IMP: Integrative Multi-species Prediction

Drosophila melanogaster

69 known processes

sif (Dmel_CG34418)

still life

(Aliases: CG34418,RhoGEF,Dmel_CG32414,Dmel_CG5406,Dmel\CG34418,CG5406,SIF,CG32414,CG5256,slf,Sif)

Entrez: 43892
FLYBASE: FBgn0085447
UniProtKB: X2JCJ4
UniProtKB: M9PHI5
UniProtKB: M9PE98
UniProtKB: M9PBR2
UniProtKB: Q8IQ62
UniProtKB: A8JNL5
UniProtKB: P91621
UniProtKB: X2JC30
UniProtKB: P91620
UniProtKB: A8JNL4
UniProtKB: A8JNL6

Process Predictions
Disease Predictions

sif biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
adult locomotory behavior	GO:0008344	76	0.689
synapse organization	GO:0050808	196	0.391
dendrite development	GO:0016358	204	0.357
regulation of cellular component biogenesis	GO:0044087	201	0.266
cell projection assembly	GO:0030031	94	0.205
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.197
synaptic growth at neuromuscular junction	GO:0051124	119	0.184
axonogenesis	GO:0007409	290	0.149
establishment of localization in cell	GO:0051649	402	0.149
neuromuscular junction development	GO:0007528	149	0.139
growth	GO:0040007	359	0.137
regulation of localization	GO:0032879	275	0.126
vesicle mediated transport	GO:0016192	381	0.126
locomotory behavior	GO:0007626	176	0.125
regulation of multicellular organismal development	GO:2000026	414	0.124
dendrite morphogenesis	GO:0048813	199	0.123
neuron neuron synaptic transmission	GO:0007270	14	0.121
synapse assembly	GO:0007416	143	0.119
establishment of synaptic vesicle localization	GO:0097480	50	0.117
neurological system process	GO:0050877	358	0.117
regulation of synapse assembly	GO:0051963	94	0.107
adult behavior	GO:0030534	137	0.107
eye development	GO:0001654	323	0.106
protein modification process	GO:0036211	438	0.104
lateral inhibition	GO:0046331	206	0.102
cell cell adhesion via plasma membrane adhesion molecules	GO:0098742	26	0.101
sensory perception	GO:0007600	196	0.092
synaptic vesicle localization	GO:0097479	53	0.084
small molecule metabolic process	GO:0044281	305	0.076	Human Mouse
cell recognition	GO:0008037	102	0.074
photoreceptor cell differentiation	GO:0046530	170	0.073
establishment of vesicle localization	GO:0051650	51	0.072
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.071	Human Mouse
cellular protein modification process	GO:0006464	438	0.069
neuron projection guidance	GO:0097485	241	0.069
compound eye development	GO:0048749	307	0.069
synaptic transmission	GO:0007268	288	0.069
positive regulation of rna metabolic process	GO:0051254	271	0.069
aromatic compound catabolic process	GO:0019439	166	0.068	Human Mouse
positive regulation of rna biosynthetic process	GO:1902680	266	0.067
regulation of synapse organization	GO:0050807	110	0.067
regulation of molecular function	GO:0065009	217	0.066	Human Mouse
single organism intracellular transport	GO:1902582	207	0.066
regulation of anatomical structure morphogenesis	GO:0022603	242	0.064
epithelial cell development	GO:0002064	274	0.061
receptor clustering	GO:0043113	3	0.061
regulation of cell differentiation	GO:0045595	302	0.059
regulation of cell projection assembly	GO:0060491	30	0.059
establishment of organelle localization	GO:0051656	122	0.058
regulation of cell development	GO:0060284	215	0.056
regulation of epithelial cell proliferation	GO:0050678	4	0.056
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.056	Mouse
regulation of protein metabolic process	GO:0051246	256	0.055
cell growth	GO:0016049	108	0.055
negative regulation of gene expression	GO:0010629	387	0.055
regulation of nervous system development	GO:0051960	248	0.054
positive regulation of macromolecule metabolic process	GO:0010604	405	0.054
appendage morphogenesis	GO:0035107	397	0.054
