IMP: Integrative Multi-species Prediction

Drosophila melanogaster

51 known processes

Six4 (Dmel_CG3871)

CG3871 gene product from transcript CG3871-RA

(Aliases: Dmel\CG3871,D-six4,six4,D-Six4,CG3871,six4/5,Dsix4,DSix4)

Entrez: 40297
FLYBASE: FBgn0027364
UniProtKB: Q9Y1P6

Process Predictions
Disease Predictions

Six4 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
tube development	GO:0035295	244	0.897	Mouse Worm
regulation of cell differentiation	GO:0045595	302	0.777	Mouse
regulation of multicellular organismal development	GO:2000026	414	0.626	Mouse
tissue morphogenesis	GO:0048729	297	0.577	Mouse Worm
ovarian follicle cell development	GO:0030707	248	0.533
biological adhesion	GO:0022610	138	0.525
muscle structure development	GO:0061061	224	0.520
germ cell migration	GO:0008354	43	0.473
salivary gland development	GO:0007431	162	0.458
columnar cuboidal epithelial cell development	GO:0002066	249	0.421
negative regulation of cellular metabolic process	GO:0031324	382	0.393	Mouse
positive regulation of macromolecule metabolic process	GO:0010604	405	0.384	Mouse Fly
negative regulation of transcription dna templated	GO:0045892	237	0.344	Mouse
heart development	GO:0007507	82	0.335
regulation of muscle organ development	GO:0048634	13	0.331	Mouse
exocrine system development	GO:0035272	162	0.313
immune system process	GO:0002376	347	0.313	Mouse
salivary gland morphogenesis	GO:0007435	145	0.307
muscle organ development	GO:0007517	127	0.298	Mouse
open tracheal system development	GO:0007424	204	0.279
regulation of response to external stimulus	GO:0032101	115	0.279
sensory organ morphogenesis	GO:0090596	260	0.268	Mouse Fly
positive regulation of biosynthetic process	GO:0009891	316	0.265	Mouse Fly
negative regulation of developmental process	GO:0051093	201	0.262	Mouse
gland development	GO:0048732	191	0.259	Mouse Fly
single organism cell adhesion	GO:0098602	47	0.256
positive regulation of rna biosynthetic process	GO:1902680	266	0.254	Mouse Fly
regulation of cell development	GO:0060284	215	0.252
establishment of localization in cell	GO:0051649	402	0.247
morphogenesis of an epithelium	GO:0002009	276	0.239	Mouse
circulatory system development	GO:0072359	82	0.238
gland morphogenesis	GO:0022612	145	0.237
ameboidal type cell migration	GO:0001667	151	0.234
renal system development	GO:0072001	72	0.230	Mouse
regionalization	GO:0003002	416	0.228
chemotaxis	GO:0006935	249	0.228
eye development	GO:0001654	323	0.226	Mouse Fly
cell motility	GO:0048870	251	0.226	Mouse Fly
positive regulation of rna metabolic process	GO:0051254	271	0.225	Mouse Fly
regulation of protein metabolic process	GO:0051246	256	0.220
eye morphogenesis	GO:0048592	260	0.219	Fly
negative regulation of signaling	GO:0023057	219	0.209
cardiovascular system development	GO:0072358	82	0.207
epithelial cell development	GO:0002064	274	0.196
cell projection assembly	GO:0030031	94	0.195
cell migration	GO:0016477	238	0.190	Mouse Fly
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.182	Mouse Fly
negative regulation of response to stimulus	GO:0048585	258	0.181
post embryonic appendage morphogenesis	GO:0035120	385	0.178
organonitrogen compound metabolic process	GO:1901564	318	0.173
positive regulation of phosphate metabolic process	GO:0045937	139	0.165
compound eye development	GO:0048749	307	0.163	Fly
positive regulation of signaling	GO:0023056	243	0.161
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.159
stem cell differentiation	GO:0048863	117	0.159	Mouse
glial cell migration	GO:0008347	31	0.157	Fly
negative regulation of cell differentiation	GO:0045596	143	0.156	Mouse
respiratory system development	GO:0060541	213	0.150	Mouse
negative regulation of gene expression	GO:0010629	387	0.150	Mouse
neuron projection guidance	GO:0097485	241	0.144
negative regulation of protein phosphorylation	GO:0001933	17	0.143
mesoderm development	GO:0007498	78	0.142
taxis	GO:0042330	304	0.141
synapse assembly	GO:0007416	143	0.141	Mouse
larval visceral muscle development	GO:0007523	9	0.140
