IMP: Integrative Multi-species Prediction

Drosophila melanogaster

94 known processes

Sox15 (Dmel_CG8404)

Sox box protein 15

(Aliases: SOX50E,Sox50E,CG13945,SOXF,SOX15,SoxE,CG8404,DSox-15,Dmel\CG8404,SoxF,Sox F,Dsox-15)

Entrez: 36575
FLYBASE: FBgn0005613
UniProtKB: P40657

Process Predictions
Disease Predictions

Sox15 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
appendage development	GO:0048736	401	0.444	Fly
negative regulation of cell communication	GO:0010648	223	0.181	Human Mouse
adult behavior	GO:0030534	137	0.168
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.140
single organism behavior	GO:0044708	391	0.134
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.121
establishment of localization in cell	GO:0051649	402	0.118
imaginal disc derived appendage development	GO:0048737	399	0.116
skeletal muscle organ development	GO:0060538	48	0.108	Mouse
embryonic morphogenesis	GO:0048598	206	0.107	Human Zebrafish Mouse
ameboidal type cell migration	GO:0001667	151	0.097	Human Zebrafish Mouse
eye photoreceptor cell differentiation	GO:0001754	145	0.092
sensory organ morphogenesis	GO:0090596	260	0.076
tissue migration	GO:0090130	155	0.075	Human
compound eye photoreceptor cell differentiation	GO:0001751	140	0.074
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.072
localization of cell	GO:0051674	257	0.069	Human Zebrafish Mouse
tissue morphogenesis	GO:0048729	297	0.068	Zebrafish Mouse
negative regulation of signaling	GO:0023057	219	0.067	Human Mouse
positive regulation of gene expression	GO:0010628	290	0.062	Human Zebrafish Mouse Fly
response to organic substance	GO:0010033	284	0.061
eye morphogenesis	GO:0048592	260	0.061
positive regulation of transport	GO:0051050	92	0.061
negative regulation of cellular biosynthetic process	GO:0031327	277	0.061
neurological system process	GO:0050877	358	0.057
locomotory behavior	GO:0007626	176	0.056
response to growth factor	GO:0070848	31	0.056
post embryonic appendage morphogenesis	GO:0035120	385	0.056	Fly
cell division	GO:0051301	248	0.056	Mouse
compound eye morphogenesis	GO:0001745	249	0.054
photoreceptor cell differentiation	GO:0046530	170	0.053
digestive tract development	GO:0048565	149	0.053	Human Zebrafish Mouse Fly
central nervous system development	GO:0007417	201	0.052	Fly
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.050	Human Zebrafish Mouse Fly
wing disc morphogenesis	GO:0007472	344	0.049
dendrite development	GO:0016358	204	0.049	Fly
cellular response to external stimulus	GO:0071496	66	0.048
anatomical structure homeostasis	GO:0060249	97	0.048
regulation of cellular localization	GO:0060341	136	0.048
positive regulation of biosynthetic process	GO:0009891	316	0.047	Human Zebrafish Mouse Fly
vesicle mediated transport	GO:0016192	381	0.046
cell proliferation	GO:0008283	299	0.046
defense response	GO:0006952	300	0.045
establishment of tissue polarity	GO:0007164	87	0.045
positive regulation of transcription dna templated	GO:0045893	266	0.044	Human Zebrafish Mouse Fly
regulation of transport	GO:0051049	181	0.043
appendage morphogenesis	GO:0035107	397	0.042	Fly
cellular response to organic substance	GO:0071310	132	0.041
dendrite morphogenesis	GO:0048813	199	0.040	Fly
negative regulation of response to stimulus	GO:0048585	258	0.040	Human Mouse
stem cell differentiation	GO:0048863	117	0.039	Mouse
compound eye development	GO:0048749	307	0.039
regulation of localization	GO:0032879	275	0.037
ovarian follicle cell development	GO:0030707	248	0.037
response to oxygen containing compound	GO:1901700	200	0.035
synaptic transmission	GO:0007268	288	0.034
branching morphogenesis of an epithelial tube	GO:0048754	45	0.034
leg disc development	GO:0035218	92	0.034
cellular protein modification process	GO:0006464	438	0.033
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.033
negative regulation of developmental process	GO:0051093	201	0.033	Mouse
developmental growth	GO:0048589	280	0.032
regionalization	GO:0003002	416	0.032	Mouse Fly