protein complex biogenesis	GO:0070271	201	0.053
regulation of cell death	GO:0010941	173	0.053
guanosine containing compound catabolic process	GO:1901069	74	0.052	Human Mouse
developmental growth	GO:0048589	280	0.052
death	GO:0016265	284	0.052
transcription from rna polymerase ii promoter	GO:0006366	368	0.052
microtubule based transport	GO:0010970	42	0.050
protein complex assembly	GO:0006461	200	0.050
intracellular transport	GO:0046907	228	0.049
regulation of developmental growth	GO:0048638	174	0.049
macromolecular complex assembly	GO:0065003	256	0.049
single organism membrane organization	GO:0044802	93	0.049
neuron recognition	GO:0008038	101	0.048
regionalization	GO:0003002	416	0.048
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.048
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.047
regulation of neuron projection development	GO:0010975	69	0.047
single organism cellular localization	GO:1902580	180	0.047
secretion by cell	GO:0032940	101	0.045
developmental growth involved in morphogenesis	GO:0060560	65	0.045
positive regulation of signaling	GO:0023056	243	0.044
cell adhesion	GO:0007155	136	0.044	Human
regulation of growth	GO:0040008	233	0.043
organonitrogen compound metabolic process	GO:1901564	318	0.041	Human Mouse
protein maturation	GO:0051604	71	0.041
synaptic vesicle recycling	GO:0036465	28	0.041
sensory organ morphogenesis	GO:0090596	260	0.041
response to organic substance	GO:0010033	284	0.040
single organism cell adhesion	GO:0098602	47	0.040
positive regulation of cellular component biogenesis	GO:0044089	80	0.040
regulation of organelle organization	GO:0033043	196	0.039
multi organism behavior	GO:0051705	175	0.039
membrane depolarization	GO:0051899	4	0.039
organic substance transport	GO:0071702	257	0.038
cell death	GO:0008219	279	0.038
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.038	Human Mouse
regulation of excitatory postsynaptic membrane potential	GO:0060079	3	0.038
gtp metabolic process	GO:0046039	72	0.038	Human Mouse
establishment of protein localization	GO:0045184	163	0.037
positive regulation of cell projection organization	GO:0031346	29	0.037
actin filament organization	GO:0007015	126	0.036
ribonucleoside metabolic process	GO:0009119	127	0.036	Human Mouse
cellular macromolecule localization	GO:0070727	220	0.035
proteolysis	GO:0006508	192	0.035
regulation of synapse structure and activity	GO:0050803	128	0.035
positive regulation of cellular component organization	GO:0051130	156	0.034
neurotransmitter secretion	GO:0007269	35	0.034
regulation of vesicle mediated transport	GO:0060627	59	0.034
endocytosis	GO:0006897	310	0.034
catabolic process	GO:0009056	409	0.034	Human Mouse
synaptic vesicle transport	GO:0048489	50	0.034
positive regulation of cellular protein metabolic process	GO:0032270	118	0.034
cell maturation	GO:0048469	144	0.034
regulation of cytoskeleton organization	GO:0051493	89	0.034
organelle localization	GO:0051640	148	0.034
neuromuscular synaptic transmission	GO:0007274	67	0.033
actin cytoskeleton organization	GO:0030036	206	0.033
membrane organization	GO:0061024	112	0.033
protein heterooligomerization	GO:0051291	4	0.033
terminal button organization	GO:0072553	19	0.033
organic substance catabolic process	GO:1901575	308	0.033	Human Mouse
phosphorylation	GO:0016310	294	0.033
tissue morphogenesis	GO:0048729	297	0.033
single organism behavior	GO:0044708	391	0.032
regulation of anatomical structure size	GO:0090066	163	0.032
compound eye morphogenesis	GO:0001745	249	0.031
columnar cuboidal epithelial cell development	GO:0002066	249	0.031
purine nucleotide catabolic process	GO:0006195	109	0.031	Human Mouse
regulation of neurogenesis	GO:0050767	158	0.031
epithelial cell differentiation	GO:0030855	322	0.031