regulation of phosphate metabolic process	GO:0019220	210	0.139
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.138
kidney development	GO:0001822	3	0.137	Mouse
regulation of phosphorylation	GO:0042325	147	0.136
urogenital system development	GO:0001655	72	0.135	Mouse
embryonic organ development	GO:0048568	50	0.134	Mouse
digestive tract morphogenesis	GO:0048546	127	0.133	Worm
negative regulation of rna metabolic process	GO:0051253	251	0.132	Mouse
camera type eye morphogenesis	GO:0048593	2	0.132
regulation of cellular ketone metabolic process	GO:0010565	3	0.132
localization of cell	GO:0051674	257	0.132	Mouse Fly
axon guidance	GO:0007411	233	0.131
cellular catabolic process	GO:0044248	372	0.128
negative regulation of multicellular organismal process	GO:0051241	142	0.125	Mouse
regulation of protein modification process	GO:0031399	112	0.125
chorion containing eggshell formation	GO:0007304	105	0.124
gliogenesis	GO:0042063	80	0.123	Fly
compound eye morphogenesis	GO:0001745	249	0.123	Fly
axon development	GO:0061564	297	0.123
epithelial cell differentiation	GO:0030855	322	0.121
negative regulation of cellular biosynthetic process	GO:0031327	277	0.120	Mouse
protein modification process	GO:0036211	438	0.118
regulation of cellular protein metabolic process	GO:0032268	243	0.115
epithelial tube morphogenesis	GO:0060562	88	0.115	Mouse
maintenance of gastrointestinal epithelium	GO:0030277	3	0.114
positive regulation of signal transduction	GO:0009967	223	0.111
imaginal disc derived appendage development	GO:0048737	399	0.110
protein phosphorylation	GO:0006468	169	0.109
phosphorylation	GO:0016310	294	0.108
cellular protein modification process	GO:0006464	438	0.108
regulation of phosphorus metabolic process	GO:0051174	210	0.108
tube morphogenesis	GO:0035239	191	0.106	Mouse Worm
actomyosin structure organization	GO:0031032	56	0.104	Mouse
nephrocyte differentiation	GO:0061319	12	0.103
transcription from rna polymerase ii promoter	GO:0006366	368	0.102	Mouse Fly
single organismal cell cell adhesion	GO:0016337	45	0.102
negative regulation of cell communication	GO:0010648	223	0.100
embryonic morphogenesis	GO:0048598	206	0.100	Mouse Worm Fly
defense response to other organism	GO:0098542	225	0.100
positive regulation of developmental process	GO:0051094	143	0.100	Mouse
embryonic pattern specification	GO:0009880	174	0.099
oxoacid metabolic process	GO:0043436	103	0.099
regulation of catalytic activity	GO:0050790	185	0.098
mesodermal cell migration	GO:0008078	7	0.094
stem cell development	GO:0048864	79	0.094
regulation of molecular function	GO:0065009	217	0.093
defense response	GO:0006952	300	0.093
negative regulation of nervous system development	GO:0051961	92	0.092
negative regulation of cellular protein metabolic process	GO:0032269	85	0.092
embryonic heart tube development	GO:0035050	22	0.092
regulation of transport	GO:0051049	181	0.091
wing disc morphogenesis	GO:0007472	344	0.090
negative regulation of phosphorylation	GO:0042326	35	0.088
immune response	GO:0006955	246	0.088
death	GO:0016265	284	0.088	Mouse Worm
cardioblast differentiation	GO:0010002	20	0.087
regulation of intracellular signal transduction	GO:1902531	236	0.086
morphogenesis of embryonic epithelium	GO:0016331	94	0.086	Mouse
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.086	Mouse
epithelium migration	GO:0090132	148	0.085
cellular amine metabolic process	GO:0044106	12	0.085
organic substance catabolic process	GO:1901575	308	0.084
axonogenesis	GO:0007409	290	0.083
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.083	Mouse
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.083	Mouse
cell adhesion	GO:0007155	136	0.082
apoptotic process	GO:0006915	159	0.082	Mouse Worm
positive regulation of cellular catabolic process	GO:0031331	95	0.082
positive regulation of response to stimulus	GO:0048584	323	0.081
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.081	Mouse Fly
negative regulation of cell development	GO:0010721	62	0.081
regulation of localization	GO:0032879	275	0.078	Mouse
