IMP: Integrative Multi-species Prediction

Drosophila melanogaster

30 known processes

Pgk (Dmel_CG3127)

Phosphoglycerate kinase

(Aliases: pgk,CG3127,l(2)23AB3,PGK,Dmel\CG3127,ESTS:169C9S,l(2)23Ac,169C9S,anon-sts18)

FLYBASE: FBgn0250906
Entrez: 33461
UniProtKB: Q01604
UniProtKB: M9PCE0

Process Predictions
Disease Predictions

Pgk biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
synaptic transmission	GO:0007268	288	0.925
generation of precursor metabolites and energy	GO:0006091	42	0.876
oxidation reduction process	GO:0055114	123	0.846
nad metabolic process	GO:0019674	1	0.780
synapse organization	GO:0050808	196	0.748
establishment of localization in cell	GO:0051649	402	0.745
carbohydrate catabolic process	GO:0016052	7	0.641
transmembrane transport	GO:0055085	139	0.618
mitochondrion organization	GO:0007005	65	0.613
single organism biosynthetic process	GO:0044711	206	0.586
organic acid metabolic process	GO:0006082	103	0.529
organonitrogen compound metabolic process	GO:1901564	318	0.480
pyruvate metabolic process	GO:0006090	7	0.452
carbohydrate metabolic process	GO:0005975	82	0.445
single organism carbohydrate metabolic process	GO:0044723	72	0.415
myotube differentiation	GO:0014902	46	0.405
striated muscle cell differentiation	GO:0051146	90	0.394
ion transport	GO:0006811	145	0.390
energy derivation by oxidation of organic compounds	GO:0015980	32	0.388
carbohydrate biosynthetic process	GO:0016051	17	0.382
oxoacid metabolic process	GO:0043436	103	0.381
secretion by cell	GO:0032940	101	0.380
carboxylic acid metabolic process	GO:0019752	92	0.349
ribonucleoside biosynthetic process	GO:0042455	3	0.342
single organism carbohydrate catabolic process	GO:0044724	7	0.332
actomyosin structure organization	GO:0031032	56	0.330
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.313
glycolytic process	GO:0006096	6	0.310
muscle cell differentiation	GO:0042692	103	0.306
nucleoside metabolic process	GO:0009116	127	0.301
myoblast fusion	GO:0007520	43	0.282
cellular component assembly involved in morphogenesis	GO:0010927	151	0.266
cellular response to chemical stimulus	GO:0070887	199	0.265
negative regulation of signaling	GO:0023057	219	0.262
lipid localization	GO:0010876	54	0.253
cation transmembrane transport	GO:0098655	88	0.241
nicotinamide nucleotide metabolic process	GO:0046496	2	0.238
cellular amino acid metabolic process	GO:0006520	61	0.236
neuron neuron synaptic transmission	GO:0007270	14	0.225
organophosphate metabolic process	GO:0019637	195	0.221
negative regulation of response to stimulus	GO:0048585	258	0.209
syncytium formation	GO:0006949	43	0.198
regulation of localization	GO:0032879	275	0.196
homeostatic process	GO:0042592	199	0.189
syncytium formation by plasma membrane fusion	GO:0000768	43	0.186
muscle structure development	GO:0061061	224	0.183
atp biosynthetic process	GO:0006754	2	0.183
cellular response to reactive oxygen species	GO:0034614	14	0.179
defense response	GO:0006952	300	0.175
small molecule metabolic process	GO:0044281	305	0.174
secretion	GO:0046903	109	0.174
monocarboxylic acid metabolic process	GO:0032787	29	0.169
programmed cell death	GO:0012501	257	0.165
regulation of transport	GO:0051049	181	0.164
cellular lipid metabolic process	GO:0044255	83	0.157
oxidoreduction coenzyme metabolic process	GO:0006733	2	0.155
regulation of synaptic transmission	GO:0050804	69	0.150
ion transmembrane transport	GO:0034220	122	0.148
signal release	GO:0023061	49	0.144
organic substance catabolic process	GO:1901575	308	0.143
response to organic substance	GO:0010033	284	0.142
single organism catabolic process	GO:0044712	228	0.138
catabolic process	GO:0009056	409	0.138
lipid storage	GO:0019915	38	0.137
synapse assembly	GO:0007416	143	0.134
negative regulation of protein metabolic process	GO:0051248	85	0.134
cellular ketone metabolic process	GO:0042180	24	0.132
inorganic cation transmembrane transport	GO:0098662	61	0.129
