Drosophila melanogaster

42 known processes

Actn (Dmel_CG4376)

alpha actinin

(Aliases: l(1)EA82,CT14163,alpha-actinin,CT14232,HM-29,CG4376,actn,EG:133E12.1,y,GA17,fliA,l(1)2Cb,Dmel\CG4376)

Actn biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
myofibril assemblyGO:0030239360.998
sarcomere organizationGO:0045214260.997
striated muscle cell differentiationGO:0051146900.994
muscle structure developmentGO:00610612240.988
actomyosin structure organizationGO:0031032560.970
striated muscle cell developmentGO:0055002500.964
muscle cell developmentGO:0055001500.936
striated muscle myosin thick filament assemblyGO:007168830.902
adult somatic muscle developmentGO:0007527140.868
cellular component assembly involved in morphogenesisGO:00109271510.810
actin cytoskeleton organizationGO:00300362060.783
muscle cell differentiationGO:00426921030.771
striated muscle tissue developmentGO:0014706270.675
Zebrafish
myosin filament assemblyGO:003103450.663
organelle assemblyGO:00709251980.634
actin filament based processGO:00300292200.502
muscle thin filament assemblyGO:007168950.460
cellular protein complex assemblyGO:0043623710.447
skeletal muscle organ developmentGO:0060538480.380
Zebrafish
cellular macromolecular complex assemblyGO:00346221530.373
skeletal myofibril assemblyGO:001486660.309
protein complex biogenesisGO:00702712010.297
Human
locomotory behaviorGO:00076261760.290
protein polymerizationGO:0051258420.268
regulation of cytoskeleton organizationGO:0051493890.262
cell deathGO:00082192790.260
Rat
regulation of actin filament depolymerizationGO:003083430.256
muscle organ developmentGO:00075171270.230
Zebrafish
tube developmentGO:00352952440.226
somatic muscle developmentGO:0007525660.217
regulation of actin cytoskeleton organizationGO:0032956420.201
regulation of actin filament lengthGO:0030832270.195
small molecule metabolic processGO:00442813050.190
actin polymerization or depolymerizationGO:0008154310.185
protein complex assemblyGO:00064612000.160
Human
skeletal muscle fiber developmentGO:004874130.156
Zebrafish
regulation of protein complex disassemblyGO:0043244290.151
actin filament organizationGO:00070151260.146
Mouse
molting cycleGO:0042303560.144
oxidation reduction processGO:00551141230.143
cell proliferationGO:00082832990.140
molting cycle chitin based cuticleGO:0007591560.139
macromolecule catabolic processGO:00090571610.137
Worm
body morphogenesisGO:001017120.131
myosin filament organizationGO:003103350.128
regulation of multicellular organismal developmentGO:20000264140.126
regulation of actin polymerization or depolymerizationGO:0008064270.123
larval developmentGO:00021641040.123
cellular homeostasisGO:0019725800.118
muscle tissue morphogenesisGO:006041520.115
skeletal muscle myosin thick filament assemblyGO:003024130.115
regulation of actin filament based processGO:0032970420.114
muscle tissue developmentGO:0060537300.112
Zebrafish
endocytosisGO:00068973100.112
Mouse
imaginal disc derived wing hair organizationGO:0035317450.106
regulation of cellular component biogenesisGO:00440872010.102
nuclear migrationGO:0007097200.100
skeletal muscle adaptationGO:004350110.094
negative regulation of gene expressionGO:00106293870.091
cell cycle arrestGO:000705040.086
regulation of actin filament polymerizationGO:0030833250.079
macromolecular complex assemblyGO:00650032560.074
Human
protein catabolic processGO:00301631010.072
Worm
reactive oxygen species metabolic processGO:0072593220.070
oxoacid metabolic processGO:00434361030.070
negative regulation of nucleobase containing compound metabolic processGO:00459342610.070
multicellular organism growthGO:0035264460.064
response to abiotic stimulusGO:00096283410.062
Rat
carboxylic acid metabolic processGO:0019752920.061
negative regulation of protein complex disassemblyGO:0043242230.060
cardiac muscle tissue developmentGO:004873890.060
growthGO:00400073590.057
regulation of protein complex assemblyGO:0043254420.057
striated muscle adaptationGO:001488810.056
single organism cellular localizationGO:19025801800.055
programmed cell deathGO:00125012570.053
Rat
myotube cell developmentGO:001490430.046
Zebrafish
nucleus localizationGO:0051647340.046
intracellular protein transportGO:00068861040.046
negative regulation of neural precursor cell proliferationGO:2000178270.045
regulation of ion transportGO:0043269390.042
Human
positive regulation of nucleobase containing compound metabolic processGO:00459353320.042
divalent inorganic cation homeostasisGO:0072507290.042
receptor mediated endocytosisGO:0006898210.041
intracellular transportGO:00469072280.041
tube morphogenesisGO:00352391910.040
regulation of multicellular organism growthGO:0040014400.040
positive regulation of protein transportGO:0051222370.040
regulation of protein polymerizationGO:0032271280.040
positive regulation of transportGO:0051050920.038
Human Mouse
organelle localizationGO:00516401480.038