photoreceptor cell differentiation	GO:0046530	170	0.078	Fly
cell proliferation	GO:0008283	299	0.077	Mouse
appendage morphogenesis	GO:0035107	397	0.077
synapse organization	GO:0050808	196	0.076	Mouse
cell death	GO:0008219	279	0.076	Mouse Worm
positive regulation of protein metabolic process	GO:0051247	128	0.075
blastoderm segmentation	GO:0007350	159	0.074
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.074	Mouse Fly
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.074	Mouse Fly
regulation of defense response	GO:0031347	102	0.073
regulation of cellular component biogenesis	GO:0044087	201	0.073	Mouse
regulation of cellular amino acid metabolic process	GO:0006521	0	0.073
establishment of organelle localization	GO:0051656	122	0.073
positive regulation of cell communication	GO:0010647	250	0.072
wnt signaling pathway	GO:0016055	98	0.072
renal filtration cell differentiation	GO:0061318	12	0.071
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.071	Mouse Fly
male gamete generation	GO:0048232	201	0.070	Mouse Fly
purine ribonucleoside metabolic process	GO:0046128	127	0.068
catabolic process	GO:0009056	409	0.068
striated muscle cell differentiation	GO:0051146	90	0.068
appendage development	GO:0048736	401	0.068
regulation of cellular amine metabolic process	GO:0033238	3	0.066
neuron recognition	GO:0008038	101	0.066
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.065
negative regulation of signal transduction	GO:0009968	206	0.065
larval development	GO:0002164	104	0.065
regulation of immune system process	GO:0002682	176	0.065
kidney morphogenesis	GO:0060993	3	0.064	Mouse
developmental programmed cell death	GO:0010623	138	0.064
positive regulation of phosphorus metabolic process	GO:0010562	139	0.064
regulation of protein phosphorylation	GO:0001932	64	0.063
intracellular signal transduction	GO:0035556	300	0.063
negative regulation of phosphate metabolic process	GO:0045936	45	0.062
gonadal mesoderm development	GO:0007506	8	0.061
epithelial cell migration	GO:0010631	148	0.061
cellular ketone metabolic process	GO:0042180	24	0.060
positive regulation of transcription dna templated	GO:0045893	266	0.060	Mouse Fly
organic acid metabolic process	GO:0006082	103	0.060
cellular amino acid metabolic process	GO:0006520	61	0.060
protein localization	GO:0008104	284	0.059	Mouse
epithelial cell migration open tracheal system	GO:0007427	32	0.059
aging	GO:0007568	143	0.058
positive regulation of response to external stimulus	GO:0032103	44	0.058
visceral muscle development	GO:0007522	14	0.058
negative regulation of protein metabolic process	GO:0051248	85	0.057
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	38	0.057
amine metabolic process	GO:0009308	12	0.057
carboxylic acid metabolic process	GO:0019752	92	0.057
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.056
malpighian tubule development	GO:0072002	64	0.056
digestive system development	GO:0055123	149	0.055	Worm
malpighian tubule morphogenesis	GO:0007443	44	0.054
small molecule metabolic process	GO:0044281	305	0.054
regulation of anatomical structure morphogenesis	GO:0022603	242	0.054	Mouse
negative regulation of phosphorus metabolic process	GO:0010563	45	0.053
actin cytoskeleton organization	GO:0030036	206	0.052	Mouse
female sex differentiation	GO:0046660	20	0.052
growth	GO:0040007	359	0.052	Mouse
signal transduction by phosphorylation	GO:0023014	107	0.051
regulation of immune response	GO:0050776	118	0.051
response to other organism	GO:0051707	293	0.051
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.051
cuticle development	GO:0042335	86	0.051
positive regulation of phosphorylation	GO:0042327	87	0.050
cuticle pattern formation	GO:0035017	27	0.050
embryonic development via the syncytial blastoderm	GO:0001700	148	0.050
gonad development	GO:0008406	50	0.050
outflow tract morphogenesis	GO:0003151	4	0.050
heart morphogenesis	GO:0003007	32	0.049
positive regulation of cellular biosynthetic process	GO:0031328	316	0.049	Mouse Fly