response to oxygen containing compound	GO:1901700	200	0.125
protein complex assembly	GO:0006461	200	0.122
appendage morphogenesis	GO:0035107	397	0.120
metal ion transport	GO:0030001	74	0.113
cellular macromolecular complex assembly	GO:0034622	153	0.110
regulation of cellular localization	GO:0060341	136	0.110
purine nucleoside metabolic process	GO:0042278	127	0.107
neurotransmitter transport	GO:0006836	37	0.104
regulation of response to stress	GO:0080134	200	0.099
negative regulation of signal transduction	GO:0009968	206	0.098
pyridine containing compound metabolic process	GO:0072524	3	0.097
response to organonitrogen compound	GO:0010243	75	0.095
single organism membrane organization	GO:0044802	93	0.094
cellular protein modification process	GO:0006464	438	0.094
cellular protein complex assembly	GO:0043623	71	0.091
regulation of cell death	GO:0010941	173	0.091
cellular respiration	GO:0045333	26	0.088
purine nucleoside biosynthetic process	GO:0042451	3	0.087
posttranscriptional regulation of gene expression	GO:0010608	145	0.086
nucleotide metabolic process	GO:0009117	161	0.085
negative regulation of cell communication	GO:0010648	223	0.084
response to abiotic stimulus	GO:0009628	341	0.084
neuromuscular synaptic transmission	GO:0007274	67	0.083
protein localization	GO:0008104	284	0.083
lipid metabolic process	GO:0006629	121	0.083
hexose metabolic process	GO:0019318	8	0.082
response to glucose	GO:0009749	2	0.082
locomotory behavior	GO:0007626	176	0.081
somatic muscle development	GO:0007525	66	0.080
cation transport	GO:0006812	110	0.080
death	GO:0016265	284	0.077
cellular polysaccharide metabolic process	GO:0044264	11	0.077
g protein coupled receptor signaling pathway	GO:0007186	136	0.076
atp metabolic process	GO:0046034	49	0.074
lipid catabolic process	GO:0016042	21	0.073
regulation of secretion by cell	GO:1903530	39	0.073
cell death	GO:0008219	279	0.073
phosphorylation	GO:0016310	294	0.070
membrane organization	GO:0061024	112	0.069
response to monosaccharide	GO:0034284	4	0.068
aging	GO:0007568	143	0.068
ribonucleoside triphosphate biosynthetic process	GO:0009201	2	0.067
synaptic transmission glutamatergic	GO:0035249	7	0.067
regulation of membrane potential	GO:0042391	35	0.067
myofibril assembly	GO:0030239	36	0.065
actin filament based process	GO:0030029	220	0.063
purine ribonucleoside metabolic process	GO:0046128	127	0.062
glucose metabolic process	GO:0006006	5	0.062
positive regulation of cell communication	GO:0010647	250	0.061
response to mechanical stimulus	GO:0009612	28	0.061
regulation of secretion	GO:0051046	44	0.061
regulation of programmed cell death	GO:0043067	152	0.059
polysaccharide metabolic process	GO:0005976	11	0.059
myosin filament organization	GO:0031033	5	0.058
negative regulation of cellular protein metabolic process	GO:0032269	85	0.057
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	65	0.055
response to extracellular stimulus	GO:0009991	116	0.052
neurotransmitter secretion	GO:0007269	35	0.052
response to oxidative stress	GO:0006979	86	0.050
regulation of mitochondrion organization	GO:0010821	12	0.050
inorganic ion transmembrane transport	GO:0098660	73	0.049
regulation of neurotransmitter levels	GO:0001505	38	0.046
response to endogenous stimulus	GO:0009719	119	0.046
purine nucleotide biosynthetic process	GO:0006164	29	0.045
response to temperature stimulus	GO:0009266	106	0.045
response to nitrogen compound	GO:1901698	90	0.045
oxidative phosphorylation	GO:0006119	9	0.044
actin cytoskeleton organization	GO:0030036	206	0.044
neuron death	GO:0070997	27	0.043
cellular carbohydrate metabolic process	GO:0044262	22	0.042
organelle assembly	GO:0070925	198	0.042
positive regulation of signaling	GO:0023056	243	0.042
adult behavior	GO:0030534	137	0.041
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.041
translation	GO:0006412	69	0.041
purine containing compound metabolic process	GO:0072521	155	0.041