muscle structure development	GO:0061061	224	0.032	Mouse
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.032
transcription from rna polymerase ii promoter	GO:0006366	368	0.032
camera type eye development	GO:0043010	4	0.031
axonogenesis	GO:0007409	290	0.031	Fly
telencephalon development	GO:0021537	2	0.031
embryonic axis specification	GO:0000578	107	0.031
imaginal disc derived wing margin morphogenesis	GO:0008587	41	0.030
regulation of multicellular organismal development	GO:2000026	414	0.030	Zebrafish Mouse
regulation of anatomical structure size	GO:0090066	163	0.030
larval development	GO:0002164	104	0.030	Fly
regulation of phosphate metabolic process	GO:0019220	210	0.029
stem cell development	GO:0048864	79	0.028
eye antennal disc development	GO:0035214	60	0.028
digestive system development	GO:0055123	149	0.028	Human Zebrafish Mouse Fly
protein complex biogenesis	GO:0070271	201	0.027
regulation of immune system process	GO:0002682	176	0.026
morphogenesis of an epithelium	GO:0002009	276	0.026	Zebrafish Mouse
cytoskeleton dependent cytokinesis	GO:0061640	81	0.026
photoreceptor cell fate commitment	GO:0046552	41	0.026
negative regulation of rna metabolic process	GO:0051253	251	0.025
establishment of planar polarity	GO:0001736	87	0.025
kidney development	GO:0001822	3	0.025
single organism intracellular transport	GO:1902582	207	0.025
pigmentation	GO:0043473	75	0.024
imaginal disc derived wing morphogenesis	GO:0007476	337	0.024
positive regulation of molecular function	GO:0044093	136	0.024	Human
negative regulation of protein metabolic process	GO:0051248	85	0.023
cellular response to chemical stimulus	GO:0070887	199	0.023
response to alcohol	GO:0097305	95	0.023
sex differentiation	GO:0007548	81	0.023
neural precursor cell proliferation	GO:0061351	75	0.023
positive regulation of ion transmembrane transporter activity	GO:0032414	4	0.023
negative regulation of rna biosynthetic process	GO:1902679	240	0.022
compound eye photoreceptor development	GO:0042051	78	0.021
muscle contraction	GO:0006936	13	0.021
chemotaxis	GO:0006935	249	0.021	Fly
embryo development ending in birth or egg hatching	GO:0009792	152	0.021	Mouse
eye development	GO:0001654	323	0.021
negative regulation of cellular metabolic process	GO:0031324	382	0.021
blastoderm segmentation	GO:0007350	159	0.021	Fly
protein modification process	GO:0036211	438	0.021
forebrain development	GO:0030900	2	0.021
columnar cuboidal epithelial cell development	GO:0002066	249	0.020
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.020
endocytosis	GO:0006897	310	0.020
regulation of catalytic activity	GO:0050790	185	0.020	Human
anterior posterior pattern specification	GO:0009952	136	0.019	Mouse
circulatory system process	GO:0003013	37	0.019
intracellular transport	GO:0046907	228	0.019
regulation of cell cycle	GO:0051726	291	0.019
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.019
adult locomotory behavior	GO:0008344	76	0.018
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.018	Human Zebrafish Mouse Fly
connective tissue development	GO:0061448	3	0.018	Zebrafish
single organism cellular localization	GO:1902580	180	0.018
regulation of phosphorylation	GO:0042325	147	0.018
secretion	GO:0046903	109	0.018
regulation of reproductive process	GO:2000241	54	0.018
negative regulation of cell differentiation	GO:0045596	143	0.018	Mouse
learning or memory	GO:0007611	141	0.018
rhythmic behavior	GO:0007622	76	0.017
immune response regulating signaling pathway	GO:0002764	2	0.017
negative regulation of programmed cell death	GO:0043069	72	0.017
homeostatic process	GO:0042592	199	0.017
cellular macromolecule localization	GO:0070727	220	0.017	Fly
regulation of phosphorus metabolic process	GO:0051174	210	0.017
skeletal muscle fiber development	GO:0048741	3	0.017
molting cycle process	GO:0022404	29	0.017	Human Mouse
circulatory system development	GO:0072359	82	0.017	Human Zebrafish Mouse
detection of external stimulus	GO:0009581	66	0.017
morphogenesis of a polarized epithelium	GO:0001738	93	0.016