oxoacid metabolic process	GO:0043436	103	0.030
organic cyclic compound catabolic process	GO:1901361	168	0.030	Human Mouse
positive regulation of cell communication	GO:0010647	250	0.030
developmental cell growth	GO:0048588	52	0.030
positive regulation of protein metabolic process	GO:0051247	128	0.030
muscle structure development	GO:0061061	224	0.030
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.030
regulation of cellular localization	GO:0060341	136	0.029
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.029	Mouse
oocyte development	GO:0048599	124	0.029
cellular macromolecular complex assembly	GO:0034622	153	0.029
response to biotic stimulus	GO:0009607	294	0.029
nucleobase containing compound catabolic process	GO:0034655	165	0.029	Human Mouse
blastoderm segmentation	GO:0007350	159	0.029
purine ribonucleoside metabolic process	GO:0046128	127	0.029	Human Mouse
gtp catabolic process	GO:0006184	72	0.029	Human Mouse
regulation of glutamate receptor signaling pathway	GO:1900449	1	0.028
cellular amino acid metabolic process	GO:0006520	61	0.028
cellular component assembly involved in morphogenesis	GO:0010927	151	0.028
regulation of cellular protein metabolic process	GO:0032268	243	0.028
purine containing compound catabolic process	GO:0072523	112	0.028	Human Mouse
developmental maturation	GO:0021700	172	0.028
response to light stimulus	GO:0009416	124	0.028
learning or memory	GO:0007611	141	0.028
positive regulation of signal transduction	GO:0009967	223	0.028
tripartite regional subdivision	GO:0007351	103	0.028
nucleoside phosphate catabolic process	GO:1901292	110	0.028	Human Mouse
positive regulation of exocytosis	GO:0045921	4	0.028
eye morphogenesis	GO:0048592	260	0.027
cytokinesis	GO:0000910	90	0.027
ribonucleoside catabolic process	GO:0042454	112	0.027	Human Mouse
intraspecies interaction between organisms	GO:0051703	4	0.027
anterior posterior axis specification embryo	GO:0008595	103	0.027
cellular catabolic process	GO:0044248	372	0.027	Human Mouse
cell division	GO:0051301	248	0.027
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.027
protein localization	GO:0008104	284	0.026
positive regulation of gene expression	GO:0010628	290	0.026
immune response	GO:0006955	246	0.026
positive regulation of developmental process	GO:0051094	143	0.026	Mouse
male gamete generation	GO:0048232	201	0.026
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.026
nucleoside triphosphate metabolic process	GO:0009141	120	0.025	Human Mouse
protein transport	GO:0015031	155	0.025
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.025	Human Mouse
positive regulation of transport	GO:0051050	92	0.025
epithelium migration	GO:0090132	148	0.025
ion transport	GO:0006811	145	0.025
multi multicellular organism process	GO:0044706	123	0.025
programmed cell death	GO:0012501	257	0.024
positive regulation of transcription dna templated	GO:0045893	266	0.024
positive regulation of secretion by cell	GO:1903532	20	0.024
protein processing	GO:0016485	68	0.024
single organism catabolic process	GO:0044712	228	0.024	Human Mouse
regulation of endocytosis	GO:0030100	37	0.024
positive regulation of response to stimulus	GO:0048584	323	0.024
positive regulation of multicellular organismal process	GO:0051240	143	0.023	Mouse
vesicle localization	GO:0051648	55	0.023
synaptic vesicle endocytosis	GO:0048488	28	0.023
regulation of catabolic process	GO:0009894	170	0.023	Human Mouse
embryonic pattern specification	GO:0009880	174	0.023
negative regulation of multicellular organismal process	GO:0051241	142	0.023
intracellular protein transport	GO:0006886	104	0.023
axis specification	GO:0009798	167	0.023
positive regulation of phosphorus metabolic process	GO:0010562	139	0.023	Human Mouse
