020
regulation of cellular amine metabolic processGO:003323830.020
intracellular transportGO:00469072280.020
meiotic nuclear divisionGO:00071261510.020
regulation of cytoskeleton organizationGO:0051493890.020
positive regulation of phosphate metabolic processGO:00459371390.019
response to organic substanceGO:00100332840.019
protein modification by small protein conjugationGO:0032446790.019
negative regulation of cell cycle phase transitionGO:19019881030.019
chromosome localizationGO:0050000200.019
localization of cellGO:00516742570.019
female germ line cyst formationGO:0048135420.019
dendrite developmentGO:00163582040.019
chitin catabolic processGO:000603230.019
ovarian follicle cell migrationGO:00072971210.019
cell growthGO:00160491080.019
entrainment of circadian clockGO:0009649160.019
organic hydroxy compound metabolic processGO:1901615830.019
segmentationGO:00352822070.019
germarium derived female germ line cyst formationGO:0030727420.019
detection of stimulusGO:00516061560.019
epidermis developmentGO:0008544650.019
dna metabolic processGO:00062592270.019
developmental growthGO:00485892800.019
associative learningGO:0008306650.018
negative regulation of phosphate metabolic processGO:0045936450.018
microtubule based movementGO:0007018510.018
cellular response to dna damage stimulusGO:00069742230.018
cation transportGO:00068121100.018
regulation of neurogenesisGO:00507671580.018
single organism intracellular transportGO:19025822070.018
cell cycle arrestGO:000705040.018
negative regulation of organelle organizationGO:0010639560.018
connective tissue developmentGO:006144830.018
positive regulation of intracellular signal transductionGO:19025331160.018
central nervous system developmentGO:00074172010.018
apoptotic processGO:00069151590.018
positive regulation of biosynthetic processGO:00098913160.018
chromatin silencingGO:0006342760.018
regulation of epithelial cell proliferationGO:005067840.018
dna dependent dna replicationGO:0006261170.017
negative regulation of catalytic activityGO:0043086420.017
positive regulation of multicellular organismal processGO:00512401430.017
positive regulation of cellular protein metabolic processGO:00322701180.017
tissue deathGO:00162711020.017
cellular polysaccharide metabolic processGO:0044264110.017
asymmetric stem cell divisionGO:0098722490.017
regulation of mitotic sister chromatid separationGO:0010965280.017
regulation of nuclear divisionGO:0051783580.017
cellular amino acid metabolic processGO:0006520610.017
histolysisGO:00075591020.017
compound eye morphogenesisGO:00017452490.017
regulation of cellular ketone metabolic processGO:001056530.017
regulation of erbb signaling pathwayGO:1901184420.017
regulation of developmental growthGO:00486381740.017
transcription from rna polymerase ii promoterGO:00063663680.017
nuclear transportGO:0051169720.017
response to organophosphorusGO:004668320.016
spindle checkpointGO:0031577110.016
developmental maturationGO:00217001720.016
response to oxygen containing compoundGO:19017002000.016
cell projection assemblyGO:0030031940.016
salivary gland histolysisGO:0035070880.016
negative regulation of mitotic cell cycleGO:00459301090.016
multicellular organismal agingGO:00102591400.016
negative regulation of cellular biosynthetic processGO:00313272770.016
ras protein signal transductionGO:0007265880.016
hindbrain developmentGO:003090220.016
mitotic spindle checkpointGO:0071174110.016
sensory organ morphogenesisGO:00905962600.016
open tracheal system developmentGO:00074242040.016
carboxylic acid metabolic processGO:0019752920.016
negative regulation of nitrogen compound metabolic processGO:00511722650.016
ribonucleotide metabolic processGO:00092591450.016
nucleoside phosphate metabolic processGO:00067531620.016
chaeta developmentGO:0022416970.016
regulation of mitotic sister chromatid segregationGO:0033047280.016