development of primary sexual characteristics	GO:0045137	50	0.049
positive regulation of gene expression	GO:0010628	290	0.048	Mouse Fly
segmentation	GO:0035282	207	0.048
single organism behavior	GO:0044708	391	0.048
positive regulation of cell differentiation	GO:0045597	64	0.048
response to external biotic stimulus	GO:0043207	293	0.047
response to wounding	GO:0009611	94	0.046
stem cell maintenance	GO:0019827	67	0.046
regulation of innate immune response	GO:0045088	71	0.046
regulation of neurogenesis	GO:0050767	158	0.045
single organism intracellular transport	GO:1902582	207	0.045
regulation of growth	GO:0040008	233	0.045	Mouse
cellular nitrogen compound catabolic process	GO:0044270	165	0.045
secretion by cell	GO:0032940	101	0.044
positive regulation of molecular function	GO:0044093	136	0.044
regulation of nervous system development	GO:0051960	248	0.044	Mouse
imaginal disc derived wing morphogenesis	GO:0007476	337	0.044
epidermal growth factor receptor signaling pathway	GO:0007173	58	0.044
regulation of cytoskeleton organization	GO:0051493	89	0.044
anterior posterior pattern specification	GO:0009952	136	0.044
response to extracellular stimulus	GO:0009991	116	0.044
kidney epithelium development	GO:0072073	3	0.044	Mouse
cell cell junction assembly	GO:0007043	38	0.044
genital disc development	GO:0035215	44	0.043
regulation of epithelial cell proliferation	GO:0050678	4	0.043	Mouse
imaginal disc pattern formation	GO:0007447	91	0.043
response to abiotic stimulus	GO:0009628	341	0.043
carbohydrate derivative metabolic process	GO:1901135	217	0.043
cytoplasmic transport	GO:0016482	130	0.042
organ formation	GO:0048645	39	0.042
purine containing compound metabolic process	GO:0072521	155	0.042
positive regulation of purine nucleotide metabolic process	GO:1900544	55	0.041
establishment of protein localization	GO:0045184	163	0.041
pericardial nephrocyte differentiation	GO:0061320	9	0.041
hindgut morphogenesis	GO:0007442	58	0.041
negative regulation of growth	GO:0045926	84	0.041
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	65	0.041
glial cell differentiation	GO:0010001	35	0.041
positive regulation of programmed cell death	GO:0043068	62	0.040
developmental growth	GO:0048589	280	0.040	Mouse
defense response to bacterium	GO:0042742	178	0.040
dna metabolic process	GO:0006259	227	0.040
regulation of protein kinase activity	GO:0045859	51	0.039
organelle localization	GO:0051640	148	0.039
skin development	GO:0043588	65	0.039
regulation of cell proliferation	GO:0042127	163	0.039	Mouse
single organism cellular localization	GO:1902580	180	0.038
negative regulation of neurogenesis	GO:0050768	53	0.038
anterior posterior pattern specification imaginal disc	GO:0007448	16	0.037
negative regulation of protein modification process	GO:0031400	29	0.037
negative regulation of biosynthetic process	GO:0009890	277	0.037	Mouse
nucleobase containing compound catabolic process	GO:0034655	165	0.037
response to bacterium	GO:0009617	198	0.036
rhythmic process	GO:0048511	106	0.036	Fly
nucleoside metabolic process	GO:0009116	127	0.036
regulation of cellular catabolic process	GO:0031329	157	0.036
regulation of catabolic process	GO:0009894	170	0.036
response to organic substance	GO:0010033	284	0.036
response to biotic stimulus	GO:0009607	294	0.036
digestive tract development	GO:0048565	149	0.036	Worm
positive regulation of nucleotide metabolic process	GO:0045981	55	0.035
intracellular transport	GO:0046907	228	0.035
branching involved in open tracheal system development	GO:0060446	45	0.035
response to nutrient levels	GO:0031667	114	0.035
determination of adult lifespan	GO:0008340	137	0.035
cytoskeleton dependent cytokinesis	GO:0061640	81	0.035
ribonucleotide metabolic process	GO:0009259	145	0.035
regulation of transferase activity	GO:0051338	58	0.035
embryonic hindgut morphogenesis	GO:0048619	48	0.034
nucleobase containing small molecule metabolic process	GO:0055086	174	0.034
response to oxygen containing compound	GO:1901700	200	0.034
cell migration involved in gastrulation	GO:0042074	9	0.034