imaginal disc derived appendage development	GO:0048737	399	0.023
glycosyl compound catabolic process	GO:1901658	112	0.022	Human Mouse
regulation of response to stress	GO:0080134	200	0.022
regulation of cellular catabolic process	GO:0031329	157	0.022	Human Mouse
cognition	GO:0050890	141	0.022
organonitrogen compound catabolic process	GO:1901565	128	0.022	Human Mouse
ribonucleotide catabolic process	GO:0009261	109	0.022	Human Mouse
sensory perception of mechanical stimulus	GO:0050954	72	0.022
amine metabolic process	GO:0009308	12	0.022
social behavior	GO:0035176	4	0.022
embryo development ending in birth or egg hatching	GO:0009792	152	0.022
cellular ketone metabolic process	GO:0042180	24	0.022
protein modification by small protein conjugation	GO:0032446	79	0.022
regulation of immune system process	GO:0002682	176	0.022
negative regulation of growth	GO:0045926	84	0.022
positive regulation of neurotransmitter secretion	GO:0001956	2	0.022
appendage development	GO:0048736	401	0.021
regulation of cellular component size	GO:0032535	98	0.021
spermatogenesis	GO:0007283	200	0.021
carboxylic acid metabolic process	GO:0019752	92	0.021
regulation of intracellular signal transduction	GO:1902531	236	0.021	Human Mouse
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.021	Human Mouse
dna metabolic process	GO:0006259	227	0.021
regulation of ion transmembrane transport	GO:0034765	27	0.021
rho protein signal transduction	GO:0007266	14	0.021
imaginal disc derived wing morphogenesis	GO:0007476	337	0.021
organophosphate catabolic process	GO:0046434	112	0.021	Human Mouse
regulation of catalytic activity	GO:0050790	185	0.021	Human Mouse
cilium morphogenesis	GO:0060271	39	0.021
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.021	Human Mouse
forebrain development	GO:0030900	2	0.020
ameboidal type cell migration	GO:0001667	151	0.020
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.020	Human Mouse
phagocytosis	GO:0006909	215	0.020
response to bacterium	GO:0009617	198	0.020
regulation of cell morphogenesis involved in differentiation	GO:0010769	61	0.020
regulation of synaptic growth at neuromuscular junction	GO:0008582	89	0.020
central nervous system development	GO:0007417	201	0.020
embryonic development via the syncytial blastoderm	GO:0001700	148	0.020
secretion	GO:0046903	109	0.020
signal release	GO:0023061	49	0.020
tissue homeostasis	GO:0001894	36	0.020
nucleoside catabolic process	GO:0009164	112	0.020	Human Mouse
negative regulation of cellular component organization	GO:0051129	108	0.020
endomembrane system organization	GO:0010256	119	0.020
regulation of neurotransmitter levels	GO:0001505	38	0.020
photoreceptor cell development	GO:0042461	96	0.020
negative regulation of response to stimulus	GO:0048585	258	0.019
positive regulation of cell development	GO:0010720	61	0.019	Mouse
positive regulation of biosynthetic process	GO:0009891	316	0.019
ovarian follicle cell development	GO:0030707	248	0.019
carbohydrate derivative catabolic process	GO:1901136	118	0.019	Human Mouse
nucleobase containing small molecule metabolic process	GO:0055086	174	0.019	Human Mouse
wing disc morphogenesis	GO:0007472	344	0.019
meiotic cell cycle	GO:0051321	171	0.018
retina development in camera type eye	GO:0060041	4	0.018
eye photoreceptor cell development	GO:0042462	81	0.018
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.018	Human Mouse
innate immune response	GO:0045087	144	0.018
intracellular signal transduction	GO:0035556	300	0.018	Human Mouse
immune system process	GO:0002376	347	0.018
embryonic axis specification	GO:0000578	107	0.018
biological adhesion	GO:0022610	138	0.018	Human
filopodium assembly	GO:0046847	33	0.018