cellular response to carbohydrate stimulus	GO:0071322	4	0.016
neuron projection guidance	GO:0097485	241	0.016	Fly
urogenital system development	GO:0001655	72	0.016	Human
long term memory	GO:0007616	62	0.016
cellular response to endogenous stimulus	GO:0071495	80	0.016
developmental growth involved in morphogenesis	GO:0060560	65	0.016
stem cell division	GO:0017145	69	0.015	Mouse
response to abiotic stimulus	GO:0009628	341	0.015
phototransduction	GO:0007602	52	0.015
neural retina development	GO:0003407	4	0.015
cellular response to mechanical stimulus	GO:0071260	2	0.015
renal system development	GO:0072001	72	0.015	Human
memory	GO:0007613	94	0.015
retina development in camera type eye	GO:0060041	4	0.015
regulation of cell differentiation	GO:0045595	302	0.015	Zebrafish Mouse
mesenchymal cell development	GO:0014031	1	0.014
response to biotic stimulus	GO:0009607	294	0.014
negative regulation of growth	GO:0045926	84	0.014	Human
muscle organ development	GO:0007517	127	0.014	Mouse
development of primary sexual characteristics	GO:0045137	50	0.014
response to nitrogen compound	GO:1901698	90	0.014
response to ketone	GO:1901654	34	0.013
limb morphogenesis	GO:0035108	1	0.013
regulation of cellular amine metabolic process	GO:0033238	3	0.013
imaginal disc pattern formation	GO:0007447	91	0.013
establishment or maintenance of cell polarity	GO:0007163	167	0.013
molting cycle	GO:0042303	56	0.013	Human Mouse
positive regulation of developmental growth	GO:0048639	62	0.013
regulation of molecular function	GO:0065009	217	0.013	Human
aging	GO:0007568	143	0.013
response to endogenous stimulus	GO:0009719	119	0.013
phosphorylation	GO:0016310	294	0.013
axon development	GO:0061564	297	0.013	Fly
negative regulation of multicellular organismal process	GO:0051241	142	0.013	Mouse
positive regulation of immune response	GO:0050778	63	0.012
positive regulation of macromolecule metabolic process	GO:0010604	405	0.012	Human Zebrafish Mouse Fly
cellular response to growth factor stimulus	GO:0071363	30	0.012
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.012
positive regulation of rna metabolic process	GO:0051254	271	0.012	Human Zebrafish Mouse Fly
limb development	GO:0060173	1	0.012
muscle tissue development	GO:0060537	30	0.012	Mouse
single organism carbohydrate metabolic process	GO:0044723	72	0.012
protein phosphorylation	GO:0006468	169	0.012
eye photoreceptor cell development	GO:0042462	81	0.012
positive regulation of response to stimulus	GO:0048584	323	0.012
mesenchymal cell differentiation	GO:0048762	1	0.011
gonad development	GO:0008406	50	0.011
regulation of stress activated mapk cascade	GO:0032872	41	0.011
embryonic organ development	GO:0048568	50	0.011	Zebrafish Mouse
embryonic pattern specification	GO:0009880	174	0.011	Fly
regulation of notch signaling pathway	GO:0008593	100	0.011
response to hormone	GO:0009725	45	0.011
smoothened signaling pathway	GO:0007224	49	0.011
formation of anatomical boundary	GO:0048859	37	0.011
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.011	Human Zebrafish Mouse Fly
taxis	GO:0042330	304	0.011	Fly
endomembrane system organization	GO:0010256	119	0.011
neuron fate commitment	GO:0048663	50	0.011
membrane organization	GO:0061024	112	0.011
golgi organization	GO:0007030	66	0.010
neuroblast proliferation	GO:0007405	74	0.010
regulation of wnt signaling pathway	GO:0030111	68	0.010	Human Mouse Fly
cellular response to organic cyclic compound	GO:0071407	32	0.010
detection of light stimulus	GO:0009583	58	0.010
myotube cell development	GO:0014904	3	0.010
regulation of anatomical structure morphogenesis	GO:0022603	242	0.010	Zebrafish Mouse
protein localization	GO:0008104	284	0.010
macromolecular complex assembly	GO:0065003	256	0.010

Sox15 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of cellular proliferation	DOID:14566	0.073
organ system cancer	DOID:0050686	0.028
cancer	DOID:162	0.028
disease of metabolism	DOID:0014667	0.010

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