multi multicellular organism processGO:00447061230.037
cell migrationGO:00164772380.037
establishment of organelle localizationGO:00516561220.037
establishment of protein localizationGO:00451841630.037
tissue morphogenesisGO:00487292970.037
camera type eye developmentGO:004301040.036
carbohydrate biosynthetic processGO:0016051170.036
response to hexoseGO:000974630.036
establishment of oocyte nucleus localization involved in oocyte dorsal ventral axis specificationGO:003072260.035
energy derivation by oxidation of organic compoundsGO:0015980320.035
regulation of transmembrane transportGO:0034762270.034
Human
transmembrane transportGO:00550851390.034
Human
reproductive system developmentGO:0061458740.034
actin filament polymerizationGO:0030041270.033
establishment of localization in cellGO:00516494020.032
regulation of cell deathGO:00109411730.032
Rat
regulation of membrane potentialGO:0042391350.032
Human
regulation of cell differentiationGO:00455953020.032
establishment of synaptic vesicle localizationGO:0097480500.031
nucleotide metabolic processGO:00091171610.031
organic substance catabolic processGO:19015753080.031
Worm
positive regulation of cellular component organizationGO:00511301560.030
Mouse
regulation of growthGO:00400082330.029
multi organism reproductive behaviorGO:00447051210.029
regulation of developmental growthGO:00486381740.029
nucleobase containing compound catabolic processGO:00346551650.029
nucleobase containing small molecule metabolic processGO:00550861740.029
positive regulation of cellular biosynthetic processGO:00313283160.029
neurotransmitter gated ion channel clusteringGO:007257820.028
single organism intracellular transportGO:19025822070.028
cellular macromolecule localizationGO:00707272200.028
Human
apoptotic processGO:00069151590.027
Rat
peptidyl amino acid modificationGO:00181931050.027
skeletal muscle tissue developmentGO:0007519130.027
Zebrafish
single organism biosynthetic processGO:00447112060.027
regulation of programmed cell deathGO:00430671520.027
Rat
multicellular organismal reproductive behaviorGO:00330571100.027
regulation of localizationGO:00328792750.027
Human Mouse
cytoplasmic transport nurse cell to oocyteGO:0007303120.027
gliogenesisGO:0042063800.027
deathGO:00162652840.026
Rat
regulation of anatomical structure morphogenesisGO:00226032420.025
purine ribonucleoside monophosphate metabolic processGO:0009167500.025
positive regulation of macromolecule biosynthetic processGO:00105572830.025
establishment of nucleus localizationGO:0040023260.025
cellular respirationGO:0045333260.025
muscle contractionGO:0006936130.025
Mouse
regulation of sarcomere organizationGO:006029720.024
atp biosynthetic processGO:000675420.024
phagocytosisGO:00069092150.024
positive regulation of molecular functionGO:00440931360.024
Human Mouse
reproductive structure developmentGO:0048608740.023
open tracheal system developmentGO:00074242040.023
cell motilityGO:00488702510.023
male mating behaviorGO:0060179700.023
cytoplasmic transportGO:00164821300.023
metal ion homeostasisGO:0055065440.022
digestive tract developmentGO:00485651490.022
germarium derived egg chamber formationGO:00072931010.022
regulation of protein depolymerizationGO:1901879270.022
carbohydrate metabolic processGO:0005975820.022
positive regulation of actin filament polymerizationGO:0030838110.022
protein modification processGO:00362114380.022
regulation of establishment of protein localizationGO:0070201610.021
matingGO:00076181200.021
protein targetingGO:0006605640.020
chemical homeostasisGO:0048878920.020
neuron recognitionGO:00080381010.020
muscle organ morphogenesisGO:004864470.019
regulation of catabolic processGO:00098941700.019
protein localization to organelleGO:0033365820.019
regulation of necrotic cell deathGO:001093910.019
regulation of cellular localizationGO:00603411360.019
Human
sequestering of calcium ionGO:005120850.019
positive regulation of multicellular organismal processGO:00512401430.019
positive regulation of nucleoside metabolic processGO:0045979470.019
gonad developmentGO:0008406500.019
embryo development ending in birth or egg hatchingGO:00097921520.019
Worm
cardiovascular system developmentGO:0072358820.019
Zebrafish
regulation of nucleotide catabolic processGO:0030811480.019
organonitrogen compound metabolic processGO:19015643180.019
positive regulation of cellular component biogenesisGO:0044089800.019
positive regulation of macromolecule metabolic processGO:00106044050.019
nucleoside phosphate metabolic processGO:00067531620.018
positive regulation of nitrogen compound metabolic processGO:00511733540.018
protein transportGO:00150311550.018
cell cycle phase transitionGO:00447701400.018
heart developmentGO:0007507820.018
Zebrafish
hematopoietic progenitor cell differentiationGO:000224410.018
nad metabolic processGO:001967410.018
striated muscle contractionGO:000694150.018
heart processGO:0003015370.018