sensory perception of sound	GO:0007605	56	0.018
heterocycle catabolic process	GO:0046700	166	0.018	Human Mouse
border follicle cell migration	GO:0007298	113	0.018
stress activated protein kinase signaling cascade	GO:0031098	55	0.018
regulation of ras protein signal transduction	GO:0046578	93	0.018	Human Mouse
regulation of cell cycle process	GO:0010564	181	0.018
nucleoside triphosphate catabolic process	GO:0009143	108	0.018	Human Mouse
mrna processing	GO:0006397	104	0.017
organic acid metabolic process	GO:0006082	103	0.017
cellularization	GO:0007349	90	0.017
regulation of peptidase activity	GO:0052547	39	0.017
chemotaxis	GO:0006935	249	0.017
epithelial cell migration	GO:0010631	148	0.017
embryonic morphogenesis	GO:0048598	206	0.017
positive regulation of intracellular signal transduction	GO:1902533	116	0.017
localization of cell	GO:0051674	257	0.017	Human
cellular nitrogen compound catabolic process	GO:0044270	165	0.017	Human Mouse
cell proliferation	GO:0008283	299	0.017
synaptic vesicle exocytosis	GO:0016079	16	0.017
sensory perception of pain	GO:0019233	4	0.017
regulation of embryonic development	GO:0045995	68	0.017
carbohydrate derivative metabolic process	GO:1901135	217	0.017	Human Mouse
cilium organization	GO:0044782	41	0.017
tissue migration	GO:0090130	155	0.017
regulation of cellular amine metabolic process	GO:0033238	3	0.017
negative regulation of signaling	GO:0023057	219	0.017
protein phosphorylation	GO:0006468	169	0.017
axon development	GO:0061564	297	0.016
purine nucleotide metabolic process	GO:0006163	146	0.016	Human Mouse
mrna metabolic process	GO:0016071	124	0.016
regulation of receptor activity	GO:0010469	10	0.016
neurotransmitter transport	GO:0006836	37	0.016
organelle assembly	GO:0070925	198	0.016
negative regulation of cell death	GO:0060548	81	0.016
exocrine system development	GO:0035272	162	0.016
positive regulation of molecular function	GO:0044093	136	0.016	Human Mouse
positive regulation of phosphorylation	GO:0042327	87	0.016
peptidyl amino acid modification	GO:0018193	105	0.016
axon extension	GO:0048675	32	0.016
protein ubiquitination	GO:0016567	70	0.016
compound eye photoreceptor cell differentiation	GO:0001751	140	0.016
regulation of hydrolase activity	GO:0051336	97	0.016	Human Mouse
negative regulation of signal transduction	GO:0009968	206	0.016
positive regulation of cellular biosynthetic process	GO:0031328	316	0.016
single organismal cell cell adhesion	GO:0016337	45	0.016
regulation of cell projection organization	GO:0031344	92	0.016
anion homeostasis	GO:0055081	3	0.016
regulation of cell shape	GO:0008360	113	0.016
cytoskeleton dependent cytokinesis	GO:0061640	81	0.016
regulation of cell morphogenesis	GO:0022604	163	0.016
mushroom body development	GO:0016319	70	0.015
defense response	GO:0006952	300	0.015
small gtpase mediated signal transduction	GO:0007264	88	0.015	Human Mouse
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.015
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.015
synaptic transmission glutamatergic	GO:0035249	7	0.015
nucleoside metabolic process	GO:0009116	127	0.015	Human Mouse
response to alcohol	GO:0097305	95	0.015
positive regulation of proteolysis	GO:0045862	52	0.015
cell migration	GO:0016477	238	0.015	Human
posttranscriptional regulation of gene expression	GO:0010608	145	0.015
chromatin assembly	GO:0031497	48	0.015
regulation of transport	GO:0051049	181	0.015
eye photoreceptor cell differentiation	GO:0001754	145	0.015
exocytosis	GO:0006887	28	0.015
organophosphate metabolic process	GO:0019637	195	0.015	Human Mouse
defense response to other organism	GO:0098542	225	0.015
nucleotide catabolic process	GO:0009166	109	0.015	Human Mouse