organic acid metabolic processGO:00060821030.016
cellular lipid metabolic processGO:0044255830.016
establishment or maintenance of polarity of follicular epitheliumGO:0016334260.016
negative regulation of cell differentiationGO:00455961430.016
cellular response to chemical stimulusGO:00708871990.016
organic cyclic compound catabolic processGO:19013611680.015
positive regulation of mapk cascadeGO:0043410630.015
copulationGO:0007620260.015
response to heatGO:0009408630.015
regulation of chromosome segregationGO:0051983320.015
morphogenesis of an epitheliumGO:00020092760.015
negative regulation of biosynthetic processGO:00098902770.015
enzyme linked receptor protein signaling pathwayGO:00071671790.015
negative regulation of cell cycle processGO:00109481090.015
acetylcholine metabolic processGO:000829120.015
autophagic cell deathGO:0048102830.015
regulation of epidermal growth factor receptor signaling pathwayGO:0042058420.015
cellular response to ethanolGO:007136140.015
negative regulation of epithelial cell proliferationGO:005068040.015
visual learningGO:000854240.015
regulation of cellular component biogenesisGO:00440872010.015
establishment or maintenance of cell polarityGO:00071631670.015
regulation of microtubule based processGO:0032886490.015
nitrogen compound transportGO:0071705850.015
chorion containing eggshell formationGO:00073041050.015
cellular biogenic amine catabolic processGO:004240210.014
positive regulation of phosphorylationGO:0042327870.014
lipid localizationGO:0010876540.014
response to temperature stimulusGO:00092661060.014
synapse organizationGO:00508081960.014
female meiotic divisionGO:0007143700.014
synapse assemblyGO:00074161430.014
cation homeostasisGO:0055080510.014
nucleocytoplasmic transportGO:0006913720.014
embryo development ending in birth or egg hatchingGO:00097921520.014
positive regulation of transportGO:0051050920.014
carbohydrate derivative catabolic processGO:19011361180.014
eggshell formationGO:00307031050.014
purine nucleoside metabolic processGO:00422781270.014
maintenance of locationGO:0051235730.014
spinal cord developmentGO:002151010.014
determination of adult lifespanGO:00083401370.014
establishment of protein localizationGO:00451841630.014
negative regulation of phosphorus metabolic processGO:0010563450.014
nucleobase containing small molecule metabolic processGO:00550861740.014
neuron recognitionGO:00080381010.014
biological adhesionGO:00226101380.014
blastoderm segmentationGO:00073501590.014
regulation of cell developmentGO:00602842150.014
organophosphate catabolic processGO:00464341120.014
sensory perception of mechanical stimulusGO:0050954720.014
positive regulation of cellular component organizationGO:00511301560.014
septate junction assemblyGO:0019991260.014
mitotic cell cycle checkpointGO:0007093880.014
protein processingGO:0016485680.014
negative regulation of cellular catabolic processGO:0031330340.014
establishment of chromosome localizationGO:0051303200.014
skin developmentGO:0043588650.014
response to ethanolGO:0045471590.014
protein transportGO:00150311550.014
photoreceptor cell differentiationGO:00465301700.013
polysaccharide metabolic processGO:0005976110.013
purine ribonucleoside metabolic processGO:00461281270.013
meiotic cell cycle processGO:19030461320.013
camera type eye morphogenesisGO:004859320.013
sensory perceptionGO:00076001960.013
organic hydroxy compound catabolic processGO:190161640.013
multicellular organismal reproductive behaviorGO:00330571100.013
negative regulation of homeostatic processGO:003284520.013
ribonucleoside metabolic processGO:00091191270.013
sensory perception of soundGO:0007605560.013
retina development in camera type eyeGO:006004140.013
monocarboxylic acid transportGO:001571830.013
jak stat cascadeGO:0007259490.013
energy derivation by oxidation of organic compoundsGO:0015980320.013