localization of cellGO:00516742570.018
sex differentiationGO:0007548810.018
imaginal disc derived appendage morphogenesisGO:00351143950.017
agingGO:00075681430.017
regulation of cytoplasmic transportGO:1903649470.017
axon developmentGO:00615642970.017
organic acid metabolic processGO:00060821030.017
positive regulation of biosynthetic processGO:00098913160.017
cellular nitrogen compound catabolic processGO:00442701650.016
negative regulation of organelle organizationGO:0010639560.016
negative regulation of cell cycle phase transitionGO:19019881030.016
nuclear transportGO:0051169720.016
ovipositionGO:0018991190.016
response to monosaccharideGO:003428440.016
regulation of protein transportGO:0051223570.016
positive regulation of protein import into nucleusGO:0042307210.016
negative regulation of cytoskeleton organizationGO:0051494300.016
maintenance of locationGO:0051235730.016
adult behaviorGO:00305341370.015
regulation of immune system processGO:00026821760.015
cell recognitionGO:00080371020.015
vesicle mediated transportGO:00161923810.015
Mouse
glycosyl compound metabolic processGO:19016571270.015
regulation of cellular amine metabolic processGO:003323830.015
regulation of protein localizationGO:0032880760.015
Human
purine nucleoside metabolic processGO:00422781270.015
nucleoside triphosphate metabolic processGO:00091411200.014
immune system processGO:00023763470.014
negative regulation of cell cycleGO:00457861160.014
multicellular organismal agingGO:00102591400.014
positive regulation of developmental processGO:00510941430.014
stem cell differentiationGO:00488631170.014
cellular carbohydrate catabolic processGO:004427520.014
ribonucleotide catabolic processGO:00092611090.014
reproductive behaviorGO:00190981220.014
cardiac muscle cell differentiationGO:005500740.014
cell adhesionGO:00071551360.014
Human
cellular metal ion homeostasisGO:0006875310.014
cellular catabolic processGO:00442483720.014
negative regulation of protein depolymerizationGO:1901880230.014
regulation of post embryonic developmentGO:0048580100.014
regulation of cell proliferationGO:00421271630.014
protein targeting to nucleusGO:0044744510.013
regulation of nucleoside metabolic processGO:0009118500.013
skin developmentGO:0043588650.013
negative regulation of homeostatic processGO:003284520.013
heterocycle catabolic processGO:00467001660.013
microtubule polymerization or depolymerizationGO:0031109390.013
regulation of cell developmentGO:00602842150.013
negative regulation of cellular protein metabolic processGO:0032269850.013
regulation of sequestering of calcium ionGO:005128230.013
single organism nuclear importGO:1902593510.013
circulatory system developmentGO:0072359820.012
Zebrafish
inorganic ion transmembrane transportGO:0098660730.012
Human
atp metabolic processGO:0046034490.012
generation of precursor metabolites and energyGO:0006091420.012
negative regulation of actin filament depolymerizationGO:003083520.012
dna metabolic processGO:00062592270.012
regulation of phosphatase activityGO:001092130.012
ovulationGO:003072840.012
axonogenesisGO:00074092900.012
cellular chemical homeostasisGO:0055082400.012
cell substrate adhesionGO:0031589100.012
Human
regulation of hydrolase activityGO:0051336970.012
regulation of intracellular transportGO:0032386640.012
cellular component disassemblyGO:0022411460.012
epithelial cell differentiationGO:00308553220.012
positive regulation of intracellular transportGO:0032388420.011
nicotinamide nucleotide metabolic processGO:004649620.011
cardiocyte differentiationGO:0035051290.011
response to endogenous stimulusGO:00097191190.011
anatomical structure homeostasisGO:0060249970.011
catabolic processGO:00090564090.011
Worm
lipid localizationGO:0010876540.011
regulation of nervous system developmentGO:00519602480.011
purine ribonucleoside metabolic processGO:00461281270.011
negative regulation of cell deathGO:0060548810.011
positive regulation of protein complex assemblyGO:0031334220.011
negative regulation of cell cycle processGO:00109481090.011
single organism carbohydrate metabolic processGO:0044723720.011
intercellular transportGO:001049620.011
positive regulation of cell motilityGO:200014730.010
ribonucleoside catabolic processGO:00424541120.010
neuroblast differentiationGO:0014016290.010
establishment of protein localization to organelleGO:0072594620.010
regionalizationGO:00030024160.010

Actn disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
musculoskeletal system diseaseDOID:1700.527
muscle tissue diseaseDOID:6600.527
heart diseaseDOID:11400.527
muscular diseaseDOID:008000000.527
disease of anatomical entityDOID:700.527
Human
cardiomyopathyDOID:005070000.527
cardiovascular system diseaseDOID:128700.527
myopathyDOID:42300.527
intrinsic cardiomyopathyDOID:006003600.266
dilated cardiomyopathyDOID:1293000.178
connective tissue diseaseDOID:6500.024
bone diseaseDOID:008000100.024