positive regulation of synaptic vesicle endocytosis	GO:1900244	4	0.015
regulation of transmembrane transport	GO:0034762	27	0.015
cellular protein complex assembly	GO:0043623	71	0.015
anterior posterior axis specification	GO:0009948	109	0.015
epithelial tube morphogenesis	GO:0060562	88	0.015
regulation of dendrite development	GO:0050773	37	0.015
positive regulation of lipid storage	GO:0010884	4	0.015
regulation of lipid storage	GO:0010883	22	0.015
regulation of neuron differentiation	GO:0045664	103	0.015
regulation of mitotic cell cycle	GO:0007346	190	0.015
rhythmic synaptic transmission	GO:0060024	2	0.015
post embryonic appendage morphogenesis	GO:0035120	385	0.015
purine nucleoside catabolic process	GO:0006152	112	0.014	Human Mouse
morphogenesis of an epithelium	GO:0002009	276	0.014
developmental programmed cell death	GO:0010623	138	0.014
regulation of membrane potential	GO:0042391	35	0.014
telencephalon development	GO:0021537	2	0.014
positive regulation of synaptic transmission	GO:0050806	15	0.014
regulation of secretion	GO:0051046	44	0.014
microtubule based movement	GO:0007018	51	0.014
glycosyl compound metabolic process	GO:1901657	127	0.014	Human Mouse
taxis	GO:0042330	304	0.014
positive regulation of synapse assembly	GO:0051965	29	0.014
striated muscle tissue development	GO:0014706	27	0.014
positive regulation of endocytosis	GO:0045807	22	0.014
negative regulation of developmental process	GO:0051093	201	0.014
convergent extension	GO:0060026	2	0.014
regulation of protein modification process	GO:0031399	112	0.014
negative regulation of cellular metabolic process	GO:0031324	382	0.014
morphogenesis of embryonic epithelium	GO:0016331	94	0.014
regulation of ras gtpase activity	GO:0032318	38	0.014	Human Mouse
response to external biotic stimulus	GO:0043207	293	0.014
regulation of apoptotic process	GO:0042981	130	0.014
purine ribonucleoside catabolic process	GO:0046130	112	0.014	Human Mouse
jnk cascade	GO:0007254	50	0.014
vesicle organization	GO:0016050	44	0.014
response to oxygen containing compound	GO:1901700	200	0.013
purine nucleoside metabolic process	GO:0042278	127	0.013	Human Mouse
negative regulation of developmental growth	GO:0048640	64	0.013
nucleoside phosphate metabolic process	GO:0006753	162	0.013	Human Mouse
dna packaging	GO:0006323	91	0.013
chromosome organization	GO:0051276	360	0.013
regulation of nucleoside metabolic process	GO:0009118	50	0.013	Human Mouse
maintenance of location	GO:0051235	73	0.013
regulation of cell cycle phase transition	GO:1901987	130	0.013
regulation of cellular ketone metabolic process	GO:0010565	3	0.013
positive regulation of catalytic activity	GO:0043085	118	0.013	Human Mouse
regulation of cellular amino acid metabolic process	GO:0006521	0	0.013
regulation of neuron death	GO:1901214	26	0.013
positive regulation of protein modification process	GO:0031401	58	0.013
jak stat cascade	GO:0007259	49	0.013
dorsal closure	GO:0007391	79	0.013
positive regulation of hydrolase activity	GO:0051345	78	0.013	Human Mouse
apoptotic process	GO:0006915	159	0.013
eye antennal disc development	GO:0035214	60	0.013
regulation of actin cytoskeleton organization	GO:0032956	42	0.013
protein polymerization	GO:0051258	42	0.012
cellular amine metabolic process	GO:0044106	12	0.012
cortical cytoskeleton organization	GO:0030865	29	0.012
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.012	Human Mouse
positive regulation of secretion	GO:0051047	22	0.012
regulation of programmed cell death	GO:0043067	152	0.012
tube morphogenesis	GO:0035239	191	0.012
protein localization to membrane	GO:0072657	19	0.012
chromatin remodeling	GO:0006338	72	0.012
regulation of cell size	GO:0008361	63	0.012