posttranscriptional regulation of gene expression	GO:0010608	145	0.034
regulation of cell division	GO:0051302	72	0.034
regulation of organ morphogenesis	GO:2000027	78	0.033	Mouse
regulation of reproductive process	GO:2000241	54	0.033
muscle attachment	GO:0016203	36	0.033
spermatid differentiation	GO:0048515	114	0.033	Mouse
regulation of cell cycle	GO:0051726	291	0.033
positive regulation of cellular component biogenesis	GO:0044089	80	0.032
aromatic compound catabolic process	GO:0019439	166	0.032
positive regulation of catalytic activity	GO:0043085	118	0.032
central nervous system development	GO:0007417	201	0.032
microtubule organizing center organization	GO:0031023	168	0.032
germ line stem cell maintenance	GO:0030718	50	0.031
mesoderm morphogenesis	GO:0048332	22	0.031	Worm
positive regulation of multicellular organismal process	GO:0051240	143	0.031	Mouse
regulation of programmed cell death	GO:0043067	152	0.031	Mouse
cellular response to chemical stimulus	GO:0070887	199	0.031
erbb signaling pathway	GO:0038127	58	0.030
lamellipodium assembly	GO:0030032	21	0.030
regulation of embryonic development	GO:0045995	68	0.030	Mouse
regulation of synapse assembly	GO:0051963	94	0.030	Mouse
regulation of wnt signaling pathway	GO:0030111	68	0.030
regulation of cell death	GO:0010941	173	0.030	Mouse
lipid metabolic process	GO:0006629	121	0.030
positive regulation of epithelial cell differentiation	GO:0030858	1	0.030
mesenchyme development	GO:0060485	9	0.029	Mouse
dorsal closure	GO:0007391	79	0.029
positive regulation of peptidyl tyrosine phosphorylation	GO:0050731	4	0.029
peptidyl amino acid modification	GO:0018193	105	0.029
regulation of locomotion	GO:0040012	42	0.029
organic substance transport	GO:0071702	257	0.029
branching morphogenesis of an epithelial tube	GO:0048754	45	0.029	Mouse
positive regulation of cell development	GO:0010720	61	0.029
negative regulation of molecular function	GO:0044092	51	0.028
regulation of erbb signaling pathway	GO:1901184	42	0.028
negative regulation of cell cycle	GO:0045786	116	0.028
purine nucleotide metabolic process	GO:0006163	146	0.028
regulation of behavior	GO:0050795	75	0.028
organelle assembly	GO:0070925	198	0.028	Mouse
digestive tract mesoderm development	GO:0007502	5	0.028
sex differentiation	GO:0007548	81	0.028
positive regulation of cell migration	GO:0030335	2	0.027
innate immune response	GO:0045087	144	0.027
programmed cell death	GO:0012501	257	0.027	Mouse Worm
actin filament organization	GO:0007015	126	0.027
positive regulation of immune response	GO:0050778	63	0.027
eye photoreceptor cell development	GO:0042462	81	0.027
muscle cell differentiation	GO:0042692	103	0.027
response to hexose	GO:0009746	3	0.027
regulation of epithelial cell migration open tracheal system	GO:2000274	11	0.027
regulation of mapk cascade	GO:0043408	92	0.026
positive regulation of lipid metabolic process	GO:0045834	4	0.026
negative regulation of cell cycle process	GO:0010948	109	0.026
organic cyclic compound catabolic process	GO:1901361	168	0.026
heterocycle catabolic process	GO:0046700	166	0.026
negative regulation of epithelial cell proliferation	GO:0050680	4	0.026
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.026	Mouse Fly
ribonucleoside catabolic process	GO:0042454	112	0.026
dorsal ventral pattern formation	GO:0009953	133	0.026
negative regulation of catalytic activity	GO:0043086	42	0.026
organonitrogen compound catabolic process	GO:1901565	128	0.026
positive regulation of defense response	GO:0031349	59	0.026
embryo development ending in birth or egg hatching	GO:0009792	152	0.025	Mouse
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.025
defense response to gram negative bacterium	GO:0050829	94	0.025
endocytosis	GO:0006897	310	0.025
positive regulation of cell motility	GO:2000147	3	0.025
hindgut development	GO:0061525	58	0.024
extrinsic apoptotic signaling pathway	GO:0097191	1	0.024
actin filament based process	GO:0030029	220	0.024	Mouse
positive regulation of catabolic process	GO:0009896	105	0.024