striated muscle myosin thick filament assembly	GO:0071688	3	0.040
regulation of response to oxidative stress	GO:1902882	4	0.039
adult locomotory behavior	GO:0008344	76	0.038
regulation of cellular component biogenesis	GO:0044087	201	0.038
glucan biosynthetic process	GO:0009250	2	0.038
nucleoside biosynthetic process	GO:0009163	3	0.037
regulation of ion transport	GO:0043269	39	0.037
monosaccharide metabolic process	GO:0005996	9	0.037
regulation of developmental growth	GO:0048638	174	0.037
glycosyl compound metabolic process	GO:1901657	127	0.036
macromolecular complex assembly	GO:0065003	256	0.036
response to organic cyclic compound	GO:0014070	89	0.035
mechanosensory behavior	GO:0007638	12	0.035
regulation of protein metabolic process	GO:0051246	256	0.035
lipid modification	GO:0030258	24	0.035
nucleobase containing small molecule metabolic process	GO:0055086	174	0.035
response to peptide hormone	GO:0043434	29	0.034
regulation of neurotransmitter secretion	GO:0046928	14	0.034
neurological system process	GO:0050877	358	0.033
cellular macromolecule localization	GO:0070727	220	0.032
male gamete generation	GO:0048232	201	0.031
carbohydrate derivative metabolic process	GO:1901135	217	0.031
potassium ion transport	GO:0006813	20	0.031
regulation of catalytic activity	GO:0050790	185	0.031
purine ribonucleoside monophosphate biosynthetic process	GO:0009168	3	0.031
protein complex biogenesis	GO:0070271	201	0.030
cellular response to growth factor stimulus	GO:0071363	30	0.030
organonitrogen compound biosynthetic process	GO:1901566	117	0.029
regulation of cellular amine metabolic process	GO:0033238	3	0.029
single organism behavior	GO:0044708	391	0.028
regulation of cellular protein metabolic process	GO:0032268	243	0.028
striated muscle cell development	GO:0055002	50	0.028
response to reactive oxygen species	GO:0000302	24	0.028
regulation of apoptotic process	GO:0042981	130	0.028
columnar cuboidal epithelial cell development	GO:0002066	249	0.027
maintenance of location	GO:0051235	73	0.027
establishment of protein localization	GO:0045184	163	0.027
response to organophosphorus	GO:0046683	2	0.026
protein phosphorylation	GO:0006468	169	0.026
eggshell chorion assembly	GO:0007306	66	0.026
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.026
camera type eye development	GO:0043010	4	0.025
negative regulation of organelle organization	GO:0010639	56	0.025
positive regulation of macromolecule metabolic process	GO:0010604	405	0.025
negative regulation of multicellular organismal process	GO:0051241	142	0.025
innate immune response	GO:0045087	144	0.024
purine nucleoside monophosphate biosynthetic process	GO:0009127	3	0.024
axon guidance	GO:0007411	233	0.024
determination of adult lifespan	GO:0008340	137	0.024
polysaccharide biosynthetic process	GO:0000271	7	0.023
electron transport chain	GO:0022900	14	0.023
intracellular protein transmembrane transport	GO:0065002	4	0.023
larval development	GO:0002164	104	0.023
negative regulation of biosynthetic process	GO:0009890	277	0.023
organic hydroxy compound metabolic process	GO:1901615	83	0.022
myosin filament assembly	GO:0031034	5	0.022
substrate adhesion dependent cell spreading	GO:0034446	2	0.022
muscle contraction	GO:0006936	13	0.022
cellular response to organic substance	GO:0071310	132	0.022
embryo development ending in birth or egg hatching	GO:0009792	152	0.022
synaptic vesicle recycling	GO:0036465	28	0.022
vesicle mediated transport	GO:0016192	381	0.022
response to heat	GO:0009408	63	0.022
organic substance transport	GO:0071702	257	0.021
response to decreased oxygen levels	GO:0036293	58	0.021
monovalent inorganic cation transport	GO:0015672	40	0.021
regulation of molecular function	GO:0065009	217	0.021
respiratory electron transport chain	GO:0022904	11	0.021
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.021
protein modification process	GO:0036211	438	0.020