negative regulation of gene expression epigenetic	GO:0045814	77	0.012
muscle organ development	GO:0007517	127	0.012
stress activated mapk cascade	GO:0051403	52	0.012
spermatid development	GO:0007286	98	0.012
protein modification by small protein conjugation or removal	GO:0070647	106	0.012
regulation of actin filament based process	GO:0032970	42	0.012
positive regulation of gtp catabolic process	GO:0033126	43	0.012	Human Mouse
cilium assembly	GO:0042384	38	0.012
negative regulation of nervous system development	GO:0051961	92	0.012
negative regulation of cell communication	GO:0010648	223	0.012
positive regulation of ras gtpase activity	GO:0032320	36	0.012	Human
spermatid differentiation	GO:0048515	114	0.012
salivary gland development	GO:0007431	162	0.012
neuron maturation	GO:0042551	31	0.012
regulation of nucleotide catabolic process	GO:0030811	48	0.012	Human Mouse
dna conformation change	GO:0071103	105	0.012
response to ethanol	GO:0045471	59	0.012
tissue death	GO:0016271	102	0.012
negative regulation of programmed cell death	GO:0043069	72	0.012
dorsal ventral pattern formation	GO:0009953	133	0.012
regulation of secretion by cell	GO:1903530	39	0.012
nitrogen compound transport	GO:0071705	85	0.011
calcium dependent cell cell adhesion via plasma membrane cell adhesion molecules	GO:0016339	9	0.011
nucleus organization	GO:0006997	45	0.011
positive regulation of developmental growth	GO:0048639	62	0.011
compound eye photoreceptor development	GO:0042051	78	0.011
lipid localization	GO:0010876	54	0.011
cell fate determination	GO:0001709	91	0.011
cytoskeleton dependent intracellular transport	GO:0030705	44	0.011
ovarian follicle cell migration	GO:0007297	121	0.011
cardiovascular system development	GO:0072358	82	0.011
hindgut morphogenesis	GO:0007442	58	0.011
segmentation	GO:0035282	207	0.011
rna localization	GO:0006403	115	0.011
intracellular mrna localization involved in pattern specification process	GO:0060810	56	0.011
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.011
defense response to bacterium	GO:0042742	178	0.011
negative regulation of biosynthetic process	GO:0009890	277	0.011
transmembrane transport	GO:0055085	139	0.011
positive regulation of cell death	GO:0010942	69	0.011
ras protein signal transduction	GO:0007265	88	0.011	Human
regulation of cell cycle	GO:0051726	291	0.011
negative regulation of cell differentiation	GO:0045596	143	0.011
transition metal ion homeostasis	GO:0055076	17	0.011
actin filament based process	GO:0030029	220	0.011
positive regulation of nucleoside metabolic process	GO:0045979	47	0.011	Human Mouse
digestive tract development	GO:0048565	149	0.011
regulation of gene expression epigenetic	GO:0040029	128	0.011
centrosome organization	GO:0051297	163	0.010
organelle fission	GO:0048285	340	0.010
regulation of ion transport	GO:0043269	39	0.010
anterior posterior pattern specification	GO:0009952	136	0.010
histolysis	GO:0007559	102	0.010
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.010	Human Mouse
regulation of gtp catabolic process	GO:0033124	44	0.010	Human Mouse
regulation of immune response	GO:0050776	118	0.010
associative learning	GO:0008306	65	0.010
positive regulation of protein phosphorylation	GO:0001934	34	0.010
protein targeting	GO:0006605	64	0.010
positive regulation of synaptic growth at neuromuscular junction	GO:0045887	26	0.010
regulation of transmembrane transporter activity	GO:0022898	6	0.010

sif disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.026
disease of cellular proliferation	DOID:14566	0.019
cancer	DOID:162	0.019
organ system cancer	DOID:0050686	0.019
nervous system disease	DOID:863	0.019
sensory system disease	DOID:0050155	0.012

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