positive regulation of innate immune responseGO:0045089380.013
negative regulation of developmental processGO:00510932010.013
negative regulation of chromosome segregationGO:0051985140.013
oocyte dorsal ventral axis specificationGO:0007310340.013
protein maturationGO:0051604710.013
spindle elongationGO:0051231830.013
forebrain developmentGO:003090020.013
regulation of transcription from rna polymerase ii promoterGO:00063573780.013
negative regulation of cell communicationGO:00106482230.013
lipid storageGO:0019915380.013
purine nucleotide metabolic processGO:00061631460.013
negative regulation of cellular macromolecule biosynthetic processGO:20001132670.013
ameboidal type cell migrationGO:00016671510.012
imaginal disc derived wing vein specificationGO:0007474480.012
positive regulation of cellular catabolic processGO:0031331950.012
generation of precursor metabolites and energyGO:0006091420.012
glycosyl compound catabolic processGO:19016581120.012
regulation of cell substrate adhesionGO:001081020.012
purine ribonucleoside triphosphate metabolic processGO:00092051190.012
regulation of programmed cell deathGO:00430671520.012
telencephalon developmentGO:002153720.012
long term memoryGO:0007616620.012
mrna processingGO:00063971040.012
ion transportGO:00068111450.012
guanosine containing compound metabolic processGO:1901068740.012
negative regulation of protein modification processGO:0031400290.012
secretion by cellGO:00329401010.012
positive regulation of developmental processGO:00510941430.012
glycerolipid metabolic processGO:0046486340.012
negative regulation of macromolecule biosynthetic processGO:00105582700.012
somatic stem cell divisionGO:0048103370.012
glycosyl compound metabolic processGO:19016571270.012
stem cell divisionGO:0017145690.012
secretionGO:00469031090.012
negative regulation of signalingGO:00230572190.012
lipid biosynthetic processGO:0008610460.012
positive regulation of catalytic activityGO:00430851180.012
regulation of synapse organizationGO:00508071100.012
small molecule catabolic processGO:0044282210.012
glutathione metabolic processGO:0006749370.012
purine containing compound metabolic processGO:00725211550.012
kidney developmentGO:000182230.012
reproductive behaviorGO:00190981220.012
regulation of neuron differentiationGO:00456641030.012
cytokinesisGO:0000910900.012
germarium derived egg chamber formationGO:00072931010.012
male mating behaviorGO:0060179700.012
regulation of cell proliferationGO:00421271630.012
ribonucleoside triphosphate metabolic processGO:00091991190.011
cilium organizationGO:0044782410.011
cilium assemblyGO:0042384380.011
negative regulation of neurogenesisGO:0050768530.011
embryonic pattern specificationGO:00098801740.011
ventral furrow formationGO:0007370170.011
rna localizationGO:00064031150.011
regulation of innate immune responseGO:0045088710.011
regulation of sequestering of calcium ionGO:005128230.011
negative regulation of nervous system developmentGO:0051961920.011
neuronal stem cell divisionGO:0036445350.011
cilium morphogenesisGO:0060271390.011
axis specificationGO:00097981670.011
metal ion homeostasisGO:0055065440.011
mitotic cytokinesisGO:0000281500.011
nucleotide metabolic processGO:00091171610.011
mrna splicing via spliceosomeGO:0000398730.011
regulation of intracellular transportGO:0032386640.011
choline metabolic processGO:001969510.011
cell recognitionGO:00080371020.011
morphogenesis of follicular epitheliumGO:0016333360.011
nucleoside metabolic processGO:00091161270.011
organonitrogen compound biosynthetic processGO:19015661170.011
spermatid developmentGO:0007286980.011

I-2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.066
disease of cellular proliferationDOID:1456600.025
nervous system diseaseDOID:86300.024
cancerDOID:16200.019
organ system cancerDOID:005068600.016
cardiovascular system diseaseDOID:128700.012
sensory system diseaseDOID:005015500.011