cellular response to oxygen containing compound	GO:1901701	79	0.020
macromolecule catabolic process	GO:0009057	161	0.020
regulation of ion transmembrane transport	GO:0034765	27	0.020
appendage development	GO:0048736	401	0.020
glycogen biosynthetic process	GO:0005978	2	0.020
cellular homeostasis	GO:0019725	80	0.020
cell motility	GO:0048870	251	0.020
regionalization	GO:0003002	416	0.020
negative regulation of cell cycle	GO:0045786	116	0.019
proteolysis	GO:0006508	192	0.019
rna localization	GO:0006403	115	0.019
regulation of organelle organization	GO:0033043	196	0.019
cellular carbohydrate biosynthetic process	GO:0034637	7	0.019
cellular amine metabolic process	GO:0044106	12	0.019
cell type specific apoptotic process	GO:0097285	38	0.019
nucleoside monophosphate metabolic process	GO:0009123	52	0.019
spermatogenesis	GO:0007283	200	0.019
negative regulation of programmed cell death	GO:0043069	72	0.018
neuromuscular junction development	GO:0007528	149	0.018
immune system process	GO:0002376	347	0.018
activation of mapk activity	GO:0000187	9	0.018
negative regulation of cell death	GO:0060548	81	0.018
axon development	GO:0061564	297	0.017
apoptotic process	GO:0006915	159	0.017
cellular response to endogenous stimulus	GO:0071495	80	0.017
positive regulation of developmental process	GO:0051094	143	0.017
regulation of cellular amino acid metabolic process	GO:0006521	0	0.017
positive regulation of molecular function	GO:0044093	136	0.017
positive regulation of cellular biosynthetic process	GO:0031328	316	0.017
divalent inorganic cation transport	GO:0072511	30	0.017
tube development	GO:0035295	244	0.017
carbohydrate derivative biosynthetic process	GO:1901137	85	0.016
pyridine nucleotide metabolic process	GO:0019362	2	0.016
forebrain development	GO:0030900	2	0.016
muscle system process	GO:0003012	21	0.016
cellular response to organonitrogen compound	GO:0071417	36	0.016
nucleoside phosphate metabolic process	GO:0006753	162	0.016
regulation of cell substrate adhesion	GO:0010810	2	0.016
imaginal disc derived wing morphogenesis	GO:0007476	337	0.016
nuclear division	GO:0000280	332	0.016
integrin mediated signaling pathway	GO:0007229	3	0.016
ribonucleoside metabolic process	GO:0009119	127	0.016
immune response	GO:0006955	246	0.015
single organism cellular localization	GO:1902580	180	0.015
endomembrane system organization	GO:0010256	119	0.015
cell migration	GO:0016477	238	0.015
developmental growth	GO:0048589	280	0.015
cellular catabolic process	GO:0044248	372	0.015
positive regulation of phosphorus metabolic process	GO:0010562	139	0.015
purine ribonucleotide metabolic process	GO:0009150	145	0.015
anion homeostasis	GO:0055081	3	0.015
intracellular mrna localization involved in pattern specification process	GO:0060810	56	0.015
purine nucleoside triphosphate biosynthetic process	GO:0009145	2	0.015
isoprenoid metabolic process	GO:0006720	8	0.014
protein catabolic process	GO:0030163	101	0.014
multi organism reproductive behavior	GO:0044705	121	0.014
morphogenesis of an epithelium	GO:0002009	276	0.014
cellular protein localization	GO:0034613	160	0.014
chemotaxis	GO:0006935	249	0.014
lateral inhibition	GO:0046331	206	0.014
response to starvation	GO:0042594	97	0.014
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.014
regulation of multicellular organism growth	GO:0040014	40	0.014
ribose phosphate biosynthetic process	GO:0046390	28	0.014
pigment metabolic process	GO:0042440	84	0.013
positive regulation of peptidyl tyrosine phosphorylation	GO:0050731	4	0.013
ribonucleotide metabolic process	GO:0009259	145	0.013
cellular response to peptide hormone stimulus	GO:0071375	28	0.013
positive regulation of phosphate metabolic process	GO:0045937	139	0.013
intracellular transport	GO:0046907	228	0.013
cellular carbohydrate catabolic process	GO:0044275	2	0.013
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.013
regeneration	GO:0031099	16	0.013