negative regulation of cell death	GO:0060548	81	0.024	Mouse
hematopoietic or lymphoid organ development	GO:0048534	57	0.024	Mouse
regulation of cellular localization	GO:0060341	136	0.024
spermatid development	GO:0007286	98	0.024	Mouse
gastrulation	GO:0007369	70	0.024	Worm
carbohydrate derivative catabolic process	GO:1901136	118	0.023
anterior posterior axis specification	GO:0009948	109	0.023
response to alcohol	GO:0097305	95	0.023
peptidyl tyrosine phosphorylation	GO:0018108	24	0.023
g protein coupled receptor signaling pathway	GO:0007186	136	0.023
cellular component assembly involved in morphogenesis	GO:0010927	151	0.023	Mouse
nuclear import	GO:0051170	51	0.023
response to glucose	GO:0009749	2	0.023
regulation of stem cell proliferation	GO:0072091	40	0.023
organelle fission	GO:0048285	340	0.022
positive regulation of cell death	GO:0010942	69	0.022
nephron morphogenesis	GO:0072028	3	0.022	Mouse
somatic muscle development	GO:0007525	66	0.022
nucleoside phosphate metabolic process	GO:0006753	162	0.022
positive regulation of intracellular signal transduction	GO:1902533	116	0.022
nephron epithelium development	GO:0072009	3	0.022	Mouse
establishment of tissue polarity	GO:0007164	87	0.022
synaptic target recognition	GO:0008039	45	0.022
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.022	Mouse
cellular macromolecule localization	GO:0070727	220	0.022	Mouse
photoreceptor cell development	GO:0042461	96	0.022
macromolecule catabolic process	GO:0009057	161	0.022
positive regulation of cellular protein metabolic process	GO:0032270	118	0.022
epidermis development	GO:0008544	65	0.022
cellular macromolecular complex assembly	GO:0034622	153	0.021
muscle cell development	GO:0055001	50	0.021	Mouse
renal tubule development	GO:0061326	64	0.021	Mouse
response to organic cyclic compound	GO:0014070	89	0.021
cell growth	GO:0016049	108	0.021
morphogenesis of a polarized epithelium	GO:0001738	93	0.021
eye photoreceptor cell differentiation	GO:0001754	145	0.021	Fly
positive regulation of cellular component organization	GO:0051130	156	0.021
purine ribonucleoside catabolic process	GO:0046130	112	0.021
organophosphate metabolic process	GO:0019637	195	0.021
epithelial cell proliferation	GO:0050673	15	0.021	Mouse
reproductive structure development	GO:0048608	74	0.020
motor neuron axon guidance	GO:0008045	58	0.020
sensory perception	GO:0007600	196	0.020
adult behavior	GO:0030534	137	0.020
positive regulation of protein modification process	GO:0031401	58	0.020
regulation of imaginal disc derived wing size	GO:0044719	20	0.020
cellular response to external stimulus	GO:0071496	66	0.020
multicellular organismal homeostasis	GO:0048871	41	0.020
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.020
cardiocyte differentiation	GO:0035051	29	0.020
larval somatic muscle development	GO:0007526	19	0.020
cell cycle phase transition	GO:0044770	140	0.020
regulation of cell fate commitment	GO:0010453	29	0.020
establishment of planar polarity	GO:0001736	87	0.020
regulation of protein transport	GO:0051223	57	0.020
regulation of cell cell adhesion	GO:0022407	21	0.020
compound eye retinal cell programmed cell death	GO:0046667	23	0.020
negative regulation of mitotic cell cycle	GO:0045930	109	0.019
peptidyl tyrosine modification	GO:0018212	24	0.019
organ growth	GO:0035265	56	0.019
purine nucleoside catabolic process	GO:0006152	112	0.019
canonical wnt signaling pathway	GO:0060070	21	0.019
instar larval development	GO:0002168	55	0.019
compound eye photoreceptor cell differentiation	GO:0001751	140	0.019	Fly
vesicle mediated transport	GO:0016192	381	0.019
lymph gland development	GO:0048542	28	0.019
purine ribonucleotide catabolic process	GO:0009154	109	0.019
regulation of anatomical structure size	GO:0090066	163	0.019
cellular protein localization	GO:0034613	160	0.019	Mouse
anatomical structure homeostasis	GO:0060249	97	0.019
glycosyl compound catabolic process	GO:1901658	112	0.019
mesodermal cell fate specification	GO:0007501	2	0.019	Worm
cell surface receptor signaling pathway involved in heart development	GO:0061311	3	0.018
embryonic axis specification	GO:0000578	107	0.018
positive regulation of protein transport	GO:0051222	37	0.018
nephron development	GO:0072006	3	0.018	Mouse
positive regulation of cellular amine metabolic process	GO:0033240	0	0.018
retinal cell programmed cell death	GO:0046666	25	0.018
regulation of cell motility	GO:2000145	23	0.018
cellular response to nitrogen compound	GO:1901699	51	0.018
negative regulation of cell proliferation	GO:0008285	69	0.018	Mouse
oocyte maturation	GO:0001556	3	0.018
nucleoside triphosphate catabolic process	GO:0009143	108	0.018
regulation of response to wounding	GO:1903034	19	0.018
compound eye photoreceptor development	GO:0042051	78	0.018
response to monosaccharide	GO:0034284	4	0.018
nucleoside triphosphate metabolic process	GO:0009141	120	0.018
bmp signaling pathway	GO:0030509	27	0.018
positive regulation of apoptotic process	GO:0043065	47	0.018
regulation of intracellular transport	GO:0032386	64	0.018
endodermal cell differentiation	GO:0035987	3	0.018
regulation of organelle organization	GO:0033043	196	0.018
nucleoside catabolic process	GO:0009164	112	0.018
protein transport	GO:0015031	155	0.018
male courtship behavior veined wing extension	GO:0048065	22	0.018
regulation of purine nucleotide catabolic process	GO:0033121	48	0.017
negative regulation of organelle organization	GO:0010639	56	0.017
regulation of developmental pigmentation	GO:0048070	24	0.017
substrate dependent cell migration	GO:0006929	3	0.017
filopodium assembly	GO:0046847	33	0.017
positive regulation of multi organism process	GO:0043902	40	0.017
eggshell formation	GO:0030703	105	0.017
regulation of response to stress	GO:0080134	200	0.017
positive regulation of cell projection organization	GO:0031346	29	0.017
regulation of steroid metabolic process	GO:0019218	2	0.017
regulation of nucleocytoplasmic transport	GO:0046822	35	0.017
regulation of protein import into nucleus	GO:0042306	28	0.017
regulation of cell cycle process	GO:0010564	181	0.017
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.017
regulation of nucleotide metabolic process	GO:0006140	62	0.017
border follicle cell migration	GO:0007298	113	0.017
development of primary female sexual characteristics	GO:0046545	12	0.017
regulation of cellular component movement	GO:0051270	42	0.017
steroid biosynthetic process	GO:0006694	16	0.017
mating	GO:0007618	120	0.017
jnk cascade	GO:0007254	50	0.017
positive regulation of nervous system development	GO:0051962	69	0.016
regulation of epithelial cell differentiation	GO:0030856	4	0.016
skeletal muscle organ development	GO:0060538	48	0.016	Mouse
cell fate specification	GO:0001708	71	0.016	Worm
secretion	GO:0046903	109	0.016
positive regulation of mapk cascade	GO:0043410	63	0.016
endodermal cell fate commitment	GO:0001711	3	0.016
cellular response to organic substance	GO:0071310	132	0.016
protein complex biogenesis	GO:0070271	201	0.016
axis specification	GO:0009798	167	0.016
axis elongation	GO:0003401	3	0.016	Mouse
proteolysis	GO:0006508	192	0.016
neurological system process	GO:0050877	358	0.016
leg disc development	GO:0035218	92	0.016
limb development	GO:0060173	1	0.016
regulation of establishment of protein localization	GO:0070201	61	0.016
ribonucleoside metabolic process	GO:0009119	127	0.016
negative regulation of epidermal growth factor receptor signaling pathway	GO:0042059	29	0.016
mitotic cytokinesis	GO:0000281	50	0.016
developmental growth involved in morphogenesis	GO:0060560	65	0.015	Mouse
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.015
regulation of hydrolase activity	GO:0051336	97	0.015
regulation of organ formation	GO:0003156	3	0.015
mapk cascade	GO:0000165	107	0.015

Six4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.051
organ system cancer	DOID:0050686	0.026
cancer	DOID:162	0.026
disease of cellular proliferation	DOID:14566	0.026
cardiovascular system disease	DOID:1287	0.020

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