purine nucleotide metabolic process	GO:0006163	146	0.013
regulation of phosphate metabolic process	GO:0019220	210	0.013
positive regulation of nucleotide metabolic process	GO:0045981	55	0.013
meiotic cell cycle	GO:0051321	171	0.013
nucleotide biosynthetic process	GO:0009165	34	0.013
spinal cord development	GO:0021510	1	0.012
organic hydroxy compound catabolic process	GO:1901616	4	0.012
negative regulation of cellular component organization	GO:0051129	108	0.012
cellular response to nutrient levels	GO:0031669	62	0.012
anatomical structure homeostasis	GO:0060249	97	0.012
cell adhesion	GO:0007155	136	0.012
skeletal muscle fiber development	GO:0048741	3	0.012
regulation of hormone levels	GO:0010817	40	0.012
cell aging	GO:0007569	2	0.012
regulation of cellular ketone metabolic process	GO:0010565	3	0.012
sperm mitochondrion organization	GO:0030382	7	0.012
negative regulation of cellular biosynthetic process	GO:0031327	277	0.012
negative regulation of developmental process	GO:0051093	201	0.012
eggshell formation	GO:0030703	105	0.012
regulation of purine nucleotide metabolic process	GO:1900542	62	0.012
regulation of cytoskeleton organization	GO:0051493	89	0.012
endocytosis	GO:0006897	310	0.012
response to hypoxia	GO:0001666	53	0.012
response to hexose	GO:0009746	3	0.012
oocyte differentiation	GO:0009994	145	0.012
nucleoside triphosphate metabolic process	GO:0009141	120	0.011
retina development in camera type eye	GO:0060041	4	0.011
regulation of nucleotide catabolic process	GO:0030811	48	0.011
sex differentiation	GO:0007548	81	0.011
regulation of cell cycle phase transition	GO:1901987	130	0.011
positive regulation of synaptic transmission	GO:0050806	15	0.011
epithelial cell differentiation	GO:0030855	322	0.011
myotube cell development	GO:0014904	3	0.011
response to calcium ion	GO:0051592	1	0.011
purine ribonucleoside triphosphate biosynthetic process	GO:0009206	2	0.011
alcohol catabolic process	GO:0046164	4	0.011
positive regulation of cellular amine metabolic process	GO:0033240	0	0.011
neuron projection guidance	GO:0097485	241	0.011
nitrogen compound transport	GO:0071705	85	0.011
regulation of intracellular signal transduction	GO:1902531	236	0.011
response to oxygen levels	GO:0070482	59	0.011
peptidyl amino acid modification	GO:0018193	105	0.011
intracellular signal transduction	GO:0035556	300	0.011
chromosome organization	GO:0051276	360	0.011
taxis	GO:0042330	304	0.011
negative regulation of molecular function	GO:0044092	51	0.011
cellular response to decreased oxygen levels	GO:0036294	30	0.011
nucleoside catabolic process	GO:0009164	112	0.011
cellular response to oxidative stress	GO:0034599	28	0.011
negative regulation of neuron apoptotic process	GO:0043524	14	0.010
apoptotic signaling pathway	GO:0097190	27	0.010
negative regulation of cell development	GO:0010721	62	0.010
mitochondrial transport	GO:0006839	8	0.010
regulation of hemocyte proliferation	GO:0035206	37	0.010
positive regulation of response to stimulus	GO:0048584	323	0.010
epithelial tube morphogenesis	GO:0060562	88	0.010
ribose phosphate metabolic process	GO:0019693	145	0.010
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.010
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.010
regulation of cell adhesion	GO:0030155	27	0.010

Pgk disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
glucose metabolism disease	DOID:4194	0.843
carbohydrate metabolism disease	DOID:0050013	0.843
acquired metabolic disease	DOID:0060158	0.843
disease of metabolism	DOID:0014667	0.843
disease of anatomical entity	DOID:7	0.068
inherited metabolic disorder	DOID:655	0.051
kidney disease	DOID:557	0.035
urinary system disease	DOID:18	0.035
synucleinopathy	DOID:0050890	0.010
nervous system disease	DOID:863	0.010
central nervous system disease	DOID:331	0.010
neurodegenerative disease	DOID:1289	